효율적인 차량 동역학 해석을 위한 부분 시스템 합성 기법

한종규,김성수 忠南大學校 産業技術硏究所 1998 산업기술연구논문집 Vol.13 No.2

A subsystem synthesis method has been proposed for an efficient dynamic analysis of vehicle systems which consist of several subsystems. This method enables the analyst to solve equations of motion for a chassis and for each subsystem separately. Therefore, it is efficient that several small size equations of motion for a chassis and subsystems are separately solved, instead of solving relatively large size equations of motion for the whole vehicle system. Computational efficiency of the proposed method has been also investigated theoretically through the operational counting method. In order to show the effectiveness of the method, a SLA(Short-Long Arm) suspension subsystem of a military vehicle has been synthesized to form equations of motion for 1/4 car and 1/2 car models.

백두대간(추풍령-덕유산)구간의 식물상

한종원, 양선규, 최슬기, 장창석, 오병운 忠北大學校部設基礎科學硏究所 2007 自然科學硏究 Vol.21 No.-

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문수산(봉화군) 일대의 식물상

한종원, 양선규, 최슬기, 장창석, 김규식, 오병운 忠北大學校部設基礎科學硏究所 2007 自然科學硏究 Vol.21 No.-

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장군봉(봉화군) 일대의 식물상

한종원, 양선규, 최슬기, 장창석, 김규식, 오병운 忠北大學校部設基礎科學硏究所 2007 自然科學硏究 Vol.21 No.-

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하부팽창형 임프란트의 유한요소 분석 및 골형성에 대한 연구

한석환,김영규,민경기,조완석,권종진 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.3

The aim of this study was to evaluate by finite element analysis influence of investigated expanding implant on stress distribution and to observe biocompatibility, bone formation feature and change in the bone contact area around the explanding implant through experimental animal study. FEA models of the mandible were constructed based on three-dimensional graphic data of the bone structure around an osseointegrated implant, analysis of stress distribution followed by 100N vertical, 50N horizontal was done. And in the animal study, expanding implant were placed in the mandibles of eight Korean mongrel dogs and analyzed the results with histomorphometric measurements. In finite element analysis, compressive stresses are produced at the bone tissue surrounding the implant, and the contact area between the implant and the bone tissue is increased, which result in increased resistance to horizontal and vertical pressure loads. In the histomorphometric analysis, the measured ratio of the contact surface and bon density between implant and bone was similar to those of the controlled group from 6 weeks. It is thought that increased horizontal and vertical resistance is a great help to the immediate loading on expanding implant and that there needs standardizing quantitative measurement of implant stability and osseointegration to determine whether or not to use the functional loading and to reduce the total treatment period reliably by placing functional loading on each implant based on both bone quality and implant stability.

정신분열병과 N-Methyl-D-Aspartate 수용체 유전자와 연관된 VNTR 표지자인 D9S158 다형성의 연합

김종원,채영규,정은기,김길숙,박강규,이영호,최인근,양병환,한진희 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

정신분열병과 NMDA 수용체와 연관된 D9S158 유전적 표지자와의 연관성을 알아보기 위해 75명의 정신분열병 환자군과 87명의 정상대조군을 대상으로 중합효소연쇄반응을 이용하여 연합연구를 시행하여 다음과 같은 결론을 얻었다. D9S158 유전좌위에는 모두 8개의 대립유전자가 있었고, 각 대립유전자는 cytosine-adenine염기가 반복되는 217염기쌍에서 233염기쌍의 형태였다. 먼저 정신분열병 환자와 정상대조군의 대립유전자의 빈도를 비교해 본 결과 통계적으로 유의한 차이를 보이지 않았다(p〉.05). 환자군을 좀 더 동질적으로 만들기 위해 정신분열병의 가족력 유무, 음성 및 양성증상, 연성신경학적 징후, DSM-IV 임상아형에 따라 환자군을 나누어 대립유전자의 빈도를 비교해 본 결과, 특정 임상양상과 관련이 있는 대립유전자를 발견하지 못하였다. 결론적으로 본 연구에서는 D9S158 유전좌위와 정신분열병의 연관성을 입증하지 못하였으나 NMDA 수용체 유전자주위의 다른 표지자나 좀 더 유전적으로 동질한 환자군을 대상으로 한 추후연구가 필요할 것으로 생각된다. An association study with Korean schizophrenic patients(N=75) and normal controls(N=87) was performed to find the relationship between D9S158 polymorphism and schizophrenia using polymerase chain reaction. Eight different alleles of a dinucleotide polymorphism on D9S158 locus were observed in both group. When we compared the frequencies of alleles between schizophrenics and normal controls, there was no significant difference between two groups. To increase homogeneity of schizophrenic group, we divided schizophrenic group by clinical phenotypes such as family history, negative and positive symptoms(PANSS), soft neurologic signs(NES-K) and DSM-IV diagnostic subtypes. Then we compared the frequencies of alleles among subgroups of clinical phenotypes, and there were no significant differences between subgroups(p〉.05). Although our findings fail to provide an evidence of association between schizophrenia and D9S158 locus, further investigation of other loci that are linked to NMDA receptor gene may be needed in genetically homogeneous subgroups of schizophrenia.

