활동성 크론병에서 초기 스테로이드 치료 반응에 따른 임상적, 생화학적, 병리학적 인자들에 관한 연구

김영호,장재권,김지은,최규완,박동일,도재혁,백승운,고광철,이풍렬,이종철,현재근,안병훈,김재준,류민규 대한소화기내시경학회 2001 Clinical Endoscopy Vol.22 No.6

Background/Aims: The predictory factors of the response to initial steroid therapy in active Crohn's disease has been controversial in numerous literature reviews. We evaluated any predictory faetor of the response to initial steroid therapy in active Crohn`s disease patients, Methods: The medical records of 32 patients with active Crohn`s disease who clinically responded to oral steroid therapy were retrospectively reviewed. The steroid responsive group was defined as the one showing maintenance of response for more than one month from steroid withdrawal and the steroid dependent group as the one showing relapse or exacerbation during steroid tapering or within 30 days from steroid withdrawal. The clinical, biochemical, and pathologic factors were evaluated. Results: There were 22 male and 10 female patients. The mean age was 28.9 years. The number of steroid responsive and dependent group was 22 (68.8%) and 10 (31.2%), respectively. There were no significant differences between these two groups in age, sex, time to diagnosis, perianal lesion, extent of disease, extraintestinal manifestations, presence of granuloma, presenting features, hemoglobin, ESR, and CRP, except serum albumin level. Conclusions: Serum albumin level was significantly lower in steroid dependent group than steroid responsive group, reflecting severe inflammation in steroid dependent group.

Ganglioside GM1 influences the proliferation rate of mouse induced pluripotent stem cells

( Jae-sung Ryu ),( Kyu-tae Chang ),( Ju-taek Lee ),( Malg-um Lim ),( Hyun-ki Min ),( Yoon-ju Na ),( Su-bin Lee ),( Gislain Moussavou ),( Sun-uk Kim ),( Ji-su Kim ),( Kinarm Ko ),( Kisung Ko ),( Kyung- 생화학분자생물학회 2017 BMB Reports Vol.50 No.6

The ACKNOWLEDGEMENTS should be corrected as follows, This research was supported by a grant (Code# PJ0074922012) from the Korean Rural Development Administration, and has been supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education Science and Technology (2010-0022316 and KCG5401011), and the KRIBB/KRCF Research Initiative Program (NAP), Korea. The published article in this journal was a part of the 2013 Doctoral thesis of Jae-Sung Ryu submitted to Wonkwang University, Korea. and not This research was supported by a grant (Code# PJ0074922012) from the Korean Rural Development Administration, and has been supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education Science and Technology (2010-0022316 and KCG5401011), and the KRIBB/KRCF Research Initiative Program (NAP), Korea.

세계 정상급 멀리뛰기 선수들의 도움닫기, 발구름 동작과 에너지 변환에 관한 연구

류재균 ( Jae Kyun Ryu1 ),송주호 ( Joo Ho Song ),장재관 ( Jae Kwan Chang ),김혜영 ( Hye Young Kim ) 한국스포츠정책과학원(구 한국스포츠개발원) 2012 체육과학연구 Vol.23 No.4

이 연구는 도움닫기 마지막 세 스트라이드 및 발구름 동작에서 일어나는 동작 변화를 세 개의 운동면에서 분석하고 발구름 구간에서의 에너지 흐름의 특성을 분석하는 것이다. 이 연구는 2011년 대구세계육상선수권대회에서 남자 멀리뛰기 결승에 진출한 선수들 중 1위에서 8위에 입상한 선수들을 대상으로 5대의 Sony 비디오 카메라를 사용하여 60Hz로 선수들의 운동장면을 촬영하였으며 Kwon3d 프로그램을 이용하여 운동학적 자료를 산출하였다. 또한 에너지 흐름의 특성을 분석하기 위하여 에너지 변환지수와 에너지 전환효율을 계산하였다. 분석 결과 다음과 같은 결론을 얻었다. 도움닫기 마지막 세 스트라이드의 보폭 변화는 전형적인 멀리뛰기 보폭 변화인 보통-길고-짧게 하는 보폭 패턴을 보였으며, 스트라이드 각은 페널티메이트에서 모든 선수들의 스트라이드 각이 크게 나타났다. 수평면에 투영한 도약각도는 이륙순간 좌우속도에 따라 구름판 이륙시점에서 우측 혹은 좌측으로 도약각이 결정되는 것으로 나타났다. 전후면에서 접지순간 다리의 각도가 작을 경우에는 구름판에서 수평속도의 제동이 되는 것으로 나타났다. 이륙순간 다리의 각도가 작게 되면 도약각도는 클 수 있으나 구름판에서 발구름 동작으로 인한 수평속도의 추진력이 떨어지는 것으로 나타났다. 좌우면에서 이륙순간 다리의 각도는 접지에서 이륙순간으로 진행되면서 발구름 다리의 각도가 서로 교차되는 것으로 나타났다. 에너지 변환지수는 경기력이 우수한 선수일수록 높게 나타났으나 Watt 선수처럼 도약각이나 구름판 이륙순간 수평속도의 감속이 크면 작게 나타났다. 에너지 전환효율은 선수들간에 큰 차이를 보이지 않았지만 구름판 이륙순간에서 수평속도의 감속이 크고 수직속도가 크게 증가되면 높게 나타났다. The purpose of this study is to reseach the kinematic variables of the last three strides on the cardinal planes and the energetic processes of take-off performance. The subject of this research were the athletes whos ranked within top eighth of the long jump competition at the 2011 Teagu world championship. Each long jump was recorded using a video camera operating at 60Hz and Kwon3D program was used to analyse the video images of the jumps and the results were as follow: 1. The stride patterns of the subjects utilized the long penultimate-short last stride strategy except Manyongga. All subject of 2nd stride angles showed higher angels. 2. The take-off angle in the horizontal plane was determined with medio-lateral velocity. If the angel of leg placement in the sagittalple was smaller the horizontal velocity decreased a lot. The angle of leg placement in the frontal plane was twiseted at the take-off phase. 3. The transformation index values were higher with the whos performed superior but lower with subject like Watt whos performed on the higher take-off angle and the higher decreased horizontal velocity at the take-off board. 4. The conversion efficiencies were not showed any differences among the subjects but were showed higher with the higher decreased horizontal velocity and increased vertical at the take-off board.

