Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

전경대원에서 발생한 결핵의 임상 양상

문창기,박상준,조민구,김영중,김소연,김윤권,정준오,안석진,김은실,서승오,김지훈,최원제,이윤영,박형기,최규영,김현근 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

Background: The purpose of this study was to document the incidence and clinical characteristics of patients with tuberculosis (TB) in combat and auxiliary police, living in a group, in Korea where the incidence rate of active TB in a general population is higher than in Western countries. Materials and Methods:We retrospectively reviewed the medical records of all tuberculosis patients diagnosed at National Police Hospital from January 2002 through December 2004. Results:In 2002-2004, a total of 156 cases of tuberculosis were identified with the mean (Standard deviation) age of 20.6 (±1.0) years. Of these, 134 (85.9%) patients were registered as new cases, 11 (7.1%) as relapse, 2 (1.3%) as failure, 5 (3.1%) as treatment-after-default cases whereas 4 (2.6 %) patients were not included in any categories. Average annual new TB rate and smear-positive TB rate were 86.5/10^(5) and 17.4/10^(5) person-years, respectively. In 12 of 31 smear-positive cases, time from onset of symptoms to diagnosis was more than 30 days. Two multidrug-resistance TB cases were identified and two suspected outbreak episodes of TB had occurred during 3 years. Conclusion:There was no statistically significant difference in the incidence rate of new cases of TB between the general population aged 20 to 29 years and combat and auxiliary police in Korea. 배경 : 국내 결핵의 발생은 감소 추세에 있으나 여전히 후진국형 발생양상을 보이고 있다. 특히 집단생활을 하는 젊은이들에서 발생하는 결핵의 유행이 간헐적으로 알려지고 있어 우려를 낳고 있다. 이에 저자들은 최근 전경대원의 결핵 발병 양상에 대해 알아보고자 본 연구를 시행하였다. 재료 및 방법 : 2002년 1월부터 2004년 12월까지 3년간 경찰병원에서 결핵 진료를 받은 전경대원의 의무기록을 후향적으로 분석하여 연도별 결핵 신환발생률, 도말양성결핵 신환율, 진단 지연, 집단발병, 다제내성결핵을 조사하였다. 결과 : 연도별 결핵 신환자 수(10만명당 발생추정치)는 2002년 50명(83.6명), 2003년 42명(83.7명), 2004년 42명(93.5명)이었고 도말양성 폐결핵 신환자 수는 2002년 10명(16.7명), 2003년 11명(21.9명), 2004년 6명(13.4명)이었다. 3년간 도말양성 폐결핵 환자는 31명이 있었고 그 중 12명은 호흡기 증상 발생 30일이 지나서 진단을 받았다. 다제내성 결핵은 2명이 있었으며 결핵의 집단발병이 의심되는 사례는 2차례 있었다. 결론 : 전경대원과 20-29세 연령군 일반인의 결핵 신환발생률, 도말양성 폐결핵 발생률의 통계적으로 유의한 차이는 없었다.

광센서 조광제어시스템에서의 광센서 최적 방향성과 위치에 관한 평가 연구

최안섭,정근영 대한건축학회 2003 대한건축학회논문집 Vol.19 No.10

The purpose of this simulation study was to improve the performance of daylight responsive dimming systems. This simulation study was to analyze the followings. ⅰ) correlation between workplane illuminance and photosensor signal ⅱ) comparison between closed loop proportional and open loop proportional control algorithms in the daylight responssive dimming system. This study used DayDim as a simulation software and four different spatial characteristics of photosensors. Each photosensor has different spatial distributions in the existing photosensor, 0 degree, 30 degree, and 60 degree from nadir. Parameters such as sky condition, seasonal changes, azimuth, photosensor location, and different spatial distribution were considered. The results showed proper photosensor position and spatial distrubution determined by the various parameters.

Predicate formula 와 Prolog 의 Clausal form 과의 關係에 關한 硏究

崔英根 光云大學校 1984 論文集 Vol.13 No.-

Logic programming is a powerful tool for AI, knowledge representation & manipulation and theorem proving. Prolog, one of popular logic programming language, performs atomatic deduction by resolution rule. Resolution rule is simple but has nice mathematical properties. In order to use resolution rule, first-order predicate must be converted to clausal form in Prolog. In this paper, this conversion algorithm and its limitations are described.

