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Seo, S H,Kim, K S,Park, S H,Suh, Y S,Kim, S J,Jeun, S-S,Sung, Y C Nature Publishing Group 2011 Gene Therapy Vol.18 No.5
<P>Owing to its tumor tropism and prolonged transgene expression, mesenchymal stem cell (MSC) has been considered as an ideal delivery vehicle for cancer gene therapies or therapeutic vaccines. In this study, we demonstrated that intratumoral (i.t.) injection of MSCs expressing modified interleukin-12 (MSCs/IL-12M) exhibited stronger tumor-specific T-cell responses and antitumor effects as well as more sustained expressions of IL-12 and interferon (IFN)-γ in both sera and tumor sites than did IL-12M-expressing adenovirus (rAd/IL-12M) in mice bearing both solid and metastatic tumors. Subcutaneous (s.c.) injection of MSCs/IL-12M at contralateral site of tumor exhibited similar levels of serum IL-12 and IFN-γ as i.t. injection, but much weaker antitumor effects in both B16F10 melanoma and TC-1 cervical cancer models than i.t. injection. Although intravenous (i.v.) injection elicited earlier peak serum levels of cytokines, it induced weaker tumor-specific T-cell responses and antitumor effects than i.t. injection, indicating that serum cytokine levels are not surrogate indicators of antitumor effects. Taken together, these results indicated that MSC is more efficient than adenovirus as a cytokine gene delivery vehicle and that i.t. injection of MSCs/IL-12M is the best approach to induce strong tumor-specific T-cell responses that correlate with anti-metastatic effects as well as inhibition of solid tumor growth, although MSCs themselves have an ability to migrate into the tumor site. In addition, MSCs/IL-12M embedded in Matrigel (MSCs/IL-12M/Matrigel) exhibited significant antitumor effects even in immunodeficient mice such as SCID and BNX mice lacking T, B and natural killer (NK) cells, but not in IFN-γ knockout mice. Our findings provide an optimal approach for designing an efficient clinical protocol of MSC-based cytokine gene therapy to induce strong tumor-specific T-cell responses and therapeutic anticancer efficacy.</P>
스퍼터링한 반금속 Bi 박막의 미세조직과 자기저항특성에 미치는 후열처리의 영향
전민홍,장준연,한석희,한준현,이우영 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.7
We explore the possibility of sputtered Bi thin film applicable for the spin device by investigating the change in microstructure and magneto-resistance (MR) of post-annealed Bi film. Randomly oriented fine grains of which size was measured to about 100 nm (nano meter) were found in as-sputtered Bi. Careful annealing done at only 1.4℃ below the melting temperature of Bi results in not only grain growth up to 1.2 pm but also textured grains well aligned to [003] preferred orientation of Bi. The MR for as-sputtered Bi film was hardly observed regardless of measuring temperature, whereas those of annealed were found to reach 30,000% at 4 K and 600% at 300 K respectively. The drastic change in MR after annealing is largely attributed to the significant grain growth decreasing grain boundary scattering as well as to the trigonal-axis oriented microstructures diminishing anisotropy scattering of moving electron. Our results demonstrate sputtered Bi thin film can be usable for spintronic devices by employing a suitable post annealing treatment. (Received March 29, 2004)
Park, S-H,Doh, J,Park, S I,Lim, J Y,Kim, S M,Youn, J-I,Jin, H-T,Seo, S-H,Song, M-Y,Sung, S Y,Kim, M,Hwang, S J,Choi, J-M,Lee, S-K,Lee, H Y,Lim, C L,Chung, Y J,Yang, D,Kim, H-N,Lee, Z H,Choi, K Y,Jeun, Macmillan Publishers Limited 2010 Gene Therapy Vol.17 No.8
