Development of patient specific anatomy based 17-segment modeling (AHA) on bull`s eye map

Joonho Jung(정준호),N Kim(김남국),D Yang(양동현),YH Kim(김영학) 한국컴퓨터그래픽스학회 2016 한국컴퓨터그래픽스학회 학술대회 Vol.2016 No.7

Patient‐specific 17‐segment myocardial modeling on a bull's‐eye map

Jung, Joonho,Kim, Young‐,Hak,Kim, Namkug,Yang, Dong Hyun unknown 2016 Journal of applied clinical medical physics Vol.17 No.5

<P>The purpose of this study was to develop and validate cardiac computed tomography (CT) quantitative analysis software with a patient‐specific, 17‐segment myocardial model that uses electrocardiogram (ECG)‐gated cardiac CT images to differentiate between normal controls and severe aortic stenosis (AS) patients. ECG‐gated cardiac CT images from 35 normal controls and 144 AS patients were semiautomatically segmented to create a patient‐specific, 17‐segment myocardial model. Two experts then manually determined the anterior and posterior interventricular grooves to be boundaries between the 1st and 2nd segments and between the 3rd and 4th segments, respectively, to correct the model. Each segment was automatically identified as follows. The outer angle of two boundaries was divided to differentiate the 1st, 4th, 5th, and 6th segments in the basal plane, whereas the inner angle divided the 2nd and 3rd segments. The segments of the midplane were similarly divided. Segmental area distributions were quantitatively evaluated on the bull's‐eye map on the basis of the morphological boundaries by measuring the area of each segment. Segmental areas of severe AS patients and normal controls were significantly different (t‐test, all p‐values<0.011) in the proposed model because the septal regions of the severe AS patients were smaller than those of normal controls and the difference was enough to divide the two groups. The capabilities of the 2D segmental areas (p<0.011) may be equivalent to those of 3D segmental analysis (all p‐values<0.001) for differentiating the two groups (t‐test, all p‐values<0.001). The proposed method is superior to the conventional 17‐segment in relation to reflection of patient‐specific morphological variation and allows to obtain a more precise mapping between segments and the AHA recommended nomenclature. It can be used to differentiate severer AS patients and normal controls and also helps to understand the left ventricular morphology at a glance.</P><P>PACS number(s): 87.57.N‐, 87.57.R‐, 87.57.qp</P>

Tenofovir alafenamide treatment may not worsen the lipid profile of chronic hepatitis B patients: A propensity score-matched analysis

Joonho Jeong,Jung Woo Shin,Seok Won Jung,Eun Ji Park,Neung Hwa Park 대한간학회 2022 Clinical and Molecular Hepatology(대한간학회지) Vol.28 No.2

Background/Aims: Tenofovir alafenamide (TAF) has shown less favorable effect on lipids compared to tenofovir disoproxil fumarate (TDF) in clinical trials. However, data regarding these outcomes in patients with chronic hepatitis B (CHB) are scarce. Therefore, this study aimed to evaluate the effect of TAF on the lipid in patients with CHB. Methods: A total of 237 TAF-treated CHB patients compared with TDF, inactive CHB, and non-hepatitis B virus (HBV)- infected control groups using propensity score matching (PSM). Results: Following PSM, each analysis was conducted on cohorts via the matching of 70:140 (TAF:TDF), 89:89 (TAF:inactive CHB), 140:560 (TAF:non-HBV infected control), and 368:1,472 (TDF:non-HBV-infected control). A significant decrease in the total cholesterol (TC) level was noted at 48 weeks in the TDF group compared to the TAF group (176.3±32.9 vs. 156.7±27.7, P<0.001) and the non-HBV-infected control group (175.0±29.5 vs. 156.2±28.3, P<0.001). However, no significant change in TC was observed in the TAF group and inactive CHB or non-HBV-infected control groups at 48 weeks. For the subgroup analyses of TAF vs. non-HBV-infected control subjects and inactive CHB patients whose detailed lipid profile information were available, no between-group differences in TC, low-density lipoprotein (LDL)-cholesterol, highdensity lipoprotein (HDL)-cholesterol, TC/HDL ratio, and LDL/HDL ratio were observed at 48 weeks. Conclusions: TDF seems to have a lipid-lowering effect compared to the non-HBV-infected control and TAF-treated groups. However, in real practice, TAF might not worsen the lipid profiles of subjects compared to non-HBV-infected controls and patients with inactive CHB.

