http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lee, Jennifer,Lee, Seon-Young,Lee, Jaeseon,Lee, Juhyun,Baek, Seungye,Lee, Dong-Gun,Kim, Eun-Kyung,Lee, Sung Hak,Cho, Mi-La,Kwok, Seung-Ki,Ju, Ji Hyeon,Park, Sung-Hwan Oxford University Press 2016 Rheumatology Vol.55 No.1
<P>Objective. Triggering receptor expressed on myeloid cells 1 (TREM-1), which amplifies the inflammation elicited by the Toll-like receptor pathway, was originally implicated in sepsis and bacterial infection. However, it has been suggested that TREM-1 may also play an important role in non-infectious inflammation. The present study was conducted to investigate whether TREM-1 is involved in human acute gouty inflammation. Methods. A total of 37 gout patients were recruited between March 2011 and January 2014 from Seoul St Mary's Hospital. The expression of TREM-1 on mononuclear cells was assessed using FACS analysis, immunostaining and real-time RT-PCR. To block the TREM-1 signal, soluble TREM-1 (sTREM-1) or the synthetic blocking peptide LP17 was used. The concentration of sTREM-1 was assessed by ELISA. Results. FACS analysis and real-time RT-PCR demonstrated that TREM-1 expression was higher in the SF mononuclear cells of acute gouty arthritis patients than in peripheral blood mononuclear cells (PBMCs). Immunohistochemical staining of tophi tissues revealed TREM-1 expression, with confocal microscopy demonstrating TREM-1 expression on tophi tissue macrophages. We also demonstrated that MSU treatment induced TREM-1 expression on the PBMCs of acute gout patients in vitro. Although blockade of TREM-1 did not directly suppress MSU-induced IL-1 beta production of PBMCs in vitro, the concentration of soluble TREM-1 was higher in the SF of gout vs OA patients and was positively correlated with serum CRP. Conclusion. TREM-1 is induced by MSU and is associated with the inflammation of human acute gouty arthritis.</P>
Korean guidelines for the management of gout
( Jennifer Jooha Lee ),( Ji Soo Lee ),( Min Kyung Chung ),( Joong Kyong Ahn ),( Hyo-jin Choi ),( Seung-jae Hong ),( Chong-hyeon Yoon ),( Su-hyun Kim ),( Kyung-hwan Jeong ),( Jong-woo Kim ),( Bo-yeon K 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.5
Gout is the most common form of arthritis, with the prevalence increasing worldwide. The present treatment guidelines provide recommendations for the appropriate treatment of acute gout, management during the inter-critical period, and prevention of chronic complications. The guidelines were developed based on evidence-based medicine and draft recommendations finalized after expert consensus. These guidelines are designed to provide clinicians with clinical evidence to enable efficient treatment of gout.
Jennifer Sang-jee Lee,Se-Jeong Kim,최지숙,Min Rye Eom,Heungsoo Shin,Seong Keun Kwon 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.91 No.-
The goal of this study was to investigate the effect of transplantation of an adipose-derived stem cell(ASC) spheroid sheet on the regeneration of ulcerated oral mucosa. The ASC spheroid sheet wasconstructed by seeding three-dimensional (3D) spheroidal ASCs on a temperature-responsive hydrogel,where cell adhesion and spreading were improved by incorporatingfibronectin. The 3D culture of ASCsenhanced their inherent paracrine properties for up to 1 week after transferring to two-dimensional (2D)culture conditions. Expansion of the hydrogel through temperature change promoted effective deliveryof ASCs to the site of injury, and viability was maintained after transferring ASCs to the target substrate. Treatment with the ASC spheroid sheet accelerated wound closure and regeneration of the stratifiedmulti-layered epithelium. The regenerated epithelium not only had structural integrity, but alsodisplayed phenotypic polarization across the mucosa; basal epithelial cells expressed cytokeratin 5,whereas cytokeratin 13-positive cells were located in the supra-basal layers. In addition, by day 7 aftertreatment, the mucosa that received the ASC spheroid sheet had significantly decreased inflammation,similar to that of the normal mucosa. These results demonstrate that the ASC spheroid sheet is aneffective treatment for ulcers in the oral cavity.
