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Molecular Cloning and Characterization of a Bile Salt Hydrolase from Lactobacillus acidophilus PF01
( Hae Keun Oh ),( Ji Yoon Lee ),( Soo Jin Lim ),( Min Jeong Kim ),( Geun Bae Kim ),( Jung Hoan Kim ),( Soon Kwang Hong ),( Dae Kyung Kang ) 한국미생물 · 생명공학회 2008 Journal of microbiology and biotechnology Vol.18 No.3
The Effects of rhBMP-2 Injection at Distraction Osteogenesis of Rats` Tibia
( Hae Ryong Song ),( Sung Eun Kim ),( Hyo Geun Kim ),( Young Pil Yun ),( Ji Hoon Bae ),( Hak Jun Kim ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.2
Distraction osteogenesis is the popular method of bone-lengthening procedure. Delayed consolidation of bone after distraction osteogenesis makes complications related to external fixator and refractures after removal of external frame. We hypothesized that only rhBMP-2(recombinant human bone morphogenetic protein-2) could accelerate the long bone healing. 18 Sprague-Dawley rats were divided into two groups after 5 mm lengthening by distraction osteogenesis. The control group was none-injected group and the experimental group was injected 0.5 cc of 0.05 mg/ml rhBMP-2. We evaluated the 6 samples respectively at different time point (2, 4, 8 weeks) using simple radiographs, micro-CT and histological stains. According to the simple radiographs, bone consolidation of percentage pixel count was higher in the experimental group at 2, 4, 8 week, and statistically significant higher than the control group at 8 weeks (p < 0.05). Percentage bone Volume, trabecular thickness in the experimental group was higher than the control group by evaluation with micro-CT. According to the histological examinations, neovascularization and new stromal cells were observed in the control group at 2 week- speciemen but intramembranous ossification was seen at 2 week- specimens in the experimental group. Intramembranous and enchondral ossification was seen in the experimental group but not seen in the control group at the 4 week-specimens. Trabeculae thickness in the experimental group was thicker than the control group at 8-week specimens. Only local injection of rhBMP- 2 at the distraction site could accelerate the bone healing during distraction osteogenesis.
Aromatic Hybrid Foldamer with a Hydrophilic Helical Cavity Capable of Encapsulating Glucose
Hwang, Ji Young,Jeon, Hae-Geun,Choi, Ye Rin,Kim, Junyoung,Kang, Philjae,Lee, Seungwon,Jeong, Kyu-Sung THE AMERICAN CHEMICAL SOCIETY 2017 ORGANIC LETTERS Vol.19 No.20
<P>An indolocarbazole–naphthyridine hybrid oligomer capable of adopting a stable helical conformation was prepared, and its folding properties were thoroughly studied in the solid state and in solution. As a result of folding, a hydrophilic cavity was generated inside the helix wherein monosaccharides were able to be encapsulated in the order of glucose (9.6 × 10<SUP>4</SUP> M<SUP>–1</SUP>) > galactose (1.0 × 10<SUP>4</SUP> M<SUP>–1</SUP>) ≫ mannose (∼0) in 10% (v/v) DMSO/CH<SUB>2</SUB>Cl<SUB>2</SUB>.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2017/orlef7.2017.19.issue-20/acs.orglett.7b02768/production/images/medium/ol-2017-02768x_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol7b02768'>ACS Electronic Supporting Info</A></P>
Choi, Hae Yoon,Park, Ji Woo,Lee, Namseok,Hwang, Soon Young,Cho, Geum Ju,Hong, Ho Cheol,Yoo, Hye Jin,Hwang, Taek Geun,Kim, Seon Mi,Baik, Sei Hyun,Park, Kyong Soo,Youn, Byung-Soo,Choi, Kyung Mook American Diabetes Association 2013 Diabetes care Vol.36 No.10
<P><B>OBJECTIVE</B></P><P>To examine the effect of a combined exercise program on C1q/tumor necrosis factor-related protein (CTRP) 3 and CTRP-5 levels and novel adiponectin paralogs suggested to be links between metabolism and inflammation and to evaluate sex differences and association with cardiometabolic risk factors in humans with use of a newly developed ELISA.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>This cross-sectional study explored the implications of CTRP-3 and CTRP-5 on cardiometabolic parameters in 453 nondiabetic Korean adults. In addition, we evaluated the impact of a 3-month combined exercise program on CTRP-3 and CTRP-5 levels in 76 obese women. The exercise program consisted of 45 min of aerobic exercise at an intensity of 60–75% of the age-predicted maximum heart rate (300 kcal/session) and 20 min of resistance training (100 kcal/session) five times per week.