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( Ki Jeong Park ),( Hye Mi Jin ),( Young Nan Cho ),( Jeong Hwa Kang ),( Hyun Ju Jung ),( Ji Hyoun Kang ),( Ji Eun Kim ),( Yi Rang Yim ),( Jeong Won Lee ),( Kyung Eun Lee ),( Dong Jin Park ),( Tae Jong 대한류마티스학회 2016 대한류마티스학회지 Vol.23 No.1
Objective. The purpose of this study is to evaluate the clinical and hematological effects of tocilizumab in active rheumatoid arthritis (RA) patients. Methods. Fourteen patients with active RA were enrolled in this study. The patients received tocilizumab 8 mg/kg intravenously every four weeks for 6 months. Disease activity, anemia-related factors including serum hepcidin-25, and hematological parameters were monitored at baseline and at 1, 3, and 6 months after the initiation of treatment. Results. Significant reductions in tender joint count, swollen joint count, visual analogue scale, erythrocyte sedimentation rate (ESR), and C-reactive (CRP) protein plus reductions in a 28-joint disease activity score were observed within one month after the first tocilizumab treatment. These effects lasted throughout the six-month study period. In addition, significant improvements in anemia-related factors such as hepcidin-25, ferritin, iron, hemoglobin, red blood cell counts and mean corpuscular volume were observed during the treatment period. Hematological parameters were improved with reductions in counts for leukocytes, monocytes, neutrophils, and platelets. The lymphocyte counts and their subset numbers were unchanged. Changes in hepcidin levels showed significant correlation with changes in CRP, ESR, ferritin, hemoglobin and counts for red blood cells, leukocytes, and neutrophils during the treatment period. Conclusion. This study demonstrates that tocilizumab significantly and meaningfully reduces disease burden in patients with active RA. In addition, tocilizumab diminishes the levels of inflammatory anemia by inhibiting hepcidin production. These clinical data provide evidence of a favorable outcome from tocilizumab in RA. (J Rheum Dis 2016;23:37-46)
A multicenter prospective study of subtype and clinical features of rosacea in Korea
( Ki Rang Moon ),( Jee Bum Lee ),( Young Chul Kye ),( Kwang Joong Kim ),( Nack In Kim ),( Young Suck Ro ),( Kui Young Park ),( Mi Youn Park ),( Margaret Song ),( Kyu Joong Ahn ),( Hyo Hyun Ahn ),( Mi 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Rosacea is a common chronic inflammatory skin condition. Although several epidemiologic and etiologic studies on Caucasians with large-sized samples have been established, data concerning Asians is quiteinsufficient. Objectives: To evaluate the prevalence, subtype classification, severity, aggravating factors and the degree of recognition of rosacea in Korean patients through a multicenterprospective study. Methods: We evaluated 580 patients who were diagnosed as rosacea from October 2014 to February 2015 at 14 university hospitals. The standard classification and grading system suggested by the National Rosacea Society(NRS) Expert Committee was used.Results: Of the 580 rosacea patients, 71% were females and 29% were males. Forties and fifties accounted for 52.1% of the total patients. While 84.1% of patients revealed single subtypes 15.9% of patients revealed mixed subtypes. Within subtypes, erythematotelangiectatic rosacea(ETR) was the most prevalent. The most common anatomic site was the face. 55.4% of mixed subtype patients elucidated progression from one subtype to another. Progression from ETR to papulopustular rosacea(PPR) was the most common. 77.6% of patients revealed mild. The most common aggravating factor of rosacea was emotional changes(51.6%) and stress(48.3%). Conclusion: By identifying the epidemiologic and etiologic features of Korean rosacea patients, we could suggest useful clinical datas for research, education and announcement of rosacea patients.
