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A non-pigmented superficial basal cell carcinoma misdiagnosed as eczematous dermatitis
( Jin-hwa Son ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ),( Gun-wook Ki 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Superficial basal cell carcinoma (BCC) typically present as a well-circumscribed, erythematous patch or plaque involving the trunk and extremities. Additional findings include focal scale or crust, a thin rolled border, and variable amounts of melanin. Especially, superficial BCC without pigmentation might be difficulty in early detection even for experienced dermatologists. We report a case of superficial BCC misdiagnosed as chronic eczematous dermatitis. A solitary erythematous plaque with long durations should be considered as malignant skin tumor in the differential diagnosis. A 48-year-old woman presented with 38 X 43 mm erythematous oozy plaque without pigmentation on her left arm that she had recognized 5 years previously. A dermoscopic examination revealed multiple small erosions on a homogenous pink background. Interestingly, multiple scars were found on face, extremities and she remembered that her father had applied chemical material for treatment of previous unknown dermatitis. The erythematous plaque had previously been diagnosed as eczema on another hospital after histologic examination. However, there was no improvement in the lesion after steroid therapy and re-biopsy was performed. The histopathologic findings revealed multifocal nests of atypical basaloid epithelium arising as buds from the basal layer of the epidermis. The diagnosis was confirmed of superficial BCC. She has been treated with Photodynamic therapy.
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The Cause of Whitening by Flame Retardants Treatment on Korean Wooden Cultural Heritage
Jin Qyu Kim,Yong Jae Chung,Hwa Soo Lee,Hyun Jeong Seo,Dong Won Son,Gyu-seong Han 한국목재공학회 2016 목재공학 Vol.44 No.4
Korean wooden cultural heritages are treated by flame retardants to protect fire hazards. Two types of flame retardants are used to treat wooden cultural heritage. These flame retardants cause some problems such as surface whitening, discoloration, and cracks due to the chemical reaction caused by Korean traditional wood painting (Dancheong), flame retardant and wood humidity. The Korean government is trying to cut down on the amount of flame retardants for the wooden cultural heritage because of these problems. This study was carried out to find the cause of whitening by flame retardants treatment. The reaction between pigment and flame retardant chemicals was analyzed by infrared spectroscopy.
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Predictor for deteriorating ward patient with repetitive Medical Emergency Team activation
( Jin Won Huh ),( Ju-ry Lee ),( Youn-kyoung Jung ),( Jin-mi Lee ),( Yujung Shin ),( Sunhui Choi ),( Jeongsuk Son ),( Eun-joo Choi ),( Da Hye Kim ),( Younsuck Koh ),( Chae-man Lim ),( Sang-bum Hong ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Purpose: Recurrent clinical deterioration and repetitive activation of Medical Emergency Team (MET) may be associated with poor outcome. The purpose of this study is to analyze the clinical characteristics of patients with repetitive MET activation and to predict the repetitive MET activation at first MET activation. Methods: We retrospectively reviewed the data of deteriorating patients who were contacted to the MET of Asan Medical Center from Jan 2012 to Nov 2016. The repetitive MET activation means the case of activation within 72 hours after the first MET activation. Results: A total of 7,470 patients were included during the study period. Of these patients, 892 (11.9%) experienced repetitive MET activation. ICU admission rate (49.0% vs. 27.8%, p<0.001) and in-hospital mortality rate (51.7% vs. 36.6%, p<0.001) were higher in the repetitive MET activation group than in the group who were once MET activation. The repetitive MET activation were independently associated with hematologic malignancies (OR: 1.45, 95% CI: 1.13-1.90), activation by respiratory distress(OR: 1.51, 95% CI: 1.20-1.89), airway suctioning (OR: 1.57, 95% CI: 1.24-1.98), apply of Bipap (OR: 1.97, 95% CI: 1.20-3.22), high SOFA (OR: 1.11, 95% CI: 1.07-1.15), and high SpO2/FiO2 score (OR: 1.14, 95% CI: 1.05-1.24) at first MET activation. Conclusion: These risk factors may be useful to identify patients at risk of repetitive MET activation at first MET activation, and then we could classify the high risk group and apply the aggressive intervention for better outcome.