Cell-permeable peptides (CPPs) promote the transduction of nonpermissive cells by recombinant adenovirus (rAd) to improve the therapeutic efficacy of rAd. In this study, branched oligomerization of CPPs significantly enhanced the transduction of human mesenchymal stem cells (MSCs) by rAd in a CPP type-independent manner. In particular, tetrameric CPPs increased transduction efficiency at 3000–5000-fold lower concentrations than did monomeric CPPs. Although branched oligomerization of CPPs also increases cytotoxicity, optimal concentrations of tetrameric CPPs required for maximum transduction are at least 300–1000-fold lower than those causing 50% cytotoxicity. Furthermore, although only ∼60% of MSCs were maximally transduced at 500 μM of monomeric CPPs, >95% of MSCs were transduced with 0.1 μM of tetrameric CPPs. Tetrameric CPPs also significantly increased the formation and net surface charge of CPP/rAd complexes, as well as the binding of rAd to cell membranes at a greater degree than did monomeric CPPs, followed by rapid internalization into MSCs. In a critical-size calvarial defect model, the inclusion of tetrameric CPPs in ex vivo transduction of rAd expressing bone morphogenetic protein 2 into MSCs promoted highly mineralized bone formation. In addition, MSCs that were transduced with rAd expressing brain-derived neurotrophic factor in the presence of tetrameric CPPs improved functional recovery in a spinal cord injury model. These results demonstrated the potential for tetrameric CPPs to provide an innovative tool for MSC-based gene therapy and for in vitro gene delivery to MSCs.
Kim, J.H.,Jeun, E.J.,Hong, C.P.,Kim, S.H.,Jang, M.S.,Lee, E.J.,Moon, S.J.,Yun, C.H.,Im, S.H.,Jeong, S.G.,Park, B.Y.,Kim, K.T.,Seoh, J.Y.,Kim, Y.K.,Oh, S.J.,Ham, J.S.,Yang, B.G.,Jang, M.H. Mosby 2016 The journal of allergy and clinical immunology Vol.137 No.2
<P>Background: The incidence of food allergies has increased dramatically during the last decade. Recently, probiotics have been studied for the prevention and treatment of allergic disease. Objective: We examined whether Bifidobacterium longum KACC 91563 and Enterococcus faecalis KACC 91532 have the capacity to suppress food allergies. Methods: B longum KACC 91563 and E faecalis KACC 91532 were administered to BALB/c wild-type mice, in which food allergy was induced by using ovalbumin and alum. Food allergy symptoms and various immune responses were assessed. Results: B longum KACC 91563, but not E faecalis KACC 91532, alleviated food allergy symptoms. Extracellular vesicles of B longum KACC 91563 bound specifically tomast cells and induced apoptosis without affecting T-cell immune responses. Furthermore, injection of family 5 extracellular solute-binding protein, a main component of extracellular vesicles, into micemarkedly reduced the occurrence of diarrhea in a mouse food allergy model. Conclusion: B longum KACC 91563 induces apoptosis of mast cells specifically and alleviates food allergy symptoms. Accordingly, B longum KACC 91563 and family 5 extracellular solute-binding protein exhibit potential as therapeutic approaches for food allergies.</P>
Jeun, J.H.,Kim, D.H.,Hong, S.H. North-Holland 2013 Materials letters Vol.105 No.-
SnO<SUB>2</SUB>/CuO nano-hybrid foam sensors were fabricated through thermal oxidation of Sn-Cu foam synthesized by electrochemical deposition, and their gas sensing properties were investigated. The macro-porous Sn-Cu foam was formed during electrodeposition, and its pore wall was composed of self-supported nano-sized dendrites. The annealing at 700<SUP>o</SUP>C converted the Sn-Cu foam into the SnO<SUB>2</SUB>/CuO nano-hybrid foam with preserving the structural integrity and pore structure. The SnO<SUB>2</SUB>/CuO nano-hybrid foam sensor responded to the reducing gases such as H<SUB>2</SUB>, CO, NH<SUB>3</SUB>, NO<SUB>x</SUB>, CH<SUB>5</SUB>OH, and H<SUB>2</SUB>S, but the foam sensor exhibited two orders of magnitude higher gas response toward H<SUB>2</SUB>S. The enhanced sensitivity and selectivity toward H<SUB>2</SUB>S gas can be attributed to the formation of resistive p-CuO/n-SnO<SUB>2</SUB> junction in nano-scale.
