동해항 관세자유지역 도입 방안

길광수 한국해운물류학회 2003 해운물류:이론과실천 Vol.- No.6

본 연구는 2000년부터 시행중인 우리나라 관세자유지역제도의 주요 내용과 관세자유지역 지정ㆍ운영 현황을 살펴본 후, 동해항의 관세자유지역 도입여건을 분석하고 향후 도입방안을 제시하는데 목적이 있다. 연구 결과, 동해항의 경우 화주 및 선사에 대한 인지도가 낮을 뿐만 아니라 컨테이너선박의 입출항 실적이 전무한 벌크화물 전용항만으로 특화되어 있어, 관세자유지역 도입여건이 매우 열악한 실정이다. 따라서 동해항에 관세자유지역을 도입ㆍ운영하기 위해서는 법률상의 지정요건을 충족해 나가면서, 동해항 활성화의 관건인 북평국가산업단지 활용방안을 적극 강구해야 할 것이다. This paper aims to review the major contents and current status of Customs-Free Zone which has been introduced into specific areas within Busan Port and Gwangyang Port in January 2002, and to suggest measures for establishing Donghae Port Customs-Free Zone. Research findings show that Donghae Port is not preferred by container shipping lines and shippers because of its geo-economical location and bulkcargo-specific port operation. For this reason, the given conditions of Donghae Port for introducing Customs-Free Zone are much inferior. Therefore, in order to establish and operate Donghae Port Customs-Free Zone, some legal requirements for designation should be met from the mid-and-long term point of view, and also measures should be sought to utilize the Bugpyung National Industrial Complex which is expected to play an crucial role for activating Donghae Port.

용량별 죽력 투여가 생쥐의 간과 신장의 조직 및 혈액학적 변화에 미치는 영향

정종길,나창수,김경수,홍광표,김정상 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

Objectives : Bambusae Caulis in Liquamen extracts (BE) has been used for various curative effect that remove intense heat from the heart, replenish deficiency Yin, nourish deficiency blood, resolve phlegm. This study was performed to investigate the toxicity of BE to mice according to the administered dosage. Methods : The experimental groups divided four. Control group treated saline, J1 group treated BE and distilled water in the ratio of 1:15(0.05ml/kg), F2 group treated BE and distilled water in the ratio of 1:7(0.05ml/kg), J3 group treated BE and distilled water in the ratio of 1:17(0.05ml/kg). We administered BE to the mice for 24 weeks at interval of 48 hours, and investigated the body weight, changes in hematological profile, activities of the transaminase(GOT, GPT) and two hepatic antioxidant enzyme(SOD, catalase), and histological changes of the liver and kidney. Results : Leukocytes of J3 group were increased in the administered for 12 weeks, but decreased in the administered for 24 weeks. Platelets were decreased about 36% in J3 group treated for 12 weeks, but increased about 50% in the same group treated for 24 weeks. Blood total proteins were decreased slightly in the all experimental groups compared with control group. The activities of the transaminase and superoxide dismutase(SOD) were increased, but decreased activities of catalase in the J2 and J3 groups administered for 12 or 24 weeks. In the light microscopical observation, ballooned and injured hepatocytes in portal vein area of J1 group occurred, and dilated hepatocytes and disoriented sinusoid observed in J2 group administered extracts to mice for 24 weeks. Apoptosis occured in the ballooned and injured hepatocytes of the portal vein area in J3 group. A agglutination of RBC in glomerular capsule of the kidney observed in the J2 group, and destructed convoluted tubule observed in the J3 group treated for 24 weeks. Conclusions : These results indicate that mice treated with high dose BE develop a hematological changes, dysfuncton of the liver and kidney.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

전격성 경과를 취한 만성 호산구성 폐렴 환자 1예

윤호상,진춘조,유광하,이상엽,이수인,정상만,김선두,이순제,이길도,전혜정 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Chronic eosinophilic pneumonia(CEP) is a rare disease of unknown etiology characterized by chronic infiltration of the lung with eosinophils. It presents with profound systemic symptoms comprising fever, night sweats, weight loss, dyspnea and blood eosinophilia with nonsegmental air-space consolidation confined to the outer third of the lung, the "photographic negative of pulmonary edema". Histopathologic features of chronic eosinophilic pneumonia are intraalveolar and interstitial infiltrations with eosinophils, histiocytes, giant cells, scattered lymphocytes and plasma cells. Glucocorticoid therapy cause prompt resolution of symptoms as well as disappearans of blood eosinophils, elevated serum Ig E levels and the roentgenographic lesions. Infrequent radiographic findings include nodular infiltrates, consolidations, cavitations, atelectasis and pleural effusions. Deaths from CEP although rare, have been reported, but the majorities of CEP have benign courses and do not need a therapy with ventilator. We report a case of chronic eosinophilic pneumonia, which had a sudden course associated with diffuse pneumonic consolidations on the both lung and bilateral pleural effusion.

