비강 및 비인두에 발생한 도립유두종과 편평상피암종의 p53단백 및 세포증식능에 관한 연구

한주호,윤기중,이재규,신대균,박근호,조향정,문형배 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2

The inverted papilloma and squamous cell carcinoma are common neoplasia in the sinonasal cavity and nasopharynx, but the incidence of these tumors are very low and the study on the oncogenesis or biological activity of the tumor cells are not well known. This study was designed to evaluate the oncogenic roles of the p53 gene and the proliferative activity of the tumor cells in the inflammatory polyp, inverted papilloma and squamous cell carcinoma. The experiment was carried by the immunohistochemical stains about the p53 protein, PCNA and Ki-67, histochemical stain about the AgNORs. and flow cytometric analysis about the DNA ploidy using the formalin fixed paraffin embedded tissues. The frequency of the expression of p53 protein was 0%(0/16 cases) in the inflammatory polyps, 18.8% (3/16 cases) in the inverted papillomas, and 87.5%(14/16 cases) in the squamous cell carcinomas. The labelling index(%) of the PCNA and Ki-67 was 5.3% and 3.3% in the inflammatoy polyps, 29.6% and 25.2% in the inverted papillomas, and 51.9% and 36.8% in the squamous cell carcinoma. The expression of the PCNA and Ki-67 was distributed in the periphery of the tumor islands of the inverted papilloma and was distributed in the both of center and periphery of the tumor islands of the squamous cell carcinoma. The number of nuclear AgNORs was increased in the order of inflammatory polyps (0.96), inverted papillomas(1.34) and squamous cell carcinoma(2.09). The frequency of the DNA aneuploidy was 0%(0/16 cases) in the inflammatory polyps, 18.8%(3/16 cases) in the inverted papillomas. and 12.5%(2/16 cases) in the squamous cell carcinomas. Above results indicates that the changes of the p53 gene and proliferative activity of the tumor cells are involved on the oncogenesis and the biological activity of the inverted papilloma or squamous cell carcinoma in the nasopharynx and sinonasa cavity.

중년남성의 골프웨어 쇼핑성향과 판매원 서비스 중요도

한기향,원명심 건국대학교 조형연구소 2004 조형연구 Vol.12 No.-

The purpose of this study was to examine the golf wear shopping orientation of middle-aged men who attain economic security and are one of the major consumer groups. The type of services favored by middle-aged men and salesperson's assessment of services provided by themselves were explored to find out whether there were any differences between the consumers and salespersons. The subjects in this study were male consumers of 40 or over living in Gyeonggi province, new cities and Daejeon and golf wear salespersons, who worked in department stores for two weeks, from April 16 through 29, 2002. 380 questionnaires collected from the consumer group were chosen for analysis, and out of 210 questionnaires from the sales representative group, 207 questionnaires were selected for analysis. The golf wear shopping orientation of the middle-aged men was classified into seven factors: pleasure pursuing, brand considering, complying with the vogue, company seeking, convenience pursuing, economy pursying, on sales associates. When cluster analysis was implemented over three factors out of them, including pleasure pursuing, brand considering and complying with the fashion, there appeared four clusters: pleasure-pursuing group, complying group, indifferent group and brand-interested group. And the middle-aged men were affected by three motivation factors when they bought golf wear: design-fashion, golf wear: design-fashion, goal-directed or economic motivations. The importance of salesperson's groups. In particular, the two groups disagreed with each other the most about the significance of sales skills.

정지영상 압축을 위한 이진적응에 관한 연구

김향태,위승정,정재영,최호진,최봉한,이웅기 조선대학교 통계연구소 1999 統計硏究所論文誌 Vol.1 No.1

대용량 저장장치의 출현, 컴퓨터 성능 및 초고속 망의 급속한 성장, 디지털 필름스캐너의 성능 향상 및 비용 감소 덕분에 디지털 형태로 영상을 다루기 위한 요구가 점차 증대되는 추세이다. 디지털 영상은 항상 고품질을 유지해야 하므로 화소 당 비트를 높게 할당하는데 이때 소요되는 방대한 비트 수를 효과적으로 감소시켜 저장용량 및 대역폭을 줄이기 위해서는 효율적인 영상 압축이 요구된다. 본 눈문은 디지털 영상의 압축을 위한 새로운 이진적응 방식을 제안한다. 먼저 변환된 예측오류를 얻기 위해 적응예측을 하고, 모델 템플리트로부터 적당한 예측오류 값 영역을 하나의 context영역이 되도록 하는 방식으로 부호화에 적절한 수의 context 영역을 결정한다. 그리고 부호화 효율을 개선하기 위해 개별적인 context 영역에서 부호화 될 예측오류가 나타날 확률을 근접하게 추정한 후, 고 빈도 예측 심볼 집합을 이진적응에 적용하여 부호화의 효율을 개선한다.

