A rare case of extensive papillary muscle calcification in senile cardiac calcification syndrome

김은진;송봉근;강민호;손형래;홍수민;박동원;허승혜;김계연;최석구 인제대학교 2011 仁濟醫學 Vol.32 No.-

광범위 유두근 석회화는 흔하지 앉으며, 원인과 임상적 중요성에 관한 문헌만 드물게 찾아볼 수 있다. 반면에 작은 석회 침착은 노인에서 흔하며 심장 첨부에 주로 나타난다. 유두근 석회화는 관상동맥질환, 확장성 심근병증, 승모관 질환, 고칼슘혈증, 그리고 말기신부전에서 인산칼슘의 중가와 연관성이 있다. 저자는 심장초옴파와 MDCT를 통해 진단된 전외측 유두근의 광범위 석회화의 드문 사례가 있어 보고한다.

관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구

강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.

육안적 혈뇨로 내원한 환자에서 발견된 방광 유전분증 : 증례보고

김은진;성 현;홍수민;정성연;박경식;손형래;박일권;구호석;고행일 인제대학교 백병원 2011 仁濟醫學 Vol.32 No.-

Amyloidosis is a disease resulting in deposition of amyloid in the body. The disease can be either primary or secondary. The amyloidosis of urinary bladder is more usually affected by primary amyloidosis and also very rare. The patient with primary amyloidosis of the bladder usually presents with gross hematuria. The amyloidosis resembles bladder cancer in cystoscopy. It can be confirmed by biopsy. The treatment consists of medication (e.g., steroid, antitumor agent, cholchicine, DMSO) and/or transurethral resection. The standard treatment is mephalan and prednisolone. A 49-year-old man complained of recently developed gross hematuria without abdominal pain. We examined urinary bladder cystoscope for gross hematuria. It revealed small bulging mass on trigone are a of bladder. Therefore we did bladder biopsy. Finally, it revealed bladder amyloidosis. The patient was improved by medication (mephalan 2mg and prednisolone 1 mg/kg po daily). We report an unusual case of amyloidosis involving bladder.

C3H/Hej 마우스에서 모발성장에 대한 생약 추출물의 효과

구성근, 주진호, 허진주, 미가, 강봉수, 김준형, 남상윤, 윤영원, 이범준, 김종수 충북대학교 동물의학연구소 2008 Journal of Biomedical and Translational Research Vol.9 No.3

본문참고

마우스에서 자외선조사에 의한 피부주름형성에 대한 생약추출물의 억제효과

구성근, 배부희, 허진주, 미가, 강봉수, 김준형, 남상윤, 윤영원, 김종수, 이범준 충북대학교 동물의학연구소 2008 Journal of Biomedical and Translational Research Vol.9 No.3

