Prediction of cancer prognosis with the genetic basis of transcriptional variations

Paik, Hyojung,Lee, Eunjung,Park, Inho,Kim, Junho,Lee, Doheon Elsevier 2011 Genomics Vol.97 No.6

<P><B>Abstract</B></P><P>Phenotypes of diseases, including prognosis, are likely to have complex etiologies and be derived from interactive mechanisms, including genetic and protein interactions. Many computational methods have been used to predict survival outcomes without explicitly identifying interactive effects, such as the genetic basis for transcriptional variations. We have therefore proposed a classification method based on the interaction between genotype and transcriptional <U>e</U>xpression <U>f</U>eatures (CORE-F). This method considers the overall “genetic architecture,” referring to genetically based transcriptional alterations that influence prognosis.</P><P>In comparing the performance of CORE-F with the ensemble tree, the best-performing method predicting patient survival, we found that CORE-F outperformed the ensemble tree (mean AUC, 0.85 vs. 0.72). Moreover, the trained associations in the CORE-F successfully identified the genetic mechanisms underlying survival outcomes at the interaction-network level. Details of the learning algorithm are available in the online supplementary materials located at http://www.biosoft.kaist.ac.kr/coref.</P> <P><B>Research highlights</B></P><P>► The classification of disease survival outcomes using genetic architecture model. ► Class labeling of survival times for predicting prognosis by individual survival time. ► Suggest genetic model for phenotype variation via training of genetic interactions. ► Higher performance comparing previous tree-based approach.</P>

주요우울증 환자의 TRH 검사 반응과 신체 증상관의 관계

백인호,이규환,어경선 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.4

Objects: This study was dwsigned for the wvaluation of the association between the TRH stimulation test response and somatic symptoms in the patients with major depression. Methods: The subjects were consisted of 26 depressed patients. They received a TRH stimulation test. Their alexithymic trend were assessed with SSPS and their subjective wymptoms were assessed with SAS and SDS at least 1 week before the test. The frequency of their somatic symptoms were evaluated through interview using the symptom list in the somatization disorder in DSM-Ⅲ-R. The subjects were divided into the blunted response group and the non-blunted response group according to the response of TRH stimulation test and the frequency of their somatic symptoms, alexithymic trend and subjective symptoms were compared between the two groups. Results: 1)There were no significant difference of sex, age and the score of current GAF(global assessment of functioning) between the blunted response group and the non-blunted response group. 2)The score of SSPS was significantly higher in the blunted response group than that in the non-blunted response group statistically(P=0.035). There were no significant difference in two self-report scales. 3)Abdominal discomforts(P=0.039) and back pain(P=0.019) were significantly higher in the blunted response group than those in the non-blunted response group. Conclusion: These results suggested that alexithymic trend, especially the score of SSPS. and some somatic symptoms such as abdominal discomforts and back pain may influence the results of TRH stimulation test in depressed patients.

Pan-Tilt-Zoom 카메라를 이용한 파노라마 배경 생성과 객체 추적

백인호(Inho Paek),임재현(Jaehyun Im),박경주(Kyoungju Park),백준기(Junki Paik) 대한전자공학회 2008 電子工學會論文誌-SP (Signal processing) Vol.45 No.3