慶北大學校 敎科課程의 改善에 關한 硏究 : The Case of Kyungpook national University

金容圭,李宇一,朴斗元,李慶燮,韓宗烈 慶北大學校 師範大學 1976 敎育硏究誌 Vol.18 No.-

This is the research paper on the curriculum improvement of Kyungpook National University. The curriculum of a college or university is the organized contents of all courses in order to accomplish the educational goals of the higher institution in an effective way. Needless to say, when curriculum is developed, the needs of the society and of the nation where the university is located, should be sufficiently reflected on its development. As an effort toward improving educatioal programs of higher institutions, the Ministry of Education has been encouraging each college or university to engage in the "Pilot Schol Project", a national experimental academic refrom project which was started in 1973 under the sponsorship of the Ministry of Education. In compliance with this policy, Kyungpook National Uuiversity has been not only making its every effort in improving the curriculum by each college within the campus since 1973, but also, continuing its research on the curriculum development in various areas. The research team has been attempted to systematize the direction of the curriculum improvement to meet the needs of the present and of the modern soceity by indicating the particelar characteristics of each college curriculum. This research paper has been focused on testing the validity of the contents of the revised curriculum which covers such areas as the minimum credit hours required for graduation, division making, and sequence of each division, etc.. As a research tool for the purpose of this study, comparative method has been utilized in order to verify the validity of the revised curriculum by means of comparing the above listed items with the current our university curriculum and those of the advanced countries.

구리 耐性菌(Pseudomonas stutzeri)의 菌體內 구리 蓄積機作

許鍾秀,曺周植,韓文圭,李洪宰,林永成 경상대학교 환경보전연구소 1994 環境保全硏究所報 Vol.2 No.1

In order to study the mechanism of the copper accumulation in the cell of copper-tolerant bacterium, Pseudomonas stutzeri, distribution of the copper in the cell were investigated. Approximately 61% of the accumulated copper was distributed on the cell wall and the other 39% portion was in cytoplasm. 78% of the copper in the cell wall fractions was present in the polyphosphate and polysaccharide fractions, but most of copper in the cytoplasm fractions was in protein and nucleic acid. Copper affected the protein synthesis in P. stutzeri. The intracellular protein content was decreased by copper addition, but the soluble protein precipitated by ammonium sulfate(30-75% saturation) was increased as compared to that from the cells grown without copper. Furthermore, in the cells grown with copper, high-molecular-weight soluble protein was increased, compared with the cells grown without copper, but low-molecular -weight soluble protein was decreased. These results indicate that copper inhibited the intracellular protein biosynthesis but enhanced the biosynthesis of the high-molecular-weight soluble protein precipitated by ammonium sulfate(30-75% saturation).

銅鑛山廢水로부터 分離한 구리 耐性菌(P.stutzeri)의 菌體內 구리 蓄積 特性

許鍾秀,曺周植,韓文圭,李洪宰,林永成 경상대학교 환경보전연구소 1994 環境保全硏究所報 Vol.2 No.1

Of the copper-tolerant 215 bacterial strains isolated from polluted river water, wastewater and activated sludges of wastewater treatment plants, or wastewater and soils of the copper mine aera in Gyeongnam province a strain, which showed considerably higher growth rate in the agar plate containing 2000ppm of copper than any other strains, was identified as a Pseudomonas stutzeri or its similar strain when analyzed by taxonomical charicteristics. Optimum pH and temperature for the growth of the P. stutzeri were 7.0 and 30℃ respectively. This strain was resistant to antibiotics, such as ampicillin and tetracycline, and heavy metals, such as lead and chromium. This strain utilized phenol benzen or toluene as a sole carbon source. The rate of copper accumulation in P. stutzeri cell was enhanced at low concentration of Cu in the growth media. The maximum copper absorption by this strain grown in 10ppm of Cu at 3 days after culture was 49%, but in 50ppm and 100ppm of Cu was 38% and 32%, respectively. The optimal temprature and pH for the effective intracellular accumulation of copper were 30℃ and initial pH 8.0 under shaking culture.

