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A new method and device of aligning patient setup lasers in radiation therapy
Hwang, Ui‐,Jung,Jo, Kwanghyun,Lim, Young Kyung,Kwak, Jung Won,Choi, Sang Hyoun,Jeong, Chiyoung,Kim, Mi Young,Jeong, Jong Hwi,Shin, Dongho,Lee, Se Byeong,Park, Jeong‐,Hoon,Park, Sung Yong,K unknown 2016 Journal of applied clinical medical physics Vol.17 No.1
<P>The aim of this study is to develop a new method to align the patient setup lasers in a radiation therapy treatment room and examine its validity and efficiency. The new laser alignment method is realized by a device composed of both a metallic base plate and a few acrylic transparent plates. Except one, every plate has either a crosshair line (CHL) or a single vertical line that is used for alignment. Two holders for radiochromic film insertion are prepared in the device to find a radiation isocenter. The right laser positions can be found optically by matching the shadows of all the CHLs in the gantry head and the device. The reproducibility, accuracy, and efficiency of laser alignment and the dependency on the position error of the light source were evaluated by comparing the means and the standard deviations of the measured laser positions. After the optical alignment of the lasers, the radiation isocenter was found by the gantry and collimator star shots, and then the lasers were translated parallel to the isocenter. In the laser position reproducibility test, the mean and standard deviation on the wall of treatment room were 32.3±0.93 mm for the new method whereas they were 33.4±1.49 mm for the conventional method. The mean alignment accuracy was 1.4 mm for the new method, and 2.1 mm for the conventional method on the walls. In the test of the dependency on the light source position error, the mean laser position was shifted just by a similar amount of the shift of the light source in the new method, but it was greatly magnified in the conventional method. In this study, a new laser alignment method was devised and evaluated successfully. The new method provided more accurate, more reproducible, and faster alignment of the lasers than the conventional method.</P><P>PACS numbers: 87.56.Fc, 87.53.Bn, 87.53.Kn, 87.53.Ly, 87.55.Gh</P>
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Jeong, Eun Sun,Park, Chiyoung,Kim, Kyoung Taek The Royal Society of Chemistry 2015 Polymer chemistry Vol.6 No.22
<▼1><P>A new class of doubly-responsive block copolymers could be utilized as new delivery vehicles for cargo molecules such as insulin.</P></▼1><▼2><P>Organoboronic acid-containing polymers and block copolymers have recently attracted attention because of their ability to recognize important natural diol compounds such as saccharides and nucleotides under physiologically relevant conditions at neutral pH. In particular, polymers and block copolymers that are responsive toward multiple stimuli can be utilized to create smart delivery vehicles for use in applications in a complex environment. Here we report the monosaccharide-responsive polymers and block copolymers comprising styreneboroxole and oligo(ethylene glycol)-functionalized styrenes (OEG-STs) as repeating units. We have shown that homopolymers and copolymers of OEG-STs are thermally responsive by demonstrating that they possess the characteristic of tunable lower critical solution temperature (LCST) in water. When copolymerized with OEG-STs, styreneboroxole units function as a switch to change the solubility of the resulting polymers in aqueous solution by recognizing monosaccharides <I>via</I> the formation of boronate ester. By introducing the minimum number of monosaccharide-responsive styreneboroxole units onto the thermally responsive OEG-ST backbone, we demonstrated the monosaccharide-responsive behavior of the resulting copolymers and their amphiphilic block copolymers in aqueous solution at physiologically relevant pH and temperature. A strategy based on doubly responsive block copolymers reported here could be utilized as new delivery vehicles for cargo molecules such as insulin, due to their ability to function in an <I>in vivo</I> environment.</P></▼2>
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차지영(Cha, Chiyoung),이경은(Lee, Kyoung-Eun),권유림(Kweon, Yoorim),정향진(Jeong, Hyang Jin) 질적연구학회 2016 질적연구 Vol.17 No.1
Purpose: The purpose of this ethnographic study was to explore the experience of Setumin college students’ adaptation to the nursing education in South Korea from their perspectives. Methods: This study used focused ethnography as its guiding methodology. Individual interviews with six Setumin nursing students were conducted using semi-structured interview questions developed from literature review and a pilot interview. Leininger and McFarland’s four phases of ethnographic analysis method was used to analyze the interview data. Results: Six main themes emerged as meaningful aspects from the Setumin nursing students’ educational adaptation experience. Those were meaning of being a nurse, never be an easy one, feeling less of myself, difficulty in relationships with colleagues and faculty members, trying to be strong despite of all difficulties, and moving one step forward to achieve my dream. Conclusion: This study is the first study that explore Setumin nursing students’ meaningful aspects of adaptation to unique academic culture in nursing education from their own perspectives. Despite the multiple challenges of different socio-cultural backgrounds and learning barriers, Setumin nursing students in this study desired to be successful and were willing to try hard to make their dreams come true, by pursuing their nursing career in South Korea. Several recommendations for further research and academic strategies that could facilitate Setumin nursing students’ adaptation and learning outcomes were suggested.
