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저용량 및 고용량 옥시토신 투여가 진통의 경과와 태아에 미치는 영향에 관한 연구
곽재환(JH Kwak),강주연(JY Kang),황소영(SY Hwang),차문석(MS Cha),황태영(TY Hwang),김현호(HH Kim),제구화(KW Je) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.8
Oxytocin is frequently used in obstetrics for induction and augmentation of labor. Injudicious use of oxytocin can cause hyperstimulation and subsequent fetal hypoxia. In this study, low and high dose protocols of oxytocin were used to augment nonprogressive labor in normal nulliparous women. In the low dose oxytocin group, the rate of oxytocin infusion was maintained at the physiologic dose (2.75 mU/min) and in the high dose oxytocin group, was started at 4 mU/min and was increased by 4 mU/min to a maximum 40 mU/min. The aim of this study was to assess the effects of the low physiologic dose and high dose oxytocin augmentation on labor and perinatal outcomes in nulliparous women. The results were as follows: 1. The mean maternal age and birth weight were comparable. 2. No statistical difference was detected in the mode of delivery. 3. No statistical difference was detected in the duration of the active phase of the first stage of labor and of the second stage of labor but marked reduction in the total amount of oxytocin in the low dose oxytocin group (p< 0.05). 4. No statistical difference was detected in the incidence of adequate labor, hyperstimulation, and fetal heart rate deceleration. 5. No statistical difference was detected in the occurrence of fetal asphyxia as measured by the incidence of meconium staining, umbilical arterial pH, umbilical arterial base excess, and Apgar score below 7 at 5 minutes. But the uric acid concentration in umbilical blood was higher in the high dose oxytocin group (p<0.05). The results suggested that the use of the low physiologic dose oxytocin was able to augment nonprogressive labor effectively, reduce the total amount of oxytocin and possibility of acute hypoxemia that was not documented by standard markers of perinatal hypoxia at delivery.
생리주기에 따른 자궁내막세포에서의 Transforming Growth Factor-β1 , β2의 발현 : 폐경기 내막과 임신중 탈락막세포와의 비교
황정혜(JH Hwang),황윤영(YY Hwang),장세진(SJ Jang) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.9
The purpose of this study was to determine the differences of expression of TGF- βS(TGF-β1 and TGF-β2) in the human proliferative endometrium, secretory endometrium, and the decidua during early pregnancy. And we also have studied the endometrial expression of TGF-β1 and TGF-β2 in the menopause and compared that to the expression in the endometrium and decidua. Methods : We have studied the expression of TGF-β1 and TGF-β2 by immunohistochemical staining method in the proliferative endometrium, secretory endometrium, decidua during early pregnancy, and menopausal endometrium. Results : In the epithelial cells, TGF-β1 was moderately expressed in the secretory phase and was weakly expressed in the proliferative phase and menopause. In the stromal cells, TGF-β1 was not expressed in the whole menstrual phase and menopause. And in the epithelial cells, TGF-β2 was moderately expressed in the proliferative phase, secretory phase, and menopause. In the stromal cells, TGF-β2 was not expressed in the whole menstrual phase and menopause. Especially, TGF-β1 and TGF-β2 were markedly expressed in the decidua during early pregnancy compared to the expression in the proliferative, secretory endometrium, and menopausal endometrium. Conclusions : These findings suggest that TGF-β1 may have an important role in the epithelial cells during the secretory phase, not stromal cells. And TGF-β1 and TGF-β2 may have a paracrine and autocrine role in the decidua/trophoblast interaction during pregnancy , especially in the normal pregnancy.
