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Risk factors predicting development of complications in 72 dogs with esophageal foreign bodies
Shin, Bohye,Kim, Hakhyun,Chang, Dongwoo,Kang, Ji-Houn,Kang, Byeong-Teck,Yang, Mhan-pyo The Korean Society of Veterinary Science 2019 大韓獸醫學會誌 Vol.59 No.1
The aim of this study was to determine predictive risk factors implicated in complications in dogs with esophageal foreign bodies. Medical records of 72 dogs diagnosed with esophageal foreign bodies by endoscopy were reviewed retrospectively. Factors analyzed included age; breed; gender; body weight, location, dimension, and type of foreign body; and duration of impaction. To identify risk factors associated with complications after foreign body ingestion, categorical variables were analyzed using the chisquare or Fisher's exact tests and multivariate analysis, as appropriate. Complications secondary to esophageal foreign body ingestion included megaesophagus, esophagitis, perforation, laceration, diverticulum, and pleuritis. Univariate analysis revealed that the location and duration of impaction after foreign body ingestion were associated with an increased risk of esophageal laceration and perforation. Multivariate analysis showed that age, duration of impaction, and foreign body dimension were significant independent risk factors associated with the development of complications in dogs with esophageal foreign bodies. In conclusion, these results showed that longer duration of impaction and larger foreign body dimensions may increase the risks of esophageal laceration, perforation, and plueritis in dogs.
Obstetrical outcomes of amniocentesis or chorionic villus sampling in dichorionic twin pregnancies
( Eunhee Ahn ),( Bohye Kim ),( Hyo J. Ki ),( Sukho Kang ),( Sung W. Chang ),( Sang H. Jung ),( Myoung J. Moon ),( Mi S. Kim ),( Soobin Lee ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: This study aimed to evaluate the procedure-related fetal loss and the obstetrical outcomes of chorionic villus sampling and amniocentesis in twin pregnancies. Methods: The data from dichorionicdiamniotic twin pregnancies for which first-trimester chorionic villus sampling or second-trimester amniocentesis was performed between December 2006 and January 2017 at a single institute, were retrospectively analyzed. The groups were compared with respect to the procedure-related and obstetrical outcomes. Results: The difference in procedure-related fetal loss rate (1.9% for chorionic villus sampling vs. 1.8% for amniocentesis; P=1.000) and overall fetal loss rate (7.4% for chorionic villus sampling vs. 4.7% for amniocentesis; P=0.489) between the two groups was not significant. The difference in miscarriage rate and early preterm delivery were not significant between the groups (miscarriage: 5.6% for chorionic villus sampling vs. 0.6% for amniocentesis; early preterm delivery: 11.1% for chorionic villus sampling vs. 10.6% foramniocentesis; P=NS). The differences in mean gestational ages at delivery, birth weights, and neonatal intensive care unit admission rate were not statistically significant. Conclusion: To our knowledge, this is one of the few studies to compare chorionic villus sampling and amniocentesis in twin pregnancy, including procedure-related fetal loss. The procedure-related fetal loss and the overall fetal loss of chorionic villus sampling appear comparable to those of amniocentesis. Both procedures can be safely used based on several factors: indications, gestational age, technical difficulties, the likelihood to proceed to selective feticide, and operators experience. These findings can be useful for clinicians when counseling parents of twins regarding their options for antenatal aneuploidy, genetic diagnosis, and the associated risks. Furthermore, randomized controlled trials are required to compare the safety of chorionic villus sampling and amniocentesis in twin pregnancies.
