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Effect of Diallyl Trisulfide on the Pharmacokinetics of Dipyridamole in Rats
Yue Wang,Gang Cheng,Meijuan Zou,Nan Zhao,Jungang Ren,Hong Zhou 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.11
This study was aimed to evaluate the effect of diallyl trisulfide (DATS), a major component derived from garlic used to inhibit platelet thromboxane formation, on the pharmacokinetics of dipyridamole. Pharmacokinetic parameters of dipyridamole were determined in rats following intragastric (80 mg/kg suspension or 40 mg/kg solution) or intravenous (3 mg/kg) administration of dipyridamole with coadministration (20 mg/kg) and long-term pretreatment of DATS (10 or 20 mg/kg/day for 15 consecutive days). In addition, everted gut sac models were used to assess transepithelial transport of dipyridamole and the effect of DATS on the intestinal absorption of dipyridamole. After coadministration and long-term pretreatment of DATS, significantly lower C_max and AUC_(0–240 h were observed for intragastric administration of dipyridamole,whereas little change was noted after intravenous dipyridamole administration. After adding DATS (10 and 50 μg/mL) in the everted gut sacs, absorption of dipyridamole was remarkably decreased in the ileum and jejunum (p < 0.01). In conclusion, DATS reduced the oral exposure of dipyridamole in rats likely by the modification of the dissolution rate and intestinal absorption of dipyridamole, indicating that combined use of DATS or DATS-containing supplements with dipyridamole may require caution as low plasma concentrations of dipyridamole may lead to a subtherapeutic effect of this agent.
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Bin Zhang,Jungang Wang,Ruina Mo 전력전자학회 2024 JOURNAL OF POWER ELECTRONICS Vol.24 No.1
With the development of new energy technologies, there has been an increasing demand for high-powered power generators. Therefore, high torque density and high stability transmission devices are needed to ensure the stable operation of generators. This paper proposes and investigates a connected double-modulated axial magnetic gear embedded H-shaped pole shoes (CDMHAMG) structure. This structure uses a spoke low-speed rotor with embedded H-shaped pole shoes and a connected modulation ring on the other side of the spoke rotor. The CDMHAMG can effectively increase the utilization of permanent magnets and suppress the leakage phenomenon, which greatly increases the torque density and suppress the torque ripple. To study the characteristics of the CDMHAMG, the electromagnetic performance of a conventional axial magnetic gear (CAMG), a spoke axial magnetic gear (SAMG), and different double-modulated axial magnetic gears are finite element analyzed. It can be found that the rotor torque density of the CMDHAMG is 80.18 kN/m3, which is 1.12 times that of the CAMG. In addition, the torque ripple of the CMDHAMG is 11.4%, which is 47.7% of that of the CAMG. Therefore, the CMDHAMG proposed in this paper has greater torque density and higher transmission stability than the CAMG and is more suitable for power generation.
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Weihong Wu,Jingjing Leng,Zheng Wang,Hongqiang Qu,Jungang Gao 한국고분자학회 2016 Macromolecular Research Vol.24 No.3
Boron-containing bisphenol-S formaldehyde resin (BBPSFR) with different amounts of nano-SiO2 by in situ formation was used to cure o-cresol formaldehyde epoxy resin (o-CFER). The curing kinetics, dynamic mechanical properties, and thermal stability of BBPSFR/o-CFER/nano-SiO2 composites (BCS) were investigated by differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), thermogravimetry (TG), and thermogravimetrymass spectrometry (TGMS). Morphology of nano-SiO2-containing BBPSFR and glass fiber laminates of the BCS were characterized by transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The mechanical properties and electrical properties were also determined. The results showed that nano-SiO2 accelerated the curing process and decreased the curing temperature; the non-isothermal curing kinetics of the BCS can be described by the two-parameter (m, n) Šesták-Berggren kinetic model, and the average value of m was 0.32 and n was 1.00. The thermal stability was enhanced by the addition of nano-SiO2, especially at higher temperatures, and the residual weight increased with increasing nano-SiO2 content. Incorporation of 6 wt% of nano-SiO2 increased the impact strength from 105 to 149 kJ/m2 and storage modulus at ambient from 6.85 to 12.7 GPa, and the TEM photograph of which showed that nano-SiO2 particles (about 50 nm) were dispersed in the matrix more uniformly. The volume resistance, Rv, and dielectric constant, ε, slightly increased when the nano-SiO2 content was 3 wt%.
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Pharmacokinetics of Carbamazepine Polymorphs and Dihydrate in Rats, Related to Dogs and Humans
Caihong Xu,Gang Cheng,Meijuan Zou,Yi Liu,Jungang Ren,Ye Tian,Jing Yan,Yiping Wang 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.11
Species differences in the oral pharmacokinetics and absolute bioavailability (F_abs) of carbamazepine polymorphs (form I and form III) and dihydrate were studied. The pharmacokinetics of each form was investigated in rats following a single oral/intravenous administration of 10 mg/kg and an oral dose of 80 mg/kg, which were compared with the published data obtained from dogs and humans. No significant differences were found in their C_max, T_max, AUC_(0-∞) and F_abs among the forms at the low dose. However, significant differences were observed at the high dose. The F_abs of each form was markedly reduced with increasing of doses in species (e.g. F_abs in rats ranged from > 82% to 38.4% - 56.0%). At a comparable dose, the C_max, and AUC_(0-∞)of rats and humans were about 3-10 times higher than in dogs. The absorption rate of form III in rats exhibited a similar trend to that in humans, and was far higher in dogs. A multi-peak phenomenon in plasma curves was observed in rats and humans, but not in dogs. In conclusion, rats appear to be a better predictor of carbamazepine polymorphs absorbed in humans,and form III may be more suitable as a pharmaceutical crystal.
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