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Moung Jin Lee,Seong Woo Jeon,Min Jeong Jo,Won Kyong Song,Byung Jin Kang 大韓遠隔探査學會 2007 大韓遠隔探査學會誌 Vol.23 No.5
This study is aiming at improving the Environmental Conservation Value Assessment Map (ECVAM) of National Land in Korea. The ECVAM items are composed of legal and environmental/ecological assessments. A popular method applied to ECVAM is an overlay environmental/ecological assessment items. The purpose of this study is to offer complementary items of the ECVAM by examining assessment items. In this study we assessed the ECVAM by five methods. Method 1 is Grade 1 areas of each administrative district; Method 2 is comparing overlapped areas of each assessment items Grade 1, 2 and permission of each assessment items duplication; Method 3 is Grade 1, 2 areas by only singular assessment items; Method 4 is Grade 1 areas only of Method 2; and Method 5 is Grade 2 areas only of Method 2. Method 1 showed Seoul and other metropolitan cities revealed a large proportion of Grade I regions by the legal assessment items. Gang won-Do, showed a large proportion of Grade I regions by the environmental/ecological assessment item. Method 2 showed 93.4 % of diameter Grade II (standard for stability); forest diameter item accounted for 99.9 % by Method 3, Method 4 showed 95.7 % of forest diameter, and forest density accounted for 66.4 % by Method 5. This study contributes to reduce the complexity in the process of manufacturing ECVAM of National Land, and to raise the flexibility in the process of managing and updating this map.
Lee, Moung-Jin,Jeon, Seong-Woo,Jo, Min-Jeong,Song, Won-Kyong,Kang, Byung-Jin The Korean Society of Remote Sensing 2007 大韓遠隔探査學會誌 Vol.23 No.5
This study is aiming at improving the Environmental Conservation Value Assessment Map(ECVAM) of National Land in Korea. The ECVAM items are composed of legal and environmental/ecological assessments. A popular method applied to ECVAM is an overlay environmental/ecological assessment items. The purpose of this study is to offer complementary items of the ECVAM by examining assessment items. In this study we assessed the ECVAM by five methods. Method 1 is Grade 1 areas of each administrative district; Method 2 is comparing overlapped areas of each assessment items Grade 1, 2 and permission of each assessment items duplication; Method 3 is Grade 1, 2 areas by only singular assessment items; Method 4 is Grade 1 areas only of Method 2; and Method 5 is Grade 2 areas only of Method 2. Method 1 showed Seoul and other metropolitan cities revealed a large proportion of Grade I regions by the legal assessment items. Gang won-Do, showed a large proportion of Grade I regions by the environmental/ecological assessment item. Method 2 showed 93.4% of diameter Grade II(standard for stability); forest diameter item accounted for 99.9% by Method 3, Method 4 showed 95.7% of forest diameter, and forest density accounted for 66.4% by Method 5. This study contributes to reduce the complexity in the process of manufacturing ECVAM of National Land, and to raise the flexibility in the process of managing and updating this map.
Song, Wung Joo,Lee, Yoon Jin,Kang, Joon Won,Chang, Mea Young,Song, Kyu Sang,Kang, Dae Young,Kim, Sook Za Korean Society of Medical Genetics and Genomics 2019 대한의학유전학회지 Vol.16 No.1
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a maternally inherited mitochondrial disorder of which m.3243A>G is the most commonly associated mutation, resulting in an inability to meet the energy requirements of various organs. MELAS poses a diagnostic challenge owing to its multiple organ involvement and great clinical variability due to its heteroplasmic nature. We report three cases from a family who were initially misdiagnosed with myasthenia gravis or undiagnosed. Although there is no optimal consensus treatment approach for patients with MELAS because of the disease's heterogeneity, our 21-year-long therapy regimen of ${\text\tiny{L}}-arginine$, ${\text\tiny{L}}-carnitine$, and coenzyme Q10 supplementation combined with dietary management appeared to provide noticeable protection from the symptoms and complications. Prompt early diagnosis is important, as optimal multidisciplinary management and early intervention may improve outcomes.
