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박정란,강진형,구효정,노지영,류형철,박상욱,고동현,조일환,이주영,황다니엘,김인경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2
Selective COX (cyclooxygenase)-2 inhibitors including celecoxib have been shown to induce apoptosis and cell cycle changes in various tumor cells. New inhibitors are recently being developed as chemomodulating agents. We evaluated celecoxib and screened 150 synthetic compounds for anti-proliferative activities in vitro. Effects of celecoxib on COX activity, cell growth, cell cycle distribution, and apoptosis induction were determined in A549 COX-2 overexpressing human non-small cell lung cancer (NSCLC) cells. The COX inhibition of celecoxib increased with concentration up to 82% at 1μM after 24 hr exposure. Forty μM and 50μM of celecoxib induce G_1 arrest, and TUNEL-positive apoptotic cells, respectively. Among 150 compounds, several compounds were selected for having greater COX-2 inhibitory activity and higher selectivity than celecoxib with growth inhibitory activity. Celecoxib showed concentration-dependent COX inhibitory activity, and ability to induce cell cycle arrest and apoptosis in human NSCLC cells in vitro. Among synthetic analogues screened, several compounds showed promising in vitro activity as COX-2 inhibitory anticancer agents, which warrant further evaluation in vitro and in vivo.
Study of Magnetomotive Force Control Type Superconducting Magnet Using BSCCO HTS Wire
Hyung-Wook Kim,Young-Sik Jo,Seog-Whan Kim,Rock-Kil Ko,Dong-Woo Ha,Ho Min Kim,Jin-Hong Joo,Hyung-Jin Kim,Seok-Beom Kim,Jin Hur Institute of Electrical and Electronics Engineers 2015 IEEE transactions on applied superconductivity Vol.25 No.3
<P>In this study, a method for controlling the magnetomotive force using the current bypass of no-insulation magnets was developed, and the characteristics of 1G high-temperature superconductivity (HTS) no-insulation magnets were elucidated through experiments. The experiments were performed using a magnet designed with bismuth strontium calcium copper oxide HTS wires. Film-type heaters were used to control the MMF. The analysis of the experimental results was carried out in conjunction with an analysis using finite elements method.</P>
지하매설 도시가스배관의 누출시나리오에 따른 사고피해영향분석
김진형(Jin Hyung Kim),고병석(Byung Seok Ko),양재모(Jae Mo Yang),고상욱(Sang-Wook Ko),고재욱(Jae Wook Ko) 한국가스학회 2014 한국가스학회지 Vol.18 No.3
인구가 밀집되어 있는 도심지역에 매설된 천연가스 공급배관은 외부 또는 내부 결함으로 인한 가스의 누출, 확산, 화재, 폭발로 발생되는 재산과 인명피해의 큰 잠재위험을 지니고 있다. 사고를 미연에 방지하기 위해 정량적 평가에 기초한 위험관리를 실시하고 있으며, 매설배관의 정량적 위험성을 평가하기 위해서는 우선적으로 사고피해영향 분석을 통한 화학물질의 누출량 계산, 확산 분석, 화재 및 폭발로 인한 복사열과 압력파 계산이 필요하다. 본 논문에서는 CCPS, TNO에서 제안하는 model 들을 통하여 실제 San Bruno 매설배관 폭발 사고 시나리오를 기반으로 천연가스의 누출량, Fireball의 복사열 계산을 수행하고 결과 값을 실제 피해결과와 비교분석 하였다. Buried natural gas pipelines in densely populated urban areas have serious hazards of property damages and casualties generated by release, dispersion, fire and explosion of gas caused by outside or inside failures. So as to prevent any accident in advance, managers implement danger management based on quantitative risk analysis. In order to evaluate quantitative risk about buried natural gas pipelines, we need calculation for radiant heat and pressure wave caused by calculation for release rate of chemical material, dispersion analysis, fire or explosion modeling through consequence analysis in priority, in this paper, we carry out calculation for release rate of pressured natural gas, radiant heat of fireball based in accident scenario of actual “San Bruno” buried high pressured pipelines through models which CCPS, TNO provide and compare with an actual damage result.
