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동종 골수이식 후 만성 이식편대숙주질환과 동반된 그레이브스병
황호인,이제중,조상희,김여경,이병환,정익주,김형준 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.1
저자들은 중증 재생불량성빈혈로 동종 골수이식 및 추가적인 동종 말초혈액 조혈모세포이식을 시행 받은 후 만성 이식편대숙주질환이 발생하여 면역억제제로 조절되었으나 자가면역성 갑상선기능항진증이 병발한 1예를 경험하였기에 이를 보고하는 바이다. Chronic graft-versus-host disease (GVHD), which is a frequent complication following bone marrow transplantation (BMT), is characterized by fibrosis of the skin, liver, lungs, and gastrointestinal tract, immunodeficiency, and the production of autoantibodies. Endocrine dysfunction, in particular thyroid disease, has been described following BMT, but this has previously meant hypothyroidism secondary to total body irradiation or transfer of autoimmune hyperthyroidism from a donor with Graves’ disease rather than in association with chronic GVHD. We report a case of a 26-year-old man who developed Graves’ disease eight years after BMT and who had remission of chronic GVHD. He received an allogeneic BMT for severe aplastic anemia. Eighteen months after BMT, diarrhea and chronic GVHD developed and were treated with cyclosporine and steroid. Four years after ceasing the cyclosporine, the patient developed weight loss, palpitations, fever, and anterior neck swelling, and was diagnosed with Graves’ disease based on typical thyroid function tests. The signs and symptoms in the patient improved with propylthiouracil and propranolol.
동종 골수이식을 시행받은 환자에서 폐색성 세기관지염에 의하여 발생한 자발성 기종격동과 피하 기종
이병환,이제중,이연경,안재숙,김여경,황호인,박무림,조상희,정익주,김형준 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2
저자들은 만성골수성백혈병으로 동종 골수이식과 이식편 부전으로 인하여 추가적인 말초혈액 조혈모세포이식을 시행 받은 환자에서 만성 이식편대숙주질환과 그 폐 합병증인 폐색성 세기관지염에 동반된 자발성 기종격동과 피하 기종이 병발한 1예를 경험하였기에 이를 보고하는 바이다. Obstructive lung disorders following after allogeneic bone marrow transplantation (BMT) in association with graft- versus-host disease (GVHD) contribute significant morbidity and mortality. We report a case of a 28-year-old man who developed spontaneous pneumomediatinum and subcutaneous emphysema complicating bronchiolitis obliterans after allogeneic BMT. He received an allogeneic BMT for chronic phase of chronic myeloid leukemia. Five months after BMT, he was boostered by allogeneic peripheral blood stem cells from the same donor due to graft failure. One month after the boostering, chronic GVHD developed and were treated with cyclosporine and steroid. The patients developed spontaneous pneumomediatinum and subcutaneous emphysema secondary to severe bronchiolitis obliterans 4 months after boostering donor cells. The air-leak syndromes were recovered by conservative management, including high-flow oxygen.
박정규,정흥배,문성환,류태권,류제영,황인영 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.4
1. 금호강물에 대한 상대독성과 수온, 전기전도도의 경우 달서천 내부, 금호강과 달서천의 합류점 하부, 합류점 상부 순으로 값의 크기를 보였고 pH의 경우 역순을 보이므로 달서천이 금호강과 달서천 합류점 하부에 영향을 주는 것으로 사료된다. 2. 금호강 하천수에 대한 Microtox 독성값과 온도, pH, 전기전도도의 상관성은 없었으므로 기존의 일반적인 몇 가지 수질 인자로는 독성변화 및 수준을 판단할 수 없다고 사료된다. 3. 36시간 연속 모니터링을 통해 짧은 시간에도 독성값이 달라지는 것으로 보아 수질의 독성 수준이나 오염 수준을 판단하기 위해서는 연속적인 독성 조사 및 분석이 필요하다고 사료된다. 4. 하천수에 대한 연속 모니터링만으로는 하천 생태 위해도를 평가하기는 어렵다. 따라서, 하천 퇴적물에 대한 특성을 병행하여 조사 분석하는 것이 유해화학물질에 의한 하천 오염을 평가하는 방법이 된다고 사료된다. The main point source of pollution of the Keumho river in Taegu, Korea, stems from waste from the areas of industrial complexes. Although it is widely accepted that pollutants in waste water negatively effects general water quality, it is difficult to evaluate the effluent effect because of varying conditions in ambient water and inconclusive knowledge of causative pollutants. To analyze the water in relation to the industrial effluent in the area, pH, temperature, conductivity, and Microtox toxicity of various river samples were measured. Water samples were collected every 2 hours for 36 hours from Keumho river and Dalseo stream. Data from continuous monitoring for 36 hours showed that effluent in Keumho river originated from Dalseo stream, which is near adjacent to industrial complexes. Change in toxicity and other factors tested during the 36 hours indicated that continuous monitoring was necessary for a satisfactory effluent toxicity test. Furthermore, in addition to water quality monitoring, it was concluded that sediment toxicity also needed to evaluate effluent effects.
Hwang, Seon-Hwan,Kwon, Soon-Kurl,Hwang, Young-Gi,Bang, Deok-Je The Korean Institute of IIIuminating and Electrica 2014 조명·전기설비학회논문지 Vol.28 No.12
This paper proposes a coordinated control for an independent multi-phase transverse flux linear synchronous motor (IM-TFLSM) based on magnetic levitation. The stator structures of the IM-TFLSM are composed of a two set, which has independent three-phase windings and a double-sided air-gap as opposed to the conventional Y-connected three-phase linear motors. A suitable control algorithm is necessary to operate the applied linear machine. This study proposes a coordinated control algorithm for adjusting the mover air-gap and thrust force of the IM-TFLSM in order to maintain air-gap and phase shifted current control of the independent 3-phase modules. In addition, the principle of operation and its special structures are described in detail and the validity and effectiveness of the control algorithm is verified through multiple experimental results.