Song Chang-Ho,Yeom Han-Gyeol,Kim Jo-Eun,Huh Kyung-Hoe,Yi Won-Jin,Heo Min-Suk,Lee Sam-Sun 대한영상치의학회 2022 Imaging Science in Dentistry Vol.52 No.3
Purpose: This study was conducted to measure the radiation exposure and image quality of various cone-beam computed tomography (CBCT) machines under common clinical conditions and to analyze the correlation between them. Materials and Methods: Seven CBCT machines used frequently in clinical practice were selected. Because each machine has various sizes of fields of view (FOVs), 1 large FOV and 1 small FOV were selected for each machine. Radiation exposure was measured using a dose-area product (DAP) meter. The quality of the CBCT images was analyzed using 8 image quality parameters obtained using a dental volume tomography phantom. For statistical analysis, regression analysis using a generalized linear model was used. Results: Polymethyl-methacrylate (PMMA) noise and modulation transfer function (MTF) 10% showed statistically significant correlations with DAP values, presenting positive and negative correlations, respectively (P<0.05). Image quality parameters other than PMMA noise and MTF 10% did not demonstrate statistically significant correlations with DAP values. Conclusion: As radiation exposure and image quality are not proportionally related in clinically used equipment, it is necessary to evaluate and monitor radiation exposure and image quality separately
Song, Jae-Jin,Yoo, Young-Tae,An, Yong-Hwi,Yoo, Jae Chul,Kim, Ji Soo,Koo, Ja-Won Otology Neurotology, Inc. 2012 Otology & Neurotology Vol.33 No.2
OBJECTIVE: To determine characteristics and their prognostic value in idiopathic sudden sensorineural hearing loss (ISSNHL) with comorbid ipsilateral benign paroxysmal positional vertigo (BPPV). STUDY DESIGN: Retrospective chart review. SETTING: Tertiary referral center. PATIENTS: Of the 374 patients with a diagnosis of ISSNHL at Seoul National University Bundang Hospital from January 2004 to December 2009, 32 patients (8.6%) with comorbid BPPV were recruited and compared with matched ISSNHL patients without BPPV. INTERVENTIONS: Otologic and neurotologic examinations, pure-tone audiometry (PTA), vestibular function tests, and brain magnetic resonance imagings. MAIN OUTCOME MEASURES: Comparison of the findings of serial audiograms for 6 months and vestibular function tests in patients with ISSNHL and concurrent BPPV with those in age-matched ISSNHL patients without BPPV. RESULTS: Patients with BPPV showed higher PTA averages than those without BPPV on initial and follow-up audiograms. Moreover, the improvement in PTA was less in the BPPV group than in the control. BPPV most commonly involved the posterior canal (17/32, 53.1%), followed by the horizontal canal (8/32, 25%), both the posterior and horizontal canals (6/32, 18.8%), and the anterior canal (1/32, 3.1%). Thirteen (40.6%) of 32 patients had recurrences of BPPV, 9 within a week and another 2 within 3 months. CONCLUSION: Comorbid BPPV is a negative prognostic indicator of auditory function in ISSNHL. Concurrent BPPV in ISSNHL suggests combined damage to the utricle and may indicate severe and widespread labyrinthine damage, leading to the poor prognosis.
