하악골에서 발생한 원발성 Ewing씨 육종 1례

고중화,전상훈,오영택,최진혁 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.2

부순모래를 사용한 강섬유보강 콘크리트의 물성에 관한 실험적 연구

崔榮和,金鍾寅,李明鎭 대구대학교 과학기술연구소 1999 科學技術硏究 Vol.6 No.2

The object of this experimental study is the comparison between the properties of the Steel Fiber Reinforced Concrete(SFRC) using crushed sand and those of SFRC using river sand. In the mix proportion, W/C is 50%, of 0, 0.5, 1.0, 1.5 and 2.0% steel fiber content, the conclusions of the flesh and hardened concrete properties are as follows, 1. The slump loss of SFRC with the passage of time was higher with the increase of fiber content, and the slump loss of crushed sand concrete was a little lower than that of river sand concrete. 2. With increasing of fiber content, the compressive strength of both SFRC using river sand and SFRC using crushed sand increased 10 to 24% compared with that of each plain concrete, and the maximum compressive strength was shown at the 1.5% fiber content. 3. The tensile strength of SFRC using crushed sand was higher than that of SFRC using river sand, and the tensile strength increased remarkably with increasing of fiber content. 4. The flexural strength and the flexural toughness of SFRC using crushed sand were higher than those of SFRC using river sand, and the flexural strength and toughness increased remarkably with increasing of fiber content.

"Mandibular Swing 접근법"에 의한 인두후벽암 치험 1례

전영명,고중화,이진석 아주대학교 의과학연구소 1996 아주의학 Vol.1 No.1

Traditionally, enbloc resection of the primary tumor with its lymphatics is the surgical procedure of choice for many oral and oropharyngeal malignancies. However, the operative fields reached by conventional approaches are too limited and narrow to remove extensive tumors, especially posterior pharyngeal tumor. The mandibular swing approach has greatly assisted tumor ablation and reconstruction of these areas. The authors essayed a mandibular swing approach for the ablation of a huge posterior pharyngeal wall carcinoma.

충남대학교 기초과학분야의 효율적 육성에 관한 연구

윤화중,진성일,윤민중,윤혜수,이영하,최철규,이천배,신대현 충남대학교 자연과학연구소 1986 忠南科學硏究誌 Vol.13 No.2

Chungnam National University (CNU) is located in Daeduk Science Town, a center of science and technology in Korea, and it is expected to play an important role in the development of science in Korea. With this in mind, the basic natural sciences at CNU should be more actively supported in both education and research. Accordingly analysis and comparison of the basic science program at major college in Korea as well as those in the USA and Europe has been performed. The current cooperative relationship between CNU and research institutes in the science town has also been analyzed. This study has resulted in propositions to make more efficient the upbringing of the basic sciences at CNU, by focusing on the following points ; a) to improve academic affairs, b) to make graduate studies substantial, c) to secure highly qualified faculty members, d) to increase cooperation in research between CNU and reserch institutes, e) to enlarge research laboratories and acquire more equipment and facilities.

Diphenylhydantoin 투여중 발생한 순수 적혈구 형성 부전증 : 증례 보고 Case Report

장진우,박종운,이종화,김영수 대한신경외과학회 1987 Journal of Korean neurosurgical society Vol.16 No.1

The authors have described a case with pure red cell aplasia (P.R.C.A.) caused by the administration of diphenylhydantoin after head injury. P.R.C.A. associated with diphenylhydantoin is very rare and easily treated with a discontinuation of diphenylhydantoin & steroids.