창작무용 수업에 있어서 협동학습과 경쟁학습이 중학생의 학업성취도에 미치는 영향

전향원,기한준,김성곤 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.3

The purpose of this study was to analyze effects on academic achievements in compare with cooperative and competitive learning models of the creative dance instruction The Experiment was performed in instruction of 12. sessions, In this experiment was participated 74 middle school students, It was divided into cooperative group(n=39) and competitive group(n=35), Each group was recognized small group of 5-6 students and was given an individual role to each others. The measuring tools used in pre-test and post-test was an academic achievement testing sheet, That was conducted by creative ability evaluation standards. The results of this study was as followings Cooperative learning model in creative dance instruction was more effective for learner's academic achievements than competitive learning model, That is, it was more effective for originality, composition and continuity among sub-factors of academic achievements, In conclusion concrete methods to activate creative dance instruction which is in the important position in educational dance of the 7th curriculum can be found in cooperative learning model.

필기체 숫자인식의 최적 신경망 구조 설계를 위한 개선된 유전자 알고리즘

박찬란,김향태,정재영,위승정,최봉한,최호진,이웅기 조선대학교 통계연구소 1999 統計硏究所論文誌 Vol.1 No.1

본 논문에서는 필기체 숫자인식의 최적 신경망 구조 설계를 위하여 유전자 알고리즘과 역전파 알고리즘을 병합하는 방법을 이용하였으며, 유전자 알고리즘은 유전인자의 역할에 따라 독립적으로 적응하는 개선된 선택, 교배, 돌연변이 연산자를 제안하였다. 실험결과는 유전인자의 역할에 적응하는 개선된 연산자들의 실행으로 최적의 신경망 구조를 설계하였고, 설계된 신경망 구조에서의 학습이 가장 좋은 성능을 나타내었다. In this study, the method of using both genetic algorithm and back propagation is proposed to design the structure of optimal neural network recognizing handwritten digits. Improved selection, crossover and mutation operator which can control the genetic algorithm independently according to the role of gene are used in the proposed method. Simulation result shows that the neural network of this method can search effectively the optimal hidden node numbers, connection weight, learning rate and the momentum because of above proposed operators.

HBx형질전환 생쥐에서 발생한 간세포암종에서 H-ras 및 c-myc의 발현에 관한 연구

문형배,소병준,김학철,윤기중,한원철,조향정,유대열,정영진 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2

<연구목적> HBx형질전환 생쥐에서 발생한 간세포암종의 발암과정에 종양유전자(H-rgs, c-myc)의 발현 정도를 조사하고자 하였다. <연구방법> 정상생쥐 12마리(4-18개월) 및 HBx 형질전환 생쥐 44마리(4-18개월)를 대상으로 포르말린에 고정하고 파라핀에 포매한 간 조직을 이용하여 면역조직화학적염색을 실시하였다. 실험군은 정상 부위, 이형성 부위 및 종양 부위로 구분하였으며, 종양 부위는 소결절성병변 부위와 간세 포암종 부위로 구분하였고, 이형성병변 부위는 이형성병변만 발견되는 부위, 소결절성병변과 동반된 이형성병변 부위 및 간세포암종과 동반된 이형성병변 부위로 구분하였다. <연구결과> H-rgs의 발현은 정상 간조직에 비하여 이형성병변 부위(P<0.05) 및 종양 부위(P<0.01)에서 증가하였으며, 소결절성병변 부위과 간세포암종 부위 사이에서는 간세포암종 부위에서 증가된 경향이었으나 통계학적으로 유의한 차이가 없었으며, 각 이형성병변 부위 사이에서도 유의한 차이는 없었다. c-myc의 발현은 정상 간조직 및 이형성병변 부위에 비해 종양 부위에서 증가하였으며(P<0.001), 소결절성병변 부위와 간세포암종 부위에서는 비슷하였고, 각 이형성병변부위 사이에서도 비슷하였다. <결론> HBx형질전환 생쥐에서 발생하는 간세포암종의 발생에 H-rgs는 이형성 변화를 일으키는 시기에 관여하며, c-myc은 이형성병변에서 암으로 이행하는 시기에 관여할 것으로 생각한다. Background: This experiment was designed for the expression of H-ras and c-myc in hepatocarcinogenesis of the HBx transgenic mice. Methods: Immunohistochemical stains in the paraffin embedded tissue of the liver were used for the detection of H-ras and c-myc in the 12 normal mice and 44 HBx transgenic mice of the 4-18 month old. Results: Expression of the H-ras was significantly increased in the dysplastic area (P<0.05) and tumor area (P<0.01) than in the normal liver. But there were no differences of H-ras expression between areas of microscopically identified hepatocellular carcinoma (MI-HCC) and grossly identified hepatocellular carcinoma (GI-HCC) and dysplastic areas among the only dysplastic areas, dysplastic areas with MI-HCC and GI-HCC. Expression of the c-myc was significantly increased in the tumor area (P<0.001) than in the normal liver and dysplastic area. But there were no differences of c-myc expression between areas of MI-HCC and GI-HCC, and dysplastic areas among only dysplastic areas, dysplastic areas with MI-HCC and GI-HCC. Conclusions: Our study suggests that H-ras is related to the dysplastic change and c-myc is related to the neoplastic change in the hepatocarcinogenesis of the HBx transgenic mice.