DY Hwang,JH oh,YK Kim,SB Shim,SW Jee,SH Lee,SJ Seo,YS Song,KT Nam,JY Cho,Jane Hwang,IS Jang,JS Cho 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.2
Type 2 or noninsulin-dependent diabetes mellitus accounts for over 90% of cases and is characterized by a triad of resistance to insulin action on glucose uptake in peripheral tissues, impaired insulin action to inhibit hepatic glucose production, and dysregulated insulin secretion. To determine whether a transgene-based small interfering RNA (siRNA) for insulin and an overexpression of human insulin degrading enzyme (hIDE) decrease the insulin level in vitro and in vivo or not, several siRNA sequences and hIDE gene for insulin were overexpressed in the insulinoma cells and mouse via tail vein. The siRNAs for insulin suppression were very effective at the regions of 88-99 bp and 109-131 bp in rat insulin sequence. Insulin suppression by the specific siRNA sequences and hIDE significantly induced endoplasmic reticulumn (ER) stress and decreased insulin receptor a expression in insulinoma cells. The insulin level in plasma significantly decreased by overexpressions of the siRNAs and hIDE gene in mouse, which may be caused by the degradation of insulin due to overexpression of hIDE protein in mouse liver. These results suggest that this plasmid for the suppression of insulin secretion by the specific siRNAs and the insulin degradation by an overexpression of hIDE protein may be useful on the development of animal model for Type 2 diabetes.
정상임신 , 자궁외임신 및 계류유산에서의 Transforming Growth Factor β1 , β2의 발현
황정혜(JH Hwang),김승룡(SR Kim),문영진(YJ Moon),박문일(MI Park),정성노(SR Chung),문형(H Moon),이재억(JA Lee),황윤영(YY Hwang),장세진(SJ Jang),박용욱(YW Park) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.5
Objectives: This study have demonstrated that transforming growth factor TGF-βs(TGF-β 1 and TGF β2) may play an important role in implantation and also to determine the defferences of in the decidua and placenta between normal pregnancy, ectopic pregnancy, and missed abortion. Methods: We have studied the expression of TGF-β1 and TGF-β2 by immunohistochemical staining method in the decidua trophoblasts of normal early pregnancy, ectopic pregnancy, and missed abortion. Results: In the epithelial cells and decidua, TFG-β1 was moderately expressed in the normal pregnancy and weakly expressed in the ectopic pregnancy. But TGF-β1 was not expressed in missed abortion. In contrast, the epithelial expression of TGF-β2 was moderately in all groups and there are no differences among the groups. And in the decidua, TFG-β2 was moderately expressed in the normal pregnancy and missed abortion and was weakly expressed in the ectopic pregnancy. In the trophoblasts, TFG-β1 was weakly expressed in all groups and TGF-β2 was moderately expressed in all groups that are no differences among the groups. Conclusions: These findings suggest that TGF-β2 may have an important role in decidua during pregnancy, especially normal pregnancy. These could indicate that the presence of troplablast and/or hormonal milieu of normal pregnancy resulted in the expression of TGF-βs, particularly TGF-β1.
근사엔트로피 ( Approximate Entropy ) : 발육지연 태아에서의 새로운 심박동변이도의 분석지표
황정혜(JH Hwang),박문일(MI Park),염명걸(MK Yum) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.1
Objectives: This study is aimed to quantify the complex dynamics of beat-to-beat fetal heart rate(FHR) fluctuations by using approximate entropy(ApEn) which is a recently developed mathematical formula quantifying regularity and also to determine the differences between normal fetuses and growth retarded fetuses. Background: Recently, some measures of heart rate variability and nonlinear complexity of heart rate dynamics have been used as indicators fetal well-being. Approximate entropy is a new mathematical approach and formula to quantify regularity in data. It has been shown to provide new information in fetal heart rate analysis. Because growth retarded fetus accounts for a significant increase in perinatal morbidity and mortality, than normal fetus, we postulated that there existed important differences between normal fetuses and growth retarded fetuses. Methods: We analyzed FHR tracings for 40 minutes, and approximately 5,000 points in normal fetuses(n=315) and growth retarded fetuses(n=76). The overall complexity of each FHR time series was quantified by its approximate entropy, measure of regularity derived from nonlinear dynamics, chaos theory. Results: Mean baseline FHR increased in growth retarded fetuses than normal fetuses. And the FHR ApEn significantly decreased in growth retarded fetuses(ApEn=0.623) compared to that of the normal fetuses(ApEn=0.868) throughout all gestational ages(p<0.001). Conclusions: The ApEn of FHR decreased in growth retarded fetuses throughout all gestational ages. These findings indicated that decreased ApEn values of FHR are associated with sickness and the greater perinatal morbidity risks. Therefore ApEn quantifies subtle changes in FHR regularity and promises for new information in FHR analysis.