Stomach clusterin as a gut-derived feeding regulator
( Cherl Namkoong ),( Bohye Kim ),( Ji Hee Yu ),( Byung Soo Youn ),( Hanbin Kim ),( Evonne Kim ),( So Young Gil ),( Gil Myoung Kang ),( Chan Hee Lee ),( Young-bum Kim ),( Kyeong-han Park ),( Min-seon K 생화학분자생물학회 2024 BMB Reports Vol.57 No.3
The stomach has emerged as a crucial endocrine organ in the regulation of feeding since the discovery of ghrelin. Gut-derived hormones, such as ghrelin and cholecystokinin, can act through the vagus nerve. We previously reported the satiety effect of hypothalamic clusterin, but the impact of peripheral clusterin remains unknown. In this study, we administered clusterin intraperitoneally to mice and observed its ability to suppress fasting-driven food intake. Interestingly, we found its synergism with cholecystokinin and antagonism with ghrelin. These effects were accompanied by increased c-fos immunoreactivity in nucleus tractus solitarius, area postrema, and hypothalamic paraventricular nucleus. Notably, truncal vagotomy abolished this response. The stomach expressed clusterin at high levels among the organs, and gastric clusterin was detected in specific enteroendocrine cells and the submucosal plexus. Gastric clusterin expression decreased after fasting but recovered after 2 hours of refeeding. Furthermore, we confirmed that stomachspecific overexpression of clusterin reduced food intake after overnight fasting. These results suggest that gastric clusterin may function as a gut-derived peptide involved in the regulation of feeding through the gut-brain axis. [BMB Reports 2024; 57(3): 149-154]
Real-time monitoring of liver fibrosis through embedded sensors in a microphysiological system
FAROOQI HAFIZ MUHAMMAD UMER,Kang Bohye,Khalid Muhammad Asad Ullah,Salih Abdul Rahim Chethikkattuveli,Hyun Kinam,박성혁,Huh Dongeun,최경현 나노기술연구협의회 2021 Nano Convergence Vol.8 No.3
Hepatic fibrosis is a foreshadowing of future adverse events like liver cirrhosis, liver failure, and cancer. Hepatic stellate cell activation is the main event of liver fibrosis, which results in excessive extracellular matrix deposition and hepatic parenchyma's disintegration. Several biochemical and molecular assays have been introduced for in vitro study of the hepatic fibrosis progression. However, they do not forecast real-time events happening to the in vitro models. Trans-epithelial electrical resistance (TEER) is used in cell culture science to measure cell monolayer barrier integrity. Herein, we explored TEER measurement's utility for monitoring fibrosis development in a dynamic cell culture microphysiological system. Immortal HepG2 cells and fibroblasts were co-cultured, and transforming growth factor β1 (TGF-β1) was used as a fibrosis stimulus to create a liver fibrosis-on-chip model. A glass chip-based embedded TEER and reactive oxygen species (ROS) sensors were employed to gauge the effect of TGF-β1 within the microphysiological system, which promotes a positive feedback response in fibrosis development. Furthermore, albumin, Urea, CYP450 measurements, and immunofluorescent microscopy were performed to correlate the following data with embedded sensors responses. We found that chip embedded electrochemical sensors could be used as a potential substitute for conventional end-point assays for studying fibrosis in microphysiological systems.
핫스탬핑 소재의 열간 피어싱 공정에서 펀치 전단각에 따른 전단면 특성 평가
전용준(Yongjun Jeon),최현석(Hyunseok Choi),강정진(Jeongjin Kang),채보혜(Bohye Chae),김동언(Dongearn Kim) 한국자동차공학회 2020 한국 자동차공학회논문집 Vol.28 No.12
Although post-processing by using trimming dies has been continuously conducted to shorten the processing time of press-hardened steel, it is quite difficult to secure the life expectancy of the dies due to its high strength at 1.5 GPa. Therefore, in this study, hot piercing was performed at 550 °C during the quenching process of press-hardened steels. The characteristics of the pierced holes were analyzed after changing the shearing angle of the piercing punch. The specimen on which a flat punch with a shear angle of 0° was applied showed a 17 % rollover, 65 % burnish, and 18% fracture, all relative to depth. However, when a piercing punch with a shear angle of 2° was applied, the surface quality deteriorated considerably, with a 14 % rollover, 12 % burnish, and 74 % fracture. These results indicated that when a piercing punch with a shearing angle was applied, the diameter of the piercing hole increased above the target dimension. This can be attributed to the unbalanced load occurring in the radial direction of the piercing punch when the active surface of the punch failed to make contact with the material in the circumferential direction. Moreover, the application of the piercing punch also reduced the effect of the shear load. This can be explained by the temperature at which the piercing process was performed (i.e., 550 °C), which was higher than the martensitic transformation temperature of press-hardened steel. Therefore, the application of a piercing punch with a shearing angle is deemed unsuitable for the piercing process, which would be conducted during the quenching of press-hardened steel, for the following reasons: decreased quality of the processed surface, increased diameter of the processed hole, and reduced impact load.