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전염성 단핵구중 림프절염의 세침흡인 세포학적 소견 - 4예 보고 -
손진희,정은하,박혜림,Sohn, Jin-Hee,Jung, Eun-Ha,Park, Hye-Rim 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.2
Infectious mononucleosis(IM) Is an acute self-limiting lymphoproliferative disorder associated with infection by the Epstein-Barr Virus(EBV), with the characteristic triad of fever, sore throat, and cervical or generalized lymphadenopathy. And also there are atypical lymphocytes in the peripheral blood. Cytological findings of IM lymphadenitis are characterized by a florid immunoblastic and atypical lymphoid cell proliferation. However, the small number of cases were studied by fineneedle aspiration cytology(FNAC) even though there was a complexity of lymph node pathology. It is important to recognize the reactive pattern of IM that would initiate EBV study and to avoid unnecessary biopsy We studied findings of lymph node FNAC from 4 patients with EBV infection confirmed by EBV-specific serologic studios. All of the cases were positive for viral capsid antigen(VCA) and one case was positive for anti-EBV nuclear antigen(EBNA). Cytologically, all of the cases exhibited high cellularity and atypia with great numbers of large immunoblastic lymphocytes.
유방 섬유선종과 유방암종의 화상 계측에 관한 연구 - 세침 홉인 세포 검사와 조직 검사간의 비교를 중심으로 -
손진희,최영희,박영의,Sohn, Jin-Hee,Choi, Young-Hee,Park, Young-Eui 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.2
Primary breast lesions diagnosed by fine needle aspiration cytology, confirmed by histologic examination were analyzed by morphometry to evaluate the difference between benign and malignant lesions, and the methods obtaining the sample. four size factors and 5 form factors were evaluated in 22 fibroadenomas and 20 carcinomas by image analyzer(Zeiss Ibas 2000) using the H-E stained slides. Nuclear size was significantly larger in the carcinoma cells than fibroadenoma cells both in the cytology and biopsy specimens, but the form factors were not significantly different. Both fibroadencma and carcinoma cells were significantly larger in cytologic smear than histologic section. The cells in the cytology were more regular and round than those in histology, but not statistically significant. Fibroadenomas having cellular proliferation and atypism exhibited larger size and more irregular nuclei than non-proliferative fibroadenoma, but not statistically significant. Therefore nuclear morphometric analysis can be a helpful method to diagnose the questionable breast lesions and is a method appropriate for use as a quality control procedure in the fine needle aspiration cytology.
세침흡인 세포검사와 조직검사의 진단 일치율 및 정확도에 대한 조사
손진희,채승완,조은윤,김어진,Sohn, Jin-Hee,Chae, Seoung-Wan,Cho, Eun-Yoon,Kim, Eo-Jin 대한세포병리학회 2003 대한세포병리학회지 Vol.14 No.2
Fine needle aspiration cytology (FNAC) has been known as a very sensitive and effective method for preoperative diagnosis. We studied cases preoperatively diagnosed by FNAC and confirmed by the histopathologic examination to define the effectiveness of FNAC. A total of 567 cases including breast, thyroid gland, lymph node, and soft tissue confirmed histologically after FNAC were enrolled, among 2,844 FNAC cases from January 1996 to March 2000. Overall sensitivity and specificity of FNAC were 93% and 100%, respectively. Sensitivity and specificity of FNAC by sites or organs were 91% and 100% in breast, 100% and 100% in thyroid, 97% and 100% in lymph node, and 71% and 100% in soft tissue, respectively. Nine cases showed diagnostic discrepancy; eight cases of sampling error and one case of interpretation error. Five cases, diagnosed as fibrocystic change at FNAC but invasive ductal carcinoma after the histopathologic examination, were categorized as sampling error due to the presence of diffuse fibrosis or deep seated location. One case of breast, diagnosed descriptively as atypical ductal and stromal cells suggesting invasive ductal carcinoma at FNAC but malignant phyllodes tumor histologically, was categorized as interpretation error. Other cases of sampling errors were two cases of soft tissue, a case of lymph node, and a case of salivary gland.
