복귀돌연변이시험을 이용한 이온화에너지 처리 우유 및 아이스크림의 유전독성학적 평가

유지숙, 한선경, 신명수, 구본철, 최지현, 이주운, 조철훈, 함준상, 이완규 충북대학교 동물의학연구소 2008 Journal of Biomedical and Translational Research Vol.9 No.1

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자동영상추적장치를 이용한 카드뮴 처리 Oryzias latipes의 행위독성연구

류지성,이철우,최필선,최성수,류홍일,이길철,정규혁,박광식 한국환경독성학회 1999 환경독성보건학회지 Vol.14 No.4

Changes in certain fish behaviors are known to be very sensitive indicators of sublethal exposure to environmental contaminants. Therefore, behavioral toxicity tests, if properly designed, can be very useful to assess the influence of hazardous chemicals on fish. However, quantitative analysis of xenobiotic -mediated changes in locomotor behavior in fishes are rare, due mainly to the methodological difficulties. In general, fish movement has been known to be hypertrophic or hypotrophic according to the chemicals. As a study of fish behavioral toxicities, we quatified the swimming movement of Orydas latipes using computer-automated video tracking system. Oryzias latipes was exposed to cadmium of 128 mg/L for 1 hour in a limited aquaria, then the total swimming distance, the average swimming velocity, the histogram of turning angles, and the turning frequency were analyzed. Fish treated with cadmium showed decreased swimming activities, decreased velocity, and decreased turning frequency, which means hypotrophic activity. From these results, the computer-automated video tracking system of this study seems to be a good tool for the evaluation of the potential ecotoxicological studies.

11β-수산화효소 결핍에 의한 선천성 부신증식증 1예

류옥현,류혜진,박수연,권순범,박상수,김희영,이계원,서지아,오정헌,김신곤,김난희,최경묵,백세현,최동섭 대한내분비학회 2004 Endocrinology and metabolism Vol.19 No.1

저자들은 국내에서 처음으로 음핵 비대와 지속적인 질출혈을 주소로 내원한 19세 여성에서 고혈압이 동반되지 않으면서 11 -수산화효소 결핍으로 인한 선천성부신증식증을 경험하였기에 문헌 고찰과 함께 이를 보고하는 바이다. Congenital adrenal hyperplasia refers to a group of autosomal recessive disorders that is defective in the synthesis of cortisol. The enzymes most often affected are 21-hydroxylase and 11 - hydroxylase. The low levels of cortisol stimulate the pituitary gland to release ACTH. Chronic elevation of the ACTH level causes bilateral adrenal hyperplasia and a secondary increase in androgen formation. We examined a 19 year-old woman presented with clitoral hypertrophy and vaginal spotting. The subjects basal level of serum cortisol was low, but the serum levels of ACTH, 17a-hydroxyprogesterone, deoxy-corticosterone were elevated. The urinary excretions of 17-ketosteroids and 17-hydroxycorticosteroids were also increased. The karyotyping study and transrectal ultrasonography showed normal findings. The patient underwent clitoris reduction surgery and received hydrocortisone. To the best of our knowledge, this is the first case of 11 -hydroxylase deficiency in Korea (J Kor Soc Endocrinol 19:58∼63, 2004).

투사형 전조등의 광학적 분석

성희진,홍사용,류지욱 公州大學校 基礎科學硏究所 1999 自然科學硏究 Vol.8 No.-

투사형 전도등의 특성을 조사하기 위해 광선 추적법으로 광학계를 분석하고 그 결과를 포물경 전도등과 비교하였다. 포물경 전도등의 경우 광학계가 단순한 장점이 있지만 광원의 일부분 만을 반사하며 실제 광원의 크기와 위치를 고려할 때 높은 수차가 불가피 했다. 투사형 전도등은 여러개의 광학부품 사용하는 복잡함과 전체적 길이가 길어지는 단점이 있지만 포물경 전도등 보다 40%이상의 빛을 더 활용하며 전체적인 수차도 상당히 줄일 수 있었다. 그러나 투사형 전도등 광학계의 성능은 비구면 렌즈의 형태에 매우 민감한 것으로 나타났다. To investigate characteristics of the projection type headlights for automobiles, we used ray tracing methods and compared the results with those from parabolic type headlights. The parabolic type headlights are simple but have two limits: first, they require large apertures. To reflect 50% of a source light, the aperture must be 4 times of focal length and to have more reflected light, apertures must grow geometrically. second, a parabolic mirror have large aberration when a source is away from a focus, since output of a headlight cannot be divergent, a source should locate far side from a mirror and moreover a light source has a finite size, large aberration is unavoidable. The projection type headlights have many optical components and longer depth compared with parabolic types, but their apertures can be made small. Advantage of using a ellipsoidal mirror is to reduce beam divergence by half and displace a focal position to another focal point, so that spherical aberration free and short focal length aspherical lens can be placed in proper position. In our study, we adopt a commercially available aspheric lens and the results were quite good compared with those from parabolic types but not optimal since output experienced total reflection at an aspheric lens. We found to improve performance of headlights, proper design of an aspheric lens was crucial.

