Prevalence of Chronic Nonspecific Low Back Pain and Its Associated Factors among Middle-Aged and Elderly People: An Analysis Based on Data from a Musculoskeletal Examination in Japan

Yoichi Iizuka,Haku Iizuka,Tokue Mieda,Daisuke Tsunoda,Tsuyoshi Sasaki,Tsuyoshi Tajika,Atsushi Yamamoto,Kenji Takagishi 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.6

Study Design: A cross-sectional study. Purpose: To clarify the prevalence of chronic nonspecific low back pain (CNSLBP) and its associated factors among middle-aged and elderly Japanese individuals using data from a musculoskeletal examination conducted in general Japanese populations. Overview of Literature: Most studies evaluating low back pain-associated factors have been conducted in Western countries, but they have not always evaluated CNSLBP. Methods: We obtained data on 213 subjects aged >50 years who responded to a survey regarding age, gender, body mass index, lifestyle-related diseases (diabetes mellitus, hypertension, and hyperlipidemia), glucocorticoid use, smoking and alcohol-drinking habits, labor intensity, and chronic low back pain (CLBP) and underwent screening for lumbar spinal stenosis, evaluation for quality of life (QOL), and evaluation for specific spinal pathology via thoracolumbar spine X-rays. We investigated the prevalence of CNSLBP and association between CNSLBP and measured variables. Results: The prevalence of CNSLBP and chronic specific low back pain (CSLBP) was 15.4% and 9.3%, respectively. Among the subjects with CLBP, 62.2% had CNSLBP. In age-adjusted logistic models, smoking habits (p =0.049, odds ratio [OR]=2.594), low back pain (p <0.001, OR=0.974), lumbar function (p =0.001, OR=0.967), and social function (p =0.023, OR=0.976) in the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) were significantly associated with CNSLBP, whereas EQ-5D utility score (p =0.024, OR=0.068), low back pain (p =0.007, OR=0.981), lumbar function (p =0.001, OR=0.963), walking ability (p =0.001, OR=0.968), and social function (p =0.002, OR=0.966) in JOABPEQ were significantly associated with CSLBP. Conclusions: CNSLBP among middle-aged and elderly individuals was associated with smoking habits and decreased QOL; however, CSLBP was considered to be more multilaterally associated decreased QOL.

Protective mechanism of agmatine pretreatment on RGC-5 cells injured by oxidative stress.

Iizuka, Y,Hong, S,Kim, C Y,Yang, W I,Lee, J E,Seong, G J Associação Brasielera de Divulga&cce 2010 Brazilian journal of medical and biological resear Vol.43 No.4

<P>Agmatine has neuroprotective effects on retinal ganglion cells (RGCs) as well as cortical and spinal neurons. It protects RGCs from oxidative stress even when it is not present at the time of injury. As agmatine has high affinity for various cellular receptors, we assessed protective mechanisms of agmatine using transformed RGCs (RGC-5 cell line). Differentiated RGC-5 cells were pretreated with 100 muM agmatine and consecutively exposed to 1.0 mM hydrogen peroxide (H2O2). Cell viability was determined by measuring lactate dehydrogenase (LDH), and the effects of selective alpha 2-adrenergic receptor antagonist yohimbine (0-500 nM) and N-methyl-D-aspartic acid (NMDA) receptor agonist NMDA (0-100 microM) were evaluated. Agmatine's protective effect was compared to a selective NMDA receptor antagonist MK-801. After a 16-h exposure to H2O2, the LDH assay showed cell loss greater than 50%, which was reduced to about 30% when agmatine was pretreated before injury. Yohimbine almost completely inhibited agmatine's protective effect, but NMDA did not. In addition, MK-801 (0-100 microM) did not significantly attenuate the H2O2-induced cytotoxicity. Our results suggest that neuroprotective effects of agmatine on RGCs under oxidative stress may be mainly attributed to the alpha 2-adrenergic receptor signaling pathway.</P>

An experimental study for work environment design for the personal information handling in public space

Shigeyoshi Iizuka,Katsuhiko Ogawa 제어로봇시스템학회 2006 제어로봇시스템학회 국제학술대회 논문집 Vol.2006 No.10

CONSIDERATION ON DCT SIGN ONLY CORRELATION FOR IMAGE IDENTIFICATION

Ikue IIZUKA,Fitri Arnia,Masaaki FUJIYOSHI,Hitoshi KIYA 대한전자공학회 2006 ITC-CSCC :International Technical Conference on Ci Vol.2006 No.2

Header Stealing Transmission Scheme of CSMA / CA for High Data Rate Wireless Access Systems using OFDM