비정상 임신 중기 혈청 태아 당단백치를 보이는 산모에서 태아 염색체 이상의 빈도 및 주산기 예후에 관한 연구
김종호(JH Kim),정성노(SR Chung),김승룡(SR Kim),황정혜(JH Hwang),황윤영(YY Hwang),이춘근(CK Lee),조율희(YH Cho) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.4
Purpose: The purpose of this study was to investigate the incidence of fetal chromosomal abnormality and perinatal outcome in pregnancy with unexplained midtrimester abnormal maternal serum alpha-fetoprotein (MSAFP) level. Methods: Eighty eight patients with high (> 2.5 MoM) (n=42) or low (< 0.5 MoM) AFP (n=46) but without any abnormal fetal sonographic findings underwent amniocentesis at 14∼20 weeks of pregnancy at the department of Obstetrics and Gynecology, Hanyang university hospital between January 1992 and June 1997. Their chromosomal analyses and perinatal outcomes were reviewed retrospectively. Results: The incidence of abnormal karyotyping was 3.4% (3/88). In high MSAFP group, it was 2.4% (1/42) and in low MSAFP group, it was 4.3% (2/46). Three abnormal karyotypes were 47 XXY, 46 XX inv (9), and 46 XY inv (9). Abnormal perinatal outcomes were found in 20.5% (18/88). In high MSAFP group, one congenital anomaly (2.4%), 2 intrauterine fetal deaths (4.8%), 4 IUGRs (9.5%), 2 PIHs (4.8%), 3 preterm deliveries (7.1%) were found. In low MSAFP group, 1 intrauterine fetal death (2.2%), 2 IUGRs (4.4%), 1 PIH (2.2%), 1 LGA (2.2%) were found. Conclusion: The risk of chromosomal abnomality were increased 4∼7 times in patients with unexplained abnormal AFP level. So, amniocentesis and fetal karyotyping are recommended for these patients. Furthermore, close observation were needed for pregnancy with abnormal MSAFP because perinatal outcomes were poorin this group.
황미정(MJ Hwang),박신근(SK Park),이동진(DJ Lee),조상래(SL Cho),김완영(WY Kim),이종학(JH Lee),김종화(JH Kim),백원영(WY Paik) 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.5
Osteogenesis imperfecta is a heterogeneous group of inherited disoders characterized by bone fragility that is accompanied by other evidence of malfunction of connective tissue including abnormalities in teech (dentinigenesis imperfecta), hearing loss, alterations in scleral hue, and evidence of soft tissue dysplasia. One of these, the perinatal from on osteogenesis imperfecta type II is rare disorder characterized by small thoracic cavity, beaded rib, and hort, bowed limbs. We recently experienced a case of osteogenesis imperfecta type II diagnosed in utero by ultrasonogram and confirmed by postnatal radiograph and autopsy. We present the case with a brief review of the literatures.
자궁경부무력증 환자에서 임신전 실시한 복식 자궁경협부 원주봉합술의 예후
최중섭(JS Choi),박문일(MI Park),황정혜(JH Hwang),김승룡(SR Kim),김대운(DW Kim),양재혁(JH Yang),이재억(JA Lee),황윤영(YY Hwang) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.9
Objective : Our purpose was to evaluate the effect of transabdominal cervicoisthmic cerclage before pregnancy among the patients who had poor obstetric outcome from previous failed trans- vaginal cervical cerclage and/or an anatomically defective cervix. Study Design : A retrospective review of pre-conceptional transabdominal cervicoisthmic cerclage patients was conducted at Hanyang University Medical Center from 1989 to 1997, and analysis of the pregnancy outcomes after preconceptional transabdominal cervicoisthmic cerclage operation. Results : The fifteen patients had 11 successful pregnancy outcomes. Two patients had two consecutive succesful pregnancies and repeat cesarean section deliveries after TCIC. Conclusion : We conclude that the transabdominal cervicoisthmic cerclage before pregnancy offers a high rate of fetal salvage with a minimal complications in patients with extremely poor obstertric histories as a result of cervical incompetence, where vaginal cerclage is not warranted.