본문참고

암석 슬러지를 이용한 건자재 개발

이필호,이구연,전철수,연규석,이윤수,인교진 강원대학교 부설 석재복합신소재 제품연구센터 2000 석재연 논문집 Vol.5 No.-

본 연구는 1993년부터 춘천시 신동면 형돌리 산 62번지 내에서 흑운모 화강암 및 편마암 암석을 원자재로 사용하여 건설기초재료인 쇄설골재 및 인공모래를 생산하는 업체로부터 제품 생산 후 발생하는 토양 스러치 케익이 연간 약 10만 입방정도 발생한다는 사실에 기초하여 석산에서 채취된 페잔토(석분)의 화학적, 물리적, 역학적 특성을 조사하여 석분의 이용 가능성을 확인하기 위한 실험으로 단위 시멘트량을 400kg, 잔골재율을 45% 그리고 물-시멘트비를 65%로 고정하고 잔골재 중 석분을ㄹ 0%, 10%, 20%, 30%, 40%, 50% 및 60%로 치환하여 제조된 콘크리트의 기초적 성질을ㄹ 시험하였다. 그 결과 석분의 치환율이 높을 수록 공기량은 증가하고 슬럼프값이 감소하였는데 이는 미세한 입자인 석분을 잔골재의 일부로 치환함으로써 비표면적이 증가하였기 때문인 것으로 사료된다. 압축강도와 휨강도는 모두 석분의 치환율이 증가할수록 압축강도와 휨강도는 다소 감소하는 경향을 나타냈으나 큰 성능차이는 보이지 않는 다는 것을 알 수 있었다. 이상의 실험을 통해 석분을 시멘트 콘크리트에 사용했을 경우 약간의 성능저하는 있지만 잔골재로의 활용이 가능하다는 것을 알 수 있었다. 그러므로 앞으로 건조수축, 균열, 크리이프 특성 및 내구성에 과한 연구가 더욱 심도있게 이루어져야 폐자원인 석분의 이용이 가능하리라 판단된다. This study aims to make cement concrete using crushed stone fines which are produced at Chuncheon city, Hyuldongri and find it's applications. According to the experimental results, when ratio of crushed stone fines was increased, air contents were increased and slump values were decreased. Also, the compressive strength and flexural strength were decreased when ration of crushed stone fines was increased. Although these strengths are decreased, the crushed stone fines can be used to construction materials because the decreased amounts are not so much.

만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의

김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.

Benzoyl peroxide의 환경에서의 초기 위해성 평가

김미경,배희경,김수현,송상환,구현주,박광식,이문순,전성환,나진균 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.1

Benzoyl peroxide is a High Production Volume Chemical, which is produced about 1,375 tons/year in Korea as of 2001 survey. The substance is mainly used as initiators in polymerization, catalysts in hte plastics industry, bleaching agents for flour nad medication for acne vulgaris. In this study, quantitative Structure-Activity Relationships(QSAR) are used for getting adequate information on the physical-chemical properties of this chemical. And hydrolysis in water, acute toxicity to aquatic and terrestrial organisms for benzoyl peroxide were studied. The physical-chemical properties of benzoyl peroxide were estimated as followed; vapor pressure=0.00929 pa, Log K_(ow)=3.43, Henry's Law constant=3.54×10^(-6) atm-m³/mole at 25℃, the half-life of photodegradation=3days and bioconcentration factor(BCF)=92. Hydrolysis half-life of benzoyl peroxide in water was 5.2hr at pH 7 at 25℃ and according to the structure of this substance hydrolysis product was expected to benzoic acid. Benzoyl peroxide has toxic effects on the aquatic organisms. 72 hr-ErC_(50)(growth rate) for algae was 0.44mg/L, 48hr-EC_(50) for daphnia was 0.07mg/L and the 96hr-LC_(50) of acute toxicity to fish was 0.24mg/L. Acute toxicity to terrestrial organisms(earth worm) of benzoyl peroxide was low(14 day-LC_(50)=>1,000mg/kg). Although benzoyl peroxide is high toxic to aquatic organisms, the substance is not bioaccumulated because of the rapid removal by hydrolysis (half life=5.2hr at pH 7 at 25℃) and biodegradation(8.% by BOD after 21days). The toxicity observed is assumed to be due to benzoyl peroxide rather than benzoic acid, which shows much lower toxicity to aquatic organisms. One can assume that effects occur before hydrolysis takes place. From the acute toxicity value of algae, daphnia and fish, an assessment factor of 100 was used to determine the predicted no effect concentration(PNEC). The PNEC was calculated to be 0.7㎍/L based on the 48hr-EC_(50) daphnia(0.07mg/L). The substance shows high acute toxicity to aquatic organisms and some information indicates wide-dispersive use of this substance. So this substance is a candidate for further work, even if it hydrolysis rapidly and has a low bioaccumulation potential. This could lead to local concern for the aquatic environment and therefore environmental exposure assessment is recommended.

