Experimental Studies and Discrete Thermodynamic Modeling on Supercritical CO2 Extractions of a Hexadecane and Crude Oil

Hwang, Jong Sic,Lim, Gio Bin,Kim, Choon Ho 한국화학공학회 1995 NICE Vol.13 No.5

Continuous multiple-contact experiments using a supercritical CO₂ were performed to study the phase equilibrium behavior of the dynamic extractions of a hexadecane and crude oil. The extraction yields increased as CO₂ density increased with a pressure rise at constant temperature. The rates of extractions were also greater at higher pressure. The simulated distillation analysis of extracted crude oil samples represented that the earlier extracts contained lighter compounds and the latter extracts contained progressively heavier compounds. These compositional changes occurring during a dynamic extraction were also ascertained by phase-equilibrium flash calculations using the equations of state and a pseudo-component lumping method. Two different equations of state, Soave-Redlich-Kwong and Peng-Robinson, were used to predict the equilibrium compositions of the extract phase that is a supercritical carbonic phase. The results of phase behavior calculations established the nature of the extraction and partitioning process as a function of time. These results also provided reasonable agreement between the experimental data and the calculated values.

EXPERIMENTAL STUDIES AND DISCRETE THERMODYNAMIC MODELING ON SUPERCRITICAL CO2 EXTRACTIONS OF A HEXADECANE AND CRUDE OIL

Hwang, Jong Sic,Kim, Choon Ho,Lim, Gio Bin 한국화학공학회 1995 Korean Journal of Chemical Engineering Vol.12 No.2

Continuous multiple-contact experiments using a supercritical CO₂ were performed to study the phase equilibrium behavior of the dynamic extractions of a hexadecane and crude oil. The extraction yields increased as CO₂ density increased with a pressure rise at constant temperature. The rates of extractions were also greater at higher pressure. The simulated distillation analysis of extracted crude oil samples represented that the earlier extracts contained lighter compounds and the latter extracts contained progressively heavier compounds. These compositional changes occurring during a dynamic extraction were also ascertained by phase-equilibrium flash calculations using the equations of state and a pseudo-component lumping method. Two different equations of state, Soave-Redlich-Kwong and Peng-Robinson, were used to predict the equilibrium compositions of the extract phase that is a supercritical carbonic phase. The results of phase behavior calculations established the nature of the extraction and partitioning process as a function of time. These results also provided reasonable agreement between the experimental data and the calculated values.

The Upgrading of Petroleum Residuum and Coal in Catalytic Coprocessing

Hwang, Jong Sic,Kim, Hong Gon,Lim, Gio Bin,Curtis, Christine W 한국화학공학회 1995 NICE Vol.13 No.3

The combined catalytic reactions using different types of petroleum residuum and coal were performed at 4250 and 60 minutes in the presence of hydrogen to upgrade both materials to high quality synthetic fuels. In order to improve this coprocessing technology, the effect of the chemical and physical properties of both materials on the coprocessing product yields was investigated through a parametric study. In all reaction combinations, substantial increase in maltene production and high coal conversions of over 84% were observed regardless of petroleum residuum type and coal rank. The petroleum residuum properties of specific gravity and conradson carbon residue had effects on asphaltene production and coal conversion. The results of quantitative analysis for the amount of coal upgraded during coprocessing lead to conclude that a large amount of coal converted to maltene fraction due to high catalytic activity and reactive hydrogen donor richness of coprocessing system. However, most of the heavier fractions were formed primarily from coal regardless of the type of residuum used.

THE UPGRADING OF PETROLEUM RESIDUUM AND COAL IN CATALYTIC COPROCESSING

Hwang, Jong Sic,Kim, Hong Gon,Lim, Gio Bin,Curtis, Christine W 한국화학공학회 1995 Korean Journal of Chemical Engineering Vol.12 No.2

The combined catalytic reactions using different types of petroleum residuum and coal were performed at 425℃ and 60 minutes in the presence of hydrogen to upgrade both materials to high quality synthetic fuels. In order to improve this coprocessing technology, the effect of the chemical and physical properties of both materials on the coprocessing product yields was investigated through a parametric study. In all reaction combinations, substantial increase in maltene production and high coal conversions of over 84% were observed regardless of petroleum residuum type and coal rank. The petroleum residuum properties of specific gravity and conradson carbon residue had effects on asphaltene production and coal conversion. The results of quantitative analysis for the amount of coal upgraded during coprocessing lead to conclude that a large amount of coal converted to maltene fraction due to high catalytic activity and reactive hydrogen donor richness of coprocessing system. However, most of the heavier fractions were formed primarily from coal regardless of the type of residuum used.

Ingenol mebutate: A possible treatment option for superficial basal cell carcinoma as neoadjuvant therapy?

( Jong Sic Kim ),( Ji Won Yun ),( Sewon Hwang ),( Yuri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Basal cell carcinoma (BCC) is usually effectively managed with surgical removal. Ingenol mebutate gel (Picato, Leo Pharma, Inc.) is a new topical drug extracted from the latex sap of a plant Euphorbia peplus approved by Food and Drug Administration (FDA) for field therapy of actinic keratosis in 2012 for its chemoablative and immune-stimulatory properties. We describe a case of a 87-year-old Korean woman presenting with 1.5 x 1.5 cm-sized blackish crusted plaque and erosion on her scalp for a year. Histopathologically, the lesion showed peripherally palisading basaloid tumor cells budding from the epidermis and limited to upper dermis with partial retraction of stroma from the tumor nest. The patient was diagnosed as superficial BCC. We applied topical ingenol mebutate gel (Picato®) 0.05% for 2 consecutive days. The patient complained of pain, erythema and erosion on the application site on the second day. After 2 weeks of application, blackish plaque disappeared, but 4 weeks later, two blackish papules reappeared. Biopsy specimen of one of the papules showed remnant tumor cells. We conducted cryotherapy on the remaining lesion. Although ingenol mebutate gel (Picato®) monotherapy is insufficient for complete elimination of superficial BCC, we suggest that application of ingenol mebutate gel (Picato®) combined with other modalities such as punch biopsy and cryotherapy may be a useful treatment option for reducing tumor burden.

