Association between dyslipidemia and asthma in children: a systematic review and multicenter cohort study using a common data model

Ji Eun Lim,Hye Min Kim,Ju Hee Kim,Hey-Sung Baek,Man Yong Han 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.8

Background: The association between dyslipidemia and asthma in children remains unclear. Purpose: This study investigated the association between dyslipidemia and cholesterol levels in children. Methods: A systematic literature review was performed to identify studies investigating the association between dyslipidemia and asthma in children. The PubMed database was searched for articles published from January 2000–March 2022. Data from a cohort study using electronic health records from 5 hospitals, converted to the Observational Medical Outcomes Partnership Common Data Model (OMOP-CDM), were used to identify the association between total cholesterol (TC) levels and asthma in children. This cohort study used the Cox proportional hazards model to examine hazard ratio (HR) of asthma after propensity score matching, and included an aggregate meta-analysis of HR. Results: We examined 11 studies reporting an association between dyslipidemia and asthma in children. Most were cross-sectional; however, their results were inconsistent. In OMOP-CDM multicenter analysis, the high TC (>170 mg/dL) group included 29,038 children, while the normal TC (≤170 mg/dL) group included 88,823 children including all hospital datasets. In a meta-analysis of this multicenter cohort, a significant association was found between high TC levels and later development of asthma in children <15 years of age (pooled HR, 1.30; 95% confidence interval, 1.12–1.52). Conclusion: Elevated TC levels in children may be associated with asthma.

폐기능 검사에 의한 소아 천식의 진행 및 기도 염증의 평가

백혜성 ( Hey Sung Baek ),정지영 ( Ji Young Cheong ),오재원 ( Jae Won Oh ),이하백 ( Ha Baik Lee ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2009 소아알레르기 및 호흡기학회지 Vol.19 No.3

목적: 천식은 소아 청소년기에 흔한 만성 기도질환으로서 전 세계적인 보건사회 문제의 초래와 경제사회적인 부담을 가중시키고 있다. 현재 천식치료가 기도염증과 기관지 과민성(airway hyper-responsiveness)의 효과적인 완화와 증상 예방에 주안점을 두고 있기는 하지만, 일부 환자들은 어려서부터 폐기능의 점진적 감소가 있고 성인기까지 증상이 지속된다. 따라서 치료와 예방을 위하여 이러한 소아기 천식의 진행과 지속에 관여하는 위험인자들의 확인이 필요하다. 본 연구는 영아기부터 청소년기에 걸쳐 천식의 진행과 지속에 관여하는 위험인자를 찾아내어 치료에 도움이 되고자 하였다. 방법: 천식의 진행과 지속에 관여하는 위험 인자를 알아보기 위하여 경증-중등증 천식을 앓는 환아 67명을 대상으로 하였다. 곧, 3세 미만 발병 28예를 조기 발병 군으로, 3세 이후 발병 39예를 후기 발병 군으로 각각 분류하였다. 이들을 대상으로 아토피 병력과 가족력, 모유수유 기간, 부모 중 흡연 경력, 흡입용 코티코스테로이드(corticosteroid) 사용 경력과 폐기능 검사, 체질량 지수, 피부단자시험, 혈청 총 IgE 및 알레르겐 특이 IgE치, 말초혈액 호산구 수와 혈청 ECP 측정 등 검사실 검사 그리고 모든 환자에서 메타콜린 흡입 흡입과 자유 운동에 의한 기관지유발 시험을 각각 시행하였다. 결과: 천식 발생의 위험인자로서 아토피피부염과 잦은 천명의 빈도가 후기 발병 군 보다 조기발병 군에서 유의하게 많았다.(P<0.05) 그러나 기관지유발시험에 따른 기관지 과민성의 빈도와 PC20 및 운동유발시험 후 FEV1 감소치는 두 군 사이에 유의한 차이가 없었지만,(P>0.05) 흡입용 코티코스테로이드 사용의 빈도는 후기 발병 군보다 조기 발병 군에서 유의하게 더 흔하였다.(P<0.0001) 한편, 천식의 지속 기간과 FEV1/FVC 사이에 역 상관관계를 나타내었다.(r=-0.376, P=0.004) 결론: 아토피피부염과 재발성 천명은 천식의 발생과 지속에 중요한 위험인자로서 평가 될 수 있을 것으로 생각된다. Purpose: The social and economic impact of asthma is remarkable worldwide. To date, there have been many unanswered questions about factors related to asthma progression and persistence. This study focused on possible risk factors for persistent asthma that had developed between infancy and late childhood. Methods: Sixty-seven children with persistent mild-to-moderate asthma were enrolled in this study. They were classified into 2 groups according to the Global Initiative for Asthma (GINA) guideline 2006: early-onset (<3 years, n=28) and late-onset (>3 years, n=39) asthmatics. All patients were interviewed on the personal and familial history of atopy, breast feeding, parental smoking and the recent use of inhaled corticosteroids. We performed spirometry, and skin prick tests and measured body mass index, serum allergen-specific IgE, serum eosinophil counts and serum ECP in asthmatics. All asthmatics underwent the bronchial challenge by methacholine inhalation and outdoor free running. Results: Risk factors such as eczema and frequent wheezing were more common in early-onset asthmatics than in late-onset asthmatics (P<0.05). However, there was no difference between the 2 groups in the overall incidence of airway hyperresponsiveness (AHR) determined by the PC20 and postexercise decrease of FEV1 (P>0.05). Inhaled corticosteroids were more frequently used in early-onset asthmatics than in late-onset asthmatics (P<0.0001). A reciprocal relationship between FEV1/FVC and the duration of asthma was also detected in persistent asthmatics (n=57, r=-0.398, P=0.002). Conclusion: The results of this study suggest that atopic dermatitis and frequent wheezing may be important risk factors for the persistence of asthma and lung function decline from early to late childhood. [Pediatr Allergy Respir Dis(Korea) 2009;19:241-249]

