An Overview of Parameters Influencing the Performance of Hermetic Reciprocating Compressor for Domestic Applications

K. John Samuel,R. Thundil Karuppa Raj,G. Edison 대한설비공학회 2018 International Journal Of Air-Conditioning and Refr Vol.26 No.4

The performance of the refrigeration system mainly depends on the hermetic compressor. Of different compressors used in the refrigeration and air conditioning industries, hermetic reciprocating compressors are still efficient and have its place in domestic applications. This paper presents a review of most critical parameters and their influence on the hermetic reciprocating compressor performance. A detailed study is done on parameters like backflow, effective force and flow areas, valve dynamic behavior, etc. This study mainly concentrated on compressor valves which influence the performance of the hermetic compressor to a much greater extent. Finally, the study reveals that these parameters are playing a vital role in influencing the performance of the refrigeration system. Advanced numerical techniques involving combining fluid flow and structural analysis involving Fluid Structure Interaction (FSI) may give a better insight of the flow physics happening inside the compressors and the effect of fluid force on valve fluttering, back pressure and dynamics characteristics can be revealed in depth to optimize the performance of the hermetic compressor for household applications involving air conditioners, refrigerators, water coolers, chillers, etc.

Functional outcomes in children with reduction glossectomy for vascular malformations - “less is more!”

John K,Thomas,Vivek Samuel Gaikwad,Telugu Ramesh Babu,John Mathai,Rohit Srinivas,Immanuel Sampath Karl 대한구강악안면외과학회 2021 대한구강악안면외과학회지 Vol.47 No.3

Objectives: Vascular malformation (VM) of the tongue can cause true macroglossia in children. Reduction glossectomy provides primary relief when sclerotherapy has failed or is not possible. In this study, we evaluated the surgical role in functional outcome of reduction glossectomy performed for VM of the tongue. Patients and Methods: We evaluated the functional and surgical outcomes of seven children who were treated at a tertiary care centre in Southern India between 2013 and 2018. Results: Six children underwent median glossectomy, while one child underwent lateral glossectomy. Functional assessment was performed at least 2 years after the date of surgery. At the time of assessment, speech was comprehensible for three children and was occasionally unintelligible in four children. Taste and swallowing were normal in all seven children. Six children exhibited a minimal residual lesion after surgery, of which only one was symptomatic. Residual lesions were managed with sclerotherapy (n=3), observation (n=2), or repeat surgery (n=1). Conclusion: Reduction glossectomy in children with macroglossia secondary to VMs has acceptable outcomes in terms of cosmesis and speech, with no gastronomic restriction.

Applications of Machine Learning Using Electronic Medical Records in Spine Surgery

John T. Schwartz,Michael Gao,Eric A. Geng,Kush S. Mody,Christopher M. Mikhail,Samuel K. Cho 대한척추신경외과학회 2019 Neurospine Vol.16 No.4

Developments in machine learning in recent years have precipitated a surge in research on the applications of artificial intelligence within medicine. Machine learning algorithms are beginning to impact medicine broadly, and the field of spine surgery is no exception. Electronic medical records are a key source of medical data that can be leveraged for the creation of clinically valuable machine learning algorithms. This review examines the current state of machine learning using electronic medical records as it applies to spine surgery. Studies across the electronic medical record data domains of imaging, text, and structured data are reviewed. Discussed applications include clinical prognostication, preoperative planning, diagnostics, and dynamic clinical assistance, among others. The limitations and future challenges for machine learning research using electronic medical records are also discussed.

Clinical and Therapeutic Aspects of Squamous Cell Carcinoma of Oral Tongue

Samuel Ryu(류삼열),Chang Gul Lee(이창걸),In Kyu Park(박인규),Chang Ok Suh(서창옥),Gwi Eon Kim(김귀언),John J.K.(노준규) 대한방사선종양학회 1987 Radiation Oncology Journal Vol.5 No.2

