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( Nae Yun Heo ),( Young Suk Lim ),( Woochang Lee ),( Minkyung Oh ),( Jiyun An ),( Dan Bi Lee ),( Ju Hyun Shim ),( Kang Mo Kim ),( Han Chu Lee ),( Yung Sang Lee ),( Dong Jin Suh2 ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.2
Background/Aims: There are few available data regarding the association between the single nucleotide polymorphisms (SNPs) of the gene encoding interleukin 28B (IL28B) and a sustained virologic response (SVR) to peginterferon (PEG-IFN) plus ribavirin (RBV) therapy in Korean chronic hepatitis C patients. Methods: This was a retrospective cohort study of 156 patients with chronic hepatitis C virus (HCV) infection who received combination treatment of PEG-IFN plus RBV. Blood samples from these patients were analyzed to identify the IL28B SNPs at rs12979860, rs12980275, rs8099917, and rs8103142. Association analyses were performed to evaluate the relationships between each IL28B SNP and SVRs. Results: Seventy six patients with HCV genotype 1 and 80 with genotype non-1 were enrolled. The frequencies of rs12979860 CC and CT genotypes were 90.4% and 9.6%, respectively; those of rs12980275 AA and AG genotypes were 87.2% and 12.8%, respectively; those of rs8099917 TT and TG genotypes were 92.3% and 7.7%, respectively; and those of rs8103142 TT and CT genotypes were 90.4% and 9.6%, respectively. Among the patients with HCV genotype 1, the SVR rates were 69.7% and 80.0% for rs12979860 CC and CT, respectively (P=0.71). Among the HCV genotype non-1 patients, SVR rates were 88.0% and 100% for rs12979860 CC and CT (P=1.00), respectively. Conclusions: Genotypes of the IL28B SNP that are known to be favorable were present in most of the Korean patients with chronic hepatitis C in this study. Moreover, the IL28B SNP did not influence the SVR rate in either the HCV genotype 1 or non-1 patients. Therefore, IL28B SNP analysis might be not useful for the initial assessment, prediction of treatment outcomes, or treatment decision-making of Korean chronic hepatitis C patients. (Clin Mol Hepatol 2014;20:177-184)
Unsteady Electroosmotic Channel Flows with the Nonoverlapped and Overlapped Electric Double Layers
Kang, Sang-Mo,Suh, Yong-Kweon The Korean Society of Mechanical Engineers 2006 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.20 No.12
In micro- and nanoflows, the Boltzmann distribution is valid only when the electric double layers (EDL's) are not overlapped and the ionic distributions establish an equilibrium state. The present study has numerically investigated unsteady two-dimensional fully-developed electroosmotic flows between two parallel flat plates in the nonoverlapped and overlapped EDL cases, without any assumption of the Boltzmann distribution. For the study, two kinds of unsteady flows are considered: one is the impulsive application of a constant electric field and the other is the application of a sinusoidally oscillating electric field. For the numerical simulations, the ionic-species and electric-field equations as well as the continuity and momentum ones are solved. Numerical simulations are successful in accurately predicting unsteady electroosmotic flows and ionic distributions. Results show that the nonoverlapped and overlapped cases are totally different in their basic characteristics. This study would contribute to further understanding unsteady electroosmotic flows in micro- and nanofluidic devices.
Gene Expression Profiling of Acetaminophen Induced Hepatotoxicity in Mice
Suh, Soo-Kyung,Jung, Ki-Kyung,Jeong, Youn-Kyoung,Kim, Hyun-Ju,Lee, Woo-Sun,Koo, Ye-Mo,Kim, Tae-Gyun,Kang, Jin-Seok,Kim, Joo-Hwan,Lee, Eun-Mi,Park, Sue-Nie,Kim, Seung-Hee,Jung, Hai-Kwan The Korean Society of Toxicogenomics and Toxicopro 2006 Molecular & cellular toxicology Vol.2 No.4
Microarray analysis of gene expression has become a powerful approach for exploring the biological effects of drugs, particularly at the stage of toxicology and safety assessment. Acetaminophen (APAP) has been known to induce necrosis in liver, but the molecular mechanism involved has not been fully understood. In this study, we investigated gene expression changes of APAP using microarray technology. APAP was orally administered with a single dose of 50 mg/kg or 500 mg/kg into ICR mice and the animals were sacrificed at 6, 24 and 72 h of APAP administration. Serum biochemical markers for liver toxicity were measured to estimate the maximal toxic time and hepatic gene expression was assessed using high-density oligonucleotide microarrays capable of determining the expression profile of >30,000 well-substantiated mouse genes. Significant alterations in gene expression were noted in the liver of APAP-administered mice. The most notable changes in APAP-administered mice were the expression of genes involved in apoptosis, cell cycle, and calcium signaling pathway, cystein metabolism, glutatione metabolism, and MAPK pathway. The majority of the genes upregulated included insulin-like growth factor binding protein 1, heme oxygenase 1, metallothionein 1, S100 calcium binding protein, caspase 4, and P21. The upregulation of apoptosis and cell cycle-related genes were paralleled to response to APAP. Most of the affected gene expressions were returned to control levels after 72 hr. In conclusion, we identified potential hepatotoxicity makers, and these expressions profiling lead to a better understanding of the molecular basis of APAP-induced hapatotoxicity.