Human Embryonic Stem Cells Co-Transfected with Tyrosine Hydroxylase and GTP Cyclohydrolase I Relieve Symptomatic Motor Behavior in a Rat Model of Parkinson′s Disease

Kil Kwang-Soo,Lee Chang-Hyun,Shin Hyun-Ah,Cho Hwang-Yoon,Yoon Ji-Yeon,Lee Gun-Soup,Lee Young-Jae,Kim Eun-Young,Park Se-Pill 한국발생생물학회 2003 한국발생생물학회 학술발표대회 Vol.2003 No.1

Main strategy for a treatment of Parkinson's disease (PD), due to a progressive degeneration of dopaminergic neurons, is a pharmaceutical supplement of dopamine derivatives or ceil replacement therapy. Both of these protocols have pros and cons; former exhibiting a dramatic relief but causing a severe side effects on long-term prescription and latter also having a proven effectiveness but having availability and ethical problems Embryonic stem (ES) cells have several characteristics suitable for this purpose. To investigate a possibility of using ES cells as a carrier of therapeutic gene(s), human ES (hES, MB03) cells were transfected with cDNAs coding for tyrosine hydroxylase (TH) in pcDNA3.1 (+) and the transfectants were selected using neomycin (250 ). Expression of TH being confirmed, two of the positive clone (MBTH2 & 8) were second transfected with GTP cyclohydrolase 1 (GTPCH 1) in pcDNA3.1 (+)-hyg followed by selection with hygromycin-B (150 ) and RT-PCR confirmation. By immune-cytochemistry, these genetically modified but undifferentiated dual drug-resistant cells were found to express few of the neuronal markers, such as NF200, -tubulin, and MAP2 as well as astroglial marker GFAP. This results suggest that over-production of BH4 by ectopically expressed GTPCH I may be involved in the induction of those markers. Transplantation of the cells into striatum of 6-OHDA- denervated PD animal model relieved symptomatic rotational behaviors of the animals. Immunohistochemical analyses showed the presence of human cells within the striatum of the recipients. These results suggest a possibility of using hES cells as a carrier of therapeutic gene(s).

Establishment of the Logistics Hub in Northeast Asia on the Basis of LME Warehouses

Kil, Kwang Soo 한국해양수산개발원 2003 해양정책연구 Vol.18 No.2

Human Embryonic Stem Cells Co-Transfected with Tyrosine Hydroxylase and GTP Cyclohydrolase Relieve Symptomatic Motor Behavior in a Rat Model of Parkinson's Disease

Kil, Kwang-Soo,Lee, Chang-Hyun,Shin, Hyun-Ah,Cho, Hwang-Yoon,Yoon, Ji-Yeon,Lee, Gun-Soup,Lee, Young-Jae,Kim, Eun-Young,Park, Se-Pill,Lim, Jin-Ho 한국수정란이식학회 2003 한국수정란이식학회 학술대회 Vol.2003 No.1

국제무역의 순수이론과 해운업

길광수 ( Kwang Soo Kil ) 한국해운물류학회(구 한국해운학회) 1988 해운물류연구 Vol.7 No.-

논문 : 부산항 컨테이너 하역시장 안정화방안

길광수 ( Kwang Soo Kil ) 한국해운물류학회(구 한국해운학회) 2011 해운물류연구 Vol.27 No.2

우리나라 제1위의 컨테이너 항만인 부산항은 신항 개장 및 글로벌 금융위기 여파로 일시적인 수급불균형이 발생함에 따라 매우 불안정한 시장상태를 보이고 있다. 이에 본 논문은 부두운영사 간 과당경쟁으로 불안정한 상황에 놓여있는 부산항 컨테이너 하역시장의 현황과 문제점을 분석한 후, 부산항 컨테이너 하역시장의 안정화방안을 제시하는데 그 목적이 있다. 연구 결과, 부산항 컨테이너 하역시장은 운영사의 수 과다 및 운영단위 소규모, 시장점유율의 변동성 심화, 시장집중률의 하락추세 등으로 경쟁적 시장구조로 변모해 가고 있다. 또한 일시적 수급불균형으로 부두운영사 간 하역요율 인하경쟁 등 과당경쟁이 고조됨에 따라 이윤율의 하락과 운영효율성 저하 등 시장성과가 악화되고 있다. 그러나 부산항 컨테이너 하역시장의 불안정 요인에 대해 관계당사자 간 진단과 처방이 상이한 바, 컨테이너 하역산업의 독특한 산업조직적 특성에 기초한 시장안정화 대책 수립이 긴요하다. 따라서 본 논문에서는 부산항 컨테이너 하역시장을 안정화시키기 위해 처리물량 상한제 등의 수급관리 강화, 개발정책과 운영정책의 연계, 운영구조 개편 및 운영단위 확대, 항만산업경쟁정책 수립 시행, 적정 하역요율 산정 및 덤핑행위 규제, 선사와의 협력 강화, 운영사 간 협력 강화, 처리물량과 연동한 임대료 체계의 탄력적 적용 등의 방안을 제시하였다. The container stevedore market in Busan port is very unstable because of the temporary supply-demand imbalance due to Busan New Port open and the global financial crisis. The objectives of this study are analyzing the current situation and problems of Busan container stevedore market and proposing the stabilization measures. The analysis result shows that the competitions among the container stevedore companies of Busan port are overheated and this is worsening the financial and operating performance of the companies. To prevent the market turmoil, establishment of the market stabilization measures based on the characteristics of stevedore market is very urgent. Therefore, this paper proposes several market stabilization schemes like fortifying the supply and demand management(including upper bound system on container throughputs per container berth), joint policy making between development and operation, improvement of operating structure, enlargement of operating unit, assessment of proper stevedoring tariffs, strengthen cooperation with shipping companies, cooperation between terminal operators, and a flexible terminal lease system considering container throughputs, and so on.