SNAI1 is Involved in the Proliferation and Migration of Glioblastoma Cells

Han, Sung-Pil,Kim, Ji-Hoon,Han, Myoung-Eun,Sim, Hey-Eun,Kim, Ki-Sun,Yoon, Sik,Baek, Sun-Yong,Kim, Bong-Seon,Oh, Sae-Ock Springer-Verlag 2011 Cellular and molecular neurobiology Vol.31 No.3

일부 치위생(학)과 학생들의 현장임상실습 만족도의 영향을 미치는 요인

심선주(Seon-Ju Sim),백하영(Ha-Oung Baek),엄정선(Jung-Sun Um),정하얀(Ha-Yan Jung),지혜미(Hey Mi Ji),황시내(Si-Nae Hwang),한지혜(Ji-Hey Han) 대한치과의료관리학회 2017 대한치과의료관리학회지 Vol.5 No.1

A Statistical Study on the Relationship among Coronal Holes, Corotating Interaction Regions, and Geomagnetic Storms

Yunhee Choi,Y.-J. Moon,Seonghwan Choi,Ji-Hey Baek 한국천문학회 2008 天文學會報 Vol.33 No.1

Analysis of monitoring Road-kill in Odaesan National Park

Sang Jin Lim,Ki Yoon Kim,Woo Chan Lim,Hyeong Woo Ji,Baek Soon Choi,Tae Il Kim,Hyo Nam Kim,Ji Hong Min,Hey Ri Kim,Eui Kyeong Kim,Yung Chul Park 강원대학교 산림과학연구소 2017 강원대학교 산림과학연구소 학술대회 Vol.2017 No.11

We surveyed mammalian roadkill at the National Route 6 (Jin-gogae to Songcheon, 18㎞) and a local road 446 (Odaesan National Park office to Sangwon-temple, 12㎞) in Odaesan National Park. Data of the surveys were analyzed by year, month, and species. Roadkills of 226 individuals were found at the survey areas. Of them, the road-killed 131 mammal individuals, 44 bird individuals, 40 reptile individual and 11 amphibian individuals were found during the survey period. High ratio of the road-kills was observed in mammals than the other animals. Among mammalian species, high ratio of the road-kills was observed in squirrels. There were road-kills of three endangered species, containing otters, yellow-throated marten and leopard cats. According to the analyses of annual road-kills, roadkills of 104 cases were occurred and highly frequent in 2014, following by roadkills of 81 cases in 2015, and then those of 41 cases in 2016. Most ases of the roadkills occurred in summer (June to September). The results will contribute to establishing management for reduction of roadkill in Odaesan National Park.

