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( Ju Hee Park ),( Jae Hong No ),( Yong Tark Jeon ),( Hye Won Jeon ),( Yong Beom Kim ) 대한산부인과학회 2010 Journal of Womens Medicine Vol.3 No.3
Objective: This study was designed to evaluate the clinical significance of preoperative serum carcinoembryonic antigen (CEA) as a prognostic marker in epithelial ovarian cancer. Methods: We performed a retrospective review of the medical records of one hundred eleven patients with epithelial ovarian cancer who underwent surgery at Seoul National University Bundang Hospital between June 2003 and March 2009. The correlations of CEA with other tumor markers (CA-125, CA 19-9, and CEA) and clinicopathological prognostic factors (tumor stage, age, residual mass, peritoneal washing cytology and preoperative tumor size) were analyzed. Results: The normal cutoff levels of CEA, CA-125, and CA 19-9 were 5 ng/mL, 35 U/mL, and 37 U/mL, respectively. Of the one hundred eleven patients, only 8.1% of the patients were positive for CEA, and all patients with an elevated CEA level had a high CA-125 level. The sensitivity of CA-125 was 83.6%, and that of CA 19-9 was 21.9%. Correlation analysis between tumor markers and prognostic factors showed that CA-125 correlated significantly with advanced tumor stage, positive washing cytology and presence of a residual mass. CA 19-9 was significantly associated with advanced tumor stage, positive washing cytology, the histological type and preoperative tumor size. However, CEA had no significant correlation with all prognostic factors except the mucinous histologic type. Conclusion: The results of this study suggest that serum CEA may have a limited role in detecting and predicting the prognosis of patients with ovarian cancer. Thus, the preoperative evaluation of serum CEA level may have a limited value in the prognosis of ovarian cancer.
Jeon, Won-Kyung,Yoo, Bo-Kyung,Ahn, Sang-Young,Lee, Ju-Hyun,Ahn, Sang-Woo,Ko, Byoung-Seob The Society of Korean Medicine 2009 대한한의학회지 Vol.30 No.6
Objectives: Formulas for treatment of yin or yang deficiency conditions have been commonly used in traditional Korean medicine. The aim of this study is to examine the possible inhibitory effects of yin- or yang-tonifying formulas on in vivo anti-platelet activity and in vivo anti-thrombotic activity. Methods: We tested the effects of 26 types of yin- or yang-tonifying formulas on platelet aggregation induced by collagen in human whole blood using the impedance method of aggregometry and accessed a biomarker of platelet activation using thromboxane $B_2$ immunoassay. We also tested the anti-thrombotic effects of effective candidates on experimental models of thrombosis in mice. Results: 3 types of yin-tonifying formulas and 3 types of yin-yang-tonifying formulas were selected to be the most effective candidates (p<0.01). Also, through in vivo study, the antithrombotic activities of Igyeong-tang, Gamisipjeondaebo-tang, and Gamisoyo-san-treated groups, with recovery rate of 60, 50, and 45.45%, respectively, were observed to be higher than those of the control group (saline, 36.8%) in mouse acute thrombosis. Conclusion: These results show that yin-tonifying formulas are more effective in anti-platelet and anti-thrombotic activity than yang-tonifying formulas.
Brominated Aromatic Furanones and Related Esters from the Ascidian <i>Synoicum</i> sp.
Won, Tae Hyung,Jeon, Ju-eun,Kim, Seong-Hwan,Lee, So-Hyoung,Rho, Boon Jo,Oh, Dong-Chan,Oh, Ki-Bong,Shin, Jongheon American Chemical Society and American Society of 2012 Journal of natural products Vol.75 No.12
<P>Nine new compounds, tris-aromatic furanones (<B>1</B>, <B>2</B>, <B>3a</B>, <B>3b</B>, and <B>4</B>) and related bis-aromatic diesters (<B>5a</B>, <B>5b</B>, <B>6a</B>, and <B>6b</B>), are described from the ascidian <I>Synoicum</I> sp. collected off the coast of Chuja-do, Korea. The structures of these compounds, designated as cadiolides E and G–I (<B>1</B>–<B>4</B>) and synoilides A and B (<B>5</B> and <B>6</B>), were determined by extensive spectroscopic analyses. The absolute configuration at the asymmetric center of cadiolide G (<B>2</B>) was assigned by ECD analysis. Of these new compounds, cadiolide I and the synoilides possess unprecedented carbon skeletons. Several of these compounds exhibited significant inhibition against diverse bacterial strains as well as moderate inhibition against the enzymes sortase A, isocitrate lyase, and Na<SUP>+</SUP>/K<SUP>+</SUP>-ATPase.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2012/jnprdf.2012.75.issue-12/np3005562/production/images/medium/np-2012-005562_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np3005562'>ACS Electronic Supporting Info</A></P>
Jeon, Hyeong-Seok,Park, Bong-Hyun,Cho, Chi-Won,Lim, Chae-Hyun,Ju, Heong-Kyu,Kim, Hyun-Suk,Kim, Sang-Sig,Lee, Seung-Beck The Institute of Electronics and Information Engin 2006 Journal of semiconductor technology and science Vol.6 No.2
Nanoscale floating-gate characteristic of colloidal Au nanoparticles electrostatically assembled on the oxidized surface of Si nanowires have been investigated. The Si nanowire split-gate transistor structure was fabricated by electron beam lithography and subsequent reactive ion etching. Colloidal Au nanoparticles with ${\sim}5$ nm diameters were selectively deposited onto the Si nanowire surface by 2 min electrophoresis. It was found that electric fields applied to the self-aligned split side gates allowed charge to be transferred on the Au nanoparticles. It was observed that the depletion mode cutoff voltage, induced by the self-aligned side gates, was shifted by more than 1 V after Au nanoparticle electrophoresis. This may be due to the semi-one dimensional nature of the narrow Si nanowire transport channel, having much enhanced sensitivity to charges on the surface.
