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Kwon, Yo Han,Woo, Sang‐,Wook,Jung, Hye‐,Ran,Yu, Hyung Kyun,Kim, Kitae,Oh, Byung Hun,Ahn, Soonho,Lee, Sang‐,Young,Song, Seung‐,Wan,Cho, Jaephil,Shin, Heon‐,Cheol,Kim, Je Y WILEY‐VCH Verlag 2012 Advanced Materials Vol.24 No.38
<P>The first ever demonstration of a cable‐type lithium ion battery architecture with outstanding omni‐directional flexibility is described by Je Young Kim, Heon‐Cheol Shin, and co‐workers on page 5192. The Front Cover image illustrates the unique battery architecture comprising a skeleton frame surrounding an empty space, that is, a hollow‐spiral anode with a multi‐helical structure. This design enables the battery to reliably power an LED screen or an MP3 player even under severe mechanical twisting and bending. </P>
Park, Jinbong,Jeon, Yong-Deok,Kim, Hye-Lin,Lim, Hara,Jung, Yunu,Youn, Dong-Hyun,Jeong, Mi-Young,Kim, Hyun-Ju,Kim, Sung-Hoon,Kim, Su-Jin,Hong, Seung-Heon,Um, Jae-Young Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Obesity has become a major health threat in developed countries. However, current medications for obesity are limited because of their adverse effects. Interest in natural products for the treatment of obesity is thus rapidly growing. Korean Medicine (KM) is characterized by the wide use of herbal formulas. However, the combination rule of herbal formulas in KM lacks experimental evidence. According to <I>Shennong's Classic of Materia Medica</I>, the earliest book of herbal medicine, <I>Veratrum nigrum</I> (VN) has antagonistic features against <I>Panax ginseng</I> (PG), and the PG-VN pair is strictly forbidden. In this study, we have shown the effects of PG, VN, and their combination on obesity in high-fat (HF) diet-induced obese mice and in 3T3-L1 cells. PG, VN, and PG-VN combination significantly reduced weight gain and the fat pad weight in HF diet-induced obese mice. They also significantly decreased lipid accumulation and the expressions of two major adipogenesis factors, PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I>, in 3T3-L1 cells. In addition, the PG-VN combination had synergistic effects compared with the mixture of extracts of PG and VN on inhibition of PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I> expressions at lower doses. These results indicate a new potential anti-obese pharmacotherapy and also provide scientific evidence supporting the usage of herbal combinations instead of mixtures in KM.</P>
( Jung Min Bae ),( Ro Woo Lee ),( Sang Ho Oh ),( Jeong Hyun Shin ),( Hee Young Kang ),( Ji Hun Park ),( Hee Jung Kim ),( Ki-heon Jeong ),( Hee Jung Lee ),( Sang Hoon Lee ),( Dong Hyun Kim ),( Dong-you 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: There have been concerns for photocarcinogenesis following long-term UV exposure. Evidence about association between the risk of skin cancer and long-term narrow-band ultraviolet B (NBUVB) phototherapy in patients with vitiligo is limited. Objectives: To investigate the risks of skin cancer and premalignant skin lesions, based on the sessions of NBUVB phototherapy in patients with vitiligo and to assess the risks in patients undergone extremely long-term phototherapeutic care (over 500 NBUVB sessions). Methods: This is a retrospective cohort study based on the Korean National Health Insurance Claims database. A total of 60,321 patients with vitiligo aged over 20 were enrolled between 2007 to 2017. Primary outcomes were the development of actinic keratosis, Bowen’s disease, nonmelanoma skin cancer, and melanoma occurred after enrollment. Results: Among the 60,321 patients with vitiligo, the risks of Bowen’s disease, nonmelanoma skin cancer, and melanoma did not increase after phototherapy; the risk of actinic keratosis increased significantly in those who had undergone ≥200 NBUVB sessions (hazard ratio, 2.280; 95% confidence interval 1.537 - 3.383). We then identified 717 patients with vitiligo who had undergone at least 500 sessions; their risks of nonmelanoma skin cancer and melanoma were no greater than those of the controls. Conclusion: Our results imply that long-term NBUVB phototherapy does not increase the risk of skin cancer in patients with vitiligo.
In vitro and Cellular Antioxidant Activity of Arginyl-fructose and Arginyl-fructosyl-glucose
Jung-Sook Lee,Gyo-Nam Kim,Sang-Hyun Lee,Eui-Su Kim,Kyoung-Soo Ha,Young-In Kwon,Heon-Sang Jeong,Hae-Dong Jang 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.6
Arginyl-fructose (AF) and arginyl-fructosyl-glucose (AFG) were chemically synthesized and purified. Their in vitro and cellular antioxidant activity was investigated using oxygen radical absorbance capacity (ORAC) and cellular antioxidant activity assay, respectively. The peroxyl radical scavenging activity of AF was much higher than that of AFG, which was in good agreement with their reduction capacity to donate electrons or hydrogen atoms. On the other hand, the hydroxyl radical scavenging activity of AF was weaker than that of AFG, which was consistent with their metal chelating activity, suggesting that AFG-Cu²? complex may be less redox-active than AF-Cu²? complex due to 1 glucose molecule attached. The cellular antioxidant activity of AF and AFG appeared to depend on both their permeability into cell membrane and the scavenging activity on peroxyl or hydroxyl radicals. These results indicate that AF and AFG, Maillard reaction products, may have a high potential as a material for the development of nutraceutical food with antioxidant activity.