전형적인 알레르기 증상으로 내원한 6세 미만 소아 환자에서 항원 감작 패턴: 단일 기관 연구

윤정원 ( Jung Won Yoon ),이상민 ( Sang Min Lee ),김준환 ( Joon Hwan Kim ),김나연 ( Na Yeon Kim ),백지현 ( Ji Hyeon Baek ),백혜성 ( Hey Sung Baek ),지혜미 ( Hye Mi Jee ),김형윤 ( Hyeung Yoon Kim ),최선희 ( Sun Hee Choi ),김기은 ( K 대한천식알레르기학회 2014 Allergy Asthma & Respiratory Disease Vol.2 No.4

Purpose: Population studies have reported that sensitization to inhalant allergens is rare in young children; however, most subjects in those studies had little or no symptoms or signs highly suggestive of allergic diseases. The aim of the present study was to assess the prevalence of sensitization to inhalant allergens in young children with symptoms and/or signs of allergic disease. Methods: We analyzed the results of all specific IgE tests performed at our hospital laboratory in children younger than 6 years presenting with symptoms and/or signs highly suggestive of allergic diseases between 2008 and 2013. Specific IgE tests for Dermatophagoides pteronyssinus, Dermatophagoides farinae, Alternaria alternata, German cockroach, cat dander, egg white or egg yolk, milk, peanut, and soybean were performed on 295 children; a specific IgE concentration ≥0.35 or ≥0.2 IU/mL was considered positive. We also compared allergen sensitization rates using the two cutoff values. Results: One hundred eighty-one children (61.4%) were positive to at least 1 allergen tested and 53 children (18.9%) were positive to at least 1 inhalant allergen when a specific IgE concentration ≥0.35 IU/mL was considered positive. The children were more likely to have asthma or allergic rhinitis when they were sensitized to any inhalant allergen, particularly house dust mites. The prevalence of sensitization to inhalant allergens increased with age (P<0.001). There was no significant difference in the prevalence of polysensitization among different age groups, but sensitization to both inhalant and food allergens significantly increased with age. Conclusion: Our results suggest that specific IgE tests to common inhalant allergens, particularly the house dust mites, may be considered when performing blood screening tests for young children presenting with symptoms and/or signs of allergic diseases

아토피피부염 환아에서 혈청 페리오스틴과 편평상피암항원

최우혁 ( Woo-hyeok Choi ),박태영 ( Tae-young Park ),김수영 ( Su-yeong Kim ),유리타미영 ( Rita Yu ),반지은 ( Ji-eun Ban ),양승 ( Seong Yang ),황일태 ( Il-tae Hwang ),백혜성 ( Hey-sung Baek ) 대한천식알레르기학회 2017 Allergy Asthma & Respiratory Disease Vol.5 No.2

Purpose: It was found that periostin and squamous cell carcinoma-related antigens (SCCAs) were strongly interleukin-13-inducible gene products. This study measures the serum periostin and SCCA levels in children suffering from atopic dermatitis (AD) and to evaluate the association between the severity of AD and their values. Methods: Seventy AD children aged 1 month to 10 years were included in our study. Subjects were characterized as having atopic eczema (AE; n=55) or non-AE (NAE; n=15) by atopic sensitization. Serum SCCA and periostin levels were measured. Results: The serum periostin levels were significantly higher in children with AE than in those with NAE (geometric mean [95% confidence interval]: 80.47 ng/mL [75.06-85.93 ng/mL] vs. 67.45 ng/mL [59.99-75.64] ng/mL, P=0.020). The serum concentrations of both SCCA1 and SCCA2 were significantly higher in children with AE than in those with NAE (geometric mean [95% confidence interval]: 1.401 [1.198-1.643] ng/mL vs. 0.969 [0.723-1.268] ng/mL, P=0.039 for SCCA1) (1.178 [0.974-1.455] ng/mL vs. 0.711 [0.540- 0.994] ng/mL, P=0.025 for SCCA2). The serum periostin levels were significantly correlated with disease severity and with peripheral blood eosinophil counts. The SCCA levels were not significantly correlated with disease severity. Both SCCA1 and SCCA2 were significantly correlated with serum periostin levels and blood eosinophil counts. Conclusion: Serum periostin levels may be significantly correlated with disease severity and blood eosinophil counts in children with AD. Serum SCCA levels can be significantly correlated with serum periostin levels and blood eosinophil counts in children with AD. (Allergy Asthma Respir Dis 2017:5:73-78)