Seon-Hwan Hwang,Soon-Kurl Kwon,Young-Gi Hwang,Deok-Je Bang 한국조명·전기설비학회 2014 조명·전기설비학회논문지 Vol.28 No.12
This paper proposes a coordinated control for an independent multi-phase transverse flux linear synchronous motor (IM-TFLSM) based on magnetic levitation. The stator structures of the IM-TFLSM are composed of a two set, which has independent three-phase windings and a double-sided air-gap as opposed to the conventional Y-connected three-phase linear motors. A suitable control algorithm is necessary to operate the applied linear machine. This study proposes a coordinated control algorithm for adjusting the mover air-gap and thrust force of the IM-TFLSM in order to maintain air-gap and phase shifted current control of the independent 3-phase modules. In addition, the principle of operation and its special structures are described in detail and the validity and effectiveness of the control algorithm is verified through multiple experimental results.
Sensorless Control of Brushless DC Motors With Torque Constant Estimation for Home Appliances
Je-Wook Park,Seon-Hwan Hwang,Jang-Mok Kim IEEE 2012 IEEE transactions on industry applications Vol.48 No.2
<P>A new sensorless control algorithm for brushless dc motors (BLDCMs) is proposed in this paper. The torque constant of a BLDCM is used as a reference signal for position detection because it is constant during the entire speed range and can be estimated by calculating the ratio of the back electromotive force (EMF) to the rotor speed. By using both a disturbance observer and the torque constant estimation error, the rotor speed can be obtained. The back EMF can be easily obtained from the voltage equation of the BLDCM. The estimated back EMF decreases simultaneously with the estimated torque constant at the commutation point. By using this phenomenon, the commutation of the phase currents can be done automatically at the drop point of the estimated torque constant. Unlike conventional back-EMF-based methods, the proposed method provides highly accurate sensorless operation even under low speeds because only the drop of the torque constant is used for position detection and current commutation. Therefore, the position accuracy is not affected by the electric parameter errors of the BLDCM. Also, this algorithm does not require an additional hardware circuit for position detection. The validity of the proposed algorithm is verified through several experiments.</P>
Hwang, Jung Jin,Kim, Yong Sook,Kim, Taelim,Kim, Mi Joung,Jeong, In Gab,Lee, Je-Hwan,Choi, Jene,Jang, Sejin,Ro, Seonggu,Kim, Choung-Soo M. Nijhoff ; Kluwer Academic Publishers 2012 Investigational new drugs Vol.30 No.4
<P>We synthesized a novel hydroxamate-based pan-histone deacetylase inhibitor (HDACI), CG200745 {(E)-2-(Naphthalen-1-yloxymethyl)-oct-2-enedioic acid 1-[(3-dimethylamino-propyl)-amide] 8-hydroxyamide]}. Like other inhibitors, for example vorinostat and belinostat, CG200745 has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Firstly, we analyzed its inhibitory activity against histone deacetylase (HDAC) in hormone-dependent LNCaP cells and hormone-independent DU145 and PC3 cells. CG200745 inhibited deacetylation of histone H3 and tubulin as much as vorinostat and belinostat did. CG200745 also inhibited growth of prostate cancer cells, increased sub-G1 population, and activated caspase-9, -3 and -8 in LNCaP, DU145 and PC3 cells. These results indicate that CG200745 induces apoptosis. Next, we examined the effect of CG200745 on cell death induced by docetaxel in DU145 cells in vitro and in vivo. Compared to mono-treatment with each drug, pre-treatment of DU145 cells with docetaxel followed by CG200745 showed synergistic cytotoxicity, and increased the apoptotic sub-G1 population, caspase activation, and tubulin acetylation. Moreover, the combination treatment decreased Mcl-1 and Bcl-(XL). Docetaxel and CG200745 combination reduced tumor size in the DU145 xenograft model. These preclinical results show that combination treatment with docetaxel and new HDACI, CG200745, potentiated anti-tumor effect in hormone-refractory prostate cancer (HRPC) cells via activation of apoptosis.</P>
Precision Control for Beam Irradiation Dose by Developing a Real-time Dose Monitoring System
Hwang Yong Seok,Kim Maengjun,석재권,Lee Chan Young,Ha Jun Mok,Kim Chorong,Kim Dong Seok,Yeo Sunmog,Jung Myung-Hwan,Cho Won-Je,Jeon Hye-Ran,Lee Jae S.,박준규 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.77 No.5
We have developed a real-time dose monitoring system for a low-energy ion-beam facility. Before we developed the monitoring system, the system had given a substantial error of ±23% when we irradiated an ion beam with a dose as much as 3.0 × 1016 cm-2 on the Si substrate. Moreover, a low irradiation dose as small as 1013 cm-2 was scarcely able to be controlled because of a too short irradiation time of several seconds, producing a greater dose error. To develop a real-time dose monitoring system, in this work, we employed a current integrator in conjunction with a beam stopper, by which a dose of 3.0 × 1016 cm-2 can be exactly irradiated on the sample with less than ±6% error, which was ensured by the measurements of Rutherford backscattering spectroscopy.