fac-Tris(L-serinato)chromium(Ⅲ) 화합물의 분광학적 연구 및 리간드장 분석

최영근,서정선,이규왕 명지대학교 자연과학연구소 1995 자연과학논문집 Vol.12 No.-

중심금속chromium(III)와 리간드인.amino acid(L-serine)[serine=HOCH₂CH(NH₂)CO₂H]사이의 결합의 특성을 파악하기 위하여 저온(13K)에서의 luminescence 스펙트럼과 excitation 스펙트럼을 측정하였다.Tris (L-serinato)chromium(III)착화합물은 산소 원자 3개와 질소원자 3개로 이루어진 facial 형태의 geometry를 가진 착화합물이다.Amino acid 를 리간드로 가진 다른 착화합물과는 달리, serine 착화합물은 β탄소위치에 hydroxy group이 치환되어 있어서 electronic effect 와 steric dffect의 효과를 기대할 수 있다. 산소원자의 π비등방성 결합을 포함한 ligand field analysis로 부터, serine 착화합물의 자세한 electronic structure와 결합특성을 살펴보기로 하겠다. Low temperature (13K)luminescence and excitation spectra were measured to anlayze the bonding characteristics between Cr(III)and amino acid(L-serne) ligand. Tris(L-serinato)chromium(III) complex has three oxygen and three nitrogen ligand atoms in facial geometry. Unlike oter complexes with amino acids, additional hydroxyl group in β-carbon tom is expected to have electronic an steric effects. From the ligand field analysis including anisotropic πbonding on oxygen atom, we found that both oxygen and nitrogen atom is weak σdonor. The splitting of electronic lines and bonding characteristics in the title compound are explained by considering the geometric effect, especially anisotropic πbonding.

우리나라 유방아마에서 CYPIA1, EPHX 유전자 다형성의 역할

최지엽,유정희,이은옥,유근영,박수경,안세현,노동영,최국진,강대희 대한암예방학회 2002 Journal of cancer prevention Vol.7 No.3

기제와 피부투과촉진제가 아포모르핀의 피부투과에 미치는 영향

최영근,최옥,김건남,박은석,지상철 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

In order to evaluate the effects of vehicles and penetration enhancers on skin permeation of apomorphine, the skin permeation rates of apomorphine from vehicles of different composition were determined using Franz diffusion cells fitted with excised rat skins. Solubility of apomorphine in various solvents was investigated to select a vehicle suitable for the percutaneous absorption of apomorphine. The solvents used were propylene glycol (PG), Transcutol^??, Labrasol^??, Labrafac hydro WL^??, Labrafil WL 2609 BS^?? and isopropyl alcohol. Even though permeation rates of apomorphine from each vehicle were low (0.08-0.36㎍/㎠/hr), the combination of PG and Labrafac^?? increased it significantly. The permeation rates of apomophine from PG/Labrafac^?? mixtures increased as the volume fraction of PG in the mixture increased. The maximum permeation rate of 18㎍/㎠/hr was achieved at 30% of PG, which decreased with further increase of PG fraction. A series of fatty acids, alcohols and monoterpenes were employed as penetration enhancers. Incorporation of each enhancer in the PG/Labrafac^?? (30:70) mixture at the level of 10% improved the skin permeation significantly. The highest permeation rate, 117㎍/㎠/hr, was attained with myristic acid.

후하소뇌동맥 동맥류에 의해 유발된 안면경련

최석근,이봉암,고준석,임영진,김국기,김태성 경희대학교 2004 慶熙醫學 Vol.20 No.1

한국구강보건사업이 초등학교 아동들의 유치 및 영구치 우식실태에 미치는 영향

최순례,유영아,조민정,송근배 韓國學校保健學會 2004 韓國學校保健學會誌 Vol.17 No.2

Purpose : The aim of this study was to evaluate the effects of oral health care programs in a school-based oral health care center among primary schoolchildren. Methods : School-based oral health care programs included fluoride mouth rinsing, pit and fissure sealing for permanent premolars and molars, fluoride gel application and chewing of xylitol candy. All of the programs were carried out by one dental hygienist among 'D' primary schoolchildren in Daegu city under the supervision of a dentist. Baseline dental examinations were completed and preventive care was implemented for 544 children during one year. All of the children visited a school-based oral health care center every three months for a regular check-up. The final oral examination was conducted from March 15 to April 1, 2004. The data analysis data was made on the basis of SAS 8.01. Mean differences between 2003 and 2004 data were compared by paired t-test. Corresponding p-values were considered significant at values less than 0.05. Results : The DMF rate and DFT index were reduced to 8.0% and 8.4% during one year respectively, but there were no statistically significant differences. The DMF rate was significantly reduced (16.3%) after a one year program of school-based oral health care practice. The DMFT(Decay Missing Filling Tooth) index was also reduced compared to 2003 throughout the entire grade. Conclusion : School-based oral health care programs can reduce the prevalence of dental caries prevalence among schoolchildren during one year. This program also improved the oral health capacity of schoolchildren. It is recommend that the school-based oral health care program should be extended to every primary school in Korea