부두운영회사(TOC)제 부두 임대료 체계 개선방안

길광수(Kwang-soo Kil),김은수(Eun-soo Kim) 한국항만경제학회 2016 韓國港灣經濟學會誌 Vol.32 No.4

본 연구는 1997년 부두운영회사(TOC)제 도입 이후 적용과정에서 다수의 문제점이 노정되어 온 현행(2003~2014) TOC제 부두의 임대료 체계를 합리적으로 개선하기 위한 방안을 제시하는데 그 목적이 있다. 이에 따라 표준화, 단순화, 형평성 도모라는 세 가지 방향으로 임대료 체계를 개편하고자 하였다. 최종 개편대안은 재산가치와 정책요율인 무역항사용료가 반영된 임대료 산정 방식을 채택하였다. 왜냐하면 현행 임대료 체계의 가장 큰 문제점을 해소하면서 개편에 따른 혼란을 최소화할 수 있기 때문이다. 나아가 적정대안에 의해 재산정된 안벽임대료의 급격한 인상을 방지하기 위해 TOC제 부두별 개편안벽임대료가 기존 선석임대료와 동일하게 되는 개별 조정률을 도입하였다. 이는 임대인인 정부와 항만공사가 부두운영회사(TOC)의 임대료 부담을 경감하는 정책적 목적이 우선될 필요성이 높았기 때문이다. 본 연구는 임대재산의 재산가치를 반영함은 물론 단순하면서도 표준화된 새로운 TOC제 부두 임대료체계를 마련했다는 데 큰 의의가 있다. 또한 정책요율(무역항 시설사용료)이 적용되는 야적장 · 통로 · 창고(상옥) 임대료를 동일한 기준으로 모든 부두에 적용시킴으로써 일정 부문 형평성을 확보한 것도 큰 성과로 평가할 수 있다. 다만 개별 조정률을 도입함에 따라 안벽임대료가 면적에 비례하여 부과되지 못해 형평성이 저해되는 한계점도 동시에 내포하고 있다. 향후 부두 운영 여건이 개선되는 정도에 따라 단계적으로 부두별 개별 조정률을 동일한 목표 조정률인 0.5 수준으로 현실화시켜야 할 것이다. This study proposes the improvement scheme of the current lease rate assessment system (2003~2014), as a major problem solving area, for the Terminal Operating Company (TOC)’s wharf since the introduction of the TOC system in 1997. The study considers the reform system using three criteria: standardization, simplification, and fairness. The final alternative presented by the study adopts the lease rate assessment system, which newly reflects changes of facilities’ property values for aprons, combining it with the related fees of the Korean seaport dues for open storage yards, warehouses (shed), passages, buildings and lands within leased facilities. The proposal anticipates that the new system will not only minimize stakeholders’ confusion, but also resolve the main problems within the current system. The study, further, introduces the adjustment ratio, which will make the new lease rate of the apron equal to the current lease rate of a berth, for the individual TOC’s wharf, in order to prevent a sharp increment in the lease rate of the apron. This is because the government or port authorities as lessors, need to give priority to lightening the burden of TOC’s costs under the deteriorating business environment such as the slowdown in port throughputs’ growth. This study makes a contribution by suggesting a new lease rate assessment system for the TOC’s wharf, reflecting the value of property as well as leading to its simplification and standardization. Additionally, it may lead to the improvement of fairness by applying the same rate to all leased wharfs for the lease rates of open storage yards, warehouses (shed) and passages. However, it has a limitation that hinders the fairness: the lease rate for the apron cannot be imposed in proportion to the leased area, by applying the individual adjustment ratios. In the future, those adjustment ratios should be, gradually, rationalized to be the same target ratio (0.5) for each wharf, following an improvement in the terminal operating business environment.