신동맥 협착 정도에 따른 도플러 초음파 소견

박재성,이혜경,김대호,최득린,권귀향,홍현숙,임한혁,김기정 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

Renal artery stenosis is the one of causes of hypertension in a small percentage of all patients but is only anatomical cause that can be treated by means of surgery and percutanecous transluminal angioplasty. Angiography is the golden standard for diagnosis of renal artery stenosis, but a little invasive. With the advent of abdominal Doppler ultrasonography, renal artery stenosis could be diagnoed noninvasively. The experienced hands appears to be valuable in the doppler examination, ut some investigators consider it almost useless. The authors studied the effect of stenosis of renal artery on the downstream intrarenal blood flow, a snare was placed around renal artery in 12 rabbits and compressed to create stenosis while Doppler ultraonographic curve and flow index were obtained from main renal and interlobar arteries by means of placement of 10-MHz curved linear tranducer directly on the surface of kidney. The Doppler measurements were compared with the percentage of stenosis on angiograms. The results were as follow: 1. Ten satisfactory angiograms and Doppler ultrasonograms were obtained. 2. Three renal arteries were created stenosis below 70% (Group A), Seven were above 70% (Group B). 3. The ranges of RI (resistance index) were 0.61-0.86 (mean 0.78±0.154) at main renal arteries, 0.57-0.85 (mean 0.77±0.231) at interlobar artery. The range of PS (peak systolic velocity) were 13.1-28.8 (mean 21.65±4.445) m/sex at main renal artery, 5.2-18.1 (mean 11.74±4.095) m/sec at interlobar arteries. The RI of rabbits were higher than those of human (mean 0.58±0.05). 4. The range of RI in stenotic arteries of group B were 0.45-0.74 (mean 0.57±0.143) at main renal artery, 0.52-0.65 (mean 59±0.051) at interlobar arteries. The range of PS were 11.2-21.3 (mean 15.04±3.755) m/sec at main renal arte교, 5.7-11.3 (mean 8.24±2.056) at interlobar artery. The difference were statistical y significant (P=0.0302), but without remarkable change in group A. 5. Doppler ultrasonographic curve during progressive compression of renal artery showed dampened systolic waveform and diagonal upstroke at main renal arteries (71.4%) and interlobar arteries (85.7%) in group B, but without remarkable change in group A. 6. Release of the arterial compression caused higher than normal peak systolic velocity initially, at main renal arteries (42.9%) and interlobar arteries (28.6%). but the curve of all rabbits returned to normal within 5 minutes. The Doppler ultrasonographic index and curve were not changed on follow up Doppler ultrasonogram at 5 min. 10 min. 30 min. and 1 hour. The change of the systolic curves that compressed experimentally is identical to change in the pulsus tardus and parvus waveforms seen in both acute and chronic severe renal artery stenosis in humans, can helpul for the diagnosis of renal artery stenosis and the effects of treatment by percutaneous tranluminal angioplasty and surgery.

Dietary fat increases solid tumor growth and metastasis of 4T1 murine mammary carcinoma cells and mortality in obesity-resistant BALB/c mice

Kim, Eun Ji,Choi, Mi-Ran,Park, Heesook,Kim, Minhee,Hong, Ji Eun,Lee, Jae-Yong,Chun, Hyang Sook,Lee, Ki Won,Yoon Park, Jung Han BioMed Central 2011 Breast cancer research Vol.13 No.4

