정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

고등학교 야영활동 참여가 인성발달에 미치는 영향

노형철(Hyung Chul Roh),정명수(Myeong Soo Jung),정순승(Soon Seung Jung),이광호(Kwang Ho Lee) 한국사회체육학회 2000 한국사회체육학회지 Vol.13 No.-

Camping activities were thought as one of educational methods. This study analyzed effects of participation in camping activities on high school students` humanity development variables, which affect humanity development were used for this study and data were collected at high schools in Kwang-ju city. At this site 600 surveys were distributed to a random sample of 300 participant and 30 non participant in camping activities. The results were as follows. 1. Participation in camping activities more positively affected humanity developments of male students` than that of female students`. 2. There was significant relationship between camping activities and sociality, leadership, activity and responsibility development. 3. There is no relationship between frequency of participation in camping activities and humanity development. Since the data were collected only at high schools in Kwang-ju city, further studies on high schools in countrysides would be required.

공공대응성과 주민참여에 관한 연구

정우열,이광수 경운대학교 산업기술연구소 2000 産業技術硏究論文誌 Vol.3 No.1(B)

The purpose of this study is to public responsiveness and citizens. The major meaning of this paper are sa follow: First, this study indicates that conception, general relation of public responsiveness and citizens partication. Second, research that interrelation of public responsiveness as typologic of citizations participation, study of mutual appropriateness relation by both groups. Finally, importance of this paper will contribute to the theory framework for emprical research.

조증에서 Lithium 치료효과의 적혈구 Lithium Efflux 와의 관계

정수영,김광일 大韓神經精神醫學會 1981 신경정신의학 Vol.20 No.2

In recent years many psychiatrists have been attracted by the promising reports about the RBC lithium efflux as a predictor of clinical response. The major impetus in this area comes from the report by Haas and his colleagues(1975) that the Li-Na counterflow system in human RBCs produces the uphill lithium efflux, which means that the lithium ion is driven up its electrochemical potential by an oppositely directed sodiumion electrochemical potential. Pandey and his colleagues (1977, 1979) reported that patients with manic depressive illness have higher lithium ratios (definedas intracellular lithium concentration/extracellular lithium concentration) and lower lithium effluxes than normal controls) presumably due to inherited Li-Na counterflow system defect. This study attempts to confirm the predictability of the clinical response to lithium with lithium efflux in RBCs. The subjects in this study were 15 manic patients and 5 normal controls. The manic patients were maintained on lithium carbonate 900 to 2,100mg per day for a minimum of 5 weeks. The controls on lithium carbonate were on fixed doses of 900mg per day for 2 weeks. Blood was sampled 12 hours after last lithium intake. In vivo lithium concentration in plasma and RBC was measured by adoption of “repetitive thawing method”to obtain complete hemolytic of the RBCs. Uphill lithium efflux was measured from erythrocytes loaded with lithium to give an erythrocyte lithium concentration at a level of mEq./L, followed by suspension in isotonic solution containing 135mM NaCl, 5mM KCI and 1.5mM LiCl for 4 hours. Leak effusions were measured from mEq./L. Li-loaded erythrocytes by suspension in solution containing NaCl 140mEq./L, and furosemide ???M for 1 hour. The following results could be obtained: Manic patients showed 3-fold interindividual variation of in vivo lithium ratio and control cases did 2-fold one. In ivo RBC lithium ratios were significantly higher in the manics than in the controls. This result suggests that there is some defect of the lithium transport system in RBC membrane of manic patient. Among the manics, RBC lithium ratio was higher in early responders than in delayed responders. Moreover uphill lithium effluxes as well as downhill lithium effluxes were evidently lower in the early responders than in the delayed responders. There was no significant correlation between leak effusion and lithium ratio. From the fact that lithium ratio has a highly reverse correlation with uphill and downhill lithium effluxes, one can suggest that early responders have more severely defective Li-Na counterflow system than delayed responders. Consequently, RBC lithium efflux was proved to be valuable for predicting the response to lithium in mania.

용량별 죽력 투여가 생쥐의 간과 신장의 조직 및 혈액학적 변화에 미치는 영향

정종길,나창수,김경수,홍광표,김정상 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

Objectives : Bambusae Caulis in Liquamen extracts (BE) has been used for various curative effect that remove intense heat from the heart, replenish deficiency Yin, nourish deficiency blood, resolve phlegm. This study was performed to investigate the toxicity of BE to mice according to the administered dosage. Methods : The experimental groups divided four. Control group treated saline, J1 group treated BE and distilled water in the ratio of 1:15(0.05ml/kg), F2 group treated BE and distilled water in the ratio of 1:7(0.05ml/kg), J3 group treated BE and distilled water in the ratio of 1:17(0.05ml/kg). We administered BE to the mice for 24 weeks at interval of 48 hours, and investigated the body weight, changes in hematological profile, activities of the transaminase(GOT, GPT) and two hepatic antioxidant enzyme(SOD, catalase), and histological changes of the liver and kidney. Results : Leukocytes of J3 group were increased in the administered for 12 weeks, but decreased in the administered for 24 weeks. Platelets were decreased about 36% in J3 group treated for 12 weeks, but increased about 50% in the same group treated for 24 weeks. Blood total proteins were decreased slightly in the all experimental groups compared with control group. The activities of the transaminase and superoxide dismutase(SOD) were increased, but decreased activities of catalase in the J2 and J3 groups administered for 12 or 24 weeks. In the light microscopical observation, ballooned and injured hepatocytes in portal vein area of J1 group occurred, and dilated hepatocytes and disoriented sinusoid observed in J2 group administered extracts to mice for 24 weeks. Apoptosis occured in the ballooned and injured hepatocytes of the portal vein area in J3 group. A agglutination of RBC in glomerular capsule of the kidney observed in the J2 group, and destructed convoluted tubule observed in the J3 group treated for 24 weeks. Conclusions : These results indicate that mice treated with high dose BE develop a hematological changes, dysfuncton of the liver and kidney.

