한국인 성인 남성 폐쇄성수면무호흡 환자의 측모 두부 방사선계측학적 비교

황상희,박인숙,남기영,김종배,조용원,서영성,안병훈,박신구,박효상 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.3

본 연구는 비만도에 따른 한국인 남성 폐쇄성수면무호흡 환자의 측모 두부 방사선계측학적 특성을 파악하기 위하여 시행되었다. 이를 위하여 계명대학교 의과대학 동산의료원 수면클리닉에 수면장애를 주소로 내원하여 수면다원검사 후 치과에서 측모 두부방사선계측사진 촬영을 한 87명의 성인 환자들을 체질량지수(BMI)와 수면무호흡지수(AHI)에 따라 비비만 단순코골이군(Non-obese, simple snorers), 비만 단순코골이군(Obese, simple snorers), 비비만 수면 무호흡군(Non-obese, OSA patients), 비만 수면무호흡군(Obese, OSA patients)의 4군으로 나누어 비교하였다. 그결과, 4군 중 비만 수면무호흡군의 수면무호흡지수가 가장 컸으며, 비만 수면무호흡군보다 비비만 수면무호흡군의 하악각이 더 크고 혀 길이는 더 작았다. 또한, 비비만 수면무호흡군보다 비만수면무호흡군의 설골이 더 전하방에 위치하였고, 수면무호흡지수에 영향을 미치는 기여 인자는 비만 수면무호흡군에서는 혀 길이, 비비만 수면무호흡군에서는 설골의 후방위치였다. 이처럼 비만 수면무호흡 환자와 비비만 수면무호흡 환자의 측모 두부방사선계측학적 특성과 기여 인자가 다르게 나타나므로, 치료방법도 따라서 다르게 선택해야 할 것이다. 비만 수면무호흡 환자들에게는 먼저 체중감량이 권고되어야 할 것이고, 비비만 수면무호흡 환자들은 폐쇄부위에 따라 구강 내 장치나 Nasal CPAP (continuous positive airway pressure), UPPP (uvulopalatopharyngoplasty) 등이 추천될 수 있을 것이다. Objective: The purpose of this study was to compare the cephalometric measurements of obese and non-obese Korean male patients with obstructive sleep apnea syndrome (OSA). Methods: Eighty-seven adults who had visited the Sleep Disorder Clinic Center in Keimyung University, Daegu, Korea were examined and evaluated with polysomnography (PSG) and lateral cephalogram. They were divided into 4 groups (non-obese simple snorers, obese simple snorers, non-obese OSA patients, obese OSA patients) according to AHI (Apnea-Hypopnea Index) and BMI (Body Mass Index). Results: The obese OSA group had the highest AHI among the 4 groups. The non-obese OSA group had a significantly steeper mandibular angle and shorter tongue length than the obese OSA group. The hyoid bone of the obese OSA group was positioned anterior and inferior as compared with the non-obese OSA group. Multiple regression analysis showed that tongue length in the obese OSA group and retroposition of hyoid bone in the non-obese OSA group were significant determinants for the severity of AHI. Conclusions: From a cephalometric point of view, the obese and non-obese pateints with OSA may be characterized by different pathogeneses. Therefore, they have to be managed by individualized treatment. For the obese OSA patients, weight control must be advised as a first choice and for the non-obese OSA patients, oral appliance, nasal CPAP, UPPP and others could be chosen according to the obstructive sites.

ICR계 마우스에서 홍화씨 에탄올 추출물의 급성독성시험

황윤환,박병권,임종환,김명석,송인배,명노일,정상일,윤효인 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2008 動物醫科學硏究誌 Vol.15 No.1

The present study was carried out to investigate the potential acute toxicity of safflower seed by a single oral dose in ICR mice. Twenty animals of each sex were randomly assigned to four groups of 5 rats each and were administered singly by gavage at dose levels of 0, and 2,500 mg/kg bodyweight. Mortalities, clinical findings, and body weight changes were found and complete gross postmortem examinations were performed. Throughout the study period, no treatment-related deaths were observed. There were no adverse effects in clinical signs, body weight, and gross findings at any dose tested. The results showed that the single oral administration of safflower seed did not cause any toxic effect at the dose levels of 2,500 mg/kg in rats and the minimal lethal dose was considered to be over 2,500 mg/kg body weight for both sexes.

