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RISS 인기검색어
- 검색키워드
- 저자 : Kang-Kyun Wang (검색결과 36 건)
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Wang, Kang-Kyun,Kim, Bong-Jin,Il-Heo, Bong-Jin,Jung, Seong-Jin,Hwang, Jeong-Wook,Kim, Yong-Rok Elsevier 2017 Surface & Coatings Technology Vol.310 No.-
<P><B>Abstract</B></P> <P>We report a photofunctional stainless steel (PSS) that has antimicrobial property which is provided by reactive oxygen species (ROS) generated from the photosensitizer (PS). For the fabrication of the photofunctional stainless steel, the photosensitizer of hematoporphyrin (HP) was covalently bonded to the surface of 316L stainless steel (316LSS) through an esterification reaction. The PSS plate was investigated by x-ray photoelectron spectroscopy (XPS), reflectance UV–Vis absorption, and fluorescence spectroscopy. ROS generation from the PSS plate was studied by using the decomposition reaction of 1,3-diphenyl-isobenzofuran (DPBF). The results suggest that the immobilized photosensitizer molecules on the surface of the PSS plate still possess their intrinsic optical and functional properties including the ROS generation. The antimicrobial property of the PSS plate was successfully demonstrated with the decomposition of biofilm and the suppression of the biofilm formation on the surface of the PSS plate.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Photofunctional stainless steel (PSS) was fabricated and characterized. </LI> <LI> Biofilm was decomposed by the reactive oxygen species generated from PSS. </LI> <LI> The biofilm formation on the surface of PSS was inhibited with light irradiation. </LI> </UL> </P>
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Wang, Kang-Kyun,Shin, Eon Pil,Lee, Hye-Jin,Jung, Seung-Jin,Hwang, Jeong-Wook,Heo, Il,Kim, Jong-Ho,Oh, Min-Kyu,Kim, Yong-Rok Elsevier 2018 Journal of photochemistry and photobiology Biology Vol.183 No.-
<P><B>Abstract</B></P> <P>To inactivate methicillin-resistant <I>Staphylococcus aureus</I> (MRSA) with minimum damage to host cells and tissue, target-oriented photofunctional nanoparticles (TOPFNs) were fabricated and characterized. MRSA is a predominant infective pathogen even in hospital and non-hospital environments due to its ability to develop high levels of resistance to several classes of antibiotics through various pathways. To solve this major problem, photodynamic inactivation (PDI) method applies to treat antibiotic-resistant bacteria. PDI involves the photosensitizer (PS) and light with a specific wavelength to be able to apply for a non-invasive therapeutic procedure to treat pathogenic bacteria by inducing apoptosis or necrosis of microorganisms. However, most current PDI researches have suffered from the instability of PDI agents in the biological environment due to the lack of selectivity and low solubility of PDI agents, which leads to the low PDI efficiency. In this study, the TOPFNs were fabricated by an esterification reaction to introduce hematoporphyrin (HP) and MRSA antibody to the surface of Fe<SUB>3</SUB>O<SUB>4</SUB> nanoparticles. The TOPFNs were designed as dispersible PDI agent in biological condition, which was effectively used for selectively capturing and killing of MRSA. The capture efficiency TOPFNs was compared with PFNs as a negative control. The results showed that the capture efficiency of TOPFNs and PFNs was 95.55% and 6.43% in MRSA and L-929 cell mixed condition, respectively. And TOPFNs have a selective killing ability for MRSA with minimum damage to L-929 cells. Furthermore, PDI effect of TOPFNs was evaluated on the mice <I>in vivo</I> condition in order to check the possibility of practical medical application.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Target-oriented photofunctional nanoparticles (TOPFNs) were successfully fabricated and characterized. </LI> <LI> Methicillin-resistant <I>Staphylococcus aureus</I> was completely photodynamic inactivated by TOPFNs. </LI> <LI> Also, photodynamic inactivation effect of MRSA by TOPFN was confirmed <I>in-vivo</I>. </LI> </UL> </P>
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Wang, Kang-Kyun,Kim, Bong-Jin,Ko, Si-Hwan,Choi, Dong Hoon,Kim, Yong-Rok Hindawi Limited 2012 Journal of nanomaterials Vol.2012 No.-