Non-infected and Infected Bronchogenic Cyst: The Correlation of Image Findings with Cyst Content
Jeon, Hong Gil,Park, Ju Hwan,Park, Hye Min,Kwon, Woon Jung,Cha, Hee Jeong,Lee, Young Jik,Park, Chang Ryul,Jegal, Yangjin,Ahn, Jong-Joon,Ra, Seung Won The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.76 No.2
We hereby report a case on bronchogenic cyst which is initially non-infected, then becomes infected after bronchoscopic ultrasound (US)-guided transesophageal fine-needle aspiration (FNA). The non-infected bronchogenic cyst appears to be filled with relatively echogenic materials on US, and the aspirate is a whitish jelly-like fluid. Upon contrast-enhanced MRI of the infected bronchogenic cyst, a T1-weighted image shows low signal intensity and a T2-weighted image shows high signal intensity, with no enhancements of the cyst contents, but enhancements of the thickened cystic wall. The patient then undergo video-assisted thoracic surgery 14 days after the FNA. The cystic mass is known to be completely removed, and the aspirate is yellowish and purulent. To understand the image findings that pertain to the gross appearance of the cyst contents will help to diagnose bronchogenic cysts in the future.
Ju, Sung-Min,Kim, Kun-Jung,Lee, Jong-Gil,Lee, Chai-Ho,Han, Dong-Min,Yun, Young-Gab,Hong, Gi-Yun,An, Won-Gun,Jeon, Byung-Hun The Physiological Society of Korean Medicine and T 2005 동의생리병리학회지 Vol.19 No.3
The tetrahydroisoquinolines included potent cytotoxic agents that showed antitumor activity,antimicrobial activity, and other biological properties. We studied the effect of CDST, 1-Chloromethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-sulfonic acid amide, a newly synthesized anti-cancer agent. The cytotoxic activity of CDST in HL-60 cells was increased in a dose-dependent manner. CDST, tetrahydroisoquinolines derivative, was cytotoxic to HL-60 cells, with IC50 of $80{\mu}g/ml$. Treatment of CDST to HL-60 cells showed the fragmentation of DNA in a dose- and time dependent manner, suggesting that thesecells underwent apoptosis. Treatment of HL-60 cells with CDST was induced in a dose- and time-dependent activation of caspase-3, caspase-8 and proteolytic cleavage of poly(ADP-ribose) polymerase. In caspase activity assay, caspase-3 and -8 was activated after 12 h and 6 h posttreatment, respectively. CDST also caused the release of cytochrome c from mitochondria into the cytosol. CDST-induced cytochrome c release was mediated by caspase-8-dependent cleavage of Bid and Bax translocation. These results suggest that caspase-8 induced Bid cleavage and Bax translocation, caused mitochondrial cytochrome c release, and induce caspase-3 activationduring CDST-induced apoptosis in HL-60 cells.
Jeon Ju-hyun,Kang Min-wan,Kim Eun-mi,Song Hyoun-gun,Choi Ka-won,Kim Young-il,Kim Jung-ho,Hong Kwon-eui,Lee Hyun,Yim Yun-kyoung 대한침구의학회 2006 대한침구의학회지 Vol.23 No.2
Objectives : To examine the effects of the collaborative Oriental and Western medicine, we treated a gouty arthritis patient with acute inflammation and liver injury with a combination of Oriental and Western treatments.Methods : Acupuncture, Bangphungtongsung-San(Fangfengtongsheng-san)', 'Kangwhaljetong-Um (Qianghuochutong-yin)', and 'Sosiho- Tang(Xiaochaihu- tang) were offered to an acute gouty arthritis patient with NSAIDs, Corticosteroids and allopurinol. Laboratory data were observed for the duration of hospital days.Results : In spite of Oriental treatments, NSAIDs administration caused liver injury, but continuous Oriental treatments with small amount of Corticosteroids and allopurinol brought recovery of liver function and gouty arthritis. Conclusion : Collaborative treatments of Oriental and Western medicine are better than independent Western treatment for gouty arthritis with acute inflammation and liver injury. Further studies will be required to ascertain the collaborative treatment with Oriental and Western medicine for gouty arthritis and other diseases.