3년내 크기 증가를 보인 위 신경초종 1예

김도현,박무인,유찬희,김규종,문원,박선자,장희경 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

저자들은 65세 남자 환자의 위 중부체부 대만부 전벽에 발생한 점막하 종양에 대하여 3년간 추적관찰 중 크기증가소견으로 쐐기 절재술을 시행하였으며, 조직검사 및 면역 조직 화학 검사에서 위 신경초종으로 진단한 1예를 경험하였기에 보고하는 바이다. Gastric schwannoma is a very rare gastrointestinal benign tumor, which represents only 0.2% of all gastric tumors and 4% of all benign gastric tumors. We report a case of gastric schwannoma with enlargement of size through serial endoscopic examination. Endoscopic examination showed a hard mass of 4 x 3 cm in size with normal overlying gastric mucosa on the great curvature of the mid-body of stomach. The pathological finding revealed a picture of spindle cell tumor. Immunohistochemical stain was strongly positive for S-100 protein and non-reactive for CD34, C-kit and smooth muscle actin, thus leading to the diagnosis of gastric schwannoma.

재발성 복부 통증을 호소한 환자에서 복벽에 발생한 자궁내막증 1예

홍현진,박성한,이준식,배용목,김지연,안광순,박선자 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1

Endometriosis is the abnormal growth of endometrial tissue outside the uterine cavity. Endometriosis in the abdominal scar following cesarean section is very rare condition among the extrapelvic endometriosis. The frequency of abdominal wall endometriosis secondary to cesarean section is from 0.03% to 0.8% in some reports. It is difficult to diagnosed in spite of the typical symptoms. The typical symptom is aching swelling in the area of the surgical scar, which is influenced by the phases of menstruation. The definitive diagnosis is established by pathologic analysis. Surgical excision remains the treatment of choice. The majority of patients presented from 1 to 2 years after the precipitating operation. We experienced an unusual case of abdominal wall endometriosis presented over 10 years after cesarean section, who was admitted to our hospital complaining of recurrent left lower abdominal pain. So, we report this case with a brief review of the concerned literatures.

시정 측정의 장비, 방법 및 대전지역 시정의 분석

소선섭,김시내,박수현 公州大學校 基礎科學硏究所 2003 自然科學硏究 Vol.10 No.-

본 논문은 대기 오염물질의 배출량이 많아지면서 대기의 혼탁도가 높아지고 이로 인해 시정이 악화됨을 규명하고자 하였다. 시정의 악화를 언급하기에 앞서 시정에 대해서 보다 명확하게 정의하였고, 대전지역의 시정 자료 값을 분석하여 대기의 오염이 얼마나 증가하였는가를 밝힘으로써 시정측정 장비 연구의 필요성을 강조하였다. In this Essay, we wished to examine closely that turbidity of air rised, visibility is worsened because the discharge amount of air contaminant increased. Before refer visibility for the worse, we defined more definitely about visibility, analyzed visibility value of DaeJon area, said how pollution of air increased, so emphasized necessity that we should have researched visibility monitoring method.