<P>Fabrication and photophysical study of photofunctional nanoporous alumina membrane (PNAM) were performed, and its application of photodynamic antimicrobial chemotherapy (PACT) was investigated. Nanoporous alumina membrane (NAM) was fabricated by two-step aluminium anodic oxidation process. Surface of the fabricated NAM was modified with organo-silane agent to induce covalent bonding between NAM and a photosensitizer (PtCP: [5,10,15-triphenyl-20-(4-methoxycarbonylphenyl)-porphyrin] platinum). PtCP was covalently bonded to the surface of the modified NAM by nucleophilic acyl substitution reaction process. The morphology and the photophysical properties of the fabricated PNAM were confirmed with field emission scanning electron microscope (FE-SEM), steady-state spectroscopies, and nanosecond laser-induced time-resolved spectroscopy. For the efficacy study of PNAM in PACT, an enveloped animal virus, vesicular stomatitis virus (VSV), was utilized as a target organism. Antiviral effect of the PNAM-PACT was measured by the extent of suppression of plaque-forming units (PFU) after the light irradiation. In the cultures inoculated with PACT-treated VSV, the suppression of PFU was prominent, which demonstrates that PNAM is a potential bio clean-up tool.</P>
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Wang, Kang-Kyun,Jang, Jin Woo,Shin, Eon Pil,Song, Hyung Wan,Hwang, Jeong Wook,Kim, Young Keun,Lim, Chae Seung,Kim, Yong-Rok American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.15
<P>We investigated the antimalarial effect of photodynamic inactivation (PDI) coupled with magnetic nanoparticles (MNPs) as a potential strategy to combat the emergence of drug-resistant malaria and resurgence of malaria after treatment. Because the malarial parasite proliferates within erythrocytes, PDI agents need to be taken up by erythrocytes to eradicate the parasite. We used photofunctional MNPs as the PDI agent because nanosized particles were selectively taken up by Plasmodium-infected erythrocytes and remained within the intracellular space due to the enhanced permeability and retention effect. Also, the magnetism of Fe3O4 nanoparticles can easily be utilized for the collection of photofunctional nanoparticles (PFNs), and the uptaken PFNs infected the erythrocytes after photodynamic treatment with external magnetics. Photofunctionality was provided by a photosensitizer, namely, pheophorbide A, which generates reactive oxygen species (ROS) under irradiation. PAs were covalently bonded to the surface of the MNPs. The morphology and structural characteristics of the MNPs were investigated by scanning electron microscopy and X-ray diffraction (XRD), whereas the photophysical properties of the PFNs were studied with Fourier transform infrared, absorption, and emission spectroscopies. Generation of singlet oxygen, a major ROS, was directly confirmed with time -resolved phosphorescence spectroscopy. To evaluate the ability of PFNs to kill malarial parasites, the PDI effect of PFNs was evaluated within the infected erythrocytes. Furthermore, malarial parasites were completely eradicated from the erythrocytes after PDI treatment using PFNs on the basis of an 8 day erythrocyte culture test.</P>
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만성 편측 장골동맥 폐색 환자에서 대퇴동맥-대퇴동맥 우회로조성술 시 혈관성형술의 의의
강석형,천영덕,민연기,하헌균,전재영,김남렬,송태진,이재복,정석인,김윤환,최상용,황정웅 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.1
Purpose: The purpose of this article is to analysis the results of combined agioplasity and femorofemoral bypass in patients with unilateral iliac arterial occlusive disease. Method: During the 11-year period from 1990 to 2000, 44 patients with iliac artery occlusion and a hemodynamically significant contralateral iliac artery stenosis were treated by using a combination of percutaneous transluminal femoral bypass (n=14) at Korea university medical center. PTA was performed if the lesions in the donor iliac artery were less than 3 ??㎝ in length with in more than one well-localized lesion in either the common or external iliac artery, or both. Stent was deployed for suboptimal PTAs. The femorofermoral bypass was done within 3 to 5 days after PTA or stenting. Result: The mean age was 61.2 years. The Indications of fermorofermoral bypass were hypertension, ischemic heart disease, chronic obstructive lung disease, old age (>75), cancer, and previous abdominal operation, The complication rate of the combination treatment was lower than that of the others. Primary patency rate at 1 and 3 years were 89%, 78% for aortobifemoral bypass, 83%, 66% for iliofemoral bypass, and 77%, 65% for femorofemoral bypass, respectively. Conclusion: The combination of PTA with or without stent deployment and femorofemoral bypass can be a useful option for treating iliac occlusion and contralateral iliac stenosis in patients with severe comorbid illness, advanced age, and intra-abdominal pathology. Angioplasity can allow more widespread use of femorofemoral pypass in these patients.
