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RISS 인기검색어
- 검색키워드
- 저자 : Jee Sung-Hyun (검색결과 1,742 건)
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( Jee Youn Oh ),( Jae Kyeom Sim ),( Jong Hyun Choi ),( Sue In Choi ),( Ji Young Park ),( Kyung Hoon Min ),( Eun Joo Lee ),( Young Hur Gyu ),( Sung Yong Lee ),( Sang Yeub Lee ),( Je Hyeoung Kim ),( Cho 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-
Objectives: We investigated the correlation between IL-27 polymorphisms in the promoter region of -964A/G and the exon region of 2095T/G, 4603G/A, and 4730T/C and the development of pulmonary TB, and its radiographic characteristics and severity. Methods: Differences in the allele and genotype distributions of the -964A/G, 2095T/G, 4603G/A, and 4730T/C polymorphisms were analyzed between 224 pulmonary TB patients and 233 healthy controls. Subgroup analysis was done between patients with single- and multi-lobar involvement, and between patients with and without cavitation. Serum IL-27 concentration was measured using an enzyme-linked immunosorbent assay. Results: There were no significant differences in the allele or genotype distributions between patients with pulmonary TB and healthy controls. However, in patients with single-lobar involvement, the -964A/A genotype was more prevalent than the -964 A/G or -964 G/G genotype in patients with multi-lobar involvement (50.0% vs. 31.3%, P=0.01, OR 2.19, 95% CI 1.17∼4.12). There was no difference between patients with and without cavitation (P>0.05). Serum median IL-27 concentration was significantly higher in patients with single-lobar involvement than those with multi-lobar involvement (P=0.03) and with -964A/A genotypes than -964A/G or -964G/G genotypes (P=0.02). Conclusions: The genetic polymorphisms of IL-27 are not associated with the development of TB. However, the -964A/G genetic polymorphism of IL-27 and serum IL-27 concentrations are associated with the severity of pulmonary TB by radiographic characteristics.Objectives: We investigated the correlation between IL-27 polymorphisms in the promoter region of -964A/G and the exon region of 2095T/G, 4603G/A, and 4730T/C and the development of pulmonary TB, and its radiographic characteristics and severity. Methods: Differences in the allele and genotype distributions of the -964A/G, 2095T/G, 4603G/A, and 4730T/C polymorphisms were analyzed between 224 pulmonary TB patients and 233 healthy controls. Subgroup analysis was done between patients with single- and multi-lobar involvement, and between patients with and without cavitation. Serum IL-27 concentration was measured using an enzyme-linked immunosorbent assay. Results: There were no significant differences in the allele or genotype distributions between patients with pulmonary TB and healthy controls. However, in patients with single-lobar involvement, the -964A/A genotype was more prevalent than the -964 A/G or -964 G/G genotype in patients with multi-lobar involvement (50.0% vs. 31.3%, P=0.01, OR 2.19, 95% CI 1.17∼4.12). There was no difference between patients with and without cavitation (P>0.05). Serum median IL-27 concentration was significantly higher in patients with single-lobar involvement than those with multi-lobar involvement (P=0.03) and with -964A/A genotypes than -964A/G or -964G/G genotypes (P=0.02). Conclusions: The genetic polymorphisms of IL-27 are not associated with the development of TB. However, the -964A/G genetic polymorphism of IL-27 and serum IL-27 concentrations are associated with the severity of pulmonary TB by radiographic characteristics.