Cell cycle evaluation of granulosa cells in the γ-irradiated mouse ovarian follicles
Song,Kang-Won,Lee,Young-Keun,Kim,Jin-Kyu,Lee,Chang-Joo,Yoon,Yong-Dal 대한방사선 방어학회 1999 방사선방어학회지 Vol.24 No.1
이온화방사선이 동물 생식세포에 미치는 생화학적 및 형태학적 영향을 알아보기 위해 본 연구를 시행하였다. 미성숙 생쥐 (ICR, 3 주령)에 γ선을 선량 LD으로 전신조사하였다. 방사선 조사 후 6시간, 12 시간, 1 일, 그리고 2 일 후에 난소를 적출하였다. 난소에서 추출한 과립세포의 세포주기를 DNA에 대한 유세포 분석으로 분석하였다. 세포자연사를 확인할 수 있는 A 세포주기는 이온화방사선이 조사된 실험군에서 대조군에 비해 현저히 높은 값을 보였다. 이온화방사선을 조사한 후 6 시간 군에서 TUNEL 면역조직화학 염색도를 나타낸 난포의 수가 대조군에 비해 현저히 증가 하였다. 따라서, 본 실험의 결과 방사선 조사에 의해 유발되는 난포의 퇴화는 6 시간 이내에 급성으로 진행되는 방사선에 의해 유발되는 세포자연사 기작의 이해와 퇴화난포의 정량화를 위한 수단이 될 수 있다. This study was carried out to evaluate the biochemical and morphological effects of ionizing radiation on mouse ovarian follicles. Immature mice (ICR, 3 week-old) were irradiated with a dose of LD at KAERI. The ovaries were collected after 6 hours, 12 hours, 1 day, and 2 days post irradiation. With the morphological basis of the histological staining with hematoxylin-eosin, immunohistochemical preparation using in situ 3'-end labeling was evaluated. Flowcytometric evaluation of DNA extracted from the whole ovary was performed. The percentage of A (subpopulation of cells with degraded DNA and with lower DNA fluorescence than G/G₁ cells), apoptotic, cells in the cell cycle was significantly higher in the irradiated group than in the control group. The number of in situ 3'-end labeled follicles increased at 6 hours post irradiation. All the analyses represented that the ionizing radiation-induced follicular atresia was taken place via an apoptotic degeneration. Such a degeneration underwent very fast and acutely. Therefore, it is concluded that the radiation-induced follicular degeneration is, like the spontaneous atresia, mediated by an acute appoptosis of follicular granulosa cells. Flowcytometric evaluation of cell cycles can make the role for quantifying the atretic follicles and understanding the mechanism of the radiation-induced cell death.
( Jin Hyoung Kim ),( Ae-rin Baek ),( Song-i Lee ),( Won-young Kim ),( Yong Sub Na ),( Bo Young Lee ),( Gil Myeong Seong ),( Moon Seong Baek ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0
Background ROX index after high-flow nasal cannula (HFNC) initiation can be helpful to identify low-risk patients of HFNC failure in patients with acute hypoxemic respiratory failure. However, it remains unknown which variables are useful for predicting HFNC failure in coronavirus disease 2019 (COVID-19) receiving HFNC. This study aims to determine the discrimination ability of the ROX index and SpO2/FiO2 ratio in COVID-19 patients after HFNC initiation. Methods This multicenter study was conducted at seven university-affiliated hospitals in Korea. We retrospectively reviewed the hospitalized patients diagnosed with COVID-19 between February 10, 2020 and February 28, 2021. The ROX index and SpO2/ FiO2 ratio were calculated at 1 hour and 4 hours after HFNC initiation. The primary outcome was HFNC failure, defined as the subsequent use of mechanical ventilation despite using HFNC. Discrimination of prediction for HFNC failure was evaluated by receiver operating characteristic (ROC) curve analysis. Results During the study period, 1,565 patients with COVID-19 were hospitalized and eligible 133 patients who received HFNC were analyzed. Among them, 63 (47.4%) were successfully weaned from HFNC, and 70 (52.6%) were intubated. SpO2/FiO2 ratio at 1 hour after HFNC initiation was a more accurate predictor of HFNC failure compared to ROX index (AUC 0.762; 95% CI: 0.679- 0.846 vs. 0.733; 95% CI: 0.640-0.826) (Figure 1). In the multivariable analysis, patients older than 70 years old had 3.4 times of HFNC failure compared to younger patients (AUC 3.367 [95% CI: 1.358-8.349], p=0.009), and SpO2/FiO2 at 1 hour (AUC 0.983 [95% CI: 0.972-0.994], p=0.003) were associated with HFNC failure. Conclusions SpO2/FiO2 ratio at 1 hour after HFNC initiation demonstrated a useful predictive ability for HFNC failure. SpO2/FiO2 could be a bedside tool to identify the need for mechanical ventilation in COVID-19 patients receiving HFNC.
Determination of single nucleotide variants in Escherichia coli DH5α by using short-read sequencing
Song, Yoseb,Lee, Bo-Rahm,Cho, Suhyung,Cho, Yoo-Bok,Kim, Seon-Won,Kang, Taek Jin,Kim, Sun Chang,Cho, Byung-Kwan Published by Elsevier/North Holland on behalf of t 2015 FEMS microbiology letters Vol.362 No.11