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Jung, Jaehoon,Kim, Hyemi,Han, Young-Kyu American Chemical Society 2011 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.133 No.15
<P>We investigated the structure and stability of several aluminum hydride complexes to understand the essence of “superatom chemistry” and to gain a right perspective on the ligand (L)-stabilized metal (M) clusters. We successfully interpret the structure and stability using molecular orbital analysis, which clearly shows the failure of an electron-shell closing model (or a superatom model) to explain it. The structure and stability of Al<SUB><I>m</I></SUB>H<SUB><I>n</I></SUB> are closely associated with the molecular orbital stabilization owing to the effective orbital overlap between Al<SUB><I>m</I></SUB> (M<SUB><I>m</I></SUB>) and <I>n</I>H (<I>n</I>L). The importance of retaining the electronic structural integrity of M<SUB><I>m</I></SUB> in M<SUB><I>m</I></SUB>L<SUB><I>n</I></SUB>?within an electron-shell closing model?has been underestimated or even disregarded, and this has created the current controversies in the scientific community.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2011/jacsat.2011.133.issue-15/ja201205k/production/images/medium/ja-2011-01205k_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja201205k'>ACS Electronic Supporting Info</A></P>
Jung, Jaehoon,Yoon, Taesook,Choi, Eung Chil,Lee, Kyunglim 梨花女子大學校 藥學硏究所 2002 藥學硏究論文集 Vol.- No.11
We reported previously that cofilin, an actin-bindingprotein, interacts with Na,K-ATPase and enhances itsactivity (Lee, K., Jung, J., Kim, M., and Guidotti,G.(2001) Biochem.J. 353,377-385). To understand the na-ture of this interaction and the role of cofilin in theregulation of Na,K-ATPase activity, we searched for co-filin-binding proteins in the rat skeletal muscle cDNAlibrary using the yeast two-hybrid system. Several cDNAclones were isolated, some of which coded for triose-phosphate isomerase, a glycolytic ensyme. The interac-tion of cofilin with triose-phosphate isomerase as well asNa,K-ATPase was confirmed by immunoprecipitationand confocal microscopy in HeLa cells. Cofilin wastranslocated to the plasma membrane along with triose-phosphate isomerase by the Rho activator Iysophospha-tidic acid but not by the pl60 Rhe-associated kinaseinhibitor Y-27632, suggesting that the phosphorylatedform of cofilin bound to TPI interacts with Na,K-ATPase.Ouabain-sensitive ^86Rb^+ uptake showed that Na,K-ATPase activity was increaged by the overexpression ofcofilin and Iysophosphatidic acid treatment, but not bythe overexpression of mutant cofilia S3A and Y-27632treatment. Pretreatment with the glycolytic inhibitoriodoacetic acid caused a remarkable reduction of Na,K-ATPase activity, whereas pretreatment with the oxida-tive inhibitor carbonyl cyanide m-chlorophenylhydra-zone caused no detectable changes, suggesting that thephosphorylated cofilin is involved in feeding glycolyticfuel for Na,K-ATPase activity. These findings provide anovel molecular mechanism for the regulation of Na,K-ATPase activity and for the nature of the functionalcoupling of cellular energy transduction.