손진희,김덕환,강경하,김인숙,서정일,Sohn, Jin-Hee,Kim, Duck-Hwan,Kang, Kyung-Ha,Kim, In-Sook,Suh, Jung-Il 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.1
Aspiration biopsy cytology is a convenient, easy and non-invasive method for diagnosis of tumors. The results and cytologic features of carcinoma in various organs have been reported frequently, however, those of soft tissue sarcoma are relatively rare to find. Here we describe fine needle aspiration cytologic features of various soft tissue sarcomas and discuss cytologic differential points. The material is 6 cases of soft tissue sarcoma that were confirmed by histologic examination. They are composed of 2 cases of dermatofibrosarcoma protuberans and one case of malignant fibrous histiocytoma, synovial sarcoma, alveolar soft pan sarcoma, and malignant schwannoma respectively.
Jin-Kyoung Oh(오진경),Hai-Rim Shin(신해림),Gyungyub Gong(공경엽),Jin Hee Sohn(손진희),Shin Kwang Khang(강신광) 한국역학회 2008 Epidemiology and Health Vol.30 No.2
목적: 우리나라에서 자궁경부암 조기검진 방법으로 사용되고 있는 Pap 검사, LBC(액상검사) 및 HPV 검사의 정확도를 파악하기 위함이었다. 연구대상 및 방법 : MEDLINE과 KoreaMed를 통하여 1995년부터 2008년 3월까지 각 검사 방법의 민감도와 특이도를 보고한 논문을 검색하였음. 각 검사 방법의 민감도와 특이도의 대표값을 산출하기 위하여 메타 분석을 실시하였다. 조직학적 확진이 이루어진 사례만 메타 분석에 포함하였으며, CIN2 이상으로 진단된 경우를 질병으로 정의하였다. 세포 검사에서는 ASCUS 이상을 양성으로 간주하였다. 연구성적 : 총 24편의 논문이 검색하였고, 이 중 Pap 검사는 15편, LBC는 3편, HPV 검사는 4편이 선정 기준에 부합하여 메타 분석에 포함하였으며, 메타 분석 결과 민감도는 LBC가 가장 높고(92%), HPV 검사(83%)와 Pap 검사(76%) 순이었고, 특이도는 LBC(79%)가 가장 높고, Pap 검사(76%)와 HPV 검사(59%) 순이었다. 그러나 LBC의 민감도(heterogeneity p-value=0.682)를 제외하고는 모두 연구간에 통계적으로 유의한 이질성을 보였다.(p-value<0.0001). 결론: 각 연구의 이질성이 심하여 본 메타 분석 결과가 각 검사 방법의 정확도를 대표한다고 하기에는 제한적이며, 향후 보다 신뢰할만한 자궁경부암 조기검진 방법의 정확도 검증과 더불어 비용-효과 분석도 이루어져야 할 것이다.
두 자매에서 관찰된 가족성 선종성 폴립증에서의 폴립의 분포상과 악성화에 관한 분석 시도
김진복(Jin Pok Kim),최규완(Kyoo Wan Choi),손진희(Jin Hee Sohn),김용일(Yong Il Kim),서정욱(Jung Wook Suh),이성규(Sung Kyu Lee) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.1
N/A Total colectomy specimens from two sisters with familial adenomatous polyposis of the large intestine were subjected to the investigation on population density of adenomatous polyps in regard with adenoma-carcinoma sequence. Total number of polyps in the elderly sister was 194 with high population density of 234/100cm in the ascending colon, while in the younger sister the polyps were 1083 with 160/100cm of maximum density in the sigmoid colon and rectum, from where microcarcinomatous foci were encountered in both cases. Potential risk of malignant transformation in the higher population density area of polyposis was added and discussed.