( Ki Jeong Park ),( Young Nan Cho ),( Hye Mi Jin ),( Kyung Eun Lee ),( Jeong Won Lee ),( Jeong Hwa Kang ),( Hyun Ju Jung ),( Yi Rang Yim ),( Jung Ho Choi ),( Dong Jin Park ),( Sung Ji Lee ),( Tae Jong 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections and play an important role in mucosal immunity. However, the role of MAIT cells remains enigmatic in autoimmune diseases. Here, we examined the level and function of MAIT cells in patients with rheumatic diseases. Methods: Patients with systemic lupus erythematosus (SLE; n = 54), rheumatoid arthritis (RA; n = 66), Behcet`s disease (n = 9), ankylosing spondylitis (n = 21), and healthy controls (n = 136) were enrolled in the study. MAIT cell, cytokine and programmed death-1 (PD-1) levels were measured by fiow cytometry. Results: Circulating MAIT cell levels were significantly reduced in SLE and RA patients. In particular, this MAIT cell deficiency was more prominent in CD8+ and double-negative T cell subsets, and significantly correlated with disease activity, such as SLE disease activity index (SLEDAI) and 28-joint disease activity score (DAS28). Interestingly, MAIT cell frequency was significantly correlated with natural killer T (NKT) cell frequency in SLE patients. IFN-γ production in MAIT cells was impaired in SLE patients, which was due to an intrinsic defect in the Ca2+/calcineurin/NFAT1 signaling pathway. In SLE patients, MAIT cells were poorly activated by a-galactosylceramide- stimulated NKT cells, thereby showing the dysfunction between MAIT cells and NKT cells. Notably, an elevated expression of PD-1 in MAIT cells and NKT cells was associated with SLE. In RA patients, MAIT cell levels were significantly higher in synovial fiuid than in peripheral blood. Conclusions: Our study primarily demonstrates that MAIT cells are numerically and functionally deficient in SLE. In addition, we report a novel finding that this MAIT cell deficiency is associated with NKT cell deficiency and elevated PD-1 expression. These abnormalities possibly contribute to dysregulated mucosal immunity in SLE.
P077 : The effectiveness of light emitting diode(LED) with 592nm yellow light for photoaged skin
( Ki Rang Moon ),( Young Jee Kim ),( Seon Yong Park ),( Hyuck Hoon Kwon ),( Sook Jung Yun ),( Dae Hun Suh ),( Jee Bum Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: As aging occurs, skin gets more wrinkles and pigmentation, becomes drier and loses its elasticity. Those changes of the skin indicate substantial damage due to UV radiation. In previous reports, LED phototherapy proved to stimulate collagen synthesis and accelerate fibroblast- myofibroblast transformation which displays a composite rejuvenation effect. Objectives: To evaluate the rejuvenation effectiveness and safety of LED phototherapy with yellow light for photoaged skin. Methods: 39 patients with photoaged skin (Korean photographic scale; grade 4~7) were enrolled and treated with a LED device irradiating 592nm yellow light for 5 minutes twice a week for 1 month. And sun-damage reduction wasassessed at 0, 2, 4, and 8 weeks by clinical photographs and the Cutometer® & Mexameter®(MPA 580, Courage +Khazaka Electronic GmbH, Koln, Germany). Results: At final visit at 8 weeks, the Cutometer® parameters R2, R5, and R7 were significantly decreased compared to before treatment, from 0.699 to 0.661 (cheek, p=0.004), 0.547 to 0.429 (cheek, p=0.002), 0.359 to 0.315 (nasolabial fold, p=0.003), respectively. Also, the melanin index(MI) were decreased significantly, from 142.1 to 130.9 (glabella, p=0.005). No severe adverse reactions were occurred. LEDphototherapy with 592nm yellow light can be effective and safe in the treatment of photoaged skin. Conclusion: The findings suggest the LED with 592nm yellow light might be an adjuvant therapeutic tool for photoaged skin.
Park, Yongwhi,Tantry, Udaya,Koh, Jin-Sin,Ahn, Jong-Hwa,Kang, Min,Kim, Kye,Jang, Jeong,Park, Hyun,Park, Jeong-Rang,Hwang, Seok-Jae,Park, Ki-Soo,Kwak, Choong,Hwang, Jin-Yong,Gurbel, Paul,Jeong, Young-Ho Thieme 2017 Thrombosis and Haemostasis Vol.117 No.5
