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Feng, Enguang,Shin, Woo-Jin,Zhu, Xuelian,Li, Jian,Ye, Deju,Wang, Jiang,Zheng, Mingyue,Zuo, Jian-Ping,No, Kyoung Tai,Liu, Xian,Zhu, Weiliang,Tang, Wei,Seong, Baik-Lin,Jiang, Hualiang,Liu, Hong American Chemical Society 2013 Journal of medicinal chemistry Vol.56 No.3
<P>In order to exploit the 430-cavity in the active sites of neuraminidases, 22 zanamivir analogs with C-1 and C-4 modification were synthesized, and their inhibitory activities against both group-1 (H5N1, H1N1) and group-2 neuraminidases (H3N2) were determined. Compound <B>9f</B> exerts the most potency, with IC<SUB>50</SUB> value of 0.013, 0.001, and 0.09 μM against H3N2, H5N1, and H1N1, which is similar to that of zanamivir (H3N2 IC<SUB>50</SUB> = 0.0014 μM, H5N1 IC<SUB>50</SUB> = 0.012 μM, H1N1 IC<SUB>50</SUB> = 0.001 μM). Pharmacokinetic studies of compound <B>9f</B> in rats showed a much longer plasma half-life (<I>t</I><SUB>1/2</SUB>) than that of zanamivir following administration (po dose). Molecular modeling provided information about the binding model between the new inhibitors and neuraminidase, with the elongated groups at the C-1-position being projected toward the 430-loop region. This study may represent a novel starting point for the future development of improved antiflu agents.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2013/jmcmar.2013.56.issue-3/jm3009713/production/images/medium/jm-2012-009713_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm3009713'>ACS Electronic Supporting Info</A></P>
Feng Li,Genfu Feng,Jian Tan 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.8
With the arrival of global economic integration, the enterprise gradually realized the joint and downstream enterprises form a complementary advantage on its importance to enhance the overall competitiveness of the supply chain. To deal with the corresponding challenges, in this paper, we conduct research on pricing and the advertising coordination of multi retailer supply chain from the general perspectives of common interest maximization. For the two stage supply chain consisting of a single manufacturer and single retailer as the background, study retailers to establish online channel and manufacturers to establish the online channel and applicable condition, the difference between two kinds of the channel model and double channel of supply chain coordination mechanism. The core idea of supply chain management is focus on supply chain node enterprise specializing in their core business, and outsources non-core business to other enterprises, so as to achieve supply chain of all enterprises focus on their good at business. Our research optimizes the traditional game theory framework to achieve the better model for the issues. The experimental analysis verifies the feasibility and the effectiveness of our approach compared with the others.
Feng-Ze Qin,Jian-Wei Ma,Zhen-Yuan Jia,Guan-Lin Li,Jian-Zhou Zhang 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.8
In the presence of extremely high precision turning the complicated curved surface with geometry features of large slope gradient and multi convex-concave characteristics, the micron-scale deviation of contour resulting from the tracking deviation of the feed axis becomes non-negligible. To diminish the micron-scale contouring deviation, this study presents a valid contouring error estimation and pre-compensation method for slow tool servo (STS) precision turning. Aiming at estimating the tracking deviation of the axis of the turning machine tool in the machining process, the steady-state tracking deviation model of the axis is first constructed. The proposed multiply tangential estimation method is derived from the Taylor series of the foot point. Since the rotation feed movement of the C axis is the main movement in cutting forming movement for STS turning machining, the monotonicity of the displacement for the C axis is ensured. The compensation value for the axis position is derived through the Jacobi matrix of the STS turning machine. With the presented approach, the tool tip location deviation induced by the tracking deviation of the feed axis reduces from 1.087 μm to 0.025 μm. The measurement results of the comparison experiments indicate that with the presented method in this study, the contouring error of the machined part reduces from 5.72 μm to 4.36 μm. The micron-scale contouring error resulting from the tracking deviation of the feed axis is effectually compensated.
중국농촌마을의 지역사회소속감 형성에 관한 연구 : 위안가마을을 중심으로
Jiane-Feng Li,황태규(Tae-Kyu Hwang),강순화(Soon-Hwa Kang) 한국비교정부학회 2022 한국비교정부학보 Vol.26 No.1
(Purpose) The purpose of this study is to analyze the process of forming a sense of belonging to the local community of rural tourist destinations and the factors influencing the sense of belonging of residents, and to investigate the process of forming a sense of belonging of belonging of rural tourism village residents. (Design/methodology/approach) The subject of this study was conducted through an interpersonal interview survey method for Yuanjia Village, the most representative example of rural tourism in China. The surveyors conducted a survey after receiving preliminary survey method training, and a total of 482 copies were analyzed as valid samples. (Findings) According to the empirical analysis, support, fairness, social networking, resident participation, and membership all had important influences on the sense of community belonging, and among them, shareholder qualifications, regional participation, and distribution definition were high. (Research implications or Originality) This study is meaningful in identifying the factors that form a sense of community belonging of the residents of Yuanjia Village through case analysis and providing abundant information to the development of other rural tourist attractions.