Staphylococcus aureus KN556를 이용한 ERIC-과 REP-PCR 반응 구성성분 농도의 최적화

서현아,김영준,김근성 中央大學校 遺傳工學硏究所 2002 遺傳工學硏究論集 Vol.15 No.1

본 실험은 Staphylococcus aureus KN556의 ERIC과 REP-PCR 산물의 fingerprinting pattern의 파악과 PCR 구성성분의 농도의 최적화를 목적으로 실시하였다. 실험결과 ERIC-PCR은 증폭된 단편수가 4∼10개 정도로 나타냈고, REP-PCR은 전체 단편수가 5∼14개를 나타내었다. 이러한 현상은 ERIC sequence에 비해 REP sequence가 세균의 염색체 상에 빈도가 더 높게 분포한다는 이론과 일치하였다. ERIC-PCR의 경우, 0.8과 1.2kb를 중심으로 작은 분자량과 큰 분자량의 범위로 점차적으로 확대되어 각 변수들의 농도의 증가에 따라 전체단편의 수와 단편들의 강도가 증가하였다. REP-PCR은 최소분자량 0.25kb에서 최대분자량 3.5kb 정도 크기의 증폭된 단편들이 각 농도에 따라 강도의 차이를 나타내며 증가되는 것이 관찰되었다. 각 성분변수별로 MgCl_2는 2.0mM, primer는 2.0μM, dNTPs는 200μM, DNA는 1.0㎕에서 각각 최대 단편수를 나타냈고, 그 이상의 농도 적용 시에도 동일한 단편의 수를 유지하였으며 각 성분농도 변수 PVR 결과 나타나는 DNA fingerprinting pattern이 동일하게 나타나서 결과적으로 PCR 성분별 최적농도는 MgCl_2는 2.0mM, primer는 2.0μM, dNTPs는 200μM, DNA는 1.0㎕로 결론 지을 수 있었다. We attempted to optimize the concentrations of PCR components such as MgCl_2, primers, dNTPs and template DNA to produce fingerprinting patterns of the ERIC- and REP-PCR products for Staphylococcus aureus KN556. The ERIC-PCR reactions resulted in a total number of 4 to 10 DNA fragments and the REP-PCR reactions a total number of 5 to 14 DNA fragments. These phenomena can be explained by the hypothesis that more copies of REP sequences are present on bacterial chromosomes than those of ERIC sequences are. ERIC-PCR reactions generated two major bands of 0.8kb and 1.2kb DNA fragments. They also had the number of PCR products and their band intensity increased as the concentrations of the above four PCR components were increased. REP-PCR reactions generated multiple PCR products between 0.25kb and 3.5kb in size including three major bands of 0.7kb and 0.95kb DNA fragments. Their band intensity was also increased as the concentrations of the above four PCR components were increased. The PCR reaction cocktails containing 2.0mM MgCl_2, 2.0μM primers, 200μM dNTPs and 1.0㎕ template DNA, respectively, yielded the maximum number of PCR products. As the above four components were added more than the concentrations mentioned above in PCR reaction cocktails, the number of PCR products was not increased and the overall fingerprinting patterns remained unchanged. Therefore, a PCR reaction cocktail containing 2.0mM MgCl_2, 2.0μM primers, 200μM dNTPs and 1.0㎕ template DNA can be suggested to generate the most optimized PCR fingerprinting patterns.

위 MALT 림프종에서 다발성 림프절 전이로 오인된 동시성 림프절 결핵 1예

김성은,김규종,김도현,송준영,문대성,장리라,유찬희,문원,박무인,박선자,김영옥 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

28세 남자가 내시경적 점막절제술을 통해 저등급 위MALT 림프종으로 진단되었다. 병기설정을 위해 18F-FDG PET 검사를 시행하였고 우측 쇄골상부, 우측상/하부 기관주위, AP window 부위에 강한 섭취가 관찰되어 전이성 림프절로 판단하였다. 그러나, 우측 쇄골상부 림프절에서 시행한 절제생검에서 만성육아종성염증소견이 관찰되었고 조직의 결핵 중합효소연쇄반응에서도 양성 반응을 보였다. 2개월간 항결핵제의 사용 후 시행한 추적 컴퓨터단층촬영 검사에서 림프절 크기의 감소를 보여 최종적으로 위 MALT 림프종에서 광범위 림프절 전이로 오인된 동시성 림프절 결핵으로 진단되었다. A 28-year-old man was diagnosed as gastric MALT lymphoma in diagnostic EMR (endoscopic mucosal resection). He subsequently underwent an 18F-FDG PET. 18F-FDG PET showed intense multifocal uptake in right supraclavicular, right upper and lower paratracheal, and AP window areas that was considered radiologically to represent widespread metastatic lymphadenopathy. Excisional biopsy of a supraclavicular lymph node, however, revealed chronic granulomatous lymphadenitis with a positive reaction of Tb-nested PCR. After antituberculosis treatment for 2 months, a follow-up CT scan showed complete resolution of the lesions. Intense 18F-FDG uptake could be due to an infectious process such as synchronous tuberculous lymphadenitis. Therefore, this could mimic a malignant condition such as lymphoma with extensive lymph node metastasis due to a false-positive finding, which may lead to a misdiagnosis.

축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.

