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( Ji Hye Kim ),( Cheonga Yee ),( Jin Yi Kuk ),( Suk Joo Choi ),( Soo Young Oh ),( Cheong Rae Roh ),( Jong Hwa Kim ) 대한산부인과학회 2016 Obstetrics & Gynecology Science Vol.59 No.5
Pregnant women with antiphospholipid syndrome (APS) carry a high risk of arterial or venous thrombosis. Such thrombotic conditions occur more frequently in patients with triple positivity to antiphospholipid antibodies or with high antibody titers. Hepatic infarction is a rare complication in pregnant women with APS, and it sometimes mimics HELLP syndrome. This report describes a preeclamptic pregnant woman with APS who had high titers of three antiphospholipid antibodies. She experienced severe epigastric pain with elevated liver enzymes; in addition, she had tachycardia and tachypnea. The clinical findings suggested hepatic infarction and pulmonary thromboembolism, a partial manifestation of catastrophic APS. Therefore, she underwent emergent cesarean section at 25+2 weeks of gestation. After the delivery, her laboratory test indicated HELLP-like features, and computed tomography confirmed hepatic infarction and pulmonary micro-thromboembolism. Here, we report a case of a partial manifestation of catastrophic APS in a pregnant woman with triple antibody positivity, including a brief literature review.
Replicative senescence of periodontal fibroblasts induces the changes in gene expression pattern
Yi, Tac Ghee,Jun, JI-Hae,Min, Byung-Moo,Kim, Moonkyu,Kim, Gwan-shik,Baek, Jeong-Hwa 대한구강생물학회 2007 International Journal of Oral Biology Vol.32 No.1
Tooth loss in elderly is mainly caused by alveolar bone loss via severe periodontitis. Although the severity of periodontitis is known to be affected by age, the aging process or the genetic changes during the aging of periodontal tissue cells are not well characterized. In this study, we investigated the effect of in vitro aging on the change of gene expression pattern in periodontal fibroblasts. Gingival fibroblasts (GF) and periodontal ligament fibroblasts (PDL) were obtained from two young patients and replicative senescence was induced by sequential subcultivation. When more than 90% cells were positively stained with senescence-associated β-galactosidase, those cells were regarded as aged cells. In aged GF and PDL, the level of phosphorylated retinoblastoma (RB) and p16^(INK4A) protein was significantly decreased and increased, respectively. However, the protein level of p53 and p21, well known senescence-inducing genes, did not increase in aged GF and PDL. Although p27^(kip1) and p15^(INK4B) another cyclin-dependent kinase inhibitors, were reported to be involved in replicative senescence of human cells, they were decreased in aged GF and PDL. Because senescent cells showed flattened and enlarged cell shape and are known to have increased focal adhesion, we examined the protein level of several integrins. Aged GF and PDL showed increased protein level of integrin α2, αv, and β1. When the gene expression profiles of actively proliferating young cells and aged cells were compared by cDNA microarray of 3,063 genes and were confirmed by reverse transcription polymerase chain reaction, 7 genes and 15 genes were significantly and commonly increased and decreased, respectively, in aged GF and PDL. Among them, included are the genes that were known to be involved in the regulation of cell cycle, gene transcription, or integrin signaling. The change of gene expression pattern in GF and PDL was minimally similar to that of oral keratinocyte. These results suggest that p16^(INK4A)/RB might be involved in replicative senescence of periodontal fibroblasts and the change of gene expression profile during aging process is cell type specific.
OB-15 : Hepatic infarction in pregnant woman with antiphospholipid syndrome : A case report
( Ji Hye Kim ),( Soo Hyun Kim ),( Jin Yi Kuk ),( Suk Joo Choi ),( Soo Young Oh ),( Cheong Rae Roh ),( Jong Hwa Kim ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
Pregnant women with antiphospholipid syndrome (APS) carries higher risk for arterial or venous thrombosis, which is often aggravated by thrombogenic trait of pregnancy. This report describes a 36-years-old pregnant woman with APS who had hepatic infarction. Her first pregnancy was terminated at 21weeks due to fetal death in utero (fetus weight: 155gm) and diagnosed as APS. Notably, she had very high titers of all antiphospholipid antibodies. During her second pregnancy, she had been treated with low molecular weight heparin (enoxaparin 60mg bid) and aspirin at outpatient clinic. Despite this treatment, small for gestational age and placental dysfunction evidenced by the elevation of multiple serum makers (AFP: 2.93MoM, hCG: 5.44MoM, inhibin A: 6.75MoM) was suspected at 20 weeks, we decided to treat her with intravenous heparinization. At 24+0 weeks, she suffered sudden onset of epigastric pain. Her aspartate aminotransferase/alanine aminotransferase (AST/ALT) level was 106/199unit/L. At 25+2 weeks, severe acute epigastric pain which did not subside even by IV morphine developed again and AST/ALT elevated up to 530/879unit/L. Tachypnea and tachycardia occurred concurrently and pulmonary thromboembolism was suspected. Emergent cesarean section was performed and male weighted 530gm was delivered with an Apgar score 4 at 1minutes and 5 at 5minutes. At post-operative 3 days, liver and pulmonary thromboembolism CT scan proved hepatic infarction in most part of liver segment 2 and 5 and pulmonary microthrombosis. Eleven days after surgery, AST/ALT level completely normalized.
암환자용 통증관리 지침서 교육이 환자 및 가족의 암성 통증관리에 대한 지식과 태도에 미치는 효과
이지은,박명화 병원간호사회 2009 임상간호연구 Vol.15 No.1
Purpose: This study was conducted to identify the effects of provision of a cancer pain guideline and education for patients with cancer and their families on their knowledge and attitude toward cancer pain control. Method: A nonequivalent control group pre-post test design was used. The participants were selected according to a selection criteria from patients and their families on the medical ward at K university hospital in D city. Both the experimental group for patients with cancer and control group consisted of 16 patients and their families. Results: The first hypothesis, which assumed that there was a difference between the patients in the experimental group and the control group on knowledge (t=-20.006, p=.000) and attitude (t=-13.492, p=.000), was accepted. The second hypothesis, which assumed there was a difference between families in the experimental group and the control group on knowledge (t=-16.087, p=.000) and attitude (t=-10.262, p=.000), was supported. Conclusion: Education for cancer related pain control with a patient guideline had a positive effect on knowledge and attitude of patients with cancer patients and their families suggesting that there is a need to developed this type of guidelines.