급성호흡기감염 입원 환아에서 FilmArray에 의한 호흡기바이러스검사의 임상적 효과

이현주 ( Hyun Joo Lee ),박준홍 ( Jun Hong Park ),김재민 ( Jae Min Kim ),김지혜 ( Ji Hye Kim ),백혜성 ( Hey-sung Baek ) 대한천식알레르기학회 2021 Allergy Asthma & Respiratory Disease Vol.9 No.1

Purpose: Respiratory virus infection is a common cause of hospitalization in children. Rapid testing for respiratory viruses, such as the FilmArray method, can be clinically useful. However, insufficient evidence exists to support its use in standard clinical care. Methods: We retrospectively analyzed data from children under 18 years old who received the multiplex real-time polymerase chain reaction array (multiplex RT-PCR) method in 2017 and by FilmArray respiratory panel (FilmArray RP) in 2018. Results: Between January, 2017 and December, 2018, we reviewed data from 1,480 hospitalized children. The number of children with virus detection in respiratory viral PCR was 523 in the multiplex RT-PCR method and 419 in the FilmArray method. Seasonal virus outbreak patterns were similar to those of Korea Centers for Disease Control and Prevention in both groups. There was no difference between the 2 groups in the mean length of hospital stay. The time from admission to isolation by influenza infection was significantly shorter in the FilmArray group than in the multiplex RT-PCR group among patients who were not diagnosed with influenza infection by rapid antigen test at the time of admission. Conclusion: The use of FilmArray method for respiratory viruses did not diminish length of hospital stay. However, the FilmArray method may quickly detect the prevalence of respiratory infection and aid in clinical treatment. In addition, it was related with a reduced time from admission to isolation by influenza infection in hospitalized children who were not identified with influenza infection by rapid antigen test at the time of admission. (Allergy Asthma Respir Dis 2021;9:12-20)

천식 소아에서 아토피와 간접유발 기관지과민성과의 연관성

박태영 ( Tae-young Park ),이민주 ( Min-ju Yi ),최우혁 ( Woo-hyeok Choi ),김수영 ( Su-yeong Kim ),유리타미영 ( Rita Yu ),반지은 ( Ji-eun Ban ),양승 ( Seong Yang ),황일태 ( Il-tae Hwang ),백혜성 ( Hey-sung Baek ) 대한천식알레르기학회 2017 Allergy Asthma & Respiratory Disease Vol.5 No.2

Purpose: Both atopy and bronchial hyperresponsiveness (BHR) are characteristic features of asthma. Several BHR studies comparing groups of atopic and nonatopic asthmatics have reported conflicting results. The aim of this study was to compare BHR to indirect stimuli, such as mannitol or exercise, between atopic and nonatopic asthmatics in children Methods: We performed a retrospective analysis of data from 110 children with asthma, aged 6-18 years using skin prick tests, and serum total and specific IgE levels. Atopy degree was measured using the sum of graded wheal size or the sum of the allergen-specific IgE. Bronchial provocation tests (BPTs) using methacholine were performed on all subjects. BPTs using indirect simuli, including exercise and mannitol, were also performed. Results: Asthma cases were classified as atopic asthma (n=83) or nonatopic asthma (n=27) from skin prick or allergen-specific IgE test results. There was no significant difference in the prevalence of BHR to mannitol or exercise between atopic and nonatopic asthmatics. Atopic asthma had a significantly lower postexercise maximum decrease in % forced expiratory volume in 1 second (FEV₁) (geometric mean [95% confidence interval]: 31.9 [22.9-40.9] vs. 14.0 [9.4-18.6], P=0.015) and a methacholine PC₂₀ (provocative concentration of methacholine inducing a 20% fall in FEV₁) than nonatopic asthmatics (geometric mean [95% confidence interval]: 1.24 [0.60-1.87] ng/mL vs. 4.97 [3.47-6.47]) ng/mL, P=0.001), whereas mannitol PD₁₅ (cumulative provocative dose causing a 15% fall in FEV₁) was not significantly different between the 2 groups. Conclusion: There was no significant difference in the prevalence of BHR to mannitol or exercise between atopic and nonatopic asthmatics in children. (Allergy Asthma Respir Dis 2017:5:83-91)