본 논문은 전 방향을 감시할 수 있는 Pan-Tilt-Zoom(PTZ) 카메라를 이용한 파노라마 배경 생성과 객체 추적 방법을 제안한다. 제안된 방법은 연속되는 두 영상의 외곽 영역에서 미리 정한 지역만 위상정합(phase correlation)을 하여 카메라의 지역 움직임을 빠르게 추정하고 벡터 양자화를 통하여 움직임 추정 오차를 최소화 한다. 추정된 움직임 값을 이용하여 겹침 영역이 존재하는 영상들을 획득하여 실린더에 투영시키고 영상을 재 정렬함으로써 파노라마 배경 영상을 생성할 수 있다. 객체 추적은 미리 생성된 파노라마 배경과 입력 영상의 차분 방법을 이용하여 배경과 객체를 분리하고 객체의 움직임을 추적한다. 제안된 객체 추적 방법은 PTZ 카메라를 이용하여 빠르고 안정적인 배경 생성이 가능하고, 전방향의 객체를 지속적으로 추적하는 것이 가능하다. 제안된 방법은 실시간 처리가 가능하며 넓은 감시 지역에서 객체의 형태를 추적하거나 얼굴인식과 같은 분야에서 이용될 수 있을 것이다. This paper presents a panorama background generation and object tracking technique using a Pan-Tilt-Zoom camera. The proposed method estimates local motion vectors rapidly using phase correlation matching at the prespecified multiple local regions, and it makes minimized estimation error by vector quantization. We obtain the required image patches, by estimating the overlapped region using local motion vectors, we can then project the images to cylinder and realign the images to make the panoramic image. The object tracking is performed by extracting object’s motion and by separating foreground from input image using background subtraction. The proposed PTZ-based object tracking method can efficiently generated a stable panorama background, which covers up to 360 degree FOV. The proposed algorithm is designed for real-time implementation and it can be applied to many commercial applications such as object shape detection and face recognition in various surveillance video systems.

Active Shape Model-Based Multiple Tracking with Improved Occlusion Handling

Jaehyun Im,Inho Paek,Joonki Paik 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7

Multiple objects tracking in multiple viewing directions gains more attention in many application areas. However if two objects come closer to each other, they are regarded as a single, combined object. To solve this problem, active shape model (ASM) can track a target object occluded with others. In this paper, we present an ASM-based multi-view tracking (AMT) algorithm, for tracking occluded objects.

암환자의 정신과 자문에 대한 임상적 고찰 : 예비적 연구(1) Preliminary Study(1)

이철,신경희,백인호 가톨릭 중앙의료원 가톨릭 암센터 1988 가톨릭 암센터 論集 Vol.2 No.2

인공감성지능 자극을 통한 내적 이미지 표출 시스템

최문찬(Moonchan Choi),백인호(Inho Paik),백준기(Joonki Paik),김형기(Hyunggi Kim) 중앙대학교 문화콘텐츠기술연구원 2006 다문화콘텐츠연구 Vol.2 No.-

본 연구의 최종 목적은 인간의 마음을 움직일 수 있는 감각자극 즉, 내적 이미지와 연결된 시각과 청각에 관한 자극과 그것을 표출해 내는 시스템 구현에 관한 연구이다. 사용자가 이 시스템 앞에 서서 작동을 주도 하는 동안 시스템은 사용자의 성격과 취향에 대한 데이터베이스와 동기화된 시, 청각적 이미지들로 마음을 움직이거나, 사용자가 원하는 어떤 행동을 유발할 수 있는 정신작용의 과정에 관여하는 것들을 불러 일으킬 수 있다. 인간은 감각, 감정, 정서, 욕구 등에 관한 종합적인 개념인 감성, 그리고 판단과 식별능력인 이성을 통해 외부의 세계로부터의 자극을 분석, 종합, 개념화, 추상화 하재 된다. [1] 이와 같은 정신작용 속에 일어나는 상기, 상상, 사고 등의 심상작용을 촉진 시키거나 관여하여 의도된 심상작용을 유도할 수 있는 감각 자극이 개입 된다면, 인간의 마음을 움직이는 일에 대한 항해의 키를 잡을 수 있다고 본다. The final goal of this study is realization of the system which can move human's mind. In other words, it can express stimulate about light sense and auditory sense linking the mental images of human being. While user lead system to be operated in front of this system, it makes emotions to move by synchronized light sense and auditory sense images and database about user's character and liking, or arouse which is relative to mental process derived some behavior which use's wants. Human can analyze, synthesize, generalize and abstract stimulate from general phenomena through the reason which is judgment and distinguish ability and general idea of synthesize like sense, feeling, emotion, desire. If sense stimulation that can promote mental image action of remembrance that happen within such mentality, imagination, thinking etc. or motive intended mental image action because being concerned is intervened, see that can catch key of sailing about work that move human's mind.