</P><P><B>RESULTS</B></P><P>Both CTRP-3 and CTRP-5 concentrations were significantly higher in women (<I>P</I> < 0.001) than in men (<I>P</I> = 0.030). In a multiple stepwise regression analysis, CTRP-3 levels were independently associated with age, sex, and triglyceride, LDL cholesterol, adiponectin, and retinol-binding protein 4 (RBP4) levels (<I>R</I><SUP>2</SUP> = 0.182). After 3 months of a combined exercise program, cardiometabolic risk factors, including components of metabolic syndrome, insulin resistance, and RBP4 levels, decreased significantly. In particular, CTRP-3 levels decreased significantly (median [interquartile range] 444.3 [373.8–535.0] to 374.4 [297.2–435.9], <I>P</I> < 0.001), whereas CTRP-5 levels were slightly increased (34.1 [28.6–44.3] to 38.4 [29.8–55.1], <I>P</I> = 0.048).</P><P><B>CONCLUSIONS</B></P><P>A 3-month combined exercise program significantly decreased CTRP-3 levels and modestly increased CTRP-5 levels in obese Korean women.</P>
Helical Aromatic Foldamers Functioning as a Fluorescence Turn-on Probe for Anions
Jeon, Hae-Geun,Jang, Han Bit,Kang, Philjae,Choi, Ye Rin,Kim, Junyoung,Lee, Ji Hyun,Choi, Moon-Gun,Jeong, Kyu-Sung American Chemical Society 2016 ORGANIC LETTERS Vol.18 No.17
<P>Indolocarbazole-pyridine hybrid foldamers are strongly fluorescent in an extended random conformation, but the fluorescence is completely quenched upon folding to a helical conformation due to the compact stacking between aryl planes in the backbone. Anion binding disturbs the helical conformation, thus regenerating the fluorescence of the foldamers. This unique property has been utilized to develop a fluorescence turn-on probe for anions such as sulfate and fluoride.</P>
Jae Geun Lee,Seon Young Bak,Ji Hae Nahm,Sang Woo Lee,Seon Ok Min,Kyung Sik Kim 한국간담췌외과학회 2015 한국간담췌외과학회지 Vol.19 No.2
Backgrounds/Aims: Stem cell therapies for liver disease are being studied by many researchers worldwide, but scientific evidence to demonstrate the endocrinologic effects of implanted cells is insufficient, and it is unknown whether implanted cells can function as liver cells. Achieving angiogenesis, arguably the most important characteristic of the liver, is known to be quite difficult, and no practical attempts have been made to achieve this outcome. We carried out this study to observe the possibility of angiogenesis of implanted bio-artificial liver using scaffolds. Methods: This study used adipose tissue-derived stem cells that were collected from adult patients with liver diseases with conditions similar to the liver parenchyma. Specifically, microfilaments were used to create an artificial membrane and maintain the structure of an artificial organ. After scratching the stomach surface of severe combined immunocompromised (SCID) mice (n=4), artificial scaffolds with adipose tissue-derived stem cells and type I collagen were implanted. Expression levels of angiogenesis markers including vascular endothelial growth factor (VEGF), CD34, and CD105 were immunohistochemically assessed after 30 days. Results: Grossly, the artificial scaffolds showed adhesion to the stomach and surrounding organs; however, there was no evidence of angiogenesis within the scaffolds; and VEGF, CD34, and CD105 expressions were not detected after 30 days. Conclusions: Although implantation of cells into artificial scaffolds did not facilitate angiogenesis, the artificial scaffolds made with type I collagen helped maintain implanted cells, and surrounding tissue reactions were rare. Our findings indicate that type I collagen artificial scaffolds can be considered as a possible implantable biomaterial.
비장절제 환자에서 전격자색반이 동반된 폐렴사슬알균 패혈증 1예
유지연 ( Ji Youn Yoo ),송혜근 ( Hae Geun Song ),이정화 ( Jung Hwa Lee ),김기성 ( Ki Seong Kim ),이승순 ( Seung Soon Lee ),김효정 ( Hyo Jung Kim ),정두련 ( Doo Ryeon Chung ) 대한내과학회 2006 대한내과학회지 Vol.70 No.6
The most serious problem after splenectomy is the increased risk of life-threatening infections caused by encapsulated bacteria such as Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis. Purpura fulminans, which is commonly associated with meningococcal sepsis, is characterized by disseminated intravascular coagulation and rapidly progressive purpuric skin lesions. Purpura fulminans can also develop in invasive pneumococcal infection especially after splenectomy, however, there has been no report in Korea. We report a case of overwhelming pneumococcal sepsis manifested as purpura fulminans in a splenectomized patient.(Korean J Med 70:725-728, 2006)