<P><B>Introduction</B></P><P>High-fat diets (HFDs) are known to cause obesity and are associated with breast cancer progression and metastasis. Because obesity is associated with breast cancer progression, it is important to determine whether dietary fat <I>per se </I>stimulates breast cancer progression in the absence of obesity. This study investigated whether an HFD increases breast cancer growth and metastasis, as well as mortality, in obesity-resistant BALB/c mice.</P><P><B>Methods</B></P><P>The 4-week-old, female BALB/c mice were fed HFD (60% kcal fat) or control diet (CD, 10% kcal fat) for 16 weeks. Subsequently, 4T1 mammary carcinoma cells were injected into the inguinal mammary fat pads of mice fed continuously on their respective diets. Cell-cycle progression, angiogenesis, and immune cells in tumor tissues, proteases and adhesion molecules in the lungs, and serum cytokine levels were analyzed with immunohistochemistry, Western blotting, and enzyme-linked immunosorbent assay (ELISA). <I>In vitro </I>studies were also conducted to evaluate the effects of cytokines on 4T1 cell viability, migration, and adhesion.</P><P><B>Results</B></P><P>Spleen and gonadal fat-pad weights, tumor weight, the number and volume of tumor nodules in the lung and liver, and tumor-associated mortality were increased in the HFD group, with only slight increases in energy intake and body weight. HF feeding increased macrophage infiltration into adipose tissues, the number of lipid vacuoles and the expression of cyclin-dependent kinase (CDK)2, cyclin D1, cyclin A, Ki67, CD31, CD45, and CD68 in the tumor tissues, and elevated serum levels of complement fragment 5a (C5a), interleukin (IL)-16, macrophage colony-stimulating factor (M-CSF), soluble intercellular adhesion molecule (sICAM)-1, tissue inhibitors of metalloproteinase (TIMP)-1, leptin, and triggering receptor expressed on myeloid cells (TREM)-1. Protein levels of the urokinase-type plasminogen activator, ICAM-1, and vascular cell adhesion molecule-1 were increased, but plasminogen activator inhibitor-1 levels were decreased in the lungs of the HFD group. <I>In vitro </I>assays using 4T1 cells showed that sICAM-1 increased viability; TREM-1, TIMP-1, M-CSF, and sICAM-1 increased migration; and C5a, sICAM-1, IL-16, M-CSF, TIMP-1, and TREM-1 increased adhesion.</P><P><B>Conclusions</B></P><P>Dietary fat increases mammary tumor growth and metastasis, thereby increasing mortality in obesity-resistant mice.</P>

Effects of Golf Wear Consumers’ Post-COVID-19 Changes of Clothing Benefits Sought on Selection Criteria and Post-Purchase Satisfaction

Ki Hyang Han 한국복식학회 2021 International journal of costume and fashion Vol.21 No.2

This study seeks to identify the factors related to golf wear-seeking benefits for consumers aged 30 to 49 who have recently been noted as new players in the golf wear market, to segment groups for comparison, and to analyze the impact of golf wear benefits sought on selection criteria and post-purchase satisfaction. The survey was conducted from April 18, 2021, to May 12, 2021, on men and women aged 30 to 49 who have experienced purchasing golf wear. A total of 270 responses were used for final analysis through SPSS 25.0. The factor analysis on benefits sought have extracted four factors: Conspicuousness Benefits Sought, Economical Factor Pursuit Benefits, Functional Benefits Sought, and Uniqueness Benefits Sought. Additionally, as a result of segmenting the population according to benefits sought, the sampled group was subdivided into four: Functional Benefits Sought Group, Conspicuousness Benefits Sought Group, Enthusiastic Pursuit Benefits Group, and Economical Factor Pursuit Benefits Group. The factor analysis of selection criteria extracted three factors: Function-oriented Selection Criteria, Aesthetics-oriented Selection Criteria, and Symbolic-oriented Selection Criteria. It is hoped that the results of this research will help golf wear brands establish profitable marketing strategies.

의상디자인학과 ; 또래문화가 프리틴 세대의 제품구매에 미치는 영향

한기향 ( Ki Hyang Han ),원명심 ( Myung Sim Won ) 건국대학교 조형연구소 2008 조형연구 Vol.16 No.-

The purpose of this study was to examine effect of peers on the purchase of preteen. Preteen is the age group between 11 to 13 who are in the high grades of elementary school and it is called tweens. They boast their intensive consumption potentials based on strong economic power and in some cases, influence the consumption of the parents. They make subjective consumptions as adults, but it is the age between youth and teenager which is a very important time to be in the peer group in developmental psychology. It is the time when they find commonness from similar behavior patterns as peer groups, especially, visible clothes. Recently, as the time to hang out with peers is increased through academic institutions after school, clothes is a good element for them to confirm their commonness with their peers since they don`t wear school uniforms as middle school and high school students. For preteen, the peer group as a conformity group has influence on the motive of purchasing products and the actual stage of purchase. The biggest characteristic of the preteen generation is the strong conformity consumption disposition. Especially, their desire to have the object when a friend has it is very strong. Preteen is good at internet does not find it difficult to find the information they want, share it with friends and desire to find and body the product of their desire. The conformity consumption condition of preteen generation is considered to be a means for relationship with friends and the big mouth influence of the leader is massive which they wish to conform with the friend they think is the leader. It is necessary to understand preteen generation cultures which are the most important time to belong to the peer group, establish marketing strategies in accordance, and educate healthy consumption cultures.