Design concept of multiband antennas under the influence of the human body

Jung, Byungwoon,Lee, Hyunkyu,Byun, Joonho,Won Jung, Chang,Park, Myun-Joo,Chung, Young-Seek,Lee, Byungje Wiley Subscription Services, Inc., A Wiley Company 2009 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.51 No.2

<P>A novel wideband antenna, consisting of a double T-shaped element and a coaxial cable, is proposed for multiband applications including AMPS, GSM, DCS, PCS, UMTS, and WiBro bands. The proposed antenna also mitigates the degradation of an antenna performance due to the human body. © 2008 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 513–515, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24086</P>

일 농촌지역 주민에서 우울증상과 심박변이도의 관계

안정우(Jung Woo Ahn),한창우(Chang Woo Han),최보율(Bo Yul Choi),김유미(Yu Mi Kim),남정현(Jung Hyun Nam),최준호(Joonho Choi),김석현(Seok Hyeon Kim) 대한스트레스학회 2008 스트레스硏究 Vol.16 No.3

목적: 이 연구의 목적은 우울증 진단을 받지 않은 일반 인구 집단에서 심박변이도(heart rate variability, HRV)와 우울증과의 연관성을 조사하여 우울증상에 따른 일반 인구 집단에서도 HRV의 변화가 있는지를 알아보는데 있다. 방법:경기도 소재 ○○군의 주민 중 건강증진 프로그램에 참가한 155명을 대상으로 하였다. 이중 HRV에 영향을 줄 수 있는 신체 질환을 가진 58명과 Beck’s depression inventory (BDI) 작성을 못한 2명을 배제한 95명의 short term electrode HRV를 측정하였고 BDI를 이용하여 우울증상을 조사하였다. 이들을 대상으로 HRV와 BDI 간의 연관성을 통계적으로 분석하였다. 결과: BDI와 HRV의 지표들 중 SDNN (standard deviation of the normal to normal interval), TP (total power), HF (high frequency), LF (low frequency), VLF (very low frequency), pNN50 (전체 normal to normal interval들 중 연속된 Normal to Normal Interval들의 변이가 50 ms 이상인 간격들의 비)이 유의하게 음의 상관관계를 가진 것으로 나타났으며 이 중 LF, HF, RMSSD (the square root of the mean squared differences of successive normal to normal intervals)는 BDI값을 이용하여 우울증을 중증 정도로 구분했을 때 유의하게 차이가 있었다. 결론: HRV의 일부 지표는 일반 인구에서 잠재성의 우울 증상의 정도를 측정할 수 있었다. Purpose: The purpose of this study is to investigate relationship between HRV (heart rate variability) and depressive symptoms in general population. This study was designed to examine the correlation of HRV and depressive symptom in general rural population. Methods: In 155 participants lived in the anonymous rural area of Gyeonggi-do, Korea, they participated in health promotion program with short term electrode HRV test and BDI (Beck’s depression inventory) self-report. Two participants were excluded due to fail to make out BDI and 58 participants were excluded because of some kinds of heart problems which were found after electrocardiogram and echocardiography exam of the health promotion program. We analyze HRV and BDI of remaining 95 subjects. Results: Our results showed that SDNN (standard deviation of the normal to normal interval), total power (TP), low frequency (LF), high frequency (HF) had negative correlation with BDI score, but only pNN50 (the proportion derived by dividing the number of interval differences of successive normal to normal intervals greater than 50 ms by the total number of normal to normal intervals) had positive correlation with BDI score. Also HF, LF and RMSSD (the square root of the mean squared differences of successive normal to normal intervals) are decreased by BDI severity grades increasing. Conclusion: In this findings of our study, some HRV variables seem to reflect subclinical depressive symptom severity in general rural population.