경동맥 내막 절제술 후 발생한 과관류 증후군 1예

송희정,박광열,정진상,조수진,이순정,허승,김동익,이광호,이병붕 대한신경과학회 1999 대한신경과학회지 Vol.17 No.2

하악 고정성 임프란트를 이용한 퇴축된 하악골의 수복

정영진,박원희,안원준,이명렬,이영수,유광희,심광섭 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.2

Transmandibular implants are used limitedly such as on remaining symphyseal basal bone of atrophic mandible, on the bony defect of symphyseal area due to trauma or tumor as surgical implants. Among the more recent advances in oral implantology are the Fixed Mandibular Implant (FMI)based on the pioneering studies and clinical applications by Irwin Small of the USA and the development very high success rates for providing attachments and abutments in areas of the oral cavity severely compromised by either atrophy or surgical loss of osseous tissues. We will present a case report of regabilitation of totally edentulous mandible with advanced alveolar atrophy using Fixed Mandibular implant (F.M.I).

有機 廢棄物의 速成 堆肥化에 관한 硏究

鄭鳳守,黃光性 진주산업대학교 농업기술연구소 1993 農業技術硏究所報 Vol.6 No.-

볏짚, 왕겨, 生活쓰레기 등을 混合한 好機性으로 速成 堆肥化하는 過程에서 堆肥의 溫度, 有機成分의 變化와 腐熟度를 調査한 結果는 다음과 같다. 1. 通氣와 뒤집기없이 12週동안 野積한 堆肥의 成分含量은 通氣와 뒤집기로 5週동안 堆肥化한 成分含量 또는 뒤집기만으로 7週동안 堆肥化한 成分含量과 近似的으로 一致하였다. 따라서 通氣와 뒤집기를 할 경우 堆肥製造期間을 短縮하여 腐熟度 높은 堆肥를 製造할 수 있다. 2. 通氣와 뒤집기로 3週 또는 뒤집기만으로 12週동안 堆肥化한 窒素含量은 各各 2.07, 2.10 C/N比는 各各 14.0, 14.9로서 堆肥腐熟度 判定에서 滿足할 만한 堆肥라고 飼料된다. The experiment was carried out to investigate the temperature of compost, a variation of orgnic ingredient, a ripe level of decomposition in the process of rapidity completiom composting which was mixed with rice straw, rice hull, rife refuce etc. through aerobic The results of experiment are as follows : 1. The ingredient content of the outdoor compost under the process of composting for 12 weeks without ventilation or turning was approximately the same as that of the composts which has been under the process of composting for 5 weeks with ventilation and turning or for 7 weeks only with turning. Accordingly, we can conclude that ventilation and turning shortens the period of composting, and that they contribute to improving the quality of compost. 2. The nitrogen content of the compost under the process of composting for 8 weeks with ventilation and turning increased to 2.07, but its C/N ratio decreased to 14.0. The nitrogen content of the compost uneder the process of composting for 12 weeks only with turning increased to 2.1, but its C/N ratio decreased to 14.9 so those were considered to be satisfactory composts according to the criterion for judging the quality of compost.

서천군 오석리 유적지의 화분화석(花粉化石)을 이용한 고환경 연구

정승균,서광수 公州大學校 基礎科學硏究所 1997 自然科學硏究 Vol.6 No.-

이 논문의 목적은 충남 서천군 서천읍 오석리 유적지의 절대연령과 그 당시의 자연환경을 밝히는데 있다. 연구 시료는 절대연대측정을 위해 4개, 화분화석연구를 위해 32개를 채취하였다. 오석리 유적지의 절대연대는 탄소동위원소 측정으로 630~470 B.C으로 밝혀졌다. 연구된 유적지에서 산출된 화석군은 대부분 균류(fungi; 菌類)였으며, 이중 일부 시료에서만 소량의 화분(花粉)화석이 관찰되었다. 소량의 화분화석군은 소나무속 (Pinus sp.)이 우세한 현재와 유사한 식생(植生)을 나타낸다. 화석군을 구성하는 화분의 조합을 볼 때, 소나무 위주에 간헐적으로 밤나무, 버드나무 둥이 발달한 사이로 초본식물이 발달한 식생을 상상할 수 있다. 벼과(Gramineae)가 상대적으로 우세하게 (13%) 산출된 것은 인간간섭(人間干涉)의 결과로 해석할 수 있다. The aim of this study is to clarify an age and the paleoenvironment of the archeological site in Seocheon region, Chungnam. I took 4 charcol samples for determination of the age and 32 soil samples to fine out the paleoenvironment. An age from the carbon isotope data of the archeological site in Seocheon region is 630~470 B.C. Pollen fauna consists mostly of fungi and pollen of Pinus. These faunas were similar to a plant community of recent, namely, composed a pine tree, a chestnut tree, a willow tree, and a herbaceouse plant. A cause consisting many Graminede predominately in a plant community at that time is a result from the fanning.

안동지방 서리현상의 예보가능성에 관한 고찰

정민수,이재균,박광오,이채욱 대구대학교 정보통신연구소 2004 情報通信硏究 Vol.3 No.2

본 연구에서는 서리 발생에 직접적인 영향을 미치는 여러 가지 기후학적인 요소들을 10년 동안 안동지방을 대상 지역으로 선정하고 분석하여 안동지역 서리 발생의 예보 가보 가능성에 관하여 연구하였다. In this paper we analyzed various meteorologicals in Andong during 10 years, so the objective forecast possibility of frost in Andong are examined and analyzed.