( Jian Zhang ),( Jian Tang ),( Zhonghui Wang ),( Feng Wang ),( Gang Yu ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.3
The tradeoff between energy conservation and traffic balancing is a dilemma problem in Wireless Sensor Networks (WSNs). By analyzing the intrinsic relationship between cluster properties and long distance transmission energy consumption, we characterize three node sets of the cluster as a theoretical foundation to enhance high performance of WSNs, and propose optimal solutions by introducing rendezvous and Mobile Elements (MEs) to optimize energy consumption for prolonging the lifetime of WSNs. First, we exploit an approximate method based on the transmission distance from the different node to an ME to select suboptimal Rendezvous Point (RP) on the trajectory for ME to collect data. Then, we define data trans-mission routing sequence and model rendezvous planning for the cluster. In order to achieve optimization of energy consumption, we specifically apply the economic theory called Di-minishing Marginal Utility Rule (DMUR) and create the utility function with regard to energy to develop an adaptive energy consumption optimization framework to achieve energy effi-ciency for data collection. At last, Rendezvous Transmission Algorithm (RTA) is proposed to better tradeoff between energy conservation and traffic balancing. Furthermore, via collabo-rations among multiple MEs, we design Two-Orbit Back-Propagation Algorithm (TOBPA) which concurrently handles load imbalance phenomenon to improve the efficiency of data collection. The simulation results show that our solutions can improve energy efficiency of the whole network and reduce the energy consumption of sensor nodes, which in turn prolong the lifetime of WSNs.
Three New 29 Carbon Skeletons Pentacyclic Triterpenoids and S-equol from Biogas Slurry
Jian-Feng Xu,Hui-Bin Wu,Ding-Cai Liu,Long Sha,Wen-Hui Wu,Hua Fan,Yishan Song,Hong-Guang Zhu 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.12
Bioactive natural products were firstly obtained from biogas slurry. Three new 29 carbon skeletons of the pentacyclic triterpenoid compounds 24-norolean-12-ene-3,22-dione (1), 3β-hydroxy-24-norolean-12-ene-22-one (2), 3α-hydroxy-24-norolean-12-ene-22-one (3), as well as one known compound S-equol (4) were isolated and purified from the MeOH extract of chicken manure biogas slurry. The molecular structures of the four compounds were elucidated based on the extensive spectroscopic data analysis, and the structure of Compound 1 was further confirmed by single-crystal X-ray diffraction. The structures of Compounds 1, 2, and 3 are similar with oleanolicum and hederagenin that has excellent anti-tumor activities. The cytotoxicity against five cancer cell lines (Hela, A549, MCF7, PC3, and B16) of Compounds 1–4 was tested. Similar to Compound 4 (S-equol), Compounds 1–3 (pentacyclic triterpenoids) showed cytotoxicity activity against different tumor cell lines. Compounds 1–3 showed slightly lower cytotoxicity activities than Compound 4. The IC50 of Compound 4 was determined to be 9.7–27.6 μM, while the IC50 values of 1–3 were 17.6–65.3 μM. There are no significant differences in the cytotoxicity capacities between Compounds 1, 2, and 3.
Feng Jian,Ren Jian,Fan Ren-Yi,Lei Jing 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.7
Mobile application for campus is an integral part of the construction of wisdom campus. CampusService - a campus information service system is designed, and is comprised of three parts, Android client, Web client and server, which are all designed according to MVC pattern. C/S architecture is adopted between the Android client and the server, B/S architecture is adopted between the Web client and the server, and JSON is used as a unified data interface for accomplishing the interactions. The architectures of three parts are described, and key technologies are represented, including database access optimization, Android display, transaction management and authentication, among which database access optimization technology has two respects: using C3P0 to maintain connection pool and prefetching data based on their popularity. According to testing, the system implements functions of user management, intramural announcements, interaction with friends, activity participation, and campus maps, and it has good performance. The system provides an efficient platform for real-time communication among teachers, students and school authority.