한국 여성사 정립을 위한 인물 유형 연구 : from Ancient Times to Tae-han Che-guk(大韓帝國) 고대에서 대한제국 시대까지

정세화,최숙경,이배용,장필화,김영미,박진숙 이화여대 한국여성연구소 1988 여성학논집 Vol.5 No.-

This study is an attempt to analyse the types of women recorded in historical documents. The categories are broadly divided in three areas; political, social and familial spheres. In the political sphere, three queens in Shilla period, the only period in Korean history when a queen was the supreme ruler, and women who had a formal right to be involved in the determination of soverign successor, to assume regency, and who had various informal political influence. In the social sphere, women's economic and religeous activities were examined. Also women specialists such as medicine women, shamans and kisaeng (entertainers) are examined in this category. In the familial sphere, conjugal relationships of first (legitimate) wives and concubines, and women's status and activities are investigated. The gradual establishment of patriarchal system initiated by the state, and the conflict of women's interests in the process was analysed. As a result of this preliminary analyses, it became clear that the social position of women in Korean history was constricted with the growth of the power of the state. In the case of ancient Korea and Koryo period women's status in the family was comparatively higher and their personal activities were freer although their political and social activities were restricted. As time progressed, the establishment and reinforcement of partriarchal system of the state based on confucian ideology had crucial importance on the position of women in society. The system of family was restructured and carefully monitored, and the members of the family were closely controlled. The state sought the material and ideological bases of the power through these control. As a result, the status of women became more structurally subjugated to make heads of the family, especially after the mid Choson dynasty.

청소년의 엽기문화와 교육적 함의

정영애,김진화 昌原大學校 人文科學硏究所 2001 人文論叢 Vol.8 No.-

중등도 심부전증 환자에서 Carvedilol의 치료 효과

차동훈,차영수,국진환,황경화,김형태,임상욱,김태용,조윤경,박필원 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.4

백혈병 마우스 모델의 동종골수이식에서 활성화된 자연살해세포들의 보충이 이식편대백혈병효과와 이식편대숙주반응에 미치는 영향

엄현석,한치화,박수정,김소연,정낙균,정대철,진종률,최일봉,양형모,서영훈,송현근,최인표,민우성,김춘추 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.1