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Undifferentiated pleomorphic sarcoma: Non-skin origin malignancy that dermatologists can meet
( Jin-hwa Son ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ),( Hoon-soo Ki 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Undifferentiated pleomorphic sarcoma (UPS) is a rare moderately aggressive mesenchymal neoplasm capable of invading soft tissue, skeletal, and retroperitoneal structures. It most commonly occurs in extremities and relatively few cases have been reported arising in the skin. Dermatologists could meet non-skin origin malignancy as skin tumor on extremities. Here, we report as case of UPS presented with subcutaneous mass on the forearm. A 70-year-old man had a large hard subcutaneous mass on the left forearm presented 3 years ago. The protruding mass was insidious at onset and increased in size progressively. On examination, 7cm-sized mass with pain was noted and it was fixed to underlying structures. Histopathological examination showed tumor composed of highly pleomorphic spindle-shaped cells arranged in sheets and irregular fascicles with myxoid stroma. Immunohistochemical stain showed that some tumor cells were focal positive for smooth muscle actin, desmin, epithelial membrane antigen and pan cytokeratin. These findings were suggestive of UPS. Necrotic soft tissue mass with adjacent muscle invasion was revealed but no metastatic lesions were detected on several imaging tests (CT, MRI and PET-CT). Therefore, skin tumor of extremities could be considered the possibility of non-skin origin malignancy such as UPS. If it is suspected, dermatologists should be able to perform further evaluation and refer to other specialists.
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Won Sun Park,Youn Kyoung Son,Eun A Ko,Seong Woo Choi,Nari Kim,Tae-Hoon Choi,Hyun Joo Youn,Su-Hyun Jo,Da Hye Hong,Jin Han 대한생리학회-대한약리학회 2010 The Korean Journal of Physiology & Pharmacology Vol.14 No.3
We investigated the effects of a hot-water extract of Artemisia iwayomogi, a plant belonging to family Compositae, on cardiac ventricular delayed rectifier K<sup>+</sup> current (I<sub>K</sub>) using the patch clamp technique. The carbohydrate fraction AIP1 dose-dependently increased the heart rate with an apparent EC<sub>50</sub> value of 56.1±5.5Ռg/ml. Application of AIP1 reduced the action potential duration (APD) in concentration-dependent fashion by activating I<sub>K</sub> without significantly altering the resting membrane potential (IC<sub>50</sub> value of APD<sub>50</sub>: 54.80±2.24, IC<sub>50</sub> value of APD<sub>90</sub>: 57.45±3.47Ռg/ml). Based on the results, all experiments were performed with 50Ռg/ml of AIP1. Pre-treatment with the rapidly activating delayed rectifier K<sup>+</sup> current (I<sub>Kr</sub>) inhibitor, E-4031 prolonged APD. However, additional application of AIP1 did not reduce APD. The inhibition of slowly activating delayed rectifier K<sup>+</sup> current (I<sub>Ks</sub>) by chromanol 293B did not change the effect of AIP1. AIP1 did not significantly affect coronary arterial tone or ion channels, even at the highest concentration of AIP1. In summary, AIP1 reduces APD by activating I<sub>Kr</sub> but not I<sub>Ks</sub>. These results suggest that the natural product AIP1 may provide an adjunctive therapy of long QT syndrome.
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Won Seok Lee,Hee-Jin Yang,Sung Bae Park,Young Je Son,Noah Hong,Sang Hyung Lee 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.1
Objective : Cubital tunnel syndrome, the most common ulnar nerve entrapment neuropathy, is usually managed by simple decompression or anterior transposition. One of the concerns in transposition is damage to the nerve branches around the elbow. In this study, the location of ulnar nerve branches to the flexor carpi ulnaris (FCU) was assessed during operations for cubital tunnel syndrome to provide information to reduce operation-related complications. Methods : A personal series (HJY) of cases operated for cubital tunnel syndrome was reviewed. Cases managed by transposition and location of branches to the FCU were selected for analysis. The function of the branches was confirmed by intraoperative nerve stimulation and the location of the branches was assessed by the distance from the center of medial epicondyle. Results : There was a total of 61 cases of cubital tunnel syndrome, among which 31 were treated by transposition. Twenty-one cases with information on the location of branches were analyzed. The average number of ulnar nerve branches around the elbow was 1.8 (0 to 3), only one case showed no branches. Most of the cases had one branch to the medial head, and one other to the lateral head of the FCU. There were two cases having branches without FCU responses (one branch in one case, three branches in another). The location of the branches to the medial head was 16.3±8.6 mm distal to the medial epicondyle (16 branches; range, 0 to 35 mm), to the lateral head was 19.5±9.5 mm distal to the medial epicondyle (19 branches; range, -5 to 30 mm). Branches without FCU responses were found from 20 mm proximal to the medial condyle to 15 mm distal to the medial epicondyle (five branches). Most of the branches to the medial head were 15 to 20 mm (50% of cases), and most to the lateral head were 15 to 25 mm (58% of cases). There were no cases of discernable weakness of the FCU after operation. Conclusion : In most cases of cubital tunnel syndrome, there are ulnar nerve branches around the elbow. Although there might be some cases with branches without FCU responses, most branches are to the FCU, and are to be saved. The operator should be watchful for branches about 15 to 25 mm distal to the medial epicondyle, where most branches come out.
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