Aspergillus Nidulans에서의 자외선에 의한 돌연변이 유발기작과 이에 관련된 유전자 uvsl의 기능

한동민,유지은,한유정,박종군 A.R. Liss 1992 ENVIRONMENTAL MUTAGENS AND CARCINOGENS Vol.12 No.2

수종보익제가 면역세포의 조절 및 Apoptosis에 미치는 영향

한종현,강성용,정현우,오찬호,권진,은재순 대한본초학회 1997 大韓本草學會誌 Vol.12 No.1

The effects of several tonifying prescriptions on the apoptosis of transplanted L1210 cells and the regulation of immune cells in L1210-transplanted mice were studied. Sa-Mul-Tang(SMT), Sa-Kunja-Tang(SKT), Sipjeon-Daebo-Tang(SDT) accelerated the apoptosis of transplanted L1210 cells, and SMT and SKT reduced the mitochondrial transmembrane potential of transplanted L1210 cells. SMT promoted the proliferation of thymocytes and splenocytes in L1210-transplanted mice. Whereas SMT increased CD8+ T_c/T_S cell, Bojung-Ikki-Tang(BIT) decreased CD4+ T_H cell population in the thymocytes of L1210-transplanted mice. SMT and SKT increased the lucigenin chemiluminescence from peritoneal macrophage of L1210-transplanted mice. These results indicate that SMT and SKT have an inductive action of apoptosis of transplanted L1210 cells and peritoneal macrophage activation.

ROSAE MULTIFLORAE RADIX의 藥理作用에 關한 硏究

殷載淳,韓宗鉉,崔動晟 又石大學校 1989 論文集 Vol.11 No.-

In an attempt to investigate the effect of ROSAE MULTIFLORAE RADIX(RME) on the diabetes in rats induced by alloxan(80 ㎎/㎏) or streptozotocin(40 ㎎/㎏) and the contractile force of isolated rabbit ileum, RME was administered per oral daily and the level of blood glucose, serum triglyceride and serum total cholesterol were measured by spectrophotometer and the contractile force of intestine was measured by physiograph. The following resuits were obtained: 1) RME did not change the level of blood glucose and serum total cholesterol, but decrease the serum triglyceirde on the 5th day in normal rats. 2) The level of blood glucose in diabetic rats induced by the alloxan was decreased on the 5th and 7th day of experiment (RME 100㎎/㎏), induced by streptozotocin was decreased on the 7th day of experiment (RME 10 ㎎/㎏) and 5th and 7th day of experiment (RME 100 ㎎/㎏). 3) The level of serum triglyceride in dibetic rats induced by the alloxan was decreased 7th day (RME 100 ㎎/㎏) and induced by streptozotocin was decreased 7th day (RME 10 ㎎/㎏) and 3th, 5th and 7th day (RME 100 ㎎/㎏) of experiment. 4) The level of serum total cholesterol in diabetic rats induced by the alloxan and streptozotocin was not changed by RME. 5) The contractile response of isolated rabbit ileum by RME was not affected by cyproheptadine, but inhibited by atropine and verapamil.

HIV 감염/AIDS을 처음 진단받은 환자들의 특성과 임상에서 보편적인 HIV 검진의 가치

김종화,김태형,추은주,전민혁,서성우,이용관,최문한 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.2

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암세포주에 대한 우황 50% MeOH 엑스와 함암제의 병용효과