Lee, Chun Geun,Hartl, Dominik,Lee, Gap Ryol,Koller, Barbara,Matsuura, Hiroshi,Da Silva, Carla A.,Sohn, Myung Hyun,Cohn, Lauren,Homer, Robert J.,Kozhich, Alexander A.,Humbles, Alison,Kearley, Jennifer The Rockefeller University Press 2009 The Journal of experimental medicine Vol.206 No.5
<P>Mouse breast regression protein 39 (BRP-39; Chi3l1) and its human homologue YKL-40 are chitinase-like proteins that lack chitinase activity. Although YKL-40 is expressed in exaggerated quantities and correlates with disease activity in asthma and many other disorders, the biological properties of BRP-39/YKL-40 have only been rudimentarily defined. We describe the generation and characterization of BRP-39<SUP>−/−</SUP> mice, YKL-40 transgenic mice, and mice that lack BRP-39 and produce YKL-40 only in their pulmonary epithelium. Studies of these mice demonstrated that BRP-39<SUP>−/−</SUP> animals have markedly diminished antigen-induced Th2 responses and that epithelial YKL-40 rescues the Th2 responses in these animals. The ability of interleukin13 to induce tissue inflammation and fibrosis was also markedly diminished in the absence of BRP-39. Mechanistic investigations demonstrated that BRP-39 and YKL-40 play an essential role in antigen sensitization and immunoglobulin E induction, stimulate dendritic cell accumulation and activation, and induce alternative macrophage activation. These proteins also inhibit inflammatory cell apoptosis/cell death while inhibiting Fas expression, activating protein kinase B/AKT, and inducing Faim 3. These studies establish novel regulatory roles for BRP-39/YKL-40 in the initiation and effector phases of Th2 inflammation and remodeling and suggest that these proteins are therapeutic targets in Th2- and macrophage-mediated disorders.</P>
Jennifer J. Lee,Hyunuk Kim 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
This research aims to understand how academic articles stimulate knowledge progress by addressing two questions: Does the level of contribution vary between different methods of research (e.g., conceptual, theoretical, and empirical)? How do we assess the potential of scholarly articles to impact and further innovate the field?
( Jennifer Jooyoun Kim ),( Young Kyung Kwon ),( Ji Hyung Kim ),( Soo Jin Heo ),( Young Deuk Lee ),( Su Jin Lee ),( Won Bo Shim ),( Won Kyo Jung ),( Jung Ho Hyun ),( Kae Kyoung Kwon ),( Do Hyung Kang ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.11
Cellulase and xylanase are main hydrolysis enzymes for the degradation of cellulosic and hemicellulosic biomass, respectively. In this study, our aim was to develop and test the efficacy of a rapid, high-throughput method to screen hydrolytic-enzyme-producing microbes. To accomplish this, we modified the 3,5-dinitrosalicylic acid (DNS) method for microwell plate-based screening. Targeted microbial samples were initially cultured on agar plates with both cellulose and xylan as substrates. Then, isolated colonies were subcultured in broth media containing yeast extract and either cellulose or xylan. The supernatants of the culture broth were tested with our modified DNS screening method in a 96-microwell plate, with a 200 μl total reaction volume. In addition, the stability and reliability of glucose and xylose standards, which were used to determine the enzymatic activity, were studied at 100ºC for different time intervals in a dry oven. It was concluded that the minimum incubation time required for stable color development of the standard solution is 20 min. With this technique, we successfully screened 21 and 31 cellulase- and xylanase-producing strains, respectively, in a single experimental trial. Among the identified strains, 19 showed both cellulose and xylan hydrolyzing activities. These microbes can be applied to bioethanol production from cellulosic and hemicellulosic biomass.