구강 내 설암은 설의 전방 삼분의 이에서 발생하는 것으로 근치적 요법으로는 수술과 방사선 치료가 그 근간을 이루어 왔으며, 같은 병기에서 두 요법간의 완치율은 거의 동일한 것으로 보고되고 있다. 특히 조기병소(T1, T2)에서는 이 두 요법간에 비슷한 국소 퇴치율을 보이므로 치료법의 선택에는 그 치료로 인해 발생하는 기능적 손상 및 미용적 결손을 최소화하는데 역점을 두어야 할 것이다. 그러므로 큰 기능적 손상 없이 용이하게 절제할 수 있는 첨단부 및 배부의 작은 병소를 제외하고 대부분의 조기병소는 방사선 요법으로 정상적인 발성 및 연하작용을 유지하며 치료할 수 있다. 그러나 비교적 진행된 병소(late T2, T3) 중 하부 침윤이 심하지 않으면 방사선 치료만으로 완치될 수 있으며 수술은 방사선 치료 후 재발암의 구원요법으로 유보해 두는 것이 바람직할 것이다. 방사선 치료의 방법으로는 외부 조사법 외에 자입요법 등이 있으나 최대의 국소 퇴치를 위해서는 자입요법이 필수적인 것으로 나타났다. 이러한 자입요법으로 치료기간을 단축할 수 있음은 말할 것도 없고 투여되는 선량을 증가시킴으로서 국소 퇴치율의 향상을 기대하고 나아가 생존율을 높일 수 가 있을 것이다. Fourty nine patients with squamous cell carcinoma of oral tongue were reviewed retrospectively for the evaluation of clinical manifestation and for the comparison between therapeutic modalites. The gross shape of the tumor was infiltrative in 22, ulcerative in 12, ad ulcer-oinfiltrative type in 10 patients. Direct extension of the tumor was most commonly to the floor of the mouth. The incidence of nodal metastasis generally increased with tumor stage. 55% of the patients showed neck nodal metastasis at the time of diagnosis. Ipsilateral subdigastric node were most commonly involved, followed by submandibular nodes. The 5-year survival rate of patients treated with surgery and radiotherapy was 58.7% in contrast to 21.6% in radiation alone group. Overall 5-year survival rate was 31% In radiation alone group, half of the patients in stage I, II were locally controlled. But the local control In stage III, IV was much inferior to early lesions. Especially, of 4 patients combined with implantation technique, 3 were completely controlled. 5-year survival rate of these implanted patients was 50%, 49.4% of patients treated over 7,000cGy survived 5 years. This was significant in contrast to 6.4% of the group treated below 7,000cGy. The most common sites of failures were primary sites. In early lesions primary radiotherapy with implantation would be an appropriate treatment in cancer of oral tongue, operation reserved for radiation failure. Operation and adjuvant radiotherapy is recommended in cases of advanced disease.

A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor: Microfibril-Associated Glycoprotein 2

Mok, Samuel C.,Bonome, Tomas,Vathipadiekal, Vinod,Bell, Aaron,Johnson, Michael E.,Wong, kwong-kwok,Park, Dong-Choon,Hao, Ke,Yip, Daniel K.P.,Donninger, Howard,Ozbun, Laurent,Samimi, Goli,Brady, John,R Elsevier 2009 CANCER CELL Vol.16 No.6

<P><B>Summary</B></P><P>Advanced stage papillary serous tumors of the ovary are responsible for the majority of ovarian cancer deaths, yet the molecular determinants modulating patient survival are poorly characterized. Here, we identify and validate a prognostic gene expression signature correlating with survival in a series of microdissected serous ovarian tumors. Independent evaluation confirmed the association of a prognostic gene microfibril-associated glycoprotein 2 (<I>MAGP2</I>) with poor prognosis, whereas in vitro mechanistic analyses demonstrated its ability to prolong tumor cell survival and stimulate endothelial cell motility and survival via the α<SUB>V</SUB>β<SUB>3</SUB> integrin receptor. Increased MAGP2 expression correlated with microvessel density suggesting a proangiogenic role in vivo. Thus, MAGP2 may serve as a survival-associated target.</P>

Radiation Therapy Results of the Non-Hodgkin's Lymphoma of the Sinonasal Cavity

Soo Kon Kim(김수곤),Samuel Ryu(류삼열),Kyung Ran Park(박경란),Chang Gul Lee(이창걸),Chang Ok Suh(서창옥),Gwi Eon Kim(김귀언),John J.K. Loh(노준규),Byung Soo Kim(김병수),Won Pyo Hong(홍원표) 대한방사선종양학회 1987 Radiation Oncology Journal Vol.5 No.2