殷載淳,康城溶,韓宗鉉 又石大學校 1994 論文集 Vol.16 No.-

The studies were conducted to investigate the combined effects of 50% MeOH extract of Be-zoar Bovis(MEB) and several anti-tumor drugs. The effects of MEB and several anti-tumor druge on the proliferation of HaLa, Hep G2, SNU-1, MOLT-4 and S 180 cells estimated by MTT colorimetric assays. MEB inhibited the proliferation of HeLa, Hep G2, SNU-1, MOLT-4 and S 180 cell. The inhibitory action of mitomycin C(MMC), cisplatin(CPT) or 5-fluorouracil(5-FU) on the proliferation of HeLa cell was increased by the combined of MEB and their drugs, and the inhibitory action of MMC or CPT on the proliferation of Hep G2 and S 180 cell was increased by the treatment of MEB and their drugs. MEB inhibited the proliferation of Balb/c 3T3 and Tlymphocyte at 10^-4g/ml. The 50% inhibitory concentration of MMC, CPT and 5-FU on T lymphocyte were 0.75, 0.57 and 28.35㎍/ml repectively. The inhibitory activity of MMC, CPT or 5-FU treated group, respectively, on the proliferation of T lymphocyte was increased by the combined treatment MEB and their drugs. MEB increased the number of leukocyte at 5th day. In the groups of the combined treatment of MMC and MEB, the number of leukocytes and the weight of thymus were increased significantly than MMC treated group. MEB increased the number of total peritoneal cells and inbibited the exudation of evans blue into peritoneum. In conclusion, this paper suggest that MEB inhibits the proliferation of HeLa, Hep G2, SNU-1, MOLT-4 and S 180 cells, and the combined treatment of anti-tumor drugs and MEB increase the inhibitory activity of their drugs on several tumor cells. MEB has the possibility of decreasing the side effect of anti-tumor drugs such as leukopenia and immunsuppression.

複合生藥製劑의 止血作用및 摘出 子宮筋에 미치는 影響(第3報) : 加減當歸補血湯

殷載淳,廉思俊,韓宗鉉 又石大學校 1989 論文集 Vol.11 No.-

These experiments were performed to investigate the effects of the KAGAM-DANGKWI-BOHYUL TANG(KDBT) extract, clinically used in gynecology, on the hemostatis and on the contractile force of the isolated uterine muscle. The bleeding time and the plasma prothrombin time test were employed as the means to estimate the hemostatic effect of KDBT extract, and the contractile effect of the extract was measured. The experimental results were summarized as followings; 1. In mice treated with KDBT extract the plasm prothrombin time and the bleeding time were remarkably shortened compared with the control group. 2. The contractile effect of KDBT extract on the isolated uterine muscle was not blocked by atropine and cyproheptadine. 3. The contractile effect of KDBT extract on the isolated uterine muscle was inhibited by the pretreatment with verapamil. From these experimental results, it is concluded that the hemostatic effect of KDBT extract might be attributed to the stimulation of prothrombin formation and the direct contraction of the uterine muscle through the increasing uptake of calcium ions into the muscle.

갑상선 유두암이 병발된 가족성 대장 용종증 1예

백종현,소창배,이은영,이지숙,신은경,박은호,서정아,양재홍,송준영,박선자,박요한,최영식 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome, typically characterized by multiple colorectal adenomas and increased incidence of colorectal carcinomas if it is not treated. Moreover, a variety of extracolonic manifestation are seen. The prevalence of thyroid tumors developing in patients with FAP is about 1∼2%. Generally, papillary thyroid cancer indicates low mortality but ,however, as people get older, the cancer becomes more aggressive. So, the operation is required. Recently we experienced a case of FAP, presenting with papillary thyroid carcinoma, and reported with a brief review of literatures.

당뇨병 및 간경변증 환자에서 발생한 Fusarium verticillioides에 의한 피부 감염 1예

이석종,전영민,원지연,송은섭,최용우,김한욱 대한의진균학회 1997 대한의진균학회지 Vol.2 No.1

Fusarum species, which are common soil saprophytes, have been implicated as a pathogen causing a variety of opportunistic infections such as keratitis, onychomycosis, burn wound infection or disseminated systemic infections in immunocompromised hosts. We report a case of cutaneous infection caused by F. verticillioides in a 59-year-old man, with a long history of diabetes mellitus and alcoholic liver cirrhosis. He presented with a few papules and fluctuant cutaneous nodules on both forearms traumatized by woodstick 4 months ago. The diagnosis of F. verticillioides infection was established by histopathologic examination and findings of tissue cultures.