Ko, Kwang Il,Park, Kyoung Sook,Lee, Mi Jung,Doh, Fa Mee,Kim, Chan Ho,Koo, Hyang Mo,Oh, Hyung Jung,Park, Jung Tak,Han, Seung Hyeok,Kang, Shin-Wook,Yoo, Tae-Hyun S. Karger AG 2014 American journal of nephrology Vol.40 No.4
<P>Abstract</P><P><B><I>Background:</I></B> The aim of this study was to investigate the association between the dialysate MCP-1 (dMCP-1) and systemic inflammatory and nutritional markers in peritoneal dialysis (PD) patients. In addition, we examined the prognostic value of dMCP-1 on all-cause or cardiovascular mortality in these patients. <B><I>Methods:</I></B> We prospectively followed 169 prevalent PD patients from April 1st 2008 to December 31st 2012. At baseline, dMCP-1 and serum biochemical parameters including high sensitivity CRP (hs-CRP) and albumin were checked. All-cause mortality and cause of death were evaluated during the follow-up period. Based on the median level of dMCP-1, patients were classified as either low or high dMCP-1 groups. <B><I>Results:</I></B> Mean age, hs-CRP, and D/Pcr ratio at 4 h were significantly higher, while serum albumin levels and %lean body mass (LBM) were significantly lower in the high dMCP-1 group. During the mean follow-up period of 47.7 months, all-cause mortality and cardiovascular mortality rate were significantly higher in the high dMCP-1 group (9.6 and 6.3 per 100 person-years, respectively) compared to the low dMCP-1 group (5.1 and 3.1 per 100 person-years, respectively; p = 0.021, 0.038). In multivariate Cox analysis, high dMCP-1 was a significant independent predictor of all-cause mortality (hazard ratio: 1.83, 95% confidence interval: 1.03-3.24, p = 0.039). <B><I>Conclusions:</I></B> dMCP-1 levels are closely correlated with nutritional and systemic inflammatory markers in PD patients. In addition, increased dMCP-1 is significantly associated with higher all-cause and cardiovascular mortality. These findings suggest that local peritoneal inflammation could contribute to poor clinical outcomes in PD patients.</P><P>© 2014 S. Karger AG, Basel</P>
Development of Antimicrobial Edible Film from Defatted Soybean Meal Fermented by Bacillus subtilis
( Hyung Wook Kim ),( Kyung Mi Kim ),( Eun Jung Ko ),( Si Kyung Lee ),( Sang Do Ha ),( Kyung Bin Song ),( Sang Kyu Park ),( Ki Sung Kwon ),( Dong Ho Bae ) 한국미생물생명공학회 2004 Journal of microbiology and biotechnology Vol.14 No.6
Improvement in Stability and Operating Characteristics of HTS Coil Using MIT Material
Hyung-Wook Kim,Jin Hur,Seog-Whan Kim,Seok-Beom Kim,Rock-Kil Ko,Dong-Woo Ha,Ho Min Kim,Jin-Hong Joo,Young-Sik Jo Institute of Electrical and Electronics Engineers 2017 IEEE transactions on applied superconductivity Vol.27 No.4
<P>This paper proposes a new method of achieving electrical stability and controllability of a high-temperature superconductor (HTS) coil. The proposed method applied a material with a metal-insulator transition (MIT) property to the turn-to-turn resistance of an HTS coil. As a result, the turn-to-turn resistance remained at the insulator level in the normal state, thus removing delay during charging and discharging. During transient state, the turn-to-turn resistance dropped to the metal level, and current bypass occurs similar to that in a noinsulation coil, thus preventing the coil from burning out. The validity of the MIT characteristic and the proposed method were verified through experiments.</P>
Ko, Seung Hwan,Lee, Daeho,Kang, Hyun Wook,Nam, Koo Hyun,Yeo, Joon Yeob,Hong, Suk Joon,Grigoropoulos, Costas P.,Sung, Hyung Jin American Chemical Society 2011 Nano letters Vol.11 No.2
<P>In this paper, in order to increase the power conversion efficiency we demonstrated the selective growth of “nanoforest” composed of high density, long branched “treelike” multigeneration hierarchical ZnO nanowire photoanodes. The overall light-conversion efficiency of the branched ZnO nanowire DSSCs was almost 5 times higher than the efficiency of DSSCs constructed by upstanding ZnO nanowires. The efficiency increase is due to greatly enhanced surface area for higher dye loading and light harvesting, and also due to reduced charge recombination by providing direct conduction pathways along the crystalline ZnO “nanotree” multi generation branches. We performed a parametric study to determine optimum hierarchical ZnO nanowire photoanodes through the combination of both length-wise growth and branched growth processes. The novel selective hierarchical growth approach represents a low cost, all solution processed hydrothermal method that yields complex hierarchical ZnO nanowire photoanodes by utilizing a simple engineering of seed particles and capping polymer.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2011/nalefd.2011.11.issue-2/nl1037962/production/images/medium/nl-2010-037962_0002.gif'></P>
Ko Ye Eun,Kim Hyung Woo,Park Jung Tak,Han Seung Hyeok,Kang Shin-Wook,Sung Suah,이규백,Lee Joongyub,Oh Kook-Hwan,유태현 대한신장학회 2024 Kidney Research and Clinical Practice Vol.43 No.3
Background: Coronary artery calcification (CAC) is highly prevalent in patients with chronic kidney disease (CKD) and is associated with major adverse cardiovascular events and metabolic disturbances. The triglyceride-glucose index (TyGI), a novel surrogate marker of metabolic syndrome and insulin resistance, is associated with CAC in the general population and in patients with diabetes. This study investigated the association between the TyGI and CAC progression in patients with CKD, which is unknown. Methods: A total of 1,154 patients with CKD (grades 1–5; age, 52.8 ± 11.9 years; male, 688 [59.6%]) were enrolled from the KNOWCKD (KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease). The TyGI was calculated as follows: ln (fasting triglycerides × fasting glucose/2). Patients were classified into tertiles (low, intermediate, high) based on the TyGI. The primary outcome was annualized percentage change in CAC score [(percent change in CAC score + 1)12/follow-up months – 1] of ≥15%, defined as CAC progression. Results: During the 4-year follow-up, the percentage of patients with CAC progression increased across TyGI groups (28.6%, 37.5%, and 46.2% in low, intermediate, and high groups, respectively; p < 0.001). A high TyGI was associated with an increased risk of CAC progression (odds ratio [OR], 2.11; 95% confidence interval [CI], 1.14–3.88; p = 0.02) compared to the low group. Moreover, a 1-point increase in the TyGI was related to increased risk of CAC progression (OR, 1.55; 95% CI, 1.06–1.76; p = 0.02) after adjustment. Conclusion: A high TyGI may be a useful predictor of CAC progression in CKD.