정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

人蔘多糖類의 理化學的 特性에 關한 硏究 : 人蔘貯藏加工中 澱粉의 理化學的 特性變化 Change of physicochemical properties of the starch during storage and heat treatment

曺哉銑,吳成基,曺羊嬉,金海中,黃明浩 경희대학교 부설 식량자원개발연구소 1985 硏究論文集 Vol.6 No.-

In order to investigate the change of physicochemical properties of ginseng root starch during storage and heat treatment. the roots were stored for 15 days at 5℃, 15℃, 30℃ and 45℃, and heated for 15 hours at 60℃, 70℃, 80℃, 90℃, respectively. The starch content was decreased from about 40% to 23-26% and sucrose content was increased from 4% to 12-16% during storage for 15 days at 5-45℃. Maltose, which was not detected in fresh samples, was increased upto 8.5% during storage or heat treatment. Granular size of the starch was decreased and some of the granules were broken during storage. Amylose content in the starch was decreased from 33% to 20%, and blue value and alkali number of the starch were increased slightly, and solubility and swelling power of the starch were decreased during storage. The higher storage temperature and the longer storage time, the starch was more susceptible to gelatinize, and the viscosity of the starch was lowered with the susceptibility of gelatinization. The susceptibility of degradation of the starch by the amylase was increased and amylolytic activities in ginseng root were, also, increased during storage.

Linux X-Window 기반 어플리케이션의 안드로이드 포팅

박병조,양희재 경성대학교 공학기술연구소 2012 공학기술연구지 Vol.18 No.-

다양한 모바일 플랫폼의 부상으로 인해 최근 개발되는 프로그램들은 크로스 플랫폼을 지원 할 수 있도록 개발되는 추세이다. 그리고 기존에 특정 플랫폼 의존적으로 개발되었던 프로그램들 중 다수가 새로운 모바일 플랫폼으로 이식되어서 이용되고 있다. 국내 사례로는 이전에 WIPI 기반으로 개발되었던 기존 모바일 게임들 중 상당수가 안드로이드 플랫폼에 그대로 이식되어서 사용되고 있는 점을 예로 들 수 있다. 또한 하드웨어의 급속한 발전으로 인하여 모바일 기기에서도 고샤양의 어플리케이션을 구동 할 수 있게 됨으로써 모바일 어플리케이션의 크로스 플랫폼화는 단순히 모바일-모바일 간의 이식뿐만 아니라 PC-모바일 이식까지 그 영역을 확장할 수 있게 되었다. 이 논문에서는 PC-모바일 이식의 한 사례로 리눅스 X-Window 기반의 어플리케이션을 안드로이드 플랫폼에 이식 하는 방법에 대해 연구해보았다.

솔-젤법에 의한 Nb_2O_5-Fe_2O_3 혼합산화물의 제조 및 산 특성조사

정석조,양희정,권재범,이내우,우희철 釜慶大學校 2000 釜慶大學校 論文集 Vol.5 No.-

In this study, some of results from a study conducted on the preparation of niobium coated hematite particles to be used as a catalyst are presented.α-Fe_2O_3 (hematite) particles obtained by aging an acidic solution of ferric(Ⅲ) ions at high temperature were first prepared as core particles and synthesised by hydrolysis at high temperature with layers of amorphous niobium pentaoxide (Nb_2O_5) deposited by the hydrolysis of niobium pentachloride. The effects of varying molecular ratio of Nb/Fe (10/1, 5/1, 1/2, 1/5, 1/10) were studied. The synthesised particles were characterized for their physical and chemical properties using XRD, SEM, TPD, BET etc. The process of the surface coating showed heterocoagulation rather than surface nucleation and growth. A preliminary investigation of the acidic characterization and specific surface area of the synthesised particles showed that these particles can achieve an acidic characteristic changed and enhanced specific surface area of that of pure niobia and α-Fe_2O_3 prepared here.

고양이 위 평활근에서 KCI에 의한 근수축에 대한 Protein Kinase의 조절

심상수,김승록,심혜선,이덕주,한상준,윤신희,조양혁,김명석 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3

고양이 위 평활근 수축에 대한 Vanadate와 Pervanadate의 효과

심상수,최효봉,심혜선,이덕주,윤신희,한상준,김명석,조양혁 大韓消化器病學會 1999 大韓消化器病學會誌 Vol.33 No.1

찰옥수수연구 XVIII 시설하우스에서 2기작 찰옥수수 교잡종의 주요 생육특성 비교

나웅현,복태규,고혁수,백승우,조양희,이희봉 충남대학교 농업과학연구소 2013 농업과학연구 Vol.40 No.2

The major characteristics of the developed corn hybrids were compared at each different planting time; 1st time(April 28) and 2nd time(August 20), respectively. Among traits surveyed, stem height showed highly at 1st time than 2nd, while ear height, stem diameter and ear length were similar at two times. Sugar content of the used hybrids showed highly at 2nd planting time than 1st. Pericarp thickness was also high at 2nd planting time. Especially, among hybrids CNU99 was the highest in stem height and ear length, CNU11 and CNU56 were high in sugar content, and CNU51 and CNU124 were thiner than other hybrids in pericarp thickness. Accordingly, these hybrids will be planted and recognized in 2nd yield trial for superior corn hybrid selection.