Fly Ash를 이용한 흡수제의 SO_2/NO_x 동시제거

정종현,손병현,유경선,김현규,이형근 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.3

본 연구에서는 비산재를 첨가한 개량흡수제를 이용하여 황산화물과 질소산화물을 동시에 제거하기 위하여 고정층반응기 실험을 수행하였으며, 제조한 혼합흡수제는 SEM-EDX, ICP, BET, XRD 등을 이용하여 물성분석을 수행하였다. 소성한 석회석에 비산재를 혼합하여 수화시킨 'fly ash 개량흡수제'는 SO_2와 NO_x를 동시에 효율적으로 제거할 수 있었으며, 비산재를 첨가하여 제조한 개량흡수제가 첨가하지 않은 흡수제에 비하여 SO_2와 NO_x 동시제거에 더 효과적이었다. 이러한 실험결과는 석회석과 개량흡수제에 비산재의 첨가로 인하여 규산캄슘 등과 같은 수화물 생성으로 인하여 포졸란반응이 유도되어 'fly ash 개량흡수제'의 비표면적과 흡습성 등이 증가되었기 때문이다. 또한, 비산재를 SO_2 및 NO_x 동시제거용 첨가제로 활용하기 위한 비산재와 개량흡수제의 최적 첨가비율은 1:9인 것으로 나타났다. The simultaneous removal of SO_2 and NO_x by advanced absorbent from coal fly ash was examined in a packed bed reactor. Also, the physicochemical properties of prepared absorbents have been measured using ICP, BET, SEM-EDX and XRD. We have found that both SO_2 and NO_x in dimulated flue gas can be effectively removed by use of fly ash advanced absorbent which was prepared by hydration of calcined limestone with or without coal fly ash. The addition of fly ash into the absorbents can result in the highly efficient simultaneous removal of SO_2 and NO_x from simulated flue gas. This is because the addition of fly ash into limestone and advanced absorbent increases the specific surface area and hygroscopicity of fly ash advanced absorbents by pozzolanic reaction which leads to the formation of calcium silicate compounds. The test results indicated that the optimal mixing ratio of fly ash to advanced absorbent sample is about 1:9 for the effective removal of SO_x/NO_x.

The Expression of p53 and erbB2 in Esophaseal Squamous Cell Carcinoma

( Hyun Young Kim ),( Sung Hoon Kim ),( Hyun Iyong Park ),( Ki Whan Kim ),( Moo In Park ),( Seun Ja Park ),( Ja Young Koo ) 대한내과학회 2001 대한내과학회 추계학술대회 Vol.61 No.-

사람의 연대와 하나님의 연민

오현선(Hyun Seun Oh) 한국여신학자협의회 2016 한국여성신학 Vol.- No.82

식물성 유용물질을 함유하는 초분자체 화장제재의 콜라겐 증가 및 육모효과

조현남 ( Hyun-nam Cho ),유동찬 ( Dong-chan Yoo ),김경란 ( Kyoung-ran Kim ),변혜정 ( Hae-jung Byun ),김정현 ( Jung-hyun Kim ),박혜빈 ( Hye-bin Park ),방대석 ( Dae-suk Bang ),양선아 ( Seun-ah Yang ),강공원 ( Gong-won Khang ),지광환 대한화장품학회 2012 대한화장품학회지 Vol.38 No.1

약용식물은 피부와 모발을 보호하는 잠재적 기능을 가지고 있다고 알려져 있다. 수용성 호스트 β-cyclodextrin 과 약용식물의 기능성 성분들과의 복합체 형성 시 나타나는 피부와 모발에 미치는 효과에 대하여 조사하였다. 기존의 연구에서 복합체 형성물의 무독성, 그리고 그람양성균과 비듬을 발생시키는 곰팡이에 대한 항균기능성을 확인하였다. 본 연구에서는 약용식물의 기능성 성분을 함유한 크림이 피부의 콜라젠 생성을 유도하여 피부의 생리활성을 증대시킴을 확인하였다. 또한 기능성 성분을 함유한 헤어토닉 처리군에서 육모의 성장이 증진되었음을 생쥐를 이용한 동물실험에서 확인하였다. 본 연구 결과, 비수용성 약용성분을 수용성 β-cyclodextrin에 포접시켜 초분자 복합체 형성을 통해, 육모기능의 향상과 피부노화지연 등 부가적 화장제재로의 개발가능성을 보여주었다. Medicinal herbs have been shown to have protective functions for skin and hair. We investigated the effects of complex of soluble β-cyclodextrin and phytochemicals on the functions of skin and hair. In previous report, we evaluated the safety of supramolecules and found their anti-microbial effects and anti-fungal effect against Gram (+) and Malassezia furfur which is known to cause dandruff. Here we present that functional supramolecules-containing cream promotes the biological skin activity by inducing the collagen formation. And treatment of supramolecules-containing hair tonic increased the rate of hair growth of mouse. Taken together, supramolecular cosmetic compounds containing water insoluble phytochemicals and water soluble β-cyclodextrin exhibit the potential ability for hair growth promotion and delaying the aging of skin.