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A Short History of the Genome-Wide Association Study: Where We Were and Where We Are Going
Ikegawa, Shiro Korea Genome Organization 2012 Genomics & informatics Vol.10 No.4
Recent rapid advances in genetic research are ushering us into the genome sequence era, where an individual's genome information is utilized for clinical practice. The most spectacular results of the human genome study have been provided by genome-wide association studies (GWASs). This is a review of the history of GWASs as related to my work. Further efforts are necessary to make full use of its potential power to medicine.
MRAM technology - Recent progress and issues
Sumio Ikegawa,Hiroaki Yoda,Shuichi Tahara 한국자기학회 2003 한국자기학회 학술연구발표회 논문개요집 Vol.13 No.1
The 1 Mbit MRAM without yoke wire and 1 kbit MRAM with the yoke wire, were successfully fabricated. Once the problems discussed in this paper are solved, MRAM will become a versatile memory applicable to both commodity and embedded memory.
Genetics of Ossification of the Posterior Longitudinal Ligament of the Spine: A Mini Review
Shiro Ikegawa 대한골대사학회 2014 대한골대사학회지 Vol.21 No.2
Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common dis-ease in aging populations and sometimes results in serious neurological problems dueto compression of the spinal cord and nerve roots. OPLL is a multi-factorial (polygenic)disease controlled by genetic and environmental factors. Studies searching for the ge-netic component of OPLL, using linkage and association analyses, are in progress andseveral susceptibility genes have been reported. This paper reviews the recent progressin the genetic study of OPLL and comments on its future task.
A Short History of the Genome-Wide Association Study: Where We Were and Where We Are Going
Shiro Ikegawa 한국유전체학회 2012 Genomics & informatics Vol.10 No.4
Recent rapid advances in genetic research are ushering us into the genome sequence era, where an individual’s genome information is utilized for clinical practice. The most spectacular results of the human genome study have been provided by genome-wide association studies (GWASs). This is a review of the history of GWASs as related to my work. Further efforts are necessary to make full use of its potential power to medicine.
Replication of Caucasian Loci Associated with Osteoporosis-related Traits in East Asians
김범준,안성희,김현목,Shiro Ikegawa,Tie-Lin Yang,Yan Guo,Hong-Wen Deng,고정민,이승훈 대한골대사학회 2016 대한골대사학회지 Vol.23 No.4
Background: Most reported genome-wide association studies (GWAS) seeking to identify the loci of osteoporosis-related traits have involved Caucasian populations. We aimed to identify the single nucleotide polymorphisms (SNPs) of osteoporosis-related traits among East Asian populations from the bone mineral density (BMD)-related loci of an earlier GWAS meta-analysis. Methods: A total of 95 SNPs, identified at the discovery stage of the largest GWAS meta-analysis of BMD, were tested to determine associations with osteoporosis-related traits (BMD, osteoporosis, or fracture) in Korean subjects (n=1,269). The identified SNPs of osteoporosis-related traits in Korean subjects were included in the replication analysis using Chinese (n=2,327) and Japanese (n=768) cohorts. Results: A total of 17 SNPs were associated with low BMD in Korean subjects. Specifically, 9, 6, 9, and 5 SNPs were associated with the presence of osteoporosis, non-vertebral fractures, vertebral fractures, and any fracture, respectively. Collectively, 35 of the 95 SNPs (36.8%) were associated with one or more osteoporosis-related trait in Korean subjects. Of the 35 SNPs, 19 SNPs (54.3%) were also associated with one or more osteoporosis-related traits in East Asian populations. Twelve SNPs were associated with low BMD in the Chinese and Japanese cohorts. Specifically, 3, 4, and 2 SNPs were associated with the presence of hip fractures, vertebral fractures, and any fracture, respectively. Conclusions: Our results identified the common SNPs of osteoporosis-related traits in both Caucasian and East Asian populations. These SNPs should be further investigated to assess whether they are true genetic markers of osteoporosis.
Arata Sakai,Hideyuki Shiomi,Takao Iemoto,Ryota Nakano,Takuya Ikegawa,Takashi Kobayashi,Atsuhiro Masuda,Yuzo Kodama 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.4
In this study, we assessed a series of our cases in which endoscopic self-expandable metal stents (SEMSs) were used to treat malignantafferent loop obstruction (ALO) that arose after pancreaticoduodenectomy (PD). We retrospectively examined the records of 7 patientswho underwent endoscopic SEMS placement for malignant ALO following PD. Clinical success was achieved in all cases. The medianprocedure time was 30 min (range, 15–50 min). There were no cases of stent occlusion, and no procedure-related adverse events wereencountered. All patients died of their primary disease, and the median overall survival period was 155 days (range, 96–374 days). Are-intervention involving endoscopic ultrasound-guided hepaticogastrostomy combined with antegrade stenting was performed forobstructive jaundice and acute cholangitis in 1 case. In conclusion, endoscopic SEMS placement may be an effective and safe treatmentfor malignant ALO that arises after PD.
Meta-analysis identifies a <i>MECOM</i> gene as a novel predisposing factor of osteoporotic fracture
Hwang, Joo-Yeon,Lee, Seung Hun,Go, Min Jin,Kim, Beom-Jun,Kou, Ikuyo,Ikegawa, Shiro,Guo, Yan,Deng, Hong-Wen,Raychaudhuri, Soumya,Kim, Young Jin,Oh, Ji Hee,Kim, Youngdoe,Moon, Sanghoon,Kim, Dong-Joon,Ko BMJ Publishing Group Ltd 2013 Journal of medical genetics Vol.50 No.4
<P><B>Background</B></P><P>Osteoporotic fracture (OF) as a clinical endpoint is a major complication of osteoporosis. To screen for OF susceptibility genes, we performed a genome-wide association study and carried out de novo replication analysis of an East Asian population.</P><P><B>Methods</B></P><P>Association was tested using a logistic regression analysis. A meta-analysis was performed on the combined results using effect size and standard errors estimated for each study.</P><P><B>Results</B></P><P>In a combined meta-analysis of a discovery cohort (288 cases and 1139 controls), three hospital based sets in replication stage I (462 cases and 1745 controls), and an independent ethnic group in replication stage II (369 cases and 560 for controls), we identified a new locus associated with OF (<I>rs784288</I> in the <I>MECOM</I> gene) that showed genome-wide significance (p=3.59×10<SUP>−8</SUP>; OR 1.39). RNA interference revealed that a <I>MECOM</I> knockdown suppresses osteoclastogenesis.</P><P><B>Conclusions</B></P><P>Our findings provide new insights into the genetic architecture underlying OF in East Asians.</P>