유기산의 해리평형에 미치는 치환기 효과와 그의 온도 및 압력의 영향. : (2) 수용액중에서 몇가지 치환나프톨류의 해리상수 (2) Dissociation Constants of Some Substituted Naphthols in Aqueous Solution

黃正儀,裵俊雄,鄭倧在,鄭在元,張景喜 慶北大學校 物理化學硏究所 1986 硏究論文集 Vol.7 No.-

치환나프톨류(4-Cl-1-Naphthol, 6-Br-2-Naphthol, 8-NH_2-2-Naphthol)의 해리상수를 온도(25∼40℃)와 압력(1∼2000 bar)을 변화시키면서 분광학적 방법으로 측정했다. 이들의 해리상수는 치환기가 들어가므로서 모두 감소했다. 이것은 치환기의 I-효과로서 설명이 가능했으며 또 온도와 압력이 증가하면 해리상수도 증가하였다. 이들 해리상수로부터 반응의 열역학적 성질을 계산하여 반응의 성질을 알아보았다. The dissociation constants of 4-Cl-1-naphthol, 6-Br-2-naphthol, 8-NH_2-2-naphthol in aqueous solution were measured by spectroscopic method in the temperature range from 25 to 40℃ and pressure up to 2000bar. The dissociation constants were decreased as the substituents were inserted in naphthol from 4.4×10 exp(-10) to 5.82×10 exp(-11) as chloride compound and 2.5×10 exp(-10) to 3.44×10 exp(-11) or 4.21×10 exp(-11) as bromine or amino compounds, respectively. This decrease can be explained with the I- or R-effects of substituents. From the dissociation constants various thermodynamic properties were claculated and discussed the characteristics of the dissociation reaction.

하악골 골절 치료를 위한 miniplate와 관련된 매복견치의 치험례

황상희,박효상,권대근,남기영,김종배 대한치과교정학회 2005 대한치과교정학회지 Vol.35 No.2

하악 좌측 견치의 미맹출을 주소로 내원한 10세 여환의 과거 병력 조사 중 3년 전 교통사고로 하악 좌측 골체부에 골절이 생겨 miniplate로 관혈적 정복술을 시행받은 것을 발견하였다. 통상적인 외과적 노출과 교정적 견인치료로는 견치 맹출에 실패하였고, miniplate를 제거함으로써 정상적인 매복 견치 맹출에 성공하였기에 보고하는 바이다. This case report describes the treatment of an impacted tooth in relation to pediatrlc mandibular fracture. A 10-year-old girl presented with an impacted mandibular canine related with a miniplate in the left mandibular body area. An ordinary surgical traction ended in failure. Good occlusion was established by removal of the miniplate. It would be considered important to make an exact diagnosis of the cause and remove the mechanical obstruction instantly for successful orthodontlc treatment of an impacted tooth.

토끼에서 Etofenprox와 Spinosad 합제의 국소자극성 시험

황윤환,김명석,송인배,박병권,양승호,임용현,송치용,안성한,남현수,임정교,정상일,명노일,윤효인 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2008 動物醫科學硏究誌 Vol.15 No.1

This study was performed to evaluation the skin and eye irritation of etofenprox 8% and spinosad 4% combination in male New Zealand White rabbits. In skin irritation test, the combination of etofenprox and spinosad did not showed any change of body weight but caused slight skin irritation with the P.I.I. (primary irritation index) value 0.25. The etofenprox and spinosad combination showed severe eye irritation 1 h, 24 h, 48 h, and 72 h after ocular treatment, having the A.O.I. (acute ocular irritation) value of 37.3. Therefore, these result indicated that the combination of etofenprox and spinosad might be irritant formulation on eye and skin.