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Kang, Bong Kyun,Woo, Moo Hyun,Lee, Jooyoung,Song, Young Hyun,Wang, Zhongli,Guo, Yanna,Yamauchi, Yusuke,Kim, Jung Ho,Lim, Byungkwon,Yoon, Dae Ho The Royal Society of Chemistry 2017 Journal of Materials Chemistry A Vol.5 No.9
<P>Mesoporous NiO/NiFe2O4multi-composite hollow nanocages<I>via</I>monodisperse Ni3[Fe(CN)6]2prussian blue analogue nanocube precursors were successfully synthesized. The three-dimensional (3D) mesoporous and hollow structures provided an efficient electrolyte diffusion path and a high surface area, resulting in the enhancement of electrocatalytic activities for the oxygen evolution reaction. The overpotential and Tafel slope of mesoporous NiO/NiFe2O4multi-composite hollow nanocages were as low as 303 mV at a current density of 10 mA cm<SUP>−2</SUP>and 58.5 mV dec<SUP>−1</SUP>, respectively. In addition, the composite showed excellent durability at approximately 60 mA cm<SUP>−2</SUP>for 12 h.</P>
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Feature point classification based global motion estimation for video stabilization
Seung-Kyun Kim,Seok-Jae Kang,Tae-Shick Wang,Sung-Jea Ko IEEE 2013 IEEE TRANSACTIONS ON CONSUMER ELECTRONICS - Vol.59 No.1
<P>The performance of video stabilization is dependent on the accuracy of global motion estimation between two successive frames. In this paper, we propose a novel method to estimate the global motion accurately using the classified background (BG) feature points (FPs). In the proposed method, global motion estimation and FP classification are jointly performed using both the FP correspondences and the global motion parameters of the previous frame. The experimental results show that video stabilization using the proposed method outperforms the conventional stabilization methods, especially when the moving foreground (FG) objects occupy a large part of the image.</P>
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Development of Fault Location Algorithm and Its Verification Experiments for HVDC Submarine Cables
Chae-Kyun Jung,Hung-Sok Park,Ji-Won Kang,Xinheng Wang,Yong-Kab Kim,Jong-Beom Lee 대한전기학회 2012 Journal of Electrical Engineering & Technology Vol.7 No.6
A new fault location algorithm based on stationary wavelet transform and its verification experiment results are described for HVDC submarine cables in this paper. For wavelet based fault location algorithm, firstly, 4th level approximation coefficients decomposed by wavelet transform function are superimposed by correlation, then the distance to the fault point is calculated by time delay between the first incident signal and the second reflected signal. For the verification of this algorithm, the real experiments based on various fault conditions and return types of fault current are performed at HVDC submarine cable test yard located in KEPCO(Korea Electric Power Corporation) Power Testing Center of South Korea. It proves that the fault location method proposed in this paper is very simple but very quick and accurate for HVDC submarine cable fault location.
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Development of an Intelligent Voltage Control System for Jeju Island in Korea
Kim, Kyun-Do,Yu, Won-Kun,Lee, Eun-Jae,Wang, In-Soo,Kang, Hyun-Jae,Shin, Jeong-Hoon,Lee, Heung-Jae The Korean Institute of Electrical Engineers 2011 The Journal of International Council on Electrical Vol.1 No.2
The reactive power, unlike frequency, has local characteristics and it has relied on the manual operation in a local reactive power control station so far. Since coordination or integrated control was possible due to the recent advances in computers and communication networks, the hierarchical voltage control system, consisting of primary, secondary, and tertiary, has been already applied to the real-life situations of several developed countries in Europe. Recently, the Korea power system has been operated more closely to stability limits because of rapid growth in load-demand as seen in Europe. For this reasons, KEPCO recognized the need of the voltage control system and developed the voltage control system. In this paper, we developed intelligent voltage control system for domestic system using numerical algorithm based on the sensitivity matrix and expert system, and dynamic response characteristics of the developed system investigated as a preliminary step for interfacing RTDS(Real Time Digital Simulator). In addition, the developed system performance was verified.
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