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- 저자 : Junping Kou (검색결과 2 건)
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Jialiang Kou,Lingling Li,Junping Shi 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.4
Uniaxial compression on high ductile concrete after erosion by different concentrations of sulfate solutions was conducted. The compressive strength, mass change fraction, corrosion resistance coefficient and other parameters on the basic mechanical properties of high ductile concrete is studied. The erosion form and uniaxial compression failure characteristics of the samples was analyzed. And using scanning electron microscope to observe the microscopic morphology of the samples, it is found that sulfate and age accelerate the damage to high ductile concrete, with its damage mechanism revealed. The test results are as follows: with the increase of age, the compressive strength and quality of high ductile concrete in 5%, 10% and saturated sulfate solution will increase first and then decrease; the mass change fraction of high ductile concrete is greater than that of ordinary concrete, it has the characteristics of self-compacting before the erosion age of 270 days, Then, as the sulfate solution concentration increases, the damage of the high ductile concrete becomes more serious. The comparison test with ordinary concrete shows that high ductile concrete has higher resistance to sulfate attack. This research can provide experimental basis for the application of high ductile concrete in engineering under sulfate corrosion environment.
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Jingui Hu,Ling Zhang,Fei Fu,Qiong Lai,Lu Zhang,Tao Liu,Boyang Yu,Junping Kou,Fang Li 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.2
Background: Ginsenoside Rb1, a bioactive component isolated from the Panax ginseng, acts as a remedy to prevent myocardial injury. However, it is obscure whether the cardioprotective functions of Rb1 are related to the regulation of endogenous metabolites, and its potential molecular mechanism still needs further clarification, especially from a comprehensive metabolomics profiling perspective. Methods: The mice model of acute myocardial ischemia (AMI) and oxygen glucose deprivation (OGD)-induced cardiomyocytes injury were applied to explore the protective effect and mechanism of Rb1. Meanwhile, the comprehensive metabolomics profiling was conducted by high-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (HPLC-Q/TOF-MS) and a tandem liquid chromatography and mass spectrometry (LC-MS). Results: Rb1 treatment profoundly reduced the infarct size and attenuated myocardial injury. The metabolic network map of 65 differential endogenous metabolites was constructed and provided a new inspiration for the treatment of AMI by Rb1, which was mainly associated with mitophagy. In vivo and in vitro experiments, Rb1 was found to improve mitochondrial morphology, mitochondrial function and promote mitophagy. Interestingly, the mitophagy inhibitor partly attenuated the cardioprotective effect of Rb1. Additionally, Rb1 markedly facilitated the phosphorylation of AMP-activated protein kinase a (AMPKa), and AMPK inhibition partially weakened the role of Rb1 in promoting mitophagy. Conclusions: Ginsenoside Rb1 protects acute myocardial ischemia injury through promoting mitophagy via AMPKa phosphorylation, which might lay the foundation for the further application of Rb1 in cardiovascular diseases.
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