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[PB-0064] Isolation of Ab-rg rich saponin mutants from EMS-induced population in soybean
Junbeom Park(Junbeom Park),Jagadeesh Sundaramoorthy(Jagadeesh Sundaramoorthy ),Jinwon Lee(Jinwon Lee),Jeong-Dong Lee(Jeong-Dong Lee),Hak Soo Seo(Hak Soo Seo),Jong Tae Song(Jong Tae Song) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Deletion of the Serotonin Receptor Type 3A in Mice Leads to Sudden Cardiac Death During Pregnancy.
Park, Hyewon,Oh, Chang-Myung,Park, Junbeom,Park, Hyelim,Cui, Shanyu,Kim, Hyung Suk,Namkung, Jun,Park, Sang-Kyu,Pak, Hui-Nam,Lee, Moon-Hyoung,Kim, Hail,Joung, Boyoung Japanese Circulation Society 2015 CIRCULATION JOURNAL Vol.79 No.8
<P>The serotonin receptor type 3 (Htr3) blocker is associated with QT prolongation and torsades de pointes. However, little is known about effects of Htr3 on the heart arrhythmia.Methods?and?Results:An electrophysiological study Involving knock-out (KO) female mice lacking functional Htr3a (Htr3a(-/-)) and their wild-type littermates during non-pregancy (NP) and late pregnancy (LP) was performed. Htr3a mRNA was present in the wild-type, but not in theHtr3a(-/-)mouse hearts. Serotonin and tryptophan hydroxylase 1 (Tph1), a rate-limiting enzyme of serotonin synthesis in hearts, is increased during pregnancy. The heart weight and size were increased in the pregnant mice regardless of a mutation. The QTc intervals were prolonged after pregnancy in both the wild (NP: 171.216.8 vs. LP: 247.714.3 ms; P<0.001) andHtr3a(-/-)mice (NP: 187.918.7 vs. LP: 275.611.0 ms, P<0.001). Compared with wild-type LP mice,Htr3a(-/-)LP mice had increased spontaneous ventricle tarchycardia (VT; 56% vs. 0%, P=0.002), VT inducibility (66% vs. 25%, P=0.002) and mortality (56% vs. 0%, P=0.002). Pharmacologic administration of serotonin and Htr3 agonists (m-CPBG) decreased the QT interval in wild mice, but not inHtr3a(-/-)mice.</P>
2018 대한부정맥학회 심방세동 환자의 통합적 관리 지침
박준범 ( Junbeom Park ),정보영 ( Boyoung Joung ),김준 ( Jun Kim ),김진배 ( Jin-bae Kim ),박형욱 ( Hyung Wook Park ),박예민 ( Yae Min Park ),엄재선 ( Jae-sun Uhm ),안진희 ( Jinhee Ahn ),이대인 ( Dae In Lee ),김준수 ( June Soo Kim 대한내과학회 2018 대한내과학회지 Vol.93 No.4
Atrial fibrillation (AF) is the most common form of sustained arrhythmia in elderly patients. However, AF is often detected during health screening, or accidentally during testing for other diseases; some patients lack clinical symptoms. Nevertheless, AF increases the incidence of ischemic stroke and other thrombotic events, and compromises cardiovascular prognosis in terms of heart failure, dementia, and hospitalization. Therefore, initial AF management should be performed at the point of primary care, not only in specialized medical centers. We wish to propose a five-step management protocol for AF. We review the evidence supporting integrated management by primary care physicians new to AF, and by specialized physicians who often diagnose and manage AF. Further, we also outline a structured goal-based follow-up protocol; this is an important part of integrated management. (Korean J Med 2018;93:336-343)
[PB-0062] Isolation of soybean ARGONAUTE protein involved in seed coat color pigmentation
Jinwon Lee(Jinwon Lee),Gyu Tae Park(Gyu Tae Park),Hyun Jo(Hyun Jo),Jeongyun Ko(Jeongyun Ko),Junbeom Park(Junbeom Park),Jeong-Dong Lee(Jeong-Dong Lee),Jong Tae Song(Jong Tae Song) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Park, Jin-Kyu,Park, Junbeom,Uhm, Jae-Sun,Joung, Boyoung,Lee, Moon-Hyoung,Pak, Hui-Nam Oxford University Press 2016 EUROPACE -LONDON- Vol.18 No.3
<P>We hypothesized that P-wave amplitude in lead I is related to left atrial (LA) remodelling and inter-atrial conduction pattern, and has a predictive value for recurrence after radiofrequency catheter ablation (RFCA) among patients with paroxysmal atrial fibrillation (PAF). A total of 525 consecutive patients with PAF (76% male, 56 +/- 12 years old) who underwent RFCA were included. We compared pre-procedural sinus rhythm electrocardiograms without antiarrhythmic drug effect with LA volume (CT), LA voltage (NavX), the earliest activation site (EAS) conduction pattern of LA, and clinical recurrence rate. P-wave amplitude in lead I was significantly lower in patients with recurrence than in those that remained in sinus rhythm (P < 0.001) during 21 +/- 10-month follow-up. P-wave amplitude in lead I was linearly correlated with LA voltage (beta = 2.52, 95% CI 0.606-4.425, P = 0.010), LA conduction velocity (beta = 1.91, 95% CI 0.941-2.876, P < 0.001), and low septal displacement of EAS (beta = -1.67, 95% CI -2.352 to -0.996, P < 0.001). P-wave amplitudes < 0.1 mV in lead I were independently associated with clinical recurrence of AF on multivariate Cox regression analysis (adjusted HR 2.163, 95% CI 1.307-3.581, P = 0.003). The integrated area under the curves was 0.705 (95% CI 0.655-0.755). Low P-wave amplitude (< 0.1 mV) in lead I is related to LA remodelling and displaced inter-atrial conduction pattern to low septum, and independently predicts clinical recurrence after RFCA in patients with PAF.</P>
Junbeom Park,Haewon Byeon 보안공학연구지원센터 2015 International Journal of Bio-Science and Bio-Techn Vol.7 No.4
Childhood apraxia of speech(CAS) is considered as an impairment of purposeful speech movements and is generally defined as a disorder of motor planning or motor programming. There have been a variety of studies about CAS and the diagnostic criteria were set up in English-speaking countries, but studies about diagnostic criteria of CAS for Korean speakers are needed. The purpose of the study was to examine voice onset time (VOT) and its variability in children with childhood apraxia of speech (CAS) compared to typically developing children. Twelve children with CAS aged 9-12 years old and 20 children who were age-matched participated in the study. This study measured VOT and variabilities of VOT during the production of /p' a/, /t' a/, /k' a/. For variability measures of VOT, each participant was asked to repeat speech tasks three times and the average value of the rates and its standard deviation were obtained The verification of the hypotheses was tested by using T-test of the significance level of 0.05.The results showed that the variability of VOT in CAS group was more significantly higher than control group. But VOT of /p' a/, /t' a/, /k' a/ between the experimental group and the control group was not significantly different. The results suggested that variability of VOT might be more distinctive speech feature to children with CAS than the VOT. This study is meaningful because of two points; one is that it was conducted to fit the characteristics of Korea language while English cases are revitalized in the domestic situation, and the other is that it could be utilized as a resource for subsequent studies.