Antiproliferative Prenylated Xanthones and Benzophenones from the Roots of <i>Cudrania tricuspidata</i> in HSC-T6 Cells

Jo, Yang Hee,Shin, Bora,Liu, Qing,Lee, Ki Yong,Oh, Dong-Chan,Hwang, Bang Yeon,Lee, Mi Kyeong American Chemical Society and American Society of 2014 Journal of natural products Vol.77 No.11

<P>Four new prenylated xanthones, cudracuspixanthones A–D (<B>1</B>–<B>4</B>), two new prenylated benzophenones, cudracuspiphenones A (<B>5</B>) and B (<B>6</B>), and 11 known xanthones (<B>7</B>–<B>17</B>) were isolated from the roots of <I>Cudrania tricuspidata</I>. The absolute configurations of compounds <B>2</B>–<B>4</B> were deduced by the comparison of the calculated optical rotation values with the measured data. Compounds <B>1</B>, <B>5</B>, and <B>6</B> showed moderate antiproliferative activity on HSC-T6 cells with IC<SUB>50</SUB> values of 9.7, 3.3, and 7.1 μM, respectively. Compounds <B>2</B>–<B>4</B>, <B>10</B>, and <B>14</B>–<B>16</B> had weaker activity. Flow cytometric analysis suggested that compounds <B>1</B> and <B>5</B> inhibited HSC-T6 cell proliferation in part by inducing apoptosis.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2014/jnprdf.2014.77.issue-11/np5002797/production/images/medium/np-2014-002797_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np5002797'>ACS Electronic Supporting Info</A></P>

Extraction of seven major compounds from Agastache rugosa (Fisch. & C.A.Mey.) Kuntze: optimization study using response surface methodology

Yang Hee Jo,Seong Mi Lee,Doo-Young Kim,Yesu Song,Hocheol Kim,Mi Kyeong Lee,Sei-Ryang Oh,Hyung Won Ryu 한국응용생명화학회 2023 Journal of Applied Biological Chemistry (J. Appl. Vol.66 No.-

The purpose of this study is to demonstrate the potential enhancement of the flavonoid contents from Agastache rugosa, which can be obtained as raw materials for functional products in the food medicine industry by identifying important factors for efficient preparation to save costs and time in terms of economic factors. For this reason, response surface methodology using Box-Behnken design was used to optimize the extraction conditions for the maximum yield of seven major compounds from A. rugosa. The optimum conditions were obtained with an ethanol concentration of 60.0%, a temperature of 50 oC, and an extraction time of 33.6 min, meaning that the regression analysis fits the experimental data well. Under these conditions, the seven major compounds 1-7 had observed values of 2.169, 2.135, 0.697, 2.485, 0.105, 1.247, and 0.551%, respectively. These results show that the observed values are in good agreement with the predicted values in the regression model. This process for optimization study exhibited a basic protocol for obtaining stable ingredients from A. rugosa that are appropriate for the development of effective functional products.

Prophylactic Antimicrobial Therapy and Antimicrobial Stewardship in Urologic Surgery

Hee Jo Yang 대한요로생식기감염학회 2023 Urogenital Tract Infection Vol.18 No.1

Postoperative infectious complications are a worrying problem for surgeons. Urological surgery has a higher risk of postoperative urinary tract infection than other surgeries because of the common use of various types of catheters. Due to the recent increase in antibiotic resistance, antimicrobial stewardship recommends using appropriate antibiotics for a suitable period. It is generally advocated that prescribing antibiotics in the absence of infection is equivalent to the inappropriate use of antibiotics. Based on numerous studies reported by several academic societies, appropriate use of antibiotics before surgery has been suggested. It was confirmed that using antibiotics according to these guidelines reduces the use of antibiotics without increasing the incidence of postoperative infectious complications. Furthermore, endourological surgery reports have proved the efficacy of antibiotics given once before surgery. Differences in antibiotic resistance by region must be taken into consideration when selecting the appropriate antibiotic type.