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Supratentorial Leptomeningeal Hemangioblstoma : Case Report
Jang, Han Won,Byun, Woo Mok,Lee, Jae Kyo,Cho, Jae Ho,Cho, Kil ho,Hwang, Mi Soo,Park, Bok Hwan,Choi, Joon Hyuk 영남대학교 의과대학 2007 Yeungnam University Journal of Medicine Vol.24 No.2S
혈관아세포종은 소뇌에 가장 흔하게 발생하며 von Hippel-Lindau disease와 연관될 수 있다. 저자들은 천막상부 연수막에서 기원한 혈관아세포종의 자기공명영상과 병리학적 소견에 대해서 기술하고자 한다. Hemangioblastoma is a benign tumor that most commonly occurs in the cerebellum and associated with von Hippel-Lindau (VHL) disease. Supratentorial hemanigoblastomas are exceptionally rare. We describe the magnetic resonance imaging (MRI) and histopathologic findings of a supratentorial leptomeningeal hemangioblastoma.
( Jang Sik Choi ),( Joon Boo Yu ),( Jin Young Jeon ),( Sang Hun Lee ),( Jae Hong Kim ),( Jang Pyo Park ),( Yong Won Jeong ),( Hyung Gi Byun ) 한국센서학회 2018 센서학회지 Vol.27 No.4
Indoor air pollution has become a serious issue, affecting the health and comfort of building occupants. Volatile organic compounds (VOCs) are among the most common indoor contaminants, and are released from numerous indoor emission sources. Among the VOCs, formaldehyde and toluene are toxic chemicals at low levels and are frequently detected indoors. Exposure to formaldehyde and toluene can irritate sensitive tissue and may increase the risk of cancer. Therefore, monitoring formaldehyde and toluene is critical for the health and comfort of residents. In addition, as human indoor activities can generate VOC gases, analysis of their influence on VOCs is needed. In this study, we compared electronic nose (E-Nose) data for formaldehyde and toluene with E-Nose data for indoor mixture gas with consideration for human indoor activities.
Byun, Hayoung,Cho, Yang-Sun,Jang, Jeon Yeob,Chung, Kyu Whan,Hwang, Soojin,Chung, Won-Ho,Hong, Sung Hwa Triological Foundation [etc.] 2013 The Laryngoscope Vol.123 No.10
<P>To evaluate the prognostic and predictive value of electroneuronography (ENoG) in acute severe inflammatory facial paralysis, including Bell's palsy and Ramsay Hunt syndrome (RHS).</P>
Nuclear Localization and Functional Characteristics of Voltage-gated Potassium Channel Kv1.3
Jang, Soo Hwa,Byun, Jun Kyu,Jeon, Won-Il,Choi, Seon Young,Park, Jin,Lee, Bo Hyung,Yang, Ji Eun,Park, Jin Bong,O'Grady, Scott M.,Kim, Dae-Yong,Ryu, Pan Dong,Joo, Sang-Woo,Lee, So Yeong American Society for Biochemistry and Molecular Bi 2015 The Journal of biological chemistry Vol.290 No.20
<P>It is widely known that ion channels are expressed in the plasma membrane. However, a few studies have suggested that several ion channels including voltage-gated K<SUP>+</SUP> (Kv) channels also exist in intracellular organelles where they are involved in the biochemical events associated with cell signaling. In the present study, Western blot analysis using fractionated protein clearly indicates that Kv1.3 channels are expressed in the nuclei of MCF7, A549, and SNU-484 cancer cells and human brain tissues. In addition, Kv1.3 is located in the plasma membrane and the nucleus of Jurkat T cells. Nuclear membrane hyperpolarization after treatment with margatoxin (MgTX), a specific blocker of Kv1.3 channels, provides evidence for functional channels at the nuclear membrane of A549 cells. MgTX-induced hyperpolarization is abolished in the nuclei of Kv1.3 silenced cells, and the effects of MgTX are dependent on the magnitude of the K<SUP>+</SUP> gradient across the nuclear membrane. Selective Kv1.3 blockers induce the phosphorylation of cAMP response element-binding protein (CREB) and c-Fos activation. Moreover, Kv1.3 is shown to form a complex with the upstream binding factor 1 in the nucleus. Chromatin immunoprecipitation assay reveals that Sp1 transcription factor is directly bound to the promoter region of the Kv1.3 gene, and the Sp1 regulates Kv1.3 expression in the nucleus of A549 cells. These results demonstrate that Kv1.3 channels are primarily localized in the nucleus of several types of cancer cells and human brain tissues where they are capable of regulating nuclear membrane potential and activation of transcription factors, such as phosphorylated CREB and c-Fos.</P>
Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation
Won, M,Park, K A,Byun, H S,Sohn, K-C,Kim, Y-R,Jeon, J,Hong, J H,Park, J,Seok, J H,Kim, J M,Yoon, W-H,Jang, I-S,Shen, H M,Liu, Z G,Hur, G M Macmillan Publishers Limited 2010 CELL DEATH AND DIFFERENTIATION Vol.17 No.12
The zinc-finger protein A20 has crucial physiological functions as a dual inhibitor of nuclear factor-κB (NF-κB) activation and apoptosis in tumor necrosis factor (TNF) receptor 1 signaling pathway. Although the molecular basis for the anti-NF-κB function of A20 has been well elucidated, the anti-apoptotic function of A20 is largely unknown. Here, we report a novel mechanism underlying the anti-apoptotic function of A20: A20 blocks TNF-induced apoptosis through suppression of c-jun N-terminal kinase (JNK) by targeting apoptosis signal-regulating kinase1 (ASK1). First, the ectopic expression of A20 drastically inhibits TNF-induced JNK activation and apoptosis in multiple cell types including those deficient of NF-κB activation. Unexpectedly, the blunting effect of A20 on TNF-induced JNK activation is not mediated by affecting the TNFR1 signaling complex formation. Instead, A20 interacts with ASK1, an important MAPKK kinase in the JNK signaling cascade. More importantly, overexpression of wild-type A20, but not of mutant A20 (ZnF4; C624A, C627A), promotes degradation of the ASK1 through the ubiquitin-proteasome system. Taken together, the results from this study reveal a novel anti-apoptotic mechanism of A20 in TNF signaling pathway: A20 binds to ASK1 and mediates ASK1 degradation, leading to suppression of JNK activation and eventually blockage of apoptosis.