좌심실비후 환자에서 베타차단제의 급중단이 임상증상 및 좌심기능에 미치는 영향

황종현,김영태,배용학,임현주,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.1

목적 : 베타 차단제와 칼슘 길항제의 장기투여로 안정상태에 있는 비후형 심근증이나 고혈압성좌심실비후 환자에서 이들 약제를 갑자기 중단하였을 때 혈역학, 심기능 및 임상상에 미치는 영향을 알아보기 위하여 본 연구를 시행하였다. 대상 및 방법 : 경북대학교 병원 순환기내과에서 통원치료중인 비후형 심근중 환자 5명과 심한좌심실비후를 동반한 고혈압 환자 6명(남자 6명, 여자 5명)을 대상으로 장기투여 중이던 베타 차단제와 칼슘 길항제를 최소 5일 중단한 후 임상증상, 혈압 및 심박수의 변동, 그리고 투약중지 전후에 도플러 심초음파도를 기록하여 좌심실내경, 벽두께, 좌심실근량, 구혈율 및 승모판혈류속도곡선의 변화를 관찰하였다. 결과 : 1) 약물치료 중단 후, 베타차단제의 경우 9명 중 6명에서, 그리고 칼슘길항제 및 디소피라미드를 복용하던 각 1명, 도합 7명의 환자에서 심계항진, 호흡곤란의 악화, 흉통이 관찰되었고, 심계항진을 호소한 1예에서는 심방세동이 재발되었다. 2) 혈압, 심박수, 확장말기 및 수축말기 좌심실내경, 심실중격 및 심실후벽 두께, 좌심실근량 및 구혈을 모두는 치료약물 중단 전후에 다소 변화하였으나 유의하지 않았다. 3) E파 최고속도와 E파 시간속도적분은 약물투여 중단 전후에 유의한 변화는 없었으나, A파 최고속도와 A파 시간속도적분은 중단 후에 각각 유의하게 증가하였으며(both P<0.01), E/A 최고속도비와 E/A 시간속도적분비는 각각 유의하게 감소하였다(both P<0.01). 한편, E파 감속시간, 등용이완시간 그리고 A-Ar 간격[A파의 최고점에서 A reversal(Ar)파의 최저점간의 시간] 모두는 중단 후 유의한 변화가 없었다. 1 결론 : 비후형 심근증 이나 고혈압성 좌심실비후 환자에서 장기투여중이던 베타 차단제와 칼슘길항제를 일시적으로 중단하였을 때 임상중상의 악화와 더불어 확장기 기능의 변화를 초래하였다. 따라서 약물치료로 비록 임상적으로 안정상태에 있더라도 치료를 갑자기 중단할 때는 주의해야 할 것으로 생각된다. Objectives : This study was done to evaluate the changes in clinical findings, hemodynamics and cardiac function after abrupt withdrawal of longterm beta-blockers and/or calcium channel blockers in hemodynamically stable patients with hypertrophic cardiomyopathy and left ventricular(LV) hypertrophy associated with hypertension. Methods : Eleven patients with hypertrophic cardiomyopathy(n=5) and LV hypertrophy associated with hypertension(n=6) were studied. Symptom assessment, blood pressure, electrocardiography and echocardiography including pulsed Doppler examination were obtained before and at least 5 days after abrupt cessation of beta-blockers and calcium antagonists. Results : 1) Deterioration in symptoms(i.e. palpitation, aggravation of dyspnea and chest pain) was observed in seven patients after abrupt withdrawal. 2) There were no significant changes in blood pressure, heart rate, end-systolic and end-diastolic LV dimensions, interventricular septal thickness, LV posterior wall thickness, LV mass, and ejection fraction before and after drug withdrawal. 3) Doppler time intervals and E wave peak-velocity and time velocity integral(TVI) were not significantly changed before and after drug withdrawal. But A wave peak-velocity and TVI after abrupt withdrawal were significantly increased(both p<0.01), and E/A peak-velocity ratio and TVI ratio were significantly decreased(both p<0.01). Conclusions : These findings suggest that temporary omission of beta blockers and calcium channel blockers develops deterioration in symptoms and LV diastolic dysfunction in hypertrophic cardiomyopathy and LV hypertrophy associated with hypertension. Physicians should avoid abrupt withdrawal of longterm beta blockers in LV hypertrophy.

포괄수가지불제도 적용에 따른 산부인과 진료수입의 변화

황태연,유병철,정귀언,정수진,김성준,배기택,손혜숙,이종태,전진호,엄상화 인제대학교 2001 仁濟醫學 Vol.22 No.1

Objectives: Under the fee-for-service system, Korean hospitals have been suffering from the worsening profitability caused by law medical care fees. To overcome the difficulties, they have maximized the quantity of medical services and made relatively large investment in developing new medical services using high-priced medical equipment, medicines and medical supplies which were not covered by medical insurance system rather than reduced running costs. Materials and Methods: This study was made to analyze and forecast the revenue change of the department of Obstetrics and gynecology of an university hospital in Seoul, expecting the implementation of DRG system in 2000. Results: The results were as follows : 1.During the first two days of hospitalization. 41% of total medical service fee was occurred, which was thought that most of the check-ups and operations were made during this period. After two days of hospitalization, the new occurrence of medical service fee tended to reduce. 2.Out of total medical service fee, 67% of admission fee was occurred after 5 days of hospitalization. This was because medical service fees in obstetrics and gynecology department occurred during the first 5 days of hospitalization. 3.Out of fees for operation, treatment, medical supplies and blood transfusion. 71% was occurred during the first two days. 4. In case of fees for examination, 50% was occurred during the first two days. 5.A total of 53% of fees for medication and injection was occurred during the first 5 days. Conclusions: By the implementation of the DRG system, the income is forecast to increase by 800 won to 310,000 won by the disease group of obstetrics and gynecology department. To increase hospital income with the implementation of DRG system, the results of this study suggest that examinations should be done at out-patient departments before the hospitalization of patient, the discharge of patient should be noticed in advance to reduce the period of hospitalization, and admission appointment system should be implemented for the immediate operation and delivery.