식중독균 항원(Salmonella typhimurium)에 의한 계란항체(IgY) 생산성과 항체특성 및 항균효과

백경연,손규목,배만종,백반석,한준표 경산대학교 생명자원개발연구소 1999 생명자원과 산업 Vol.3 No.-

본 연구는 식중독균을 항원으로 하여 산란계에 면역시킨 후 계란 항체(IgY)의 생산 가능성을 검토하고, 그 항체의 특성과 항균성을 조사하고자 실시하였다. 그 방법으로는 항원으로 사용된 Salmonella typhimurium(ATCC 14028) 등을 incomplete Freund's adjuvant와 동량으로 혼합하여 면역시킨 후 10주간 생산된 계란을 수집하여, 계란항체(IgY)의 분리 및 식중독균 항원에 대한 항체의 특성, 항균성, 생화학적 특성을 측정하였다. S. typhimurium 항원에 면역된 산란계의 계란항체(IgY)생산 및 증가를 측정한 결과, 산란계가 이들 항원에 면역반응을 일으켜 2주 후 혈청과 난황에서 각각 normal군에 비하여 뚜렷한 항체가 생성능을 보였으며, 혈청내의 IgG생성에 비하여 계란항체(IgY)의 생성이 다소 낮은 것으로 나타났다. 혈청 및 난황내의 단백질 함량은 normol군에 비하여 약간 높은 경향을 나타내어 산란계의 혈청 및 난황내의 단백질이 이들 항원에 의하여 증가하는 것으로 나타났다. DEAE-Sephacel column을 통과한 fraction은 두 개의 peak를 나타내었다. 각 fraction의 IgY농도를 ELISA법으로 확인한 결과 두 번째 peak에서 대부분 측정되었다. 분리 정제된 IgY의 분자량을 SDS-polyacrylamide 전기영동법으로 측정한 결과, heavy chain 72∼75KD, light chain 30∼40KD정도였다. Anti-S. typhimurium 항체의 온도에 대한 활성은 60℃에서 30분 가열시 91.5%, 65℃에서 15분 가열시 각각 73.2%의 활성도를 나타내었으며, 80℃에서 15분간 가열시는 거의 활성이 없는 것으로 나타났다. pH에 대한 안정성은 pH 7부터 pH 4까지는각각 98.7%의 활성도를 유지하다가 pH 3부터 급격히 감소하여, pH 2에서는 9.6%로 거의 활성도를 나타내지 않았다. 항균활성을 응집가, 생균수, disc diffusion susceptibility test 등으로 측정한 결과 anti-S. typhimurium 항체의 항균활성도는 매우 미약하게 나타났다. 이상의 결과에서, 본 실험에서 사용된 IgY는 항원에 대한 특이성 및 생화학적 특성 등을 고려해 볼 때 앞으로 식중독균 제거 및 예방 치료뿐만 아니라 식품산업 소재, 각종 질병예방을 위한 의약품 소재, 연구용 kit와 진단용 kit 및 축산분야 등 여러 분야에 응용될 수 있으리라 기대된다. This study was carried out to investigated to get a industrial information from discussion about productive a possibility if IgY antibody, antimicrobial activity and properties of IgY antibody in egg yolk. Immunoglobulin Y in egg yolk and immunoglobulin G in serum were obtained from gens which were immunized with Salmonella typhimurium(ATCC14028). These antibody titers were evaluated in serum and egg yolk by ELISA. After the initial immunization the anti-Salmonella typhimurium IgY antibody level gradually were decreased from firth week to tenth week. On the other hand, the antibody level in the serum were increased from the first week, reaching its peak in the sixth week. The residual antibody activities of IgY were 91.5% after heating for 30min at 60℃. At the same time, were 73.2% after heating 15min at 65℃ and decreased vapidly at 70℃ and little antibody activity was left after heating for 15min at 80℃. When the prepared IgY was stable from pH 7 to 4 and remained to 69.8% at pH 3, respectively.