<B>Summary</B><P>The role of platelet-leukocyte interaction in the infarct myocardium still remains unveiled. We aimed to determine the linkage of platelet activation to post-infarct left ventricular remodelling (LVR) process. REMODELING was a prospective, observational, cohort trial including patients (n = 150) with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. Patients were given aspirin plus clopidogrel therapy (600 mg loading and 75 mg daily). Platelet reactivity (PRU: P2Y12 Reaction Units) was assessed with VerifyNow P2Y12 assay on admission. Transthoracic echocardiography was performed on admission and at one-month follow-up. The primary endpoint was the incidence of LVR according to PRU-based quartile distribution. LVR was defined as a relative ≥ 20 % increase in LV end-diastolic volume (LVEDV) between measurements. Adverse LVR was observed in 36 patients (24.0 %). According to PRU quartile, LVR rate was 10.8 % in the first, 23.1 % in the second, 27.0 % in the third, and 35.1 % in the fourth (p = 0.015): the optimal cut-off of PRU was ≥ 248 (area under curve: 0.643; 95 % confidence interval: 0.543 to 0.744; p = 0.010). LVR rate also increased proportionally according to the level of high sensitivity-C reactive protein (hs-CRP) (p = 0.012). In multivariate analysis, the combination of PRU (≥ 248) and hs-CRP (≥ 1.4 mg/l) significantly increased the predictive value for LVR occurrence by about 21-fold. In conclusion, enhanced levels of platelet activation and inflammation determined the incidence of adverse LVR after STEMI. Combining the measurements of these risk factors increased risk discrimination of LVR. The role of intensified antiplatelet or anti-inflammatory therapy in post-infarct LVR process deserves further study.</P>
The Imprinted Messenger RNA Expression in Cloned Porcine Pre-implantation Embryos
Park, Mi-Rung,Kim, Bong-Ki,Lee, Hwi-Cheul,Lee, Poong-Yeon,Hwang, Seong-Soo,Im, Gi-Sun,Woo, Jae-Seok,Cho, Chang-Yeon,Choi, Sun-Ho,Kim, Sang-Woo 韓國受精卵移植學會 2010 한국동물생명공학회지 Vol.25 No.2
The objective of this study was to determine the mRNA expression patterns of several putative imprinted genes in in vivo and in vitro fertilized, parthenogenetic, and cloned porcine preimplantation embryos. Both maternally (Dlk1, IGF2, Peg1/Mest and Ndn) and paternally (IGF2r, H19 and Xist) imprinted genes were selected. We have used reverse transcription polymerase chain reaction (RT-PCR) to investigate gene expression patterns in the porcine embryos. IGF2 transcripts were detected in the most of embryos. In nuclear transfer (NT), Peg1/MEST transcripts showed fluctuating pattern. Dlk1 was only expressed partially from the morula and blastocyst stage of NT embryos. Ndn gene expression was started somewhat early for in vivo embryos. However, the expressions of maternally imprinted genes were similar in all types of blastocysts (NT, in vivo and in vitro fertilized, and parthenogenetic embryos). The IGF2R gene expression level was somewhat irregular and varied among samples. However, for the majority samples of all types of embryos, IGF2R expression was diminished after one- to two-cell stages and reappeared at the morulae or blastocyst stage embryos. H19 gene was only expressed early in parthenogenetic and in vivo embryos. For NT embryos, H19 was only expressed in blastocysts. Xist expression was detected in all blastocysts with the earliest being in vivo 8-cell stage embryos and the last one being NT blastocysts. These putative imprinted genes appeared to have stage specific expression patterns with a fluctuating pattern for some genes (Peg/Mest, IGF2r, H19). These results suggest that stage specific presence of imprinted genes can affect the embryo implantation and fetal development.
Fungal proliferation and calcium accumulation in the orange slime of Cornus controversa
Park, Junhyung,Kwon, Jun Hyeong,Kim, Hae Rang,Kwon, Ohkyung,Koh, Sang-Hyun,Kim, Pan-Gi,Bae, Kwan Ho,Kim, Dong Geun,Kwon, Oh Kyu,Joo, Sung Hyun,Jung, Sung-Gwan,Kim, Ki Woo Sage Publishing 2017 Forest Science And Technology Vol.13 No.4
Park Jeong Rang,Jung Tae Sik,Jung Jung Hwa,Lee Gyeong Won,Kim Me Ae,Park Ki Jong,김덕룡,장세호,Chung Soon Il,Hahm Jong Ryeal 대한의학회 2005 Journal of Korean medical science Vol.20 No.3
Primary hypothyroidism and type 2 diabetes are both typically associated with the increased level of triglycerides. To date, there have been only a few case reports of type 2 diabetes patients with both type V hyperlipoproteinemia and eruptive xanthomas, but there have been no reports of hypothyroidism patients associated with eruptive xanthomas. We report here on a case of a 48-yr old female patient who was diagnosed with type 2 diabetes and primary hypothyroidism associated with both type V hyperlipoproteinemia and eruptive xanthomas. We found rouleaux formation of RBCs in peripheral blood smear, elevated TSH, and low free T4 level, and dyslipidemia (total cholesterol 18.1 mM/L, triglyceride 61.64 mM/L, HDL 3.0 mM/L, and LDL 2.54 mM/L). She has taken fenofibrate, levothyroxine, and oral hypoglycemic agent for 4 months. After treatment, both TSH level and lipid concentration returned to normal range, and her yellowish skin nodules have also disappeared.