Duty, Task, Step 분석울 통한 전기·컴퓨터 분야의 DACUM Chart 활용 방안

박성종,지명석,류지호 한국직업능력개발원 2003 직업능력개발연구 Vol.6 No.2

Recently the DACUM methodology is widely used in vocational education fields because Curricula in vocational education, especially in engineering technology education, do not adequately mirror the needs of the work fields. DACUM Chart which contains a graphic portrayal of the duties and tasks identified, plus the descriptive lists of general knowledge and skills, future trends and concerns, worker behaviors, tools, equipments, supplies and materials is also useful. Certainly the DACUM methodology is effective, quick and low cost, but do not reflect the educational situation of internal vocational education institute effectively. The purpose of this study is to modify DACUM Chart for various work based learning strategies aimed at providing hands-on experience for students and consequently apply to curricula development. We performed the duty, task and step analyses through the verifications by expert workers, technicians and engineers of the workplace on the electricity and computer fields. Through this study, the practical tasks which must be instructed on the vocational education institute are suggested and modules are developed through the step analyses. So, we can reflect both the educational situation of vocational education institute internally and workplace effectively. And also we can manage curricula emphasizing the smooth transition of students from school to work to accept the needs of strategies for work based learning.

범불안장애 혹은 공황장애 환자에서 Mindfulness에 기반한 인지치료의 장기치료 효과 : 1년 추적관찰

윤지원,이상혁,김용우,김묘정,육근영,류미,최태규,김근향 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.1

Objectives Mindfulness-base cognitive therapy (MBCT) has been used to treat patients with depression to prevent relapse. The purpose of this study was to examine the effectiveness of Mindfulness-Base Cognitive Therapy for patients who suffer with generalized anxiety disorder or panic disorder for 1 year. Methods 19 patients with generalized anxiety disorder or panic disorder were assigned to receive MBCT for a period of 8 weeks. The Hamiltion Anxiety Rating Scale (HAM-A), the Hamilton Depression Rating Scale (HAM-D), the Beck Anxiety Inventory (BAI) and the Beck Depression inventory (BDI) were used at 0 weeks, 8 weeks and 1 year to assess the results. Results MBCT demonstrated significantly decreases on all the anxiety scale scores (HAM-A, p=0.00 ; BAI, p=0.00) and depressive scale scores (HAM-D, p=0.99 ; BDI, p=0.00). The patients who received 8-week of MBCT showed a higher remission rate (15/19, 78%) during the 1-year follow-up period. Conclusion MBCT may be effective at relieving the anxiety and depressive symptoms of patients who suffer with generalzed anxiety disorder or panic disorder for 1 year. However, further well-designed controlled trials are needed to assess the value of MBCT.

비선형성을 가진 직류 전동기의 고장 검출 진단 : A Neural Network based Multiple Observer Scheme

이기상,류지수 단국대학교 1998 論文集 Vol.32 No.-

A Fault Detection and Isolation (FDI) Scheme for a class of nonlinear systems is proposed and applied to design fault detection system for a DC motor with nonlinear characteristics. The proposed FDI scheme consists of an observer bank, a simple residual generation algorithm, and an artificial neural network for fault isolation. Gain scheduled observers, each of which is able to cope with nonlinearities, are employed to generate residuals that will be further processed to detect and to isolate the faults. Observer gains are tuned by trained artificial neural networks so that observer poles are invariant over all operating points. Another well trained ANN is employed for fault isolation and/or diagnosis. The type of faults in the motor application is parametric one which is difficult to treat with conventional FDI schemes. Simulation results show the applicability of the FDI scheme to a class of nonlinear systems including DC motors.