고해상도 식도내압검사에서 경한 식도 운동 장애로 진단된 환자에서의 항역류 치료 효과

정준호 ( Joonho Jeong ),김성은 ( Sung Eun Kim ),박무인 ( Moo In Park ),박선자 ( Seun Ja Park ),문원 ( Won Moon ),김재현 ( Jae Hyun Kim ),정경원 ( Kyoungwon Jung ),최윤정 ( Youn Jung Choi ),이준엽 ( Jun Yeob Lee ),이영달 ( Young D 대한소화기학회 2017 대한소화기학회지 Vol.69 No.4

Background/Aims: Minor disorders of peristalsis are esophageal motility disorders categorized by the Chicago Classification (CC), version 3.0, which was announced in 2014. This study evaluated the efficacy of anti-reflux therapy in patients with minor peristaltic disorders. Methods: Patients with minor peristaltic disorders in accordance with CC v3.0 were included. We reviewed the medical records of patients with esophageal high-resolution manometry findings, and investigated the demographic and clinical information as well as the medical therapy. Thereafter, the response to treatment was assessed after at least 4 weeks of treatment. Results: A total of 24 patients were identified as having minor disorders of peristalsis from January 2010 to December 2015. The mean follow-up period was 497 days, and there were 17 patients (70.8%) patients with ineffective esophageal motility. In terms of anti-reflux therapy, proton pump inhibitors (PPIs) with prokinetic agents and PPIs alone were prescribed in 19 patients (79.2%) and 5 patients (20.8%), respectively. When the rate of response to the treatment was assessed, the responders rate (complete+satisfactory [≥50%] responses) was 54.2% and the non-responders rate (partial [<50%]+refractory responses) was 45.8%. Patients in the responder group were younger than those in the non-responder group (p=0.020). Among them, 13 patients underwent 24-hour multichannel intraluminal impedance-pH, and 10 patients (76.9%) were pathologic gastroesophageal reflux. Conclusions: The majority of esophageal minor peristaltic disorders were accompanied by gastroesophageal reflux, and therefore, they might respond to acid inhibitor. Further well-designed, prospective studies are necessary to confirm the effect of anti-reflux therapy in these patients. (Korean J Gastroenterol 2017;69:212-219)

KEC 제정과 설계대가의 산출방안 개선 필요성

안준호(Joonho Ahn),임영택(Young-Taek Lim),정훈(Hoon Jung),심민주(Min-Ju Shim),정상웅(Sang-ung Jung),남기범(Ki-Beom Nam) 한국조명·전기설비학회 2022 한국조명·전기설비학회 학술대회논문집 Vol.2022 No.5

Incremental Value of Subtended Myocardial Mass for Identifying FFR-Verified Ischemia Using Quantitative CT Angiography : Comparison With Quantitative Coronary Angiography and CT-FFR

Yang, Dong Hyun,Kang, Soo-Jin,Koo, Hyun Jung,Kweon, Jihoon,Kang, Joon-Won,Lim, Tae-Hwan,Jung, Joonho,Kim, Namkug,Lee, June-Goo,Han, Seungbong,Ahn, Jung-Min,Park, Duk-Woo,Lee, Seung-Whan,Lee, Cheol Wha American College of Cardiology 2019 JACC. Cardiovascular imaging Vol.12 No.4

