http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Localization and persistence of hepatitis A virus in artificially contaminated oysters
Park, Hyunkyung,Jung, Soontag,Shin, Hansaem,Ha, Sang-Do,Park, Tae Jung,Park, Jong Pil,Seo, Dong Joo,Choi, Changsun Elsevier 2019 International journal of food microbiology Vol.299 No.-
<P><B>Abstract</B></P> <P>Bivalve molluscan shellfish, such as oysters, clams, and cockles, are well-recognized as vectors that concentrate foodborne pathogens by filter feeding. The objective of this study was to investigate the distribution and persistence of hepatitis A virus (HAV) in experimentally contaminated oysters that were either fed or not fed with algae. Oysters were experimentally contaminated with HAV and maintained in depuration conditions. qRT-PCR, immunohistochemistry (IHC), and <I>in situ</I> hybridization (ISH) were performed on oyster samples collected at 0, 1, 3, 5, and 7 days post-inoculation. When HAV-contaminated oysters were depurated for 7 days, HAV was detected in 91.1–97.8% of the digestive glands and gills. While the high viral load in the digestive glands in oysters did not change significantly regardless of algae-feeding, the viral load of the gills gradually decreased in both groups during the depuration. HAV antigen and RNA were detected in the digestive diverticula and connective tissues by both IHC and ISH. HAV was detected in the stomach, intestine, and gills by only ISH. The distribution of HAV in various oyster tissues may explain the persistence of contamination in oysters during the depuration process.</P> <P><B>Highlights</B></P> <P> <UL> <LI> High titer of HAV was accumulated in the digestive gland and gills of oysters. </LI> <LI> HAV capsid was localized in the hemocyte and digestive gland by immunohistochemistry. </LI> <LI> HAV RNA was visualized in the hemocytes and digestive gland by <I>in situ</I> hybridization. </LI> <LI> HAV was persistently detected in oysters for 7 days under depuration condition. </LI> </UL> </P>
Hyunkyung Park,Jeonghwan Youk,Seongcheol Cho,Ji Hyun Lee,Yeonjoo Choi,Youngil Koh 순천향대학교 순천향의학연구소 2015 Journal of Soonchunhyang Medical Science Vol.21 No.2
Catastrophic antiphospholipid syndrome (APS) is defined as a rare, life-threatening autoimmune disorder leading to multiorgan failure. Probable APS, with clinical manifestations similar to APS without antiphospholipid antibodies, was suggested to be seronegative catastrophic APS. The triggering factors of catastrophic APS are various, including infection, trauma, malignancy, and surgery. In approximately 40% of patients, catastrophic APS develops from an unknown cause. We report a case of seronegative catastrophic APS due to an unknown origin. A 20-year-old man presented with cough, abdominal pain, skin lesions, tunnel vision, and watery diarrhea without fever. His symptoms and laboratory test suggested disseminated intravascular coagulation. Considering seronegative catastrophic APS, we treated with intravenous steroid and intravenous immunoglobulin, but the effects were limited. After weekly treatment with rituximab, an immune-modulating agent, his laboratory findings including thrombocytopenia and coagulation tests, returned to normal. We conclude that rituximab can be an effective treatment for seronegative catastrophic APS.
