정신과 문제로 병사용 진단서를 발급받은 환자들의 임상적 특징

장혁진,김학렬,박상학,김상훈,조용래,표경식 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : Most Korean young men should take a military physical examination. This study attempted to search the social, economical and psychological features of Korean youths who have psychiatric problems in taking the military physical examination. So this study was intended to help decide whether the youths enter the military service or not. Materials and Methods : This study analyzed diagnostic features that were grouped by 7 categories (antisocial and borderline personality disorder group, the other personality disorders group, psychosis group, organic mental disorder group, neurosis group, pervasive developmental disorders group, the other groups). The study was conducted from 1994 to May 1999 at Chosun University hospital with about 143 patients who were issued the psychiatric certificate for military affairs. Results : According to the results of the psychiatric examination, the antisocial and borderline personality disorder group had increased more year by year than the other groups. Classified by the residential distribution, the residents of agricultural areas belonged to the psychosis group more than others. Classified by the job distribution, the antisocial and borderline personality disorder group had more gangsters than the other groups. Also the pervasive developmental disorders group included those Who were without an occupation. Classified by visiting companion, those who were included in the antisocial and borderline personality disorder group and pervasive developmental disorders group used to come alone as compared with the other groups. In the case of those who have experienced psychiatric treatment in the past and who have been treated psychiatrically after being given the psychiatric certificate, the psychosis group comprised more than 50% statistically. In the case of the existence of a tattoo and self-injured scars, the antisocial and borderline personality disorder group has more than the others statistically. According to psychological examination, by measure of validity scale of MMPI, the antisocial and borderline personality disorder group appeared as the inverted V shape that L, K value was low and F value was high. And the antisocial and borderline personality disorder group measured by the Pd, Pa measure. Pd, Pa measure value got higher points than the organic mental disorder group statistically. Conclusion : The number of the antisocial and borderline personality disorder patients’ visits increased at the psychiatric hospital year by year and there were many gangsters or persons without regular occupation in that kind of patients’group. And there were many visitors who came by themselves to the hospital. Also they tended to have a tattoo or self-injured scars. And most of patients didn’t do commuting psychiatric care after receiving the psychiatric certificate. In the aspect of the psychological examination, they were likely to exaggerate their symptoms or disguise having psychiatric trouble intentionally.

ATM망 트래픽 제어 알고리즘 연구

유진호,손준영,안재환,박성우,김명수,장혁수 明知大學校 産業技術硏究所 1996 産業技術硏究所論文集 Vol.15 No.-

ATM(Asynchronous Transfer Mode) is a transmission technique for the B-lSDN(Broadband Integrated Service Digital Network). Congestion problems are unavoidable in the ATM networks, since various traffic typos coexist in the networks. The preventive congestion control algorithm is widely used for the real time traffics such as voice and video. The reactive congestion control algorithm works well for the non-real time traffic within a short distance. A mixed traffic control algorithm is proposed, which works either preventively or reactively based on traffic types. The proposed algorithm sets a high and low threshold value at the output buffers and modifies the EPRCA(Enhanced Proportion Rate Control Algorithm) to control loss-sensitive cells. Delay-sensitive cells are handled by the priority control and the UPC(Usage Parameter Control) algorithm. The performance analysis shows that the proposed traffic control algorithm works well for both the VBR(Variab1e Bit Rate) and ABR(Available Bit Rate) traffic with small buffers

GMAHN 환경에 적응하는 에러 복구기능을 이용한 AODV 라우팅 프로토콜

정찬혁,오세덕,배진승,이기원,장양근,이광배,김현욱,유충렬,하재승 明知大學校 産業技術硏究所 2006 産業技術硏究所論文集 Vol.25 No.-

Mobile nodes in ad hoc mobile networks typically communicate over wireless channels and are capable of movement. These are networks that support multihop communication and can be formed on a temporary basis. This paper proposes a solution that allows mobile nodes to access the wired Internet and to roam from base station to base station. And we also develop the efficient method that adapts in Global MANET which can be changed over time. It is observed that we can reduce not only error detection time but also network load, thus increasing the data reception rate in Global MANET Environment.

PCA와 ANN을 이용한 VOC 측정기기 개발

이장훈,권혁구,박승호,김동진,홍철호 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.2

Air quality monitoring is a primary activity for industrial and social environment. The government identifies the pollutants that each industry must monitor. Especially, the VOCs(Volatile Organic Compounds), which are very harmful to human body and environment atmosphere, should be controlled under the government policy. However, the VOCs, which have not been confirmed in emission sources are very difficult to monitor. It is needed to develop the monitoring system that allow the continuous and in situ measurement of VOCs mixture in different environmental matrices. Gas chromatography and mass spectrometry are the most prevalent current techniques among those available for the analysis of VOCs. But, they need a large size analytical instrument, which costs a great deal for purchase and operation. In addition, it has some limitations for real time environmental monitoring such as location problems and slow processing time. Recently, several companies have commercialized a portable VOCs measurement systems, which cannot classify various kinds of VOCs but total quantities. We have developed a VOCs measurement system, which recognizes various kinds and quantities of VOCs, such as benzene, toluene, and xylene(BTX). Also, it can be used as a stand-alone type and/or fixed type in the vehicle with rack for real-time environmental monitoring.

일 대학병원에 입원한 주요우울장애의 증상 특성

이진,김상훈,김학렬,박상학,황걸,장혁진 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Objectives: The purpose of this study was to investigate the frequency and kinds of symptoms and the profile of depressive symptoms and somatic symptoms of admitted patients with major depressive disorder in a university hospital. Methods: The study was cross-sectional study in Chosun university hospital. A total of 299 patients who met the diagnostic criteria of major depressive disorder according to DSM-IV were participated in this study. Forty four item questionnaires were developed to check symptoms and the questionnaires checked from patient's medical record. Results: Common depressive symptoms were the following order: depressive mood (55.2%), initial insomnia (52.8%), anxious/tense (47.8%), tired/no energy (35.1%), suicidal ideation (28.8%). Common somatic symptoms were the following order: decreased appetite (33.1%), headache (22.1%). gastric discomfort (16.7%), palpitation (15.4%), chest discomfort (11.4%). Comparing depressive symptoms and somatic symptoms in terms of gender, anxious/tense, emotional/cry a lot, decreased appetite, gastric discomfort, palpitation, were more frequent in female patients (p<0.05), On the other hand, interpersