Association of SNP Haplotypes at the Myostatin Gene with Muscular Hypertrophy in Sheep

Gan, S.Q.,Du, Z.,Liu, S.R.,Yang, Y.L.,Shen, M.,Wang, X.H.,Yin, J.L.,Hu, X.X.,Fei, J.,Fan, J.J.,Wang, J.H.,He, Q.H.,Zhang, Y.S.,Li, N. Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.7

The myostatin gene of seven important meat (Beltex (Australia), Beltex$\times$Huyang (F1), Meat and Multi-Prolific Chinese Merino Fine Wool, Meat Chinese Merino Fine Wool and Dorper (South Africa)) and non-meat (Huyang and Kazak) sheep breeds was analyzed to study the genetic basis of muscular hypertrophy (double muscling) phenotype in sheep. SNPs, four in regulatory regions and several in the introns in the myostatin gene, were identified, and the former four SNPs were used for further studies. Twelve haplotypes were predicted by PHASE program, of which four main haplotypes (1, 3, 7, 9) were present in 90% of the 364 sheep in the study. Haplotypes 1-4 were mainly present in meat breeds while haplotypes 7 and 9 dominated the non-meat breeds. The association between haplotypes and average daily gain (ADG) was analyzed among 116 sheep with production data, Haplo2 (CGAA) and Haplo8 (TGAA) were identified to have significant (p<0.05) effect on ADG by the model (JMP5.1 software) taking into account the effects of breed, family background, haplotype, birth weight and sex. ADG of these haplotype groups also correlated well (r = 0.82) with hypertrophic phenotype scores. In conclusion, the mutations -956 (T$\rightarrow$C), -41 (C$\rightarrow$A) and 6223 (G$\rightarrow$A) involved in Haplo2 and 8 may be associated with the double-muscling trait by influencing myostatin function and be suitable markers in selecting meat sheep.

A switched-system approach to formation control and heading consensus for multi-robot systems

Jin, J.,Ramirez, J. P.,Wee, S.,Lee, D.,Kim, Y.,Gans, N. SPRINGER SCIENCE + BUSINESS MEDIA 2018 Intelligent service robotics Vol.11 No.2

<P>This paper proposes a novel, hybrid and decentralized, switched-system approach for formation and heading consensus control of mobile robots under switching communication topology, including collision avoidance capability. The set of robots consists of nonholonomic wheeled mobile robots and can include a teleoperated UAV. The key feature of this approach is a virtual graph, which is derived by adding a set of relative translation vectors to the real graph of the multiple robots. Our approach results in the robots in the real graph moving to the desired formation and achieving heading consensus while the virtual robots on the virtual graph reach pose consensus. If any robot detects a nearby obstacle or other robot, the robot will temporarily move along an avoidance vector, which is perpendicular and positively projected onto the attractive vector, such that collision is avoided while minimally deviating from its formation control path. Experimental results are provided by two different research groups to demonstrate the effectiveness of our approach. These experiments extend the theoretical development by introducing a teleoperated quadrotor as a leader robot of the multi-robot systems. The same control law works for the extended system, with no modifications.</P>

Erratum: Cis-regulatory architecture of a brain signaling center predates the origin of chordates

Yao, Yao,Minor, Paul J,Zhao, Ying-Tao,Jeong, Yongsu,Pani, Ariel M,King, Anna N,Symmons, Orsolya,Gan, Lin,Cardoso, Wellington V,Spitz, Franç,ois,Lowe, Christopher J,Epstein, Douglas J Nature Publishing Group, a division of Macmillan P 2016 Nature genetics Vol.48 No.8

IRRADIATION PERFORMANCE OF U-Mo MONOLITHIC FUEL

Meyer, M.K.,Gan, J.,Jue, J.F.,Keiser, D.D.,Perez, E.,Robinson, A.,Wachs, D.M.,Woolstenhulme, N.,Hofman, G.L.,Kim, Y.S. Korean Nuclear Society 2014 Nuclear Engineering and Technology Vol.46 No.2

High-performance research reactors require fuel that operates at high specific power to high fission density, but at relatively low temperatures. Research reactor fuels are designed for efficient heat rejection, and are composed of assemblies of thin-plates clad in aluminum alloy. The development of low-enriched fuels to replace high-enriched fuels for these reactors requires a substantially increased uranium density in the fuel to offset the decrease in enrichment. Very few fuel phases have been identified that have the required combination of very-high uranium density and stable fuel behavior at high burnup. U-Mo alloys represent the best known tradeoff in these properties. Testing of aluminum matrix U-Mo aluminum matrix dispersion fuel revealed a pattern of breakaway swelling behavior at intermediate burnup, related to the formation of a molybdenum stabilized high aluminum intermetallic phase that forms during irradiation. In the case of monolithic fuel, this issue was addressed by eliminating, as much as possible, the interfacial area between U-Mo and aluminum. Based on scoping irradiation test data, a fuel plate system composed of solid U-10Mo fuel meat, a zirconium diffusion barrier, and Al6061 cladding was selected for development. Developmental testing of this fuel system indicates that it meets core criteria for fuel qualification, including stable and predictable swelling behavior, mechanical integrity to high burnup, and geometric stability. In addition, the fuel exhibits robust behavior during power-cooling mismatch events under irradiation at high power.