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Kim, Min-Jung,Koo, Jeong-Eun,Han, Gi-Yeon,Kim, Buyun,Lee, Yoo-Sun,Ahn, Chiyoung,Kim, Chan-Wha The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.3
<P>Cancer stem cells (CSCs) have tumor initiation, self-renewal, metastasis and chemo-resistance properties in various tumors including colorectal cancer. Targeting of CSCs may be essential to prevent relapse of tumors after chemotherapy. Phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) signals are central regulators of cell growth, proliferation, differentiation, and apoptosis. These pathways are related to colorectal tumorigenesis. This study focused on PI3K and mTOR pathways by inhibition which initiate differentiation of SW620 derived CSCs and investigated its effect on tumor progression. By using rapamycin, LY294002, and NVP-BEZ235, respectively, PI3K and mTOR signals were blocked independently or dually in colorectal CSCs. Colorectal CSCs gained their differentiation property and lost their stemness properties most significantly in dual-blocked CSCs. After treated with anti-cancer drug (paclitaxel) on the differentiated CSCs cell viability, self-renewal ability and differentiation status were analyzed. As a result dual-blocking group has most enhanced sensitivity for anti-cancer drug. Xenograft tumorigenesis assay by using immunodeficiency mice also shows that dual-inhibited group more effectively increased drug sensitivity and suppressed tumor growth compared to single-inhibited groups. Therefore it could have potent anti-cancer effects that dual-blocking of PI3K and mTOR induces differentiation and improves chemotherapeutic effects on SW620 human colorectal CSCs.</P>
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Sa, Young Jin,Park, Chiyoung,Jeong, Hu Young,Park, Seok‐,Hee,Lee, Zonghoon,Kim, Kyoung Taek,Park, Gu‐,Gon,Joo, Sang Hoon WILEY‐VCH Verlag 2014 Angewandte Chemie Vol.126 No.16
<P><B>Abstract</B></P><P>A facile, scalable route to new nanocomposites that are based on carbon nanotubes/heteroatom‐doped carbon (CNT/HDC) core–sheath nanostructures is reported. These nanostructures were prepared by the adsorption of heteroatom‐containing ionic liquids on the walls of CNTs, followed by carbonization. The design of the CNT/HDC composite allows for combining the electrical conductivity of the CNTs with the catalytic activity of the heteroatom‐containing HDC sheath layers. The CNT/HDC nanostructures are highly active electrocatalysts for the oxygen reduction reaction and displayed one of the best performances among heteroatom‐doped nanocarbon catalysts in terms of half‐wave potential and kinetic current density. The four‐electron selectivity and the exchange current density of the CNT/HDC nanostructures are comparable with those of a Pt/C catalyst, and the CNT/HDC composites were superior to Pt/C in terms of long‐term durability and poison tolerance. Furthermore, an alkaline fuel cell that employs a CNT/HDC nanostructure as the cathode catalyst shows very high current and power densities, which sheds light on the practical applicability of these new nanocomposites.</P>
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Kim, Hojin,Kwak, Jungwon,Jeong, Chiyoung,Cho, Byungchul Korean Society of Medical Physics 2017 의학물리 Vol.28 No.3
Eclipse Scripting Application Programming Interface (ESAPI) was devised to enhance the efficiency in such treatment related workflows as contouring, treatment planning, plan quality measure, and data-mining by communicating with the treatment planning system (TPS). It is provided in the form of C# programming based toolbox, which could be modified to fit into the clinical applications. The Scripting program, however, does not offer all potential functionalities that the users intend to develop. The shortcomings can be overcome by combining the Scripting programming with user-executable program on Windows or Linux. The executed program has greater freedom in implementation, which could strengthen the ability and availability of the Scripting on the clinical applications. This work shows the use of the Scripting programming throughout the simple modification of the given toolbox. Besides, it presents the implementation of combining both Scripting and user-executed programming based on MATLAB, applied to automated dynamic MLC wedge and FIF treatment planning procedure for promoting the planning efficiency.
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박중선(Joongsun Park),정성우(SungWoo Jeong),이치영(ChiYoung Lee),이남용(NamYong Lee) 한국정보과학회 2005 한국정보과학회 학술발표논문집 Vol.32 No.2
소프트웨어의 품질인증을 위해서는 소프트웨어의 특성에 맞는 평가 항목 및 평가 기준이 적절히 마련되어 있어야 하며, 이를 위해서는 해당 소프트웨어의 적합한 품질특성을 정의하고 검증된 척도를 사용하여야 한다. 따라서 본 연구에서는 스토리지 관리 소프트웨어의 일반적인 품질특성을 분석하고 국제표준인 ISO/IEC 9126을 바탕으로 한 품질평가 항목을 제시한다.
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Park Min-Jae,Lee Gyemin,Kwak Jungwon,Jeong Chiyoung,Goh YoungMoon,Kim Sung-woo,Cho Byungchul,Song Si Yeol,Kim Jong Hoon,Jung Jinhong,Shin Young Seob,Oh Jungsu 한국물리학회 2024 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.84 No.9
To enhance effi ciency and minimize errors, we automated the quality assurance (QA) process in radiation oncology, specifi - cally laser localization. Additionally, we explored the use of a convolutional neural network (CNN) to enhance the detection of small cube-ball phantoms in noisy images. Laser localizations were measured manually on the acquired images. To automate the QA workfl ow, we developed a Linux server equipped with database and web servers. Digital Imaging and Communications in Medicine (DICOM) fi les were retrieved 40 times for 10 linear accelerators (LINACs). The center of the cube-ball phantoms was estimated through Gaussian fi tting. We applied CNN using 6,968 stored results to improve the estimation performance in noisy megavoltage (MV) images. Subsequently, both analysis time and accuracy were compared. Our hospital has been employing the automated QA system since 2018, notably reducing the time for laser localization from 30 min to just 1 min. The average and standard deviation (SD) of inter-observer variability in the X- and Y-axes were 0.06 ± 0.01 mm and 0.05 ± 0.01 mm, respectively. Absolute diff erences between manual assessment and Gaussian fi tting presented average and SD values of 0.40 ± 0.51 mm and 0.23 ± 0.24 mm, respectively. In contrast, absolute diff erences between manual assessment and CNN presented average and SD values of 0.12 ± 0.10 mm and 0.11 ± 0.09 mm, respectively. Overall, the automated QA system signifi cantly hastened procedures in our large hospital and improved the estimation of the cube-ball phantom’s position in noisy images through deep learning.
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