Development of a Semi-quantitative Food Frequency Questionnaire Based on Dietary Data from the Korea National Health and Nutrition Examination Survey

Younjhin Ahn,Ji Eun Lee,Hee Young Paik,Hong Kyu Lee,Inho Jo,Kuchan Kimm 한국영양학회 2003 Nutritional Sciences Vol.6 No.3

철도교량 설계하중조합의 통계적 안전율 분석

정주승(Juseung Jeong),김희성(Heeseong Kim),여인호(Inho Yeo),백인열(Inyeol Paik) 한국철도학회 2018 한국철도학회논문집 Vol.21 No.7

고속철도 WIM 데이터에 대한 통계분석을 통한 철도교량 설계활하중 분석

박수민,여인호,백인열,Park, Sumin,Yeo, Inho,Paik, Inyeol 한국전산구조공학회 2015 한국전산구조공학회논문집 Vol.28 No.6

이 논문에서는 고속철도교량 설계를 위한 활하중 모델을 통계 및 확률적 방법으로 검토하고, 하중조합의 하중계수가 주는 안전율을 분석하였다. 이 연구는 철도교량 설계기준에 대한 한계상태설계법 개발의 일환이며, 이를 위하여 경부고속철도를 운행하는 열차를 대상으로 약 한달 동안 실측하여 데이터를 수집하고 분석하였다. 이 데이터를 대상으로 교량의 설계수명에 맞도록 4가지 통계 방법들을 적용하여 설계하중을 추정하여 비교 검토하였다. 또한, 철도교량의 설계하중조합이 주는 안전율을 검토하기 위하여 신뢰도지수를 구하고 이를 분석하였다. 실측 데이터로부터 추정한 활하중효과에 대하여, 현행 고속철도 설계활하중인 표준열차하중의 0.75배를 적용한 설계활하중 효과의 크기가 최소 30~22% 더 크게 나왔다. 신뢰도분석을 통하여, 극한한계상태만을 기준으로 본다면, 추가적인 하중계수 감소의 가능성이 있음을 알 수 있다. In this paper, the live load model for the design of high-speed railway bridge is analyzed by statistic and probabilistic methods and the safety level that is given by the load factors of the load combination is analyzed. This study is a part of the development of the limit state design method for the railway bridge, and the train data collected from the Gyeongbu high-speed railway for about one month are utilized. The four different statistical methods are applied to estimate the design load to match the bridge design life and the results are compared. In order to examine the safety level that the design load combination of the railway bridge gives, the reliability indexes are determined and the results are analyzed. The load effect from the current design live load for the high-speed rail bridge which is 0.75 times of the standard train load is came out greater than at least 30-22% that from the estimated load from the measured data. If it is judged based on the ultimate limit state, there is a possibility of additional reduction of the safety factors through the reliability analysis.

The Serotonin Transporter Gene Polymorphism may not be Associated with Antipsychotic Treatment Response in Patients with Schizophrenia

ChiUn Pae,TaeSuk Kim,JungJin Kim,ChangUk Lee,SooJung Lee,Chul Lee,InHo Paik 대한신경정신의학회 2005 PSYCHIATRY INVESTIGATION Vol.2 No.2

This study investigated the influence of the polymorphism of the serotonin transporter gene (SLC6A4, a 44 base pair insertion/deletion in the promoter region, 5- HTTLPR) on the development of schizophrenia, as well as its effect on the symptomatology, family history, age of onset and the antipsychotic treatment response. Genomic DNA analysis with polymerase chain reaction was used for the genotyping. One hundred and fifty-two patients with schizophrenia and 152 normal controls participated in the study. Any associations between the 5-HTTLPR polymorphism and schizophrenia were not found. However, marginal association between the subjects with the 5-HTTLPR s allele (ss plus sl) and the presence of a family history of schizophrenia was found (p=0.026). This study suggests that the 5-HTTLPR polymorphism does not significantly contribute to the susceptibility to schizophrenia, and it is not associated with such clinical variables as the antipsychotic treatment response and the psychopathologica features, except for the family history of disease, at least in the Korean population.