해상 유류 유출 사고 후, 유류 해양 오염에 따른 주요 해산 어ㆍ패류내 PAHs 추적

황인영,박정규,박관하,김정상,정흥배,배철한 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.2

Marine organisms such as fish (Sebastes schlegeli) and mussels were cultured in sea water tanks placed at Dukpo area which was contaminated by the two oil spill accidents. Results showed that PAHs concentrations in fish tissue were higher than in fish liver. This was explained by the cytochrome P450 IA induction in fish liver after PAHs exposure. Other studies showed that higher PAHs levels were detected in mussels cultures in oil contaminated area than in control site. From these results, we concluded that Dukpo area is still polluted by oil including PAHs and it takes a long time to recover of oil contamination after the oil spill accidents.

브라켓 간접부착시 레진 베이스의 재료에 따른 전단결합강도와 파절양상 비교

전만배,황현식,김종철 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.2

본 연구의 목적은 브라켓 간접부착술식에서 레진 베이스의 재료에 따른 전단 결합강도와 파절양상을 비교해 봄으로써 광중합형 레진 베이스 사용의 타당성을 평가해보는데 있다. 소의 하악 중절치를 포매하여 만든 시편의 석고 모형에 화학중합형 레진 접착제인 Excel과 광중합형 레진 접착제인 Light-Bond 및 열중합형 레진 접착제인 Therma Cure를 이용하여 금속 브라켓을 위치시킨 후 transfer tray를 사용하여 시편에 옮겨 부착한 다음 만능물성 시험기를 이용하여 전단결합강도를 측정하고, 파절양상을 관찰하여 다음과 같은 결과를 얻었다. 1. 평균 전단결합강도가 화학중합형 레진 베이스를 사용한 군에서 154.20±35.53 kg/㎠로 나타났으며, 세군간에 유의한 차이가 없었다(P>0.05). 2. 접착제 잔류지수를 통하여 파절양상을 비교 관찰한 결과 세 군간에 유의한 차이를 보이지 않았다(P>0.05). 이상의 실험결과는 브라켓 간접부착술식에서 레진 베이스의 재료로 화학중합형, 열중합형 레진과 함께 광중합형 레진도 사용될 수 있음을 시사하였다. The purpose of this study was to evaluate the propriety of making use of light-cured resin base in indirect bracket bonding technique by study of shear bond strength and failure patterns according to the material of resin base. Metal brackets were bonded to the stone models of specimens involving bovine lower incisor with chemical-cured(Excel), light-cured(light-Bond)and thermal-cured(Therma-Cure)resin. They were transferred to the specimens and bonded using sealant. The shear bond strength was tested on Instron. After bracket removal, the bracket base was examined and assessed with the adhesive remnant index(ARI), The result were as follows: 1. No significant differences in shear bond strength were found among the three groups(P>0.05). 2. No significant differences in ARI score were found among the three groups(P>0.05). The above results suggest that light-cured resin base in addition to chemical-cured and thermal-cured resin bases is useful in the indirect bonding technique.

당뇨병 환자의 안면부 파라핀 주사부위에 발생한 피부 모균병

김종현,황소민,전재용,배용찬 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

Mucormycosis is an opportunistic fungal infection caused by the mucorales, which consist of the Rhizophus, Absidia, Mortierella, and Mucor. The diverse clinical forms of mucormycosis can be categorized as rhinocerebral, pulmonary, disseminated, gastrointestinal, cutaneous and miscellaneous. Although it can cause disease in healthy people, it most commonly affects patients who are diabetic or immunosup-pressed. Rarely, mucormycosis develops confined to the subcutaneous tissue. We experienced a case of cutaneous mucormycosis developed in a well-controlled diabetic patient who had previously injected foreign material on her face for an aesthetic purpose at the behest of an unlicensed physician. The patient had tissue necrosis and purulent discharge on her left cheek. Following histologic examination, we diagnosed the condition as cutaneous mucormycosis and treated it by wide excision combined with amphotericin B therapy. The disease was cured without any significant sequelae within 6 months of follow up. Cutaneous mucormycosis is rarely reported but it can cause facial deformity due to tissue necrosis, so that early diagnosis and appropriate treatment are important. Currently, foreign material injection for aesthetic purposes is still performed by unlicensed physicians. We present a case report concluding that one should consider the possibility of fungal infection in skin lesion in diabetic or other immunosup-pressed patients. We also emphasize the seriousness of illegal injection of foreign material.