Masataka Iizuka,Hitoshi Takanashi,Masahiro Morikura 대한전자공학회 1998 대한전자공학회 심포지엄 논문집 Vol.3 No.-

Assessment of the Relationship between Pelvic Tilt and the Sacro-Femoral-Pubic Angle in Middle- Aged and Elderly Asian Individuals

Takanori Kitagawa,Yoichi Iizuka,Hiroki Kobayashi,Tokue Mieda,Daisuke Tsunoda,Atsushi Yamamoto,Tsuyoshi Tajika,Haku Iizuka,Kenji Takagishi 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.6

Study Design: Cross-sectional study. Purpose: The purpose of this study was to evaluate the correlation between pelvic tilt (PT) and the sacro-femoral-pubic (SFP) angle, which is easier to identify than PT, in middle-aged and elderly Asian subjects from the general population. Overview of Literature: Measuring PT is important in the diagnosis and treatment of adult spinal deformity. However, identifying femoral heads, which are necessary to determine PT, using sagittal radiographs is often difficult. Methods: Standing coronal and sagittal pelvic radiographs of individuals aged more than 50 years were taken during a local medical examination. The subjects were divided into female, male, and total groups at the time of evaluation. Linear regression analysis was performed to investigate the relationship between PT and the SFP angle, which were obtained from the X-rays. Results: The present study included 291 subjects. There were no statistically significant differences between the left and right SFP angles, and there was gender difference regarding the SFP angle. However, a gender difference was observed regarding PT. The correlation between PT and the SFP angle was substantiated in each group. Pearson’s correlation coefficients between PT and the SFP angle in the total, female, and male groups were 0.696, 0.853, and 0.619, respectively. In the linear regression analysis, PT was calculated as follows: PT=60.1−0.77×(SFP angle) in the total group, PT=62.8−0.80×(SFP angle) in the female group, and PT=51.5−0.64×(SFP angle) in the male group. Conclusions: A significant correlation between PT and the SFP angle was observed in middle-aged and elderly Asian subjects from the general population.

A matrix model for baryons and nuclear forces

Hashimoto, Koji,Iizuka, Norihiro,Yi, Piljin Springer-Verlag 2010 Journal of high energy physics Vol.2010 No.10

식물의 성홀몬 ( 2 ) : Cytokinins 및 핵산 관연 물질에 의한 포도속 수개체에서의 암생식기관의 유발 INDUCTION OF FEMALE SEXUAL ORGANS IN MALE VITIS FLOWERS BY CYTOKININS AND NUCLEIC ACID DERIVATIVES

하스즈메다께시,이이주까무네오 생화학분자생물학회 1974 BMB Reports Vol.4 No.2

Processes and boreal summer impacts of the 2004 El Niño Modoki: An AGCM study

Ashok, Karumuri,Iizuka, Satoshi,Rao, S. A.,Saji, N. H.,Lee, W.-J. American Geophysical Union 2009 Geophysical research letters Vol.36 No.4

Isolation of primary mouse retinal ganglion cells using immunopanning-magnetic separation

Hong, Samin,Iizuka, Yoko,Kim, Chan Yun,Seong, Gong Je Molecular Vision 2012 Molecular vision Vol.18 No.-

<P><B>Purpose</B></P><P>To establish an effective system for isolating primary retinal ganglion cells (RGCs) from newborn mice.</P><P><B>Methods</B></P><P>The retinas were separated from enucleated eyeballs of Crl:CD-1 mice on postnatal day 1 to 4. RGCs were purified using three different methods, including two-step immunopanning (TSI), direct magnetic separation (DMS), and immunopanning-magnetic separation (IMS). Harvested cells were maintained for 24 h in a defined medium and then examined with immunocytochemistry, western immunoblotting, and real-time reverse transcription polymerase chain reaction (RT-PCR) for glial cell–specific glial fibrillary acidic protein (GFAP) and amacrine cell-specific syntaxin 1.</P><P><B>Results</B></P><P>As determined with immunofluorescence staining, RGCs purified by TSI were sparsely mixed with GFAP-positive astrocytes, and RGCs isolated by DMS were frequently mixed with syntaxin 1-positive amacrine cells. However, RGCs collected by IMS were seldom contaminated by GFAP-positive or syntaxin 1-positive cells. On western immunoblots, TSI cells showed significant GFAP expression, and DMS cells showed apparent syntaxin 1 expression, but IMS cells did not. Results of the real-time RT–PCR showed a similar tendency to those of the immunocytochemistry and western immunoblots.</P><P><B>Conclusion</B></P><P>Primary mouse RGCs were highly purified by the IMS method, combining the benefits of the TSI and DMS methods. This isolation method may provide a good experimental system for studying glaucoma in vitro.</P>