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( Sang Hyung Lee ),( Hyun Ji Kang ),( Woo Jin Lee ),( Chong Hyun Won ),( Sung Eun Chang ),( Mi Woo Lee ),( Jee Ho Choi ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Primary cutaneous diffuse large B-cell lymphoma, leg type is a well-defined entity of cutaneous B-cell lymphoma affecting predominantly elderly patients, mostly women. The typical clinical presentation is characterized by solitary or multiple, rapidly growing plaques or tumors on 1 leg. We report this lymphoma in a 61-year-old man. He presented with a 2-year history of erythematous drug eruption-like morbiliform eruption on his chest, flank, back, and extremities. Complete staging investigations revealed no extracutaneous involvement. Histological examination of the morbiliform eruption showed perivascular infiltration composed predominantly of small lymphocytes admixed with several large blasts. They stained positively for CD20, CD79, and bcl-2 and revealed the negativity for bcl-6, CD4, and CD8. Our case suggest that drug eruption-like morbiliform eruption is a novel clinical feature of primary cutaneous diffuse large B-cell lymphoma
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A case of hydroa vacciniforme-like lymphoproliferative disorder with indolent clinical course
( Sang Hyung Lee ),( Hyun Ji Kang ),( Woo Jin Lee ),( Chong Hyun Won ),( Sung Eun Chang ),( Mi Woo Lee ),( Jee Ho Choi ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Primary cutaneous hydroa vacciniforme(HV)-like lymphoma is a rare, Epstein-Barr virus-associated cutaneous neoplasm occurring mainly in childhood and usually associated with poor prognosis. This report presents a case of primary cutaneous HV-like lymphoma with unusual indolent clinical course and favorable prognosis during the follow-up periods of 6 months. She presented with 20-year history of erythema, papules, and tiny ulcerations without progression on the face and 2-month history of solitary pinkish mass on the left thigh. Skin biopsy revealed spongiotic vesicle or necrosis with dense infiltration of small- to medium sized atypical lymphoid cells in the dermis. The lymphoid cells were immunoreactive to CD3, CD4 and CD8, mixed, and revealed the negativity for CD56. The Epstein-Barr virus genomes were also found in skin biopsy. By genetic analysis, she showed βF-1/T-cell receptor gene clonal rearrangement. Fortunately, solitary mass of the left thigh was spontaneously resolved before treatment. The patients underwent minocycline and NSAIDs treatment and obtained remarkable clinical improvement with regression of skin lesions. No sign of recurrence and extracutaneous manifestation was found during the period of follow-up. A long-term follow-up is suggested to be performed to inspect the progression for this tumor.
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Epidemiology and clinical patterns of melasma in Korean patients
( Hyun Ji Kang ),( Tai Kyung Noh ),( Bo Young Chung ),( Mi Hye Lee ),( Chong Hyun Won ),( Mi Woo Lee ),( Jee Ho Choi ),( Sung Eun Chang ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Melasma is a common acquired hyperpigmentary disorder that predominantly affects face. It frequently occurs among women with darker skin types and impacts quality of life. Objectives: To characterize the clinicoepidemiological features and the precipitating or aggravating factors of melasma in Korean patients. Methods: Present cross-sectional, multicenter study conducted in dermatological clinics of five tertiary hospitals in Korea. Four hundred and eleven patients with melasma completed a questionnaire concerning the clinical features and factors associated to their melasma, from January 2011 to August 2012. Results: Mean disease onset is 33.7【8.67. Most common triggering factor is sun exposure (68.4%) followed by pregnancy (27.0%) and emotional stress. Inflammatory status of face triggered and/or aggravated melasma in 61.1% of patients at least once. Dryness is the most common aggravating factor, followed by erythema/telangiectasia and itching/tingling. Concomitant pigmented disorders were post-inflammatory hyperpigmentation in 15.1%, followed by pigmented contact dermatitis including Riehl’s melanosis, and ABNOM. Conclusion: As it is well known that sun exposure and hormonal changes are most common cause of triggering the melasma, however, the inflammatory features may aggravate melasma in Asian patients. Therefore, these individual differences should be considered in the prevention as well as treatment of melasma.
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( Sang Hyung Lee ),( Woo Jin Lee ),( Mi Hye Lee ),( Chong Hyun Won ),( Sung Eun Chang ),( Jee Ho Choi ),( Kee Chan Moon ),( Chan Sik Park ),( Mi Woo Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Few studies have evaluated the histopathological features of cutaneous extranodal NK/T-cell lymphoma, and the histopathological spectrum of this disease according to its clinical morphology remains unclear. Objectives: This study investigated the differences in histopathlogical findings of cutaneous extranodal NK/T- cell lymphoma depending on their clinical morphology. Methods: A total of 41 cases of cutaneous extranodalNK/T-cell lymphoma were included. Skin lesions were classified according to clinical morphology as: 1) nodular lesions, 2) cellulitis or abscess-like swellings, and 3) erythematous to purpuric patches. Histopathological variables were compared between groups. Results: Perivascular infiltration of tumor cells and vasculopathy in the dermis and subcutaneous layer werecommon histopathological findings irrespective of clinical morphology. Erythematous to purpuric patches were mainly composed of small-sized tumor cells, whereas medium- to large-tumor cells were predominant in lesions of other clinical morphologies. The density of tumor cellinfiltration was significantly higher in cellulitis or abscess-like lesions or nodular lesions compared to erythematous to purpuric patches. A panniculitis-like pattern and angiocentricity were less common in patch lesions than in cellulitis-like swelling and nodular lesions. Conclusion: There is a histopathological spectrum of cutaneous extranodal NK/T-cell lymphoma that is dependent on the clinical morphology.
