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Ping Zhou,Feicong Zhou,Jiayong Lin,Jinyi Li,Yifan Jiang,Bao Yang,Zhijie Wang 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.12
The Xigeda Formation has the characteristics of poor cementation, variable structure, and softening in water. It is prone to lead to failure of the initial support structures, arch collapse, and even roof fall. The key to the problem lies in the exploration of the interaction between surrounding rock and support. Therefore, based on the constraint loss theory of the tunnel face space effect, this paper constructively introduces multiple dependent variables, including the intermediate principal stress, the dilatancy of the surrounding rock, the timeliness of the shotcrete support stiffness, and the water content of the Xigeda formation, to decouple the whole process of the interaction between the surrounding rock and support, and discusses the influence of each variable. The research results show that: i) there is a critical support point in the tunnel under the influence of the unified strength theoretical parameter b and water content, and when the unified strength theoretical parameter b is constant, the critical distance of the support will decrease with the increase of the water content; ii) from the perspective of deformation control, the stress of support structure will increase with the increase of dilatancy angle of Xigeda surrounding rock; iii) considering the hardening characteristics of shotcrete, the initial support stiffness of Xigeda tunnel increases nonlinearly, and the whole process of stress and deformation can be divided into four stages; iv) the combined support structure of section steel and grille has little difference in the deformation control effect of the surrounding rock and the stress of the support structure, but the combined support structure of the grille steel frame is more sensitive to the hardening parameters.
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Key Parameters Design Method of AGF Method for Metro Connecting Passage in Water-Rich Coastal Area
Feicong Zhou,Ping Zhou,Jinyi Li,Tiancheng Ge,Jiayong Lin,Zhijie Wang 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.12
Artificial Ground Freezing Method (AGF) is an efficient, environmentally friendly reinforcement method for the construction of metro connecting passage in water-rich and weak stratum. The core of AGF is the design of frozen wall thickness and freezing temperature. In order to obtain the quantitative relationship between the freezing temperature and the frozen wall thickness, this study firstly equates the frozen wall to a rectangular frame mechanical model based on the stress state of the frozen wall formed by AGF. And then the calculation method of frozen wall thickness based on strength conditions is obtained by theoretical estimation. Furthermore, based on the relationship between the strength of the frozen soil and the freezing temperature obtained from the experiment, the freezing temperature and the frozen wall thickness are related to propose a frozen wall thickness design method considering the freezing temperature. In addition, experimental studies revealed that the compressive strength and shear strength of frozen soil increase linearly as the freezing temperature decreases. Secondly, the lower the freezing temperature, the smaller the frozen wall thickness required. Notably, the relationship between the frozen wall thickness and freezing temperature formed by the AGF method can be obtained through the design method proposed in this paper. Taking actual case as an example, when the frozen wall thickness is selected from 1.2 to 2.2 m, the required freezing temperature range is (-5) to (-25)oC. Finally, the feasibility of the designed freezing parameters in the connecting passage construction is verified through numerical simulation and field measurement, which shows that the design method has a promotion prospect.
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RGS2 promotes estradiol biosynthesis by trophoblasts during human pregnancy
Tang Chao,Jin Meiyuan,Ma Bingbing,Cao Bin,Lin Chao,Xu Shouying,Li Jiayong,Xu Qiang 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Production of estradiol (E2) by the placenta during human pregnancy ensures successful maintenance of placental development and fetal growth by stimulating trophoblast proliferation and the differentiation of cytotrophoblasts into syncytiotrophoblasts. Decreased levels of E2 are closely associated with obstetrical diseases such as preeclampsia (PE) in the clinic. However, the mechanisms underlying the inhibition of placental E2 biosynthesis remain poorly understood. Here, we report that regulator of G-protein signaling 2 (RGS2) affects E2 levels by regulating aromatase, a rate-limiting enzyme for E2 biosynthesis, by using human trophoblast-derived JEG-3 cells and human placental villus tissues. RGS2 enhanced the protein degradation of the transcription factor heart and neural crest derivatives expressed 1 (HAND1) by suppressing ubiquitin-specific protease 14 (USP14)-mediated deubiquitination of HAND1, resulting in the restoration of HAND1-induced trans-inactivation of the aromatase gene and subsequent increases in E2 levels. However, aromatase bound to RGS2 and repressed RGS2 GTPase activating protein (GAP) activity. Moreover, we observed a positive correlation between RGS2 and aromatase expression in clinical normal and preeclamptic placental tissues. Our results uncover a hitherto uncharacterized role of the RGS2-aromatase axis in the regulation of E2 production by human placental trophoblasts, which may pinpoint the molecular pathogenesis and highlight potential biomarkers for related obstetrical diseases.
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