림프구 침윤이 풍부한 갑상선 유두상 호산성세포 암종 - 1예 보고 -
김순란,손진희,Kim, Soon-Ran,Sohn, Jin-Hee 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.2
Lymphoid infiltration can be seen in some lesions such as Hashimoto's thyroiditis, subacute thyroiditis and several neoplasm of the thyroid. In case of malignancy, there are a few reports of lymphoid infiltration in the diffuse sclerosing variant of papillary carcinoma. But heavy lymphoid infiltraton without evidence of sclerosis is uncommon. We experienced a case of papillary oxyphilic carcinoma with massive lymphoid infiltration, which looks like Warihin tumor of salivary gland. However cytological feature of epithelial cells exhibit that of papillary carcinoma.
세침흡인 세포검사로 진단된 악성 흉선종 - 1예 보고 -
강경하,손진희,김덕환,팽성숙,양성은,서정일,Kang, Kyung-Ha,Sohn, Jin-Hee,Kim, Duck-Hwan,Pang, Sung-Suk,Yang, Seong-Eun,Suh, Jung-Il 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.2
Malignant thymoma is usually manifested as a mediastinal mass. Occasiomally, these tumors may be associated with a variety of systemic syndromes, such as myasthenia gravis, pure red cell aplasia or hypogammaglobulinemia However, it is generally accepted that thymomas rarely metastasize and the frequency of extrathoracic metastasis has been reported as 1 to 15%. In general, nuclear changes of tumor cells such as enlarged size, irregular shape and altered textures are determining factors in the assessment of the grade of malignancy. We experienced a case of malignant thymoma of anterior mediastinum in a 35-year-old woman. After 3 years, she developed recurrent malignant thymoma in the right supraclavicular area, diagnosed by aspiration biopsy cytology.
김민경,손진희,김철환,최종상,Kim, Min-Kyung,Sohn, Jin-Hee,Kim, Chul-Hwan,Choi, Jong-Sang The Korean Society for Cytopathology 2005 대한세포병리학회지 Vol.16 No.1
The objective of this study was to ascertain whether or not the high-risk human papillomavirus (HPV) test, when coupled with Papanicolaou (Pap) smears, would prove useful in the screening and management of patients in whom abnormal Pap smear results had been obtained. Concomitant high-risk HPV detection using the hybrid capture II test and colposcopy with a Pap smear were performed with 176 patients, all of whom had been screened for both cervical carcinoma and precancerous lesions. We concomitantly performed colposcopies on these patients. Upon the follow-ups, the histologic diagnoses of these patients were confirmed via either biopsy or hysterectomy. The rate of high-risk HPV detection was correlated with cytologic diagnoses and colposcopic findings. The group composed of the high-risk HPV-positive ASCUS patients exhibited a 55.7% rate of cervical intraepithelial neoplasia (CIN), a significantly higher rate than the 7.5% result obtained in the high-risk HPV-negative ASCUS group. HPV test showed high sensitivity (87%) and low specificity (62.6%) in detection of CIN and colposcopy also showed high sensitivity (88%) and low specificity (22%). Any combination of these tests improve sensitivity, but not specificity. High-risk HPV tests, when coupled with Pap smears, constituted a useful triage approach with regard to colposcopy-directed biopsies in patients in whom a cytologic diagnosis of ASCUS had been rendered.
좌측 난소적출술 후 자궁내막암을 동반하는 우측 난소에 발생한 과립막세포종
이경희(Kyung Hee Lee),박만철(Man Chul Park),이용우(Yong Woo Lee),손진희(Jin Hee Sohn),류문근(Moon Kn Ryu) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.7
Granulosa cell tumors are uncommon neoplasm of ovary that are characterized by their long natural history and for their tendency to recur years after an aparrent clinical cure. Endometrial cancer occurs in association with these tumor in at least 5% of cases and 25%-50% are associated with endometrial hyperplasia. In this study, we present a case of granulosa cell tumor of right ovary with endometrial cancer after left oophrectomy.