<P><B>Graphical abstract</B></P><P>[Figure]</P><P><B>Abstract</B></P><P><B>Objectives</B></P><P>This study examined the incremental value of subtended myocardial mass (V<SUB>sub</SUB>) as assessed by coronary computed tomography angiography (CTA) for identifying lesion-specific ischemia verified by invasive fractional flow reserve (FFR) in quantitative coronary CTA.</P><P><B>Background</B></P><P>FFR is determined not only by coronary stenosis severity, but also by V<SUB>sub</SUB>. One-step evaluation of combined V<SUB>sub</SUB> and coronary lesion morphology may improve the accuracy of coronary CTA for identifying ischemia-producing lesions.</P><P><B>Methods</B></P><P>A total of 246 intermediate coronary artery lesions (30% to 80% diameter stenosis) in 220 patients (mean age 61.7 years, 168 men) interrogated by FFR were retrospectively studied. Coronary CTA data were used to assess the V<SUB>sub</SUB> by coronary artery stenosis, minimal lumen area (MLA), percentage of aggregated plaque volume (%APV), positive remodeling, and low-attenuation plaque. The ability of V<SUB>sub</SUB>/MLA<SUP>2</SUP> to discriminate lesions with FFR ≤0.80 was examined. Diagnostic performance, odds ratios, and category-less net reclassification improvements of coronary CTA parameters for FFR-verified (≤0.80) ischemia were evaluated. On-site computed tomography (CT) derived–FFR (CT-FFR) and quantitative coronary angiography (QCA) data were also compared.</P><P><B>Results</B></P><P>Of 246 lesions, 84 (34.1%) showed an FFR ≤0.80. V<SUB>sub</SUB> was independently associated with an FFR ≤0.80 (odds ratio: 1.04/1 cm<SUP>3</SUP>; p = 0.032) and showed incremental value over MLA. V<SUB>sub</SUB>/MLA<SUP>2</SUP> >4.16 was the best single parameter for discriminating an FFR ≤0.80 with 83.3% sensitivity and 67.9% specificity. The area under the curve (AUC) of V<SUB>sub</SUB>/MLA<SUP>2</SUP> >4.16 (0.80 [95% confidence interval: 0.75 to 0.85]) was better than that of MLA (change in [Δ]AUC: 0.069; p < 0.001), %APV (ΔAUC: 0.096; p = 0.017), and diameter stenosis of QCA (ΔAUC: 0.080; p = 0.037) and was comparable to that of CT-FFR (AUC 0.77; ΔAUC: 0.035; p = 0.304).</P><P><B>Conclusions</B></P><P>V<SUB>sub</SUB> is an independent determinant of an FFR ≤0.80. The mathematical index of V<SUB>sub</SUB>/MLA<SUP>2</SUP> >4.16 assessed by coronary CTA shows better diagnostic performance for the detection of ischemia-producing lesions than CT-derived MLA alone or %APV and QCA parameters and was comparable to that of on-site CT-FFR.</P>

Development of enhanced synthetic elastomer for energy-efficient polymer actuators

Jung, Kwangmok,Lee, Joonho,Cho, Misuk,Koo, Ja Choon,Nam, Jae-do,Lee, Youngkwan,Choi, Hyouk Ryeol Institute of Physics Publishing 2007 Smart materials & structures Vol.16 No.2

<P>In this paper, a new material, called a synthetic elastomer, is presented as a means of actuation. The material displays enhanced performances in terms of electrical as well as mechanical aspects such as dielectric constant, elastic strength and stress relaxation. We begin by developing synthesis procedures for the material, which result in its general recipe with chemical composition. In addition, the effects of respective chemical constituents are studied with regard to the electrical and mechanical characteristics of the actuator. Finally, experimental tests are performed to evaluate the actuation performance of the material, and its advantages are clarified by conducting comparative studies with other existing materials.</P>

Recurrent Cervical Spontaneous Spinal Epidural Hematoma with Conservative Management: A Case Report

Jung Myung Koo,Sung Hwan Hwang,Joonho Yoon,Sang Hoon Yoon,Byung-Kyu Cho 대한신경손상학회 2021 Korean Journal of Neurotrauma Vol.17 No.2

Cervical spontaneous spinal epidural hematoma (CSSEH) is a rare condition that can be potentially fatal if not properly diagnosed and managed. While prompt surgical decompression and evacuation of the hematoma are generally considered as the first line of treatment, mild cases that were managed through observation and conservative treatment have been reported. Our patient was a 24-year-old man who experienced two CSSEH events 8 months apart, both of which were managed conservatively. This was a rare case of recurrent CSSEH in which recovery was achieved without surgical intervention. We believe conservative treatment with close observation may be effective in CSSEH patients presenting with mild neurologic symptoms who have a tendency towards spontaneous neurologic improvement.