Irradiation Performance of U-Mo Monolithic Fuel

M.K. Meyer,J.GAN,D.D. KEISER,E. PEREZ,A. ROBINSON,D.M. WACHS,N. WOOLSTENHULME,G.L. Hofman,Y. S. Kim 한국원자력학회 2014 Nuclear Engineering and Technology Vol.46 No.2

High-performance research reactors require fuel that operates at high specific power to high fission density, but atrelatively low temperatures. Research reactor fuels are designed for efficient heat rejection, and are composed of assemblies ofthin-plates clad in aluminum alloy. The development of low-enriched fuels to replace high-enriched fuels for these reactorsrequires a substantially increased uranium density in the fuel to offset the decrease in enrichment. Very few fuel phases havebeen identified that have the required combination of very-high uranium density and stable fuel behavior at high burnup. UMoalloys represent the best known tradeoff in these properties. Testing of aluminum matrix U-Mo aluminum matrixdispersion fuel revealed a pattern of breakaway swelling behavior at intermediate burnup, related to the formation of amolybdenum stabilized high aluminum intermetallic phase that forms during irradiation. In the case of monolithic fuel, thisissue was addressed by eliminating, as much as possible, the interfacial area between U-Mo and aluminum. Based on scopingirradiation test data, a fuel plate system composed of solid U-10Mo fuel meat, a zirconium diffusion barrier, and Al6061cladding was selected for development. Developmental testing of this fuel system indicates that it meets core criteria for fuelqualification, including stable and predictable swelling behavior, mechanical integrity to high burnup, and geometric stability. In addition, the fuel exhibits robust behavior during power-cooling mismatch events under irradiation at high power

A New Chemiluminescence Method for Determination of Cytosine Arabinoside in Pharmaceutical Preparations

Cai, Z.,Zhang, X.,Lu, D.F.,Gan, J.N. Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.1

A novel chemiluminescence (CL) system was established for the determination of cytosine arabinoside (Ara-C) in pharmaceutical preparations. It was showed that a clear CL signal was observed when Eosin Y mixed with Fenton reagent. The CL intensity was decreased significantly when Ara-C was added to the reaction system and partially scavenged the hydroxyl radicals in the solution. The extent of decrease in the CL intensity had a good stoichiometrical relationship with the Ara-C concentration. Based on this, we developed a new method for the determination of Ara-C using a flow injection analysis (FIA) technique with CL detection. Under the optimal conditions, the linear range of Ara-C concentration was $6.0{\times}10^{-9}\sim1.0{\times}10^{-7}mol/L$ (R = 0.9982) with a detection limit of $7.6{\times}10^{-10}mol/L$ (S/N=3), the RSD was 5.6% for $6.0{\times}10^{-8}mol/L$ Ara-C (n = 11). The method was successfully applied to the determination of Ara-C in injection samples. The possible chemiluminescence reaction mechanism was discussed.

A New Chemiluminescence Method for Determination of Cytosine Arabinoside in Pharmaceutical Preparations

Z. Cai,X. Zhang,D. F. Lu,J. N. Gan 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.1

A novel chemiluminescence (CL) system was established for the determination of cytosine arabinoside (Ara-C) in pharmaceutical preparations. It was showed that a clear CL signal was observed when Eosin Y mixed with Fenton reagent. The CL intensity was decreased significantly when Ara-C was added to the reaction system and partially scavenged the hydroxyl radicals in the solution. The extent of decrease in the CL intensity had a good stoichiometrical relationship with the Ara-C concentration. Based on this, we developed a new method for the determination of Ara-C using a flow injection analysis (FIA) technique with CL detection. Under the optimal conditions, the linear range of Ara-C concentration was 6.0 × 10−9 ~ 1.0 × 10−7 mol/L (R = 0.9982) with a detection limit of 7.6 × 10−10 mol/L (S/N=3) , the RSD was 5.6% for 6.0 × 10−8 mol/L Ara-C (n = 11). The method was successfully applied to the determination of Ara-C in injection samples. The possible chemiluminescence reaction mechanism was discussed.

Effects of the Zr concentration on transparent Y2O3 ceramics fabricated by vacuum pre-sintering and a subsequent HIP treatment

Zhu, L. L.,Park, Y. J.,Gan, L.,Go, S. I.,Kim, H. N.,Kim, J. M.,Ko, J. W. Chapman and Hall 2017 Journal of materials science Materials in electron Vol. No.

<P>Highly transparent Y2O3 ceramics doped with different Zr concentrations were successfully fabricated by vacuum pre-sintering at temperatures ranging from 1600 to 1800 degrees C combined with a subsequent hot-isostatic pressing (HIP) treatment using commercial powders as the starting materials. All of the 1 mol% Zr-doped Y2O3 ceramics exhibit very good optical quality. The sample with the highest transparency level was realized by vacuum sintering at 1650 degrees C for 4 h followed by a post-HIP treatment at 1450 degrees C lasting 5 h. It has a fine microstructure and the grain size is 1.48 mu m. Furthermore, the in-line transmittance reaches 83.3% at 1100 nm (1.2 mm thickness). It was found that a relatively low vacuum sintering temperature (1650 degrees C) and relatively low Zr doping concentration (1 mol%) are more appropriate to achieve optimally transparent Y2O3 ceramics with a subsequent HIP treatment.</P>