Park, Hyunkyung,Lee, Yoo Jin,Shin, Sang-Jin,Lee, Jayoun,Park, Silvia,Kim, Inho,Moon, Joon-ho,Lee, Hyewon,Jang, Jun Ho,Yoon, Sung-Soo,Koh, Youngil Elsevier 2018 Leukemia research Vol.69 No.-
<P><B>Abstract</B></P> <P>A substantial proportion of patients requiring allogeneic stem cell transplantation (alloSCT) do not have a human leukocyte antigen-matched sibling donor and need an alternative donor. In this multicenter retrospective study, we compared the outcomes of 176 patients with myelodysplastic syndrome and acute leukemia undergoing alloSCT from haploidentical (<I>n</I> = 121) and international (<I>n</I> = 55) donors between 2002 and 2016. For recipients of haploidentical and international donors, the 2-year overall survival rates were 33.4% and 35.3%, respectively (<I>P</I> = 0.347), and relapse-free survival rates were 31.7% and 34.4% (<I>P</I> = 0.264), respectively. In addition, there were no significant differences in the cumulative incidences of acute and chronic graft versus host disease or incidences of infection within 30 days (all <I>P ></I> 0.05). Similarly, there were no significant differences in these measures for acute leukemia patients (<I>n</I> = 143; all <I>P ></I> 0.05). A multivariate analysis revealed that the donor type was not an independent prognostic or predictive factor. These data suggest that both haploidentical and international donors are feasible alternative sources for alloSCT when a matched donor is not available domestically.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Haploidentical and international donor recipients have similar survival rates. </LI> <LI> Transplant-related complications occur similarly with both donor types. </LI> <LI> Both donor types are alternatives if a matched donor is not available domestically. </LI> </UL> </P>
Development of high durability plasma filter for air circulating disinfection system
Park Joo Young,Baek Ki Ho,Kim Sang-jin,Choi Joon-Hwan,Yoon Hyunkyung,Park Hunkwan,Kim Giyeong,이승훈 한국물리학회 2022 Current Applied Physics Vol.41 No.-
Deadly diseases are caused by pathogenic bacteria and viruses that spread, among other means, through air circulating systems; hence, it is important to focus on pathogen removal from the air before circulating air through the system. Our paper introduces a novel plasma-based filter that, when used in an air circulating system with particulate air filter, disinfects the air flow. This device, based on dielectric filter discharge (DFD) structure with low pressure drops, indicates easy installation into existing air circulating system. Its performance was evaluated in accordance with the specifications of duct used in hospitals, with consistent O3 generation during 200 h showing high durability. Escherichia coli and Micrococcus luteus were used as the target airborne bacteria; the system exhibited a removal efficiency of approximately 99.99% on bacterial aerosols and continuous bactericidal action, demonstrating that the DFD system can be directly applied to existing air circulating systems.
Clinical features of vascular events in patients with al amyloidosis
( Hyunkyung Park ),( Ji-won Kim ),( Youngil Koh ),( Jeong-ok Lee ),( Ki Hwan Kim ),( Soo-mee Bang ),( Inho Kim ),( Seonyang Park ),( Sung-soo Yoon ) 대한내과학회 2015 대한내과학회 추계학술발표논문집 Vol.2015 No.1
Background and Aims: AL amyloidosis can cause various vascular events, which are mainly related to vascular amyloid deposition or thromboembolism. Despite their clinical importance, only few reports have been published on the manifestations of vascular events in these patients. Methods: We retrospective reviewed medical records of patients including various imaging study results such as angiography, Doppler sonography, computed tomography, and magnetic resonance imaging to find out clinically significant vascular stenosis and thromboembolism. Results: Between January 2001 and March 2014, 106 patients (male/female=60/46) with biopsy-proven AL amyloidosis were included from 3 hospitals. The median age was 58 years (range, 23-79 years). During a median follow-up of 12.6 months (range, 0.1-156.8 months), 13 events of thromboembolism developed in 13 patients: 10 patients (9.4%) experienced cerebral infarction, 2 patients (1.9%) pulmonary embolism and 1 patient (0.9%) deep vein thrombosis. Patients with higher free light chain difference suffered significantly more from vascular events than the others in multivariable analysis. (20.2% vs. 8.9%, p=0.022). The median overall survival (OS) from pathologic diagnosis was 20.9 months (95% CI, 5.7-36.2). In multivariable analysis, higher BM plasma cell percentage and higher serum B2 microglobulin levels were poor prognostic factors. (p<0.05) Conclusions: The incidence of vascular events was substantial in patients with AL amyloidosis. Vascular events significantly occurred in patients with higher free light chain difference. Poor prognostic factor for overall survival was higher serum beta-2 microglobulin.