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Takao, Manabu,Katsube, Haruka,Alam, M.M.A.,Fukuma, Seisuke,Okuhara, Shinya,Kinoue, Yoichi Korean Society for Fluid machinery 2018 International journal of fluid machinery and syste Vol.11 No.1
Wells turbine, widely used to harness the wave energy, has high efficiency at a low flow rate. However, it has severe stall problem. In order to alleviate this problem, a dual-turbine system of Wells turbine with a booster impulse turbine was proposed. In the present study, the effect of impulse turbine geometries on the performance of combined turbine system was investigated by CFD analysis. As a result, the boosting effect of impulse turbine depends on the pressure differences that caused by the setting angles at a high flow rate. Moreover, the decrease of flow rate with the setting angle has a significant influence on the efficiency.
Manabu Takao,Haruka Katsube,M. M. A. Alam,Seisuke Fukuma,Shinya Okuhara,Yoichi Kinoue 한국유체기계학회 2018 International journal of fluid machinery and syste Vol.11 No.1
Wells turbine, widely used to harness the wave energy, has high efficiency at a low flow rate. However, it has severe stall problem. In order to alleviate this problem, a dual-turbine system of Wells turbine with a booster impulse turbine was proposed. In the present study, the effect of impulse turbine geometries on the performance of combined turbine system was investigated by CFD analysis. As a result, the boosting effect of impulse turbine depends on the pressure differences that caused by the setting angles at a high flow rate. Moreover, the decrease of flow rate with the setting angle has a significant influence on the efficiency.
Masayuki Yamasaki,Tetsuro Ogawa,Li Wang,Takuya Katsube,Yukikazu Yamasaki,Xufeng Sun,Kuninori Shiwaku 한국영양학회 2013 Nutrition Research and Practice Vol.7 No.4
The anti-obesity effects of a hot water extract from wasabi (Wasabia japonica Matsum.) leaves (WLE), without its specific pungent constituents, such as allyl-isothiocyanate, were investigated in high fat-diet induced mice. C57J/BL mice were fed a high-fat diet (control group) or a high-fat diet supplemented with 5% WLE (WLE group). Physical parameters and blood profiles were determined. Gene expression associated with lipid metabolism in liver and white adipose tissue were analyzed. After 120 days of feeding, significantly lower body weight gain, liver weight and epididymal white adipose tissue weight was observed in the WLE group compared to the control group. In liver gene expression within the WLE group, PPARα was significantly enhanced and SREBP-1c was significantly suppressed. Subsequent downstream genes controlled by these regulators were significantly suppressed. In epididymal white adipose tissue of the WLE group, expression of leptin, PPARγ, and C/EBPα were significantly suppressed and adiponectin was significantly enhanced. Acox, related to fatty acid oxidization in adipocytes, was also enhanced. Our results demonstrate that the WLE dietary supplement induces mild suppression of obesity in a high-fat diet induced mice, possibly due to suppression of lipid accumulation in liver and white adipose tissue.
Effects of quercetin derivatives from mulberry leaves
Xufeng Sun,Masayuki Yamasaki,Takuya Katsube,Kuninori Shiwaku 한국영양학회 2015 Nutrition Research and Practice Vol.9 No.2
BACKGROUND/OBJECTIVES: Mulberry leaves contain quercetin derivatives, which have the effects of reducing obesity and improving lipid and glucose metabolism in mice with obesity. It is not clear whether or not mulberry leaves can directly affect metabolic disorders, in the presence of obesity, because of the interaction between obesity and metabolic disorders. The aim of the current study was to assess the direct action of quercetin derivatives on metabolic disorders in non-obese conditions in short-term high-fat diet fed mice. MATERIALS/METHODS: C57BL/6N mice were fed a high-fat diet, supplemented with either 0% (control), 1%, or 3% mulberry leaf powder (Mul) or 1% catechin powder for five days. Anthropometric parameters and blood biochemistry were determined, and hepatic gene expression associated with lipid and glucose metabolism was analyzed. RESULTS: Body and white fat weights did not differ among the four groups. Plasma triglycerides, total cholesterol, and free fatty acids in the 1%, 3% Mul and catechin groups did not differ significantly from those of the controls, however, plasma glucose and 8-isoprostane levels were significantly reduced. Liver gene expression of gp91phox, a main component of NADPH oxidase, was significantly down-regulated, and PPAR-α, related to β-oxidation, was significantly up-regulated. FAS and GPAT, involved in lipid metabolism, were significantly down-regulated, and Ehhadh was significantly up-regulated. Glucose-metabolism related genes, L-PK and G6Pase, were significantly down-regulated, while GK was significantly up-regulated in the two Mul groups compared to the control group. CONCLUSIONS: Our results suggest that the Mul quercetin derivatives can directly improve lipid and glucose metabolism by reducing oxidative stress and enhancing β-oxidation. The 1% Mul and 1% catechin groups had similar levels of polyphenol compound intake (0.4 × 10<SUP>-5</SUP> vs 0.4 × 10<SUP>-5</SUP> mole/5 days) and exhibited similar effects, but neither showed dose-dependent effects on lipid and glucose metabolism or oxidative stress.
1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization
Ghani, Lubna,Munk, Chastine F.,Zhang, Xiang,Katsube, Satoshi,Du, Yang,Cecchetti, Cristina,Huang, Weijiao,Bae, Hyoung Eun,Saouros, Savvas,Ehsan, Muhammad,Guan, Lan,Liu, Xiangyu,Loland, Claus J.,Kobilka American Chemical Society 2019 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.141 No.50
<P>Despite their major biological and pharmacological significance, the structural and functional study of membrane proteins remains a significant challenge. A main issue is the isolation of these proteins in a stable and functional state from native lipid membranes. Detergents are amphiphilic compounds widely used to extract membrane proteins from the native membranes and maintain them in a stable form during downstream analysis. However, due to limitations of conventional detergents, it is essential to develop novel amphiphiles with optimal properties for protein stability in order to advance membrane protein research. Here we designed and synthesized 1,3,5-triazine-cored dimaltoside amphiphiles derived from cyanuric chloride. By introducing variations in the alkyl chain linkage (ether/thioether) and an amine-functionalized diol linker (serinol/diethanolamine), we prepared two sets of 1,3,5-triazine-based detergents. When tested with several model membrane proteins, these agents showed remarkable efficacy in stabilizing three transporters and two G protein-coupled receptors. Detergent behavior substantially varied depending on the detergent structural variation, allowing us to explore detergent structure-property-efficacy relationships. The 1,3,5-triazine-based detergents introduced here have significant potential for membrane protein study as a consequence of their structural diversity and universal stabilization efficacy for several membrane proteins.</P> [FIG OMISSION]</BR>