고삼투압성 비케톤성 상태의 예후인자

안성훈,김양원,김미란,진헌철,안지영,이상래,류석용,김홍용,김성준,이병권,김경환 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2

Background: A hyperosmolar nonketotic state has been known to have a high mortality, and even now, despite this high mortality, only a few studies of this disease have been performed. We studied the prognostic factors for the hyperosmolar nonketotic state. Methods: We retrospectively studied the cases of 40 patients who were in a hypersomolar nonketotic state when admitted to Sanggye Paik Hospital during the 6-year Period from 1995 through 2000. We divided the hyperosmolar nonketotic patients into two groups, the complete recovery group and the incomplete recovery group, and compared the clinical features, the laboratory findings, and the precipitating factors between two groups. Results: 1) A total of 40 patients were studied: 24 in the complete recovery group and 16 patients in the incomplete recovery group. The mortality rate was 32.5%. 2) No significant statistical difference existed among the clinical features of the two groups, except for the sex(p<0.01). 3) Among the laboratory findings of both groups, analysis revealed that the effective osmolarity was significantly higher among those in the incomplete recovery group(p<0.01). Serum sodium concentration was also significantly higher among those in the incomplete recovery group(p<0.01). Serum creatinine was also significantly higher among those in the incomplete recovery group(p<0.05). Serum bicarbonate concentration, on the other hand, was significantly lower among those in that group(p<0.05).4) Infection was identified as the most common precipitating factor(62.5%). Among the precipitating factors of the two groups, there were significant statistical difference in pneumonia, UTI, and inappropriate glucose control. 5) A significant statistical difference existed among the initial level of consciousness of both groups(p<0.05). 6) The only significant independent factor responsible for prognosis of nonketotic hyperosmolar state patients was the sex. Conclusion: The sex was only significant independent prognostic factor of nonketotic hyperosmolar state patients.

돼지의 전염성 흉막 폐렴의 병리조직학적 관찰

문지영,손화영,류시윤,조성환 忠南大學校 獸醫科大學 動物醫科學硏究所 2005 動物醫科學硏究誌 Vol.13 No.-

6 pigs suddenly died of severe dyspnea at the piggery in Chungbuk and Daejeon, Korea. Authors diagnosed it as porcine pleuropneumonia resulting in A. pleuropneumoniae on the ground of pathological findings and bacteriological isolation. The clinical signs were high fever, depression, dyspnea, blood-tinged discharge through the mouth and nostrils, cough, sialism. In grossly, congestion and hemorrhage were showed in the acute pleuropneumonia in 4 pigs. In 2 pigs, the chronic pleuropnuemonia characterized by adhesion between visceral pleura and parietal pleura resulting in fibrous exudate was observed. The histopathologic changes were characterized by congestion, hemorrhage, neutrophil infiltration, edema, vascular thrombosis, macrophage activation, and fibrinous exudate in the acute pleuropneumonia. In the chronic stages of this disease, fibrous pleuritis, macrophage infiltration, lymphocyte infiltration, and marked fibrosis around areas of necrosis were observed. Also there were oat cells, the characters of porcine pleuropneumonia. Actinobacillus pleuropneumonia was isolated from pneumonic lesions and biochemical identification was carried out. A. pleuropneumoniae was particularly susceptible in vitro to Amoxicillin/clavulanic acid, Ampicillin, Ciprofloxacin. Norfloxacin, Gentamycin, Tiamulin, Cefazolin, Ceftiofur, and Colistin.

자발성 심막기종 1례

안지영,이상래,안성훈,류석용,김홍용 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Pneumopericardium, as a form of barotrauma, refers to the presence of air within the pericardial sac. The causes of pneumopericardium are various, Clinically, pneumopericardium is typically present with dyspnea and precordial chest pain. On physical examination, heart sounds are usually distant, and precordial tympany may be elicited. The diagnosis can be made by clinical and radiographic findings. Management of pneumopericardium depends on many factors, such as the age of the patient, the suspected causes, and the extent of clinically observed respiratory compromise. The case shown here, a patient who developed pneumopericardium, involved an associated underlying pulmonary parenchymal process as the cause of pneumopericardium.