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Histopathological analysis of rosacea according to clinical subtypes
( Hyun Ji Kang ),( Woo Jin Lee ),( Joon Min Jung ),( Ye Jin Lee ),( Chong Hyun Won ),( Sung Eun Chang ),( Jee Ho Choi ),( Kee Chan Moon ),( Mi Woo Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: The histopathological features of rosacea have not been described in detail. Objectives: To evaluate the histopathological features of rosacea according to clinical characteristics such as subtype and severity. Methods: We retrospectively analyzed histopathological findings in 226 patients with rosacea, which included 52 patients with the erythematotelangiectatic rosacea (ETR) and 174 patients with the papulopustular rosacea (PPR) subtype. Histopathological features were compared according to the severity through subgroup analysis within each subtype group. Results: Perivascular and perifollicular lymphohistiocytic infiltration were common dermal findings in both subtype groups, but the intensity of dermal inflammatory infiltration was higher in PPR than in ETR. Follicularspongiosis and exocytosis of inflammatory cells into hair follicles were noted in both subtypes, but these findings were significantly more common in the PPR subtype. The intensity of perifollicular inflammation and the presence of follicular inflammatory reactions were dependent on the severity of rosacea in both subtype groups. Conclusion: No distinct histopathological patterns associated with rosacea subtypes were found, but the intensity of inflammatory reactions was higher in PPR patients than in ETR patients. Rosacea has a spectrum of histopathological features that are related to clinical progression between rosacea subtypes.
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Sung, Hwa Jung,Hong, Soon Cheol,Yoo, Ji Hyun,Oh, Jee Hyun,Shin, Hye Jin,Choi, In Young,Ahn, Ki Hoon,Kim, Sun Haeng,Park, Yong,Kim, Byung Soo The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.10
<P>This study was done to evaluate the stemness of human mesenchymal stem cells (hMSCs) derived from placenta according to the development stage and to compare the results to those from adult bone marrow (BM). Based on the source of hMSCs, three groups were defined: group I included term placentas, group II included first-trimester placentas, and group III included adult BM samples. The stemness was evaluated by the proliferation capacity, immunophenotypic expression, mesoderm differentiation, expression of pluripotency markers including telomerase activity. The cumulative population doubling, indicating the proliferation capacity, was significantly higher in group II (<I>P</I><0.001, 31.7±5.8 vs. 15.7±6.2 with group I, 9.2±4.9 with group III). The pattern of immunophenotypic expression and mesoderm differentiation into adipocytes and osteocytes were similar in all three groups. The expression of pluripotency markers including ALP, SSEA-4, TRA-1-60, TRA-1-81, Oct-4, and telomerase were strongly positive in group II, but very faint positive in the other groups. In conclusions, hMSCs from placentas have different characteristics according to their developmental stage and express mesenchymal stemness potentials similar to those from adult human BMs.</P>
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Classification of Nasal Index in Koreans According to Sex
Sung-Suk Bae,Hee-Jeung Jee,Min-Gyu Park,Jeong-Hyun Lee 한국치위생과학회 2023 치위생과학회지 Vol.23 No.3
Background: The nose is located at the center of the face, and it is possible to determine race, sex, and the like. Research using the nasal index (NI) classification method to classify the shape of the nose is currently in progress. However, domestic research is required as most research is being conducted abroad. In this study, we used a 3D program to confirm the ratio of the nose shape of Koreans.Methods: One hundred patients (50 males and 50 females) in their 20s were evaluated (IRB approval no. DKUDH IRB 2020-01-007). Cone beam computed tomography was performed using the Mimics ver.22 (Materialise Co., Leuven, Belgium) 3D program to model the patient’s skull and soft tissues into three views: coronal, sagittal, and frontal. To confirm the ratio of measurement metrics, analysis was performed using the SPSS ver. 23.0 (IBM Co., Armonk, NY, USA) program. Results: Ten leptorrhine (long and narrow) type, 76 mesorrhine (moderate shape) type, and 14 platyrrhine (broad and short) type noses were observed. In addition, as a result of sex comparison, five males had the leptorrhine (long and narrow) type, 40 mesorrhine (moderate shape), and five platyrrhine (broad and short) types. For females, five patients had the leptorrhine (long and narrow) type, 36 patients had the mesorrhine (moderate shape) type, and nine patients had the platyrrhine (broad and short) type. Conclusion: This study will be helpful when performing nose-related surgeries and procedures in clinical practice and for similar studies in the future.
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