1970년부터 1980년까지 연세대학교 치료방사선과에서 방사선치료 받은 비강 및 부비동에 발생한 NHL 환자 15예를 대상으로 후향성 분석을 하여 다음과 같은 결과를 얻었다. 1. 병기분포는 13예가 IE 2예가 IIE였고 TNM병기에 따르면 7예가 국소병변이 진행된 T₃, T₄ 환자였다. 2. Overall 5년 생존율을 25%, IE는 28%, IIE는 0%였다. 3. 병기별 치료실패율은 T₁, T₂는 33%(2/6), T₃, T₄ 는 86%(6/7), IIE에서는 100%(2/2)였다. 4. 방사선 조사량이 55Gy 이상인 경우 1000%의 완전 관해율을 보였으며 55Gy이하인 경우 73%의 완전 관해율을 보였다. 5. 비강 및 부비동의 NHL의 Ann Arbor 병기 분류와 함께 TNM 병기도 예후에 중요한 요인이 될 것 같다. 6. 국소병변이 진행된 병기 T₃, T₄와 IIE 환자에서는 화학요법제의 병용치료가 필요할 것 같다. From January 1970 through December 1984, 15 patients with sinonasal Non-Hodgkin's lymphoma combined to the head and neck were treated by external irradiation.13 patients were stage It and 2 were stage IIE by Ann Arbor Classification. However, when using TNM system, 7 were locally advanced T3, T4 lesions. All patients had follow up from 3.7 to 16 years with the median follow-up of 8.5 years. The overall actuarial 5-year survival rates were 25%, 28% for IE and 0% for IIE. Total tumor dose varied from 40 to 68 Gy. 100% complete response with a total tumor dose of more than 55 Gy and 73% complete response with less than 55Gy. When the disease was staged using the TNM (AJC) system, the five-year disease free survival for T1 and T2 patients was 50% as compared with 14% for T3 and T4. Failure rate by stage was 33%(2/6) for T1 and T2, 86%(6/7) for T3 and T4, and 100%(2/2) for IIE. The results suggest that 1. Higher CR could be obtained with a total tuner dose of more than 55 Gy. 2. Use of TNM staging system is as important as Ann arbor in management of sinonasal NHL. 3. The addition of combination chemotherapy should be considered for T3, T4 and IIE the sinonasal Non-Hodgkin's lymphoma although the disease is limited to head and neck.

Emerging Technologies in the Treatment of Adult Spinal Deformity

Akshar V. Patel,Christopher A. White,John T. Schwartz,Nicholas L. Pitaro,Kush C. Shah,Sirjanhar Singh,Varun Arvind,Jun S. Kim,Samuel K. Cho 대한척추신경외과학회 2021 Neurospine Vol.18 No.3

Outcomes for adult spinal deformity continue to improve as new technologies become integrated into clinical practice. Machine learning, robot-guided spinal surgery, and patient-specific rods are tools that are being used to improve preoperative planning and patient satisfaction. Machine learning can be used to predict complications, readmissions, and generate postoperative radiographs which can be shown to patients to guide discussions about surgery. Robot-guided spinal surgery is a rapidly growing field showing signs of greater accuracy in screw placement during surgery. Patient-specific rods offer improved outcomes through higher correction rates and decreased rates of rod breakage while decreasing operative time. The objective of this review is to evaluate trends in the literature about machine learning, robot-guided spinal surgery, and patient-specific rods in the treatment of adult spinal deformity.

Clinical and Therapeutic Aspects of Squamous Cell Carcinoma of Oral Tongue

류삼열,이창걸,박인규,서창옥,김귀언,노준규,Ryu Samuel,Lee Chang Gul,Park In Kyu,Suh Chang Ok,Kim Gwi Eon,Loh John J.K. The Korean Society for Radiation Oncology 1987 Radiation Oncology Journal Vol.5 No.2

