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( Kalyan Ramesh ),( Sonita A. P. Siboro ),박찬,임권택 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
In the present study, a series of amphiphilic AB2-type miktoarm star block copolymers consisting of hydrophobic poly(L-lactide) (PLLA) as a A arm and hydrophilic poly(N-acryloylmorpholine) (PNAM) as two B arms were synthesized via the combination of ring opening polymerization and xanthate-mediated reversible addition-fragmentation chain transfer polymerization. Resultant polymers were analyzed by 1H NMR spectroscopy and gel permeation chromatography. Aggregation properties of the amphiphilic miktoarm star block copolymers were studied by fluorescence spectroscopy, transmission electron microscopy and dynamic light scattering. Doxorubicin (DOX)was successfully loaded into the miktoarm star block copolymer micelles. The result revealed that DOX release was enhanced as the pH reduced from 7.4 to 6.4.
Ramesh, Kalyan,Thangagiri, Baskaran,Mishra, Avnish Kumar,Ahn, Byung-Hyun,Gal, Yeong-Soon,Lim, Kwon Taek Elsevier 2018 Reactive & functional polymers Vol.132 No.-
<P><B>Abstract</B></P> <P>In this study, a series of amphiphilic AB<SUB>2</SUB>-type miktoarm star block copolymers consisting of hydrophobic poly(<SMALL>L</SMALL>-lactide) (PLLA) as a A arm and hydrophilic poly(<I>N</I>-acryloylmorpholine) (PNAM) as two B arms were synthesized <I>via</I> the combination of ring opening polymerization and xanthate-mediated reversible addition-fragmentation chain transfer polymerization. Resultant polymers were analyzed by <SUP>1</SUP>H NMR spectroscopy and gel permeation chromatography. Aggregation properties of the amphiphilic miktoarm star block copolymers were studied by fluorescence spectroscopy, transmission electron microscopy and dynamic light scattering. Doxorubicin (DOX) was successfully loaded into the miktoarm star block copolymer micelles and the DLC and DLE of the DOX-loaded micelles increased (9.4 to 13.6% and 55.6 to 78.7%) with an increase in the hydrophilic PNAM chain length of the miktoarm star block copolymer. The result revealed that DOX release was enhanced as the pH reduced from 7.4 to 6.4 and the rate of release slightly increased with increasing the PNAM hydrophilic chain length of the micelles.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Ramesh, Kalyan,Anugrah, Daru Seto Bagus,Lim, Kwon Taek Elsevier 2018 Reactive & functional polymers Vol.131 No.-
<P><B>Abstract</B></P> <P>In the present study, a pseudo-block copolymer was prepared from <I>β</I>-cyclodextrin terminated poly(<I>N</I>-acryloylmorpholine) (<I>β</I>-CD-PNAM) and adamantine-terminated linear poly(D,L-lactide) (AD-PDLLA), through host-guest interaction between <I>β</I>-CD and AD groups. Initially, the hydrophilic polymer PNAM was synthesized using reversible addition fragmentation polymerization, which was further linked to N<SUB>3</SUB>-<I>β</I>-CD through click reaction. In parallel, an AD terminated hydrophobic polymer, AD-PDLLA was synthesized using ring opening polymerization. The synthesized polymers were characterized by means of <SUP>1</SUP>H NMR, gel permeation chromatography and fourier transform infrared. Subsequently, the formation of a pseudo-block copolymer <I>via</I> inclusion complexation between the <I>β</I>-CD core and AD-moiety was confirmed by 2D-NOESY NMR and self-aggregation of the pseudo-block copolymer was investigated by fluorescence spectroscopy. In addition, doxorubicin (DOX) a hydrophobic drug was loaded into the supramolecular micelles and the release kinetics of DOX from the micelles was studied. The result revealed that DOX release was accelerated as the pH reduced from 7.4 to 6.4.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
임권택,홍성수,( Kalyan Ramesh ) 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Reduced graphene oxide (rGO) is presently considered for many potential applications due to its unique properties. The stable conjugated structure of rGO is mostly associated with covalent functionalization strategy, which is more advantageous than non-covalent routes. In the present study, we prepared an efficient method for covalent functionalization of reduced graphene oxide (rGO) via Diels-Alder (DA) click reaction in deep eutectic solvents (DESs). Firstly, Poly(ionic liquid)s featuring furfuryl moieties (P(F-ILs)) was synthesized by the functionalization of poly(chloromethyl styrene-alt-maleic anhydride) with 1-methylimidazole and furfuryl amine. Then, the polymer was directly grafted on the surface of untreated rGO in choline:ethylene glycol (ChCl:EG) based DES without any catalyst. The obtained hybrid materials were characterized by FT-IR, TGA, FT-Raman spectroscopy, XPS and TEM.