감압증류에 의한 석유정제 상압잔사유와 폐윤활유의 혼합처리 및 공정모사

황종식,김형락,김명수 한국화학공학회 1995 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.33 No.2

자동차용 내연기관에서 발생하는 폐윤활유를 석유정제 중질유분인 상압잔사유와 배합한 후 고비점 진증류 (TBP) 장치를 이용한 감압증류실험을 통해 재정제함으로써 폐유 내 존재하는 유해물질들의 제거효율을 평가하였다. 본 실험을 통해 고품질의 정제연료유분과 아스팔트를 얻었으며 폐유 내 중금속, 회분 그리고 잔류탄소분의 95% 이상이 감압잔사유쪽으로 제거되었다. 상압잔사유분에 대한 폐유의 혼합비율을 0-20%까지 변화시키면서 수행된 감압증류실험을 통해 폐유 혼합비가 증가함에 따라 정제연료유분의 수율 증가와 물성개선 효과가 입증되었다. 이러한 실험결과는 PRO II를 이용한 공정모사 결과 값과도 잘 일치된 결과를 보여주었다. The removal efficiency of the contaminated constituents existing in the waste automobile lube oils mixed with petroleum atmospheric residues during a re-refining process was investigated by a vacuum TBP distillation. The refined fuel oils and asphalts with higher qualities were obtained by this process and more than 95% of heavy metals, ash and carbon residue contents in the waste lube oils were eliminated to vacuum residues. The increased yield and improved quality of distilled products were identified in the range of 0-20% blending ratio of waste Tube oils to atmospheric residues. These experimental results showed the reasonable agreements with the calculated values provided by process simulation using PRO II.

Cutaneous mastocytosis in Korean patients : a clinical features of 77 cases

( Jong Sic Kim ),( Ji Hong Lim ),( Sewon Hwang ),( Yuri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Mastocytosis represents a group of rare disorders characterized by a neoplastic proliferation of abnormal mast cells in one or more tissues, involving mainly skin, bone marrow, gastrointestinal tract, and liver. Cutaneous mastocytosis is classified according to clinical presentation and is further defined by onset of disease. Objectives: To analyze clinical characteristics of cutaneous mastocytosis in Korean patients. Methods: We performed a retrospective review in 77 patients diagnosed as cutaneous mastocytosis. Patients were evaluated for onset of disease, sex, distribution, associated symptoms and distribution of lesions. Results: There were 16 (20.7%) cases of telangiectasia macularis eruptive perstans cases, 25 (32.5%) cases of urticaria pigmentosa, 22 (28.6%) cases of mastocytoma, and 14 (18.2%) cases of diffuse cutaneous mastocytosis. In 30% of cases disease onset was in the first year of life. There was a male predominance 2.1 : 1. The most common presentation was involvement of trunk together with both extremities. Conclusion: The most frequent clinical form of mastocytosis was urticarial pigmentosa followed by mastocytoma, telangiectasia macularis eruptiva perstans and diffuse cutaneous mastocytosis. Cutaneous mastocytosis is a benign disease in children without systemic involvement.

IBD associated with an increased risk of inflammatory skin diseases: a population-based cross-sectional study

( Jong Sic Kim ),( Se Won Hwang ),( Kwang Hyun Choi ),( Miri Kim ),( Jung Min Bae ),( Hyun Jeong Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Background: Inflammatory bowel disease (IBD) is chronic disease of the gastrointestinal tract attributed to aberrant activity of the immune system. Increasing evidence suggests that IBD patients are at an increased risk of inflammatory skin diseases (ISDs). Objectives: We sought to clarify the association between IBD and ISDs using a nationwide health claims database maintained in Korea. Methods: We interrogated Korean health claim database data from 2009 to 2013. We enrolled all patients with IBD, and age- and sex-matched controls, and evaluated the risks of ISDs, including psoriasis, rosacea, and atopic dermatitis, and the risks of autoimmune skin diseases (ASDs), including vitiligo and alopecia areata. We used multivariable logistic regression to this end. Results: ISDs including rosacea, psoriasis, and atopic dermatitis were significantly associated with IBD, whereas the associations between IBD and ASDs including vitiligo and alopecia areata were less marked or non-existent. Ulcerative colitis and Crohn’s disease were both associated with ISDs. Conclusion: IBD was significantly associated with ISDs, but less so or not at all with ASDs.

PRD공법으로 시공한 암반 근입된 현장타설말뚝의 지지력 연구

황원수(Hwang Won Soo),정진호(Jeong Jin Ho),진종태(Jin Jong Tae),김종식(Kim Jong Sic) 대한토목학회 2008 대한토목학회 학술대회 Vol.2008 No.10

FRP Rod를 이용한 표면매립 및 단면 확대 복합 보수,보강 공법

황금식 ( Gum Sic Hwang ),박찬기 ( Chan Ki Park ),원종필 ( Jong Pil Won ) 한국복합재료학회 2005 Composites research Vol.18 No.4