( Jung Min Bae ),( Ki-heon Jeong ),( Chong Won Choi ),( Ji Hun Park ),( Hee Jung Lee ),( Hee Jung Kim ),( Sang Hoon Lee ),( Sang Ho Oh ),( Jeonghyun Shin ),( Hee Young Kang ),( Weon Ju Lee ),( Hyun Je 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Vitiligo remains a major challenge in dermatology. However, much of the treatment remains unclear, because little evidence is available. Objectives: To answer some critical questions pertaining to management of vitiligo patients. Methods: A modified Delphi process among 31 vitiligo experts was conducted. A total of 12 clinical vitiligo treatment questions without clear answers were collected via a vote. To address each question, two members performed systematic literature reviews and prepared draft statements along with the levels of evidence and strength of recommendation. After reviewing the draft, all expressed their extent of agreement from 1 (strong disagreement) to 9 (strong agreement) for each item. The drafts were revised to reflect suggested comments. Voting continued until the agreement rate did not change. Results: The consensus process was completed after five rounds. We identified the best answers to 12 key questions, including issues on long-term phototherapy, systemic and topical corticosteroids, topical calcineurin inhibitors, immunosuppressants, excimer laser treatment, and surgical interventions. Conclusion: This consensus would complement current guidelines and aid both physician and patient decisionmaking in the treatment of vitiligo.
Sang-Heon Cho,Jung-Hee Lee,Hyeong-Seok Lim,Kyoo-Hyung Lee,Dae-Young Kim,Sangmin Choe,Kyun-Seop Bae,Je-Hwan Lee 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.3
The objective of this study was to externally validate a new dosing scheme for busulfan. Thirty-seven adult patients who received busulfan as conditioning therapy for hematopoietic stem cell transplantation (HCT) participated in this prospective study. Patients were randomized to receive intravenous busulfan, either as the conventional dosage (3.2 mg/kg daily) or according to the new dosing scheme based on their actual body weight (ABW) (23×ABW<sup>0.5</sup> mg daily) targeting an area under the concentration-time curve (AUC) of 5924 μM∙min. Pharmacokinetic profiles were collected using a limited sampling strategy by randomly selecting 2 time points at 3.5, 5, 6, 7 or 22 hours after starting busulfan administration. Using an established population pharmacokinetic model with NONMEM software, busulfan concentrations at the available blood sampling times were predicted from dosage history and demographic data. The predicted and measured concentrations were compared by a visual predictive check (VPC). Maximum a <i>posteriori</i> Bayesian estimators were estimated to calculate the predicted AUC (AUC<sub>PRED</sub>). The accuracy and precision of the AUC<sub>PRED</sub> values were assessed by calculating the mean prediction error (MPE) and root mean squared prediction error (RMSE), and compared with the target AUC of 5924 μM∙min. VPC showed that most data fell within the 95% prediction interval. MPE and RMSE of AUC<sub>PRED</sub> were -5.8% and 20.6%, respectively, in the conventional dosing group and –2.1% and 14.0%, respectively, in the new dosing scheme group. These findings demonstrated the validity of a new dosing scheme for daily intravenous busulfan used as conditioning therapy for HCT.
Jung Yeon Choi,Heon Soo Shin,Sung Boo Chung,Jin Woo Park,Min Sup Park,Ki Hwan Eom 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
This paper develop a nurse call system using the wireless communication to resolve that a portable problem of established nurse call system. The established nurse call system has a problem that don’t use outside of the sickroom because using a wire communication. The proposed nurse call system is composed of a terminal for nurse, a terminal for patient and a server part. The efficacy of the proposed system is verified by means of experimental. Experimental results are presented that show the effectiveness.
Enhanced solubility and dissolution rate of itraconazole by a solid dispersion technique
Jung, Jae-Young,Yoo, Sun Dong,Lee, Sang-Heon,Kim, Kye-Hyun,Yoon, Doo-Sun,Lee, Kyu-Hyun 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-
The aim of the present study was to improve the solubility and dissolution rate of a poorly water-soluble drug, itraconazole, by a solid dispersion technique. Solid dispersion particles of itraconazole were prepared with various pH-independent and -dependent hydrophilic polymers and were characterized by differential scanning calorimetry, powder X-ray diffraction and scanning electron microscopy. Of the polymers tested, pH-dependent hydrophilic polymers, AEA® and Eudragit® E 100, resulted in highest increases in drug solubility (range, 141.4-146.9-fold increases). The shape of the solid dispersion particles was spherical, with their internal diameter ranging from 1-10 ㎛. The dissolution rate of itraconazole from the tablets prepared by spray drying (SD-T) was fast, with >90% released within 5 min. SD-T prepared with AEA® or Eudragit® E 100 at a 1:1 drug to hydrophilic polymer ratio (w/w) showed approximately 70-fold increases in the dissolution rate over a marketed product. ⓒ 1999 Published by Elsevier Science B.V. All rights reserved.