Jung, Yoonhwa,Jung, Jaehoon,Kim, Byungil,Han, SangUk Elsevier 2020 JOURNAL OF CLEANER PRODUCTION Vol.250 No.-
<P><B>Abstract</B></P> <P>The sites selected for solar PV facilities significantly affect the amount of electric power that can be generated over the long term. Therefore, predicting the power output of a specific PV plant is important when evaluating potential PV sites. However, whether prediction models built with data from existing PV plants can be applied to other plants for long-term power forecasting remains poorly understood. In this case, topographical and meteorological conditions, which differ among sites and change over time, make it challenging to accurately estimate the potential for energy generation at a new site. This study proposes a monthly PV power forecasting model to predict the amount of PV solar power that could be generated at a new site. The forecasting model is trained with time series datasets collected over 63 months from 164 PV sites with data such as the power plant capacity and electricity trading data, weather conditions, and estimated solar irradiation. Specifically, a recurrent neural network (RNN) model with long short-term memory was built to recognize the temporal patterns in the time series data and tested to evaluate the forecasting performance for PV facilities not used in the training process. The results show that the proposed model achieves the normalized root-mean-square-error of 7.416% and the mean absolute-percentage-error (MAPE) of 10.805% for the testing data (i.e., new plants). Furthermore, when the previous 10 months’ data were used, the temporal patterns were well captured for forecasting, with a MAPE of 11.535%. Thus, the proposed RNN approach successfully captures the temporal patterns in monthly data and can estimate the potential for power generation at any new site for which weather information and terrain data are available. Consequently, this work will allow planning officials to search for and evaluate suitable locations for PV plants in a wide area.</P> <P><B>Highlights</B></P> <P> <UL> <LI> An LSTM-RNN-based forecasting model is presented for investigation of PV sites. </LI> <LI> Time series data of spatial and meteorological conditions depict input variables. </LI> <LI> Monthly solar photovoltaic power generation at any specific site can be predicted. </LI> <LI> nRMSE of 7.416% is achieved for long-term power prediction of new candidate sites. </LI> </UL> </P>
Molecular mechanism of cofilin dephosphorylation by ouabain
Jung, Jaehoon,Kim, Moonhee,Choi, Suenghee,Kim, Min-Jeong,Suh, Jae-kyung,Choi, Eung Chil,Lee, Kyunglim 이화여자대학교 약학연구소 2008 藥學硏究論文集 Vol.- No.17
We previously reported that phosphorylated cofilin-triosephosphate isomerase(TPI) complex interacts with Na,K-ATPase and enhances the pump activity through the phosphorylation of cofilin via Rho-mediated signaling pathway, In this study, we tested the hypothesis that the dephosphorylation of cofilin may be induced through Na,K-ATPase inhibition by ouabain. The phosphorylation level of cofilin by ouabain which decreases in a time- and dose-dependent manner in various human cell lines, remains unchanged by pretreatment with Src inhibitor, PP2; epidermal growth factor receptor (EGFR) inhibitor, AG1478; Raf-1 kinase (Raf) inhibitor, GW5074; and ERK. kinase (MEK) inhibitor, PD98059, and by transfection of Ras dominant negative mutant (RasN17). This suggests that ouabain dephosphorylates cofilin through the Src/EGFR/Ras/Raf/MEK pathway. Ouabain activates Ras/Raf/MEK pathway, but down-regulates Rho kinase (ROCK)/LIM kinase (LIMK)/cofilin pathway, implying that there may be a cross-talk by ouabain between the Ras/Raf/MEK. and the ROCK/LIMK/cofilin pathways. Immunofluorescence and flow cytometry suggest that ouabain-induced active form of cofilin may be involved in cytoskeletal reorganization and cell volume regulation. Thus, these findings demonstrate a new molecular mechanism for the dephosphorylation of cofilin through the inhibition of Na,K-ATPase by ouabain. ⓒ 2006 Elsevier Inc. All rights reserved.
Jung, Jaehoon,Kim, Jongyoung,Lee, Han Sup,Kang, Il-Suk,Choi, Kiwoon American Chemical Society 2019 ACS NANO Vol.13 No.9
<P>Biological ion channels exhibiting selective and rectified ion transport properties feature nanoscale asymmetries in their physical structure, chemical composition, and charge distribution. Inspired by this, a multi-asymmetric ion-diode membrane (IDM) having a heterojunction between a positively charged anodic aluminum oxide membrane with conical macropores and a negatively charged Nafion membrane with very narrow mesopores was designed and practically fabricated in this study. Experiments and theoretical calculations demonstrated that the proposed membrane has the highest selectivity among IDMs and provides complete suppression of the concentration polarization (CP) effect limiting the current density in ion-exchange membrane electrodialysis. These findings present direct evidence that the physical and chemical design of the channel structure can provide both superior selectivity and a zero CP effect to IDMs and practical fabrication methods of IDMs for diverse, promising membrane applications.</P> [FIG OMISSION]</BR>