허혈성 심질환에서 염증지표에 관한 연구

번정득,권영주,박상호,한대희,이상철,강진환,김명구,심규혁,최병조,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background : Atherosclerosis is the chief underlying cause of ischemic heart disease and there is increasing evidence that inflammation is an important determinant of the development of atherosclerosis. We assessed the levels of inflammatory markers in patients with ischemic heart disease and normal group who has normal coronary angiograms. Materials and Methods : Coronary angiography was performed in 142 patients. 107 patients of ischemic heart disease(stable angina pectoris 58, unstable angina pectoris 30, Acute myocardial infarction 19) and 38 normal control subjects. We assessed the level of inflammatory markers, such as CRP, ESR, fibrinogen and leukocyte. Results : CRP, ESR and fibrinogen values of the patients with stable angina pectoris and unstable angina pectoris were higher than that of normal control group, but there were no statistical significance. Leukocyte value of the patients with unstable angina pectoris(9003.3±701.5/mm^(3)) was significantly higher than that of the patients with stable angina pectoris(6685.5±245.8/mm^(3)) and normal control subjects(6394.3±235.1/mm^(3)). CRP, ESR and fibrinogen values of the patients with acute myocardial infarction were also higher than that of normal control subjects. CRP was 3.88±2.05 mg/dL in acute mocardial infarction group, and 0.29±0.15 mg/dL in normal control subject group(p<0.05). Fibrinogen was 541.6±45.1 mg/dL in acute myocardial infarction group, 321.4±25.6 mg/dL in normal control subject group(p<0.05). Leukocyte was 10942.1±737.6/mm^(3) in acute myocardial infarction group, 6394.3±235.1/mm^(3) in normal control subject group(p<0.05). Conclusions : This study demonstrate that CRP, fibrinogen and leukocyte values of acute myocardial infarction group were significantly higher than that of control group and stable, unstable argina pectoris group. Leucokyte values were significantly elevated in unstable angina group, but CRP values were not in unstable angina group.

Occurrence and risk-assessment of tropane alkaloids in grains and infant foods in Korea

Su-jin Oh,Songyi Han,Su kyung Jang,Hwa-jeong Lee,Yong-oui Koo 한국분석과학회 2021 학술대회논문집 Vol.2021 No.11

Tropane alkaloids (TAs) are naturally occurring secondary metabolites in plant. Some TAs such as Atropine and Scopolamine are known to cause acute neurotoxicity when consumed over a certain amount in food. Risk assessment studies are being conducted actively in foreign countries, but related research is lacking in Korea. Analysis of 15 TAs using UPLC-MS/MS was conducted with 100 samples including domestic and imported grains (rice, barley, buckwheat, wheat, sorghum, millet) and infant foods (follow-up formulas, baby foods for infants and young children). As a result, 4 low-molecular type of TAs (Tropinone, Pseudotropine, Scopine, 6-Hydroxytropine) and 2 Datura-type (Atropine, Scopolamine) were detected in 4 samples (baby foods for infants and young children, millet, barley, follow-up formula). The detection rate (%) of TAs was baby foods for infants and young children 3 cases (13%), millet 2 cases (20%), barley 1 cases (10%), and follow-up formula 1 cases (8%). The maximum level of Pseudotropine in baby foods for infants and young children was 19.28 μg/kg, 6-Hydroxytropine in follow-up formula was 2.78 μg/kg, Atropine in millet and baby food for infants and young children were 1.23, 0.52 μg/kg respectively. Scopolamine was detected in millet and baby food for infants and young children were 0.57, 0.25 μg/kg respectively. The exposure level of TAs estimated through the average intake of baby foods for infants and young children in 0-2 age groups ranged from 0.07 × 10<SUP>-3</SUP> μg/kg bw/day (lower bound) to 0.5 × 10<SUP>-3</SUP> μg/kg bw/day (upper bound), lower than ARfD 0.016 μg/kg bw/day(sum of atropine and scopolamine set by EFSA). It is expected that the results of the contamination degree and risk assessment derived from this study will be used as basic data in food safety management policies.