Numerical and Experimental Study on a Channel Mixer with a Periodic Array of Cross Baffles
Suh, Yong-Kweon,Heo, Seong-Gyu,Heo, Young-Gun,Heo, Hyeung-Seok,Kang, Sang-Mo 대한기계학회 2007 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.21 No.3
In this study we show an enhanced mixing effect with a simple channel having a periodic array of cross baffles. We performed numerical computation to obtain the steady flow field within the channel at low Reynolds numbers by using a commercial code, ANSYS CFX 10.0. A visualization experiment was also conducted to validate our numerical results qualitatively. In evaluating the mixing performance, we employed the Lyapunov exponent. It was shown that the visualized mixing pattern was in a good agreement with that numerically given. Our Liapunov exponent distribution in the space also demonstrates that the proposed channel design indeed exhibits a chaotic stirring at low Reynolds numbers. Our design is thus assumed to be applicable to designing a microchannel mixer with enhanced mixing effect.
Kang, Hyun-Jae,Oh, Il-Young,Chung, Jin-Wook,Yang, Han-Mo,Suh, Jung-Won,Park, Kyung Woo,Kwon, Taek Keun,Lee, Hae-Young,Cho, Young-Seok,Youn, Tae-Jin,Koo, Bon-Kwon,Kang, Won-Yu,Kim, Weon,Rha, Seung-Woon W.B. Saunders [etc.] 2012 European heart journal Vol.33 No.21
<P>In the previous COREA-TAXUS trial, a 6-month adjunctive use of celecoxib reduced target-lesion revascularization (TLR) without increased thrombotic risk. We aimed to confirm the effects of 3-month celecoxib in patients receiving drug-eluting stent (DES) implantation in the larger prospective, randomized trial.</P>
Gene Expression Profiling of Genotoxicity Induced by MNNG in TK6 Cell
Suh, Soo-Kyung,Kim, Tae-Gyun,Kim, Hyun-Ju,Koo, Ye-Mo,Lee, Woo-Sun,Jung, Ki-Kyung,Jeong, Youn-Kyoung,Kang, Jin-Seok,Kim, Joo-Hwan,Lee, Eun-Mi,Park, Sue-Nie,Kim, Seung-Hee,Jung, Hai-Kwan The Korean Society of Toxicogenomics and Toxicopro 2007 Molecular & cellular toxicology Vol.3 No.2
Genotoxic stress triggers a variety of biological responses including the transcriptional activation of genes regulating DNA repair, cell survival and cell death. In this study, we investigated to examine gene expression profiles and genotoxic response in TK6 cells treated with DNA damaging agents MNNG (N-methyl-N'-nitrosoguanidine) and hydrogen peroxide $(H_2O_2)$. We extracted total RNA in three independent experiments and hybridized cRNA probes with oligo DNA chip (Applied Biosystems Human Genome Survey Microarray). We analyzed raw signal data with R program and AVADIS software and identified a number of deregulated genes with more than 1.5 log-scale fold change and statistical significancy. We indentified 14 genes including G protein alpha 12 showing deregulation by MNNG. The deregulated genes by MNNG represent the biological pathway regarding MAP kinase signaling pathway. Hydrogen peroxide altered 188 genes including sulfiredoxins. These results show that MNNG and $H_2O_2$ have both uniquely regulated genes that provide the potential to serve as biomarkers of exposure to DNA damaging agents.
강흥모,서환조 대한감염학회 1986 감염 Vol.18 No.2
For bacteriologic diagnosis of lower respiratory tract infection, bronchoscopic aspirates culture and sputum culture were evaluated in 41 cases with pulmonary infection who were admitted to Department of Internal Medicine, Kyung Hee Medical Center, from Jan. 1982 to Feb. 1983. We compare the bacteriologic study of bronchoscopic aspirates with the culture of expectorated sputum. The results in this study were as follows; 1) In 41 cases, the clinical diagnoses were 23 pneumonias, 9 lung abscesses, 2 empyemas, 1 hemothorax and 1 acute respiratory failure. The male patients were 27 and females were 14. 2) Most frequently cultured organisms were α-streptococcus and B. catarrhalis on expectorated sputum culture. On bronchoscopic aspirates culture, pseudomonas, K. pneumoniae and α-streptococcus were frequently cultured. 3) Bacteria were not cultured in 9 patients by sputum culture and 6 patients by bronchoscopic aspirates culture. Bacteria were cultured in only 2 patients on blood culture. 4) Causative agents were cultured in 16 patients(39%) on sputum culture and in 23 patients(56%) on bronchoscopic aspirates culture. In 9 patients(22%), the same organisms were cultured on sputum and bronchoscopic aspirates culture.
강홍모,서환조 대한감염학회 1992 감염 Vol.24 No.1
Cefodizime is a new third generation cephalosporin antibiotic which has broad antibacterial activity against gram positive, gram negative bacteria, Hemophilus spp. and Neisseria spp. Clinical usefulness of cefodizime was studied in 30 cases of lower respiratiory tract infections. The drug was administered intravenously in daily dose of 2.0 g. The results were as follows: 1) Cefodizime was clinically effective in 25 cases of all patients treated with efficacy rate of 83.3%. 2) Any significant side effects were not noted except mild elevation of liver enzymes (5 cases) and decrement of hemoglobin (1 case).