Jeun, J.H.,Kim, W.S.,Hong, S.H. North-Holland 2013 Materials letters Vol.112 No.-
Network structured Sn-C composites were fabricated by combining electrochemical deposition and electrophoretic deposition (EPD). The porous dendritic Sn foams were prepared by electrodeposition on copper foil, and carbon nanoparticles were deposited on the Sn foams by EPD. The carbon content of composites was controlled by changing the EPD time and the concentration of sulfuric acid in electrolyte, and it increased up to ~35wt%. The combined electrochemical techniques are expected to be applicable to various porous metal foams and carbon nanomaterials to improve the functionality in a wide range of applications.
Enhanced solvent resistance of acrylonitrile-butadiene rubber by electron beam irradiation
Jung, S.T.,Kim, D.Y.,Kim, H.B.,Jeun, J.P.,Oh, S.H.,Lee, B.J.,Kang, P.H. Korean Society of Industrial and Engineering Chemi 2013 Journal of industrial and engineering chemistry Vol.19 No.2
In this study, we investigated the effect of electron beam irradiation on NBR (acrylonitrile-butadiene rubber) with TMPTMA (trimethylolpropane trimethacrylate), focusing on the polar and non-polar solvent resistance at different electron beam radiation doses. The electron beam irradiation on NBR containing TMPTMA sheets was performed over a range of absorbed doses from 20 to 200kGy to make three-dimensional network structures. The solvent resistance was characterized according to ASTM D 471 in benzene and THF solvent. The solvent resistance of NBR was enhanced by the addition of TMPTMA in a dose-dependent manner. In addition, the volume change of immersed NBR in THF solvent was slightly lower than in benzene solvent.
Bae, S.,Jeoung, J.W.,Jeun, M.,Jang, J.t.,Park, J.H.,Kim, Y.J.,Lee, K.,Kim, M.,Lee, J.,Hwang, H.M.,Paek, S.H.,Park, K.H. IPC Science and Technology Press 2016 Biomaterials Vol.101 No.-
<P>Magnetically softened iron oxide (MSIO) nanofluid, PEGylated (Mn0.5Zn0.5)Fe2O4, was successfully developed for local induction of heat shock proteins (HSPs) 72 in retinal ganglion cells (RGCs) for ocular neuroprotection. The MSIO nanofluid showed significantly enhanced alternating current (AC) magnetic heat induction characteristics including exceptionally high SLP (Specific Loss Power, > 2000 W/g). This phenomenon was resulted from the dramatically improved AC magnetic softness of MSIO caused by the magnetically tailored Mn2+ and Zn2+ distributions in Fe3O4. In addition, the MSIO nanofluid with ultra thin surface coating layer thickness and high monodispersity allowed for a higher cellular uptake up to a 52.5% with RGCs and enhancing 'relaxation power' for higher AC heating capability. The RGCs cultured with MSIO nanofluid successfully induced HSPs 72 by magnetic nanofluid hyperthermia (MNFH). Moreover, it was interestingly observed that systematic control of 'AC magnetically-induced heating up rate' reaching to a constant heating temperature of HSPs 72 induction allowed to achieve maximized induction efficiency at the slowest AC heating up rate during MNFH. In addition to in-vitro experimental verification, the studies of MSIO infusion behavior using animal models and a newly designed magnetic coil system demonstrated that the MSIO has promising biotechnical feasibility for thermally-induced HSPs agents in future glaucoma clinics. Published by Elsevier Ltd.</P>