구강 내 설암은 설의 전방 삼분의 이에서 발생하는 것으로 근치적 요법으로는 수술과 방사선 치료가 그 근간을 이루어 왔으며, 같은 병기에서 두 요법간의 완치율은 거의 동일한 것으로 보고되고 있다. 특히 조기병소(T1, T2)에서는 이 두 요법간에 비슷한 국소 퇴치율을 보이므로 치료법의 선택에는 그 치료로 인해 발생하는 기능적 손상 및 미용적 결손을 최소화하는데 역점을 두어야 할 것이다. 그러므로 큰 기능적 손상 없이 용이하게 절제할 수 있는 첨단부 및 배부의 작은 병소를 제외하고 대부분의 조기병소는 방사선 요법으로 정상적인 발성 및 연하작용을 유지하며 치료할 수 있다. 그러나 비교적 진행된 병소(late T2, T3) 중 하부 침윤이 심하지 않으면 방사선 치료만으로 완치될 수 있으며 수술은 방사선 치료 후 재발암의 구원요법으로 유보해 두는 것이 바람직할 것이다. 방사선 치료의 방법으로는 외부 조사법 외에 자입요법 등이 있으나 최대의 국소 퇴치를 위해서는 자입요법이 필수적인 것으로 나타났다. 이러한 자입요법으로 치료기간을 단축할 수 있음은 말할 것도 없고 투여되는 선량을 증가시킴으로서 국소 퇴치율의 향상을 기대하고 나아가 생존율을 높일 수 가 있을 것이다. Fourty nine patients with squamous cell carcinoma of oral tongue were reviewed retrospectively for the evaluation of clinical manifestation and for the comparison between therapeutic modalites. The gross shape of the tumor was infiltrative in 22, ulcerative in 12, ad ulcer-oinfiltrative type in 10 patients. Direct extension of the tumor was most commonly to the floor of the mouth. The incidence of nodal metastasis generally increased with tumor stage. $55\%$ of the patients showed neck nodal metastasis at the time of diagnosis. Ipsilateral subdigastric node were most commonly involved, followed by submandibular nodes. The 5-year survival rate of patients treated with surgery and radiotherapy was $58.7\%$ in contrast to $21.6\%$ in radiation alone group. Overall 5-year survival rate was $31\%$ In radiation alone group, half of the patients in stage I, II were locally controlled. But the local control In stage III, IV was much inferior to early lesions. Especially, of 4 patients combined with implantation technique, 3 were completely controlled. 5-year survival rate of these implanted patients was $50\%,\;49.4\%$ of patients treated over 7,000cGy survived 5 years. This was significant in contrast to $6.4\%$ of the group treated below 7,000cGy. The most common sites of failures were primary sites. In early lesions primary radiotherapy with implantation would be an appropriate treatment in cancer of oral tongue, operation reserved for radiation failure. Operation and adjuvant radiotherapy is recommended in cases of advanced disease.

Radiation Therapy Results of the Non-Hodgkin's Lymphoma of the Sinonasal Cavity

김수곤,박경란,이창걸,서창옥,김귀언,노준규,홍원표,김병수,류삼열,Kim Soo Kon,Park Kyung Ran,Lee Chang Gul,Suh Chang Ok,Kim Gwi Eon,Loh John J.K.,Hong Won Pyo,Kim Byung Soo,Ryu Samuel The Korean Society for Radiation Oncology 1987 Radiation Oncology Journal Vol.5 No.2

1970년부터 1980년까지 연세대학교 치료방사선과에서 방사선치료 받은 비강 및 부비동에 발생한 NHL환자 15예를 대상으로 후향성 분석을 하여 다음과 같은 결과를 얻었다. 1. 병기분포는 13예가 IE 2예가 IIE였고 TNM병기에 따르면 7예가 국소병변이 진행된 T3, T4 환자였다. 2. Overall 5년 생존율을 $25\%$, IE는 $28\%$, IIE는 $0\%$였다. 3. 병기별 치료실패율은 T1, T2는 $33\%(2/6),\; T3,\;T_4는\;86\%(6/7),\;IIE$에서는 $100\%(2/2)$였다. 4. 방사선 조사량이 55Gy 이상인 경우 $100\%$의 완전 관해율을 보였으며 55Gy이하인 경우 $73\%$의 완전 관해율을 보였다. 5. 비강 및 부비동의 NHL의 Ann Arbor병기 분류와 함께 TNM 병기도 예후에 중요한 요인이 될 것 같다. 6. 국소병변이 진행된 병기 T3, T4와 IIE 환자에서는 화학요법제의 병용치료가 필요할 것 같다. From January 1970 through December 1984, 15 patients with sinonasal Non-Hodgkin's lymphoma combined to the head and neck were treated by external irradiation.13 patients were stage It and 2 were stage IIE by Ann Arbor Classification. However, when using TNM system, 7 were locally advanced T3, T4 lesions. All patients had follow up from 3.7 to 16 years with the median follow-up of 8.5 years. The overall actuarial 5-year survival rates were $25\%,\;28\%$ for IE and $0\%$ for IIE. Total tumor dose varied from 40 to 68 Gy. $100\%$ complete response with a total tumor dose of more than 55 Gy and $73\%$ complete response with less than 55Gy. When the disease was staged using the TNM (AJC) system, the five-year disease free survival for T1 and T2 patients was $50\%$ as compared with $14\%$ for T3 and T4. Failure rate by stage was $33\%(2/6)$ for T1 and T2, $86\%(6/7)$ for T3 and T4, and $100\%$(2/2) for IIE. The results suggest that 1. Higher CR could be obtained with a total tuner dose of more than 55 Gy. 2. Use of TNM staging system is as important as Ann arbor in management of sinonasal NHL. 3. The addition of combination chemotherapy should be considered for T3, T4 and IIE the sinonasal Non-Hodgkin's lymphoma although the disease is limited to head and neck.