배경: 백혈병에서 동종골수이식 (allogeneic bone marrow transplantation)의 성공적 치료 효과를 얻기 위해서는 이식편대숙주반응 (graft-versus-host disease, GVHD) 발생의 극복과 재발의 방지가 중요한 과제이다. 골수를 역류원심성 세포분리 (counterflow centrifugal elutriation, CCE) 방법으로 분리하여 얻은 rotor off (R/O) 세포분획은 T 세포의 수는 적지만 조혈모세포들을 다량 포함하고 있어 동종골수이식에서 주조직적합복합체 (major histocompatibility complex, MHC) 차이를 극복할 수 있고, 이식편의 생착 성공과 GVHD 발생 예방에 효과적이다. 그러나 골수로부터 T 세포를 제거하면 백혈병세포를 공격하는 이식편대백혈병 (graft-versus-leukemia, GVL) 효과가 감소되기 때문에 백혈병 재발의 빈도가 높다. 자연살해세포 (natural killer cell, NK cell)의 보충 첨가는 동종골수이식 후 GVHD 발생을 줄이면서 충분한 GVL 효과를 얻을 수가 있다. 따라서 저자는 분리 후 IL-2로 활성화시킨 NK 세포들을 골수 R/O 세포분획과 함께 백혈병 마우스 모델에 동종이식함으로써 GVHD와 GVL에 미치는 효과를 관찰하였다. 방법: Balb/c (H-2^(d)) 마우스에서 유래된 A20 (murine B-lymphoma/leukemia cell line, H-2^(d)) 백혈병 세포를 이식 2 일 전에 Balb/c 마우스에 주입하고, 치사량의 전신 방사선을 조사한 직후에 Balb/c 또는 C57BL/6 (H-2^(b)) 마우스의 골수 R/O 세포분획을 꼬리정맥을 통하여 주입하였다. 이들은 모두 이식 후 6-8 주 이내에 사망하였다. 동종이식의 대조군 (n=9)에는 1 × 10^(7)의 R/O 세포분획만을 주입하였고, 실험군 (n=9)에는 C57BL/6 마우스의 비장세포들로부터 단클론항체들을 이용한 negative selection방법으로 분리한 후 IL-2로 활성화된 5 × 10^(5)의 NK 세포분획을 1 × 10^(7)의 R/O 세포분획과 함께 주입하였다. GVL 효과의 판정은 이식 후 14 일과 28 일 째 되는 날 마우스에서 골수, 비장, 간 등을 얻어 백혈병 세포들의 침윤을 조직학적으로 관찰하였으며, GVHD의 정도는 육안적 관찰법으로 평가하였다. 결과: R/O 세포분획만을 이식한 대조군의 골수, 비장, 그리고 간 조직에서는 A20 백혈병 세포의 침윤이 각각 89% (8/9), 78% (7/9)와 22% (2/9)에서 관찰되었고, R/O 세포분획과 NK 세포분획을 함께 이식한 실험군에서는 비장과 간을 제외한 골수에서만 89% (8/9)에서 A20 백혈병 세포의 침윤이 관찰되어 두 군 사이에 장기별 분포의 차이를 볼 수 있었다 (P= 0.0001). 한편 GVHD는 두 군 모두에서 경하게 나타나서 유의한 차이는 없었다. 또한 생착 부전으로 사망한 마우스는 없었다. 결론: CCE를 이용하여 T 세포를 제거한 동종골수이식에서 NK 세포의 보충은 GVHD의 악화는 일으키지 않으면서, 백혈병의 진행을 억제하는 GVL 효과를 얻을 수 있었다. Background: Allogeneic bone marrow transplantation (BMT) with T cell-depleted marrow accompanies engraftment failure and relapse of leukemia by a loss of the graft-versus-leukemia (GVL) effect frequently, while it can prevent GVHD. Supplement of NK cells could prevent GVHD and enhance GVL effect in several murine allogeneis BMT models Roter off (R/O) cell fraction obtained by counterflow centriation elutriatio (CCO) contains small number of T cells and many hematopoietic stem cells. The aim of this study was to determine the effect of R/O cell fraction supplemented with IL-2 activated NK cells on GVL and GVHD within the leukemic mouse BMT model. Methods: Inoculation of A20 (H-2d, murine B-lymphoma/leukemia, Balb/c origin) cells into Balb/c mice via the tail vein 2 days prior to lethal total body irradiation (TBI) and infusion of the Balb/c BM or C57BL/6 (H-2b) R/O fraction were performed. It resulted in 100% mortality within 6 to 8 weeks. The irradiated mice in the control group were injected with 1 × 107 R/O cell fraction alone (n=9) and in the experimental group mice were injected with 1 × 107 R/O cell fraction plus 5 × 105 negatively selected IL-2 activated NK cell fractions of the spleens via the tail vein (n=9). On day 14 and 28 after BMT, the bone marrows, spleens, and livers of mice were harvested for histopathologic analysis of the infiltrations of leukemic cells. We then evaluated the GVHD within the mice. Results: A histopathologic study of the recipients receiving R/O fraction alone showed infiltration of leukemic cells, 89% (8/9) in bone marrows, 78% (7/8) in spleens, and 22% (2/9) in livers. The experimental group of mice showed only the infiltration of leukemic cells 89% (8/9) in bone marrows, not in spleens and livers. There were the organ differences of the leukemic cells infiltrations between the two groups (P=0.0001). There were no obvious differences in the GVHD scores between these two groups, and severe GVHD was not observed. There was no engraftment failure among groups. Conclusion: Thus, our findings suggest that R/O cell fraction obtained by CCE and supplemented with NK cells can promote GVL effect without mediating clinically overt GVHD in allogeneic BMT of mouse leukemia.

Epidermal Growth Factor(EGF)가 개의 손상된 슬관절 전방십자인대의 치유에 미치는 영향

김용식,정도현,정진화,우영균,임영욱,이화성,권순용 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2