‘문재인케어’와 영국의 치과의료제도

전지은(Ji-Eun Jeon),류재인(Jae-In Ryu) 대한치과보험학회 2017 대한치과보험학회지 Vol.7 No.1

The public and the organizations related with medical and dental care payed high attention for the Moon Jae-in Care announced at August 9th 2017. The Moon Jae-in Government presented that they will cover all the necessary medical expense by National Health Insurance(NHI). The first step is to get rid of the non-covered items, such as listed in NHI as necessary but non-covered and limited number of permission even though they are essential. In dental care, the percentage of out-of-pocket payment for dentures and implants decreased from 50 to 30. The resin for children and adolescent will be covered by NHI since 2018. This study aims to deal with the critical issues, for example three ‘low’s of payment-fees-coverage, proper health care delivery system, and possibility to extend the coverage by selected or preliminary lists. Also the change of National Health Service(NHS) in U.K. during recent decades will be researched. In conclusion, it is necessary to extend the coverage with patient-centered delivery system. Primary preventive approach needs to apply based on the clinical leadership by the professionals.health insurance coverage.

Cystic Medullary Thyroid Carcinoma: A Case of Undergoing Endoscopic Thyroid Lobectomy

Dong Hae Chung,Jae Yeon Seok,Yoo Seung Chung1,Eun Mee Oh1,Jung Won Ryu1,Young Don Lee1 대한갑상선-내분비외과학회 2015 The Koreran journal of Endocrine Surgery Vol.15 No.1

On ultrasonography, medullary thyroid carcinoma (MTC) shows hypoechogenicity, an irregular margin, a predominantly solid composition, and microcalcifications, similar to those observed in papillary thyroid carcinoma (PTC). MTC presenting as a cystic lesion is rare, and endoscopic thyroidectomy can be performed for benign thyroid masses and early stage PTC, however it is inappropriate for MTC regardless of cystic change. The authors report a case of cystic MTC found after endoscopic thyroid lobectomy and provide a review of the literature on this topic.

조직배양 감자의 플러그육묘재배에 있어서 식물재료가 지하괴경 형성에 미치는 영향

이현숙(Hyun Suk Lee),정재동(Jae Dong Chung),류정아(Iung A Ryu1),황형백(Huyng Baek Hwang),최경배(Kyung Bae Choi) 한국원예학회 2002 한국원예학회 학술발표요지 Vol.2002 No.3

LT, Others : PE-133 ; A case of hepatic hemangioma appearing atypical finding confirmed by dynamic MRI in patients with high risk of hepatocellular carcinoma