Paraquat 투여에 의한 가토 간장의 변화에 관한 연구

이종민,김의한,강상균 순천향대학교 1992 논문집 Vol.15 No.2

Paraquat(이하 PQ)에 의한 간장의 변화를 알아 보기 위하여 25마리의 가토에 PQ를 1㎏당 10㎎, 20㎎, 40㎎, 80㎎, 160㎎을 복강 및 정맥주사하여 G. P. T와 G. O. T치를 측정하고 간장의 조직소견과 비교 관찰하여 다음과 같은 결론을 얻었다. 1) PQ에 의한 G. P. T와 G. O. T의 변화는 일단 독성을 일으킬 만한 양이 투여되면 투여양이나 투여방법에 상관없이 투여 후 바로 상승하여 3∼4일 지속되다가 떨어진 후 7∼9일 후 다시 상승하는데 정맥주사한 예에서 조금 빠르게 나타나는 양상을 보였다. 2) PQ투여로 인한 간장의 변화가 직접적인 사망원인으로 작용하는 것 같지는 않으나 적은예에서 죽기 직전 심한 G. P. T와 G. O. T의 상승을 보이는 경우가 있어 PQ로 인한 사망원인에 하나의 인자로써 작용하는 것 같았다. 3) PQ로 인한 간장의 조직학적소견은 전반적인 울혈을 볼 수 있고 3일이상 생존한 가토의 심정맥 주위에서 세포 종창, 지방변성, 풍선화 및 간소엽의 산란등이 주로 관찰되며 변화의 정도는 투여양이나 생화학적 변화와 비례해서 나타나지 않았다. To investigate the effect of PQ on the liver, PQ was injected at dose of 100mg/kg, 20mg/kg, 40mg/kg, 80mg/kg, 160mg/kg intraperitoneally and 20mg/kg, 40mg/kg, 80mg/kg intravenously. The changes in hepatic funtion were estimated by determining G.P.T. and G.O.T. and compared to histologic findings of liver tissue. From these, we concluded : 1. Once sufficient toxic concetration of PQ is administrated, PQ led to increase in GPT. and GOT, which lasts for 3-4days regardless of the route and amount of adminstration. The gradual return of the GPT and GOT to the upper normal limit was followed. After 7-9days, the GPT and GOT level is again elevated. The occurence of elevation in GPT and GOT appeared earlier when intravenous injection than intraperitoneal injection. 2. The hepatic change by PQ was not the direct cause of death, though occasionally observed marked GPT and GOT elevation prior to death. It is likely that the liver damage is a contributing factor causing death in PQ intoxication. 3. Histologically, hepatic changes such as fatty change, ballooning degeneration, cell cord disarray were mostly limited in the centrilobular area in the rabbits survived for more than 3days. The degree of histological hepatic changes was not necessarily proportional to either the dose of PQ or the biochemical level.

최근 개발된 cone beam computed tomography의 흡수선량 및 유효선량 평가

이종녕,한원정,김은경 대한구강악안면방사선학회 2007 Imaging Science in Dentistry Vol.37 No.2

Purpose : Cone beam computed tomography (CBCT) provides a lower dose and cost alternative to conventional CT, promising to revolutionize the practice of oral and maxillofacial radiology. The purpose of this study was to evaluate the absorbed and effective doses of Implagraphy and VCT (Vatech Co., Hwasung, Korea) and compare them with those of panoramic radiography. Materials and Methods : Thermoluminescent dosimeter (TLD) chips were placed at 27 sites throughout the layers of Female ART Head and Neck Phantom for dosimetry. Implagraphy, VCT units, and Planmeca Proline XC panoramic unit were used for radiation exposures. Radiation weighted doses and effective doses were measured and calculated using 1990 and 2005 ICRP tissue weighting factors. Results : Effective doses in Sv (ICRP 2005, ICRP 1990) were 90.19, 61.62 for Implagraphy at maxillay molar area, 123.20, 90.02 for Implagraphy at mandibular molar area, 183.55, 139.26 for VCT and 40.92, 27.16 for panoramic radiography. Conclusion : Effective doses for VCT and Implagraphy were only about 2.2 to 4.5 times greater than those for panoramic radiography. VCT and Implagraphy, CBCT machines recently developed in Korea, showed moderately low effective doses.