( Dong Won Park1 ),( Soo Hyung Ryu1 ),( Myung Ki Oh ),( Seong Yeon Jeong ),( Kyeong Sam Ok ),( Jae Chan Shim ),( Jin Nam Kim ),( You Sun Kim ),( Jeong Seop Moon ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Hemangioma is the most common benign hepatic tumor. Many hepatic hemangiomas tend to be found incidentally, but should be differentiated from malignant tumors. We report an interesting case of hepatic hemangioma in patient who has high risks of hepatocellular carcinoma. Case: A 52-year-old woman, who was a chronic alcoholic abuser and hepatitis C virus carrier with no treatment experience, was admitted due to diarrhea. The patient had suffered from intermittent abdominal pain in the right subcostal area for recent 3 months. Also the patient had easy bruising and frequent epistaxis. She had used oral contraceptives for almost 20 years. Systolic blood pressure was 160 mmHg and diastolic blood pressure was 80 mmHg. Body temperature was normal. Physical examination revealed icteric sclerae and tenderness in right upper quadrant of the abdomen. Laboratory study showed platelet count of 31,000/ul, AST/ALT of 302/127 IU/L, and total bilirubin of 2.7 mg/dl. 3-phased contrast-enhanced abdominal computed tomography (CT) revealed a 4 cm × 4 cm sized hepatic mass involving both segment 5 and 6. Abdominal CT finding suggested hepatic hemangioma, however, typical finding of hemagioma was unclear, therefore, could not rule out the malignancy. Since she had risk factors for hepatocellular carcinoma, abdominal ultrasonography was performed for further evaluation. But abdominal ultrasonography also showed atypical finding. The confirmative diagnosis could be done by dynamic magnetic resonance imaging (MRI) using primovist®, which is an innovative liver cell-specific contrast medium. Dynamic MRI presented peripheral globular enhancement and a centripetal fill-in pattern, confirmatory findings of hepatic hemangioma, on the delayed image. The patient got relief from abdominal pain and diarrhea during admission, now is being followed-up at a general out-patient clinics. Conclusions: Hemangiomas with atypical abdominal CT and ultrasonographic findings in patients with high risks of hepatocellular carcinoma can be easily characterized with primovist-enhanced dynamic MRI.

Skin Irritation and Sensitization Studies on Rosin<SUP>®</SUP> Powder

Jae Myun Ryu,Im Kwon Seo,Tae Myoung Kim,Yun-Bae Kim,Si-Kwan Kim,Seung Bok Hong,Seock-Yeon Hwang 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.2

Primary skin irritation and skin sensitization induced by Rosin<SUP>®</SUP>, an extract of pine tree, were assessed in rabbits and guinea pigs, respectively, according to the guidelines of Korea Food and Drug Administration. In primary skin irritation test, 5% and 10% of Rosin<SUP>®</SUP> (in 80% ethanol) exhibited mean score 1.17 and 1.33, respectively, leading to primary irritation indices (PII) of 0.29 and 0.33. Thus, the test compound Rosin<SUP>®</SUP> was evaluated to be a ‘non-irritant’ material. In skin sensitization study using guinea pig maximization test (GPMT), 5% and 10% Rosin<SUP>®</SUP> did not induce erythema or edema, displaying sensitization score 0 and rate 0%, whereas 0.1% 2,4-dinitrochrolobenzene (DNCB), a positive control, induced sensitization scores 1-2 and rate 80%. Therefore, Rosin<SUP>®</SUP> and DNCB were classified to grade Ⅰ and Ⅳ, indicating weak and strong sensitizers, respectively. Taken together, it is suggested that Rosin<SUP>®</SUP> is a pratically-safe material to skin without potential of irritation or allergic sensitization.

Chemopreventive Effects of Magnolia ovobata Extracts on Colonic Aberrant Crypt Foci Induced by 1,2-Dimethylhydrazine in F344 Rats

Jae Myun Ryu,Im Kwon Seo,Tae Myoung Kim,Yun-Bae Kim,Sung Kwon Moon,Kyung-Hwan Jung,Keerang Park,Seung Bok Hong,Seock-Yeon Hwang 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.2

The chemopreventive effects of Magnolia ovobata water extract (MWE) and 70% ethanol extract (MEE) on the development of colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine (DMH) were investigated. Six-week-old male F344 rats were divided to 7 experimental groups; 1) DMH alone, 2) DMH+0.3% MWE, 3) DMH+1% MWE, 4) DMH+3% MWE, 5) DMH+1% MEE, 6) 3% MWE alone and 7) normal control. Animals were subcutaneously injected with DMH (30 mg/kg) 4 times to induce colonic ACF during the initial 2 weeks, and fed with a basal containing various concentrations of test materials (MWE or MEE) for 8 weeks including the DMH-treatment period. The formation of ACF on colonic mucosa was observed after staining with methylene blue. There are no specific effects of MWE and MEE on body weight, feed and water consumptions, organ weights, histopathological observations, and hematological and blood chemistry analyses. Challenge with DMH alone induced mean number of 270.1 ACF/colon which was somewhat inhibited by MWE treatment, showing average numbers of 234.3-242.1 ACF/colon. In comparison, the ACF number was significantly suppressed to 216.5 by administration of 1% MEE. Therefore, these results suggest that Magnolia ovobata extracts, especially MEE, exert a chemopreventive effect on the DMH-induced colon cancer by inhibiting the early development of ACF.

Biological and biochemical modulation of Trichomonas vaginalis KT9 isolate after shifting of culture medium from TPS-1 into TYM

Jae-Sook RYU(류재숙),Ryung CHOI(최령),So-Young PARK(박소영),Hyun PARK(박현),Duk-Young MIN(민득영) 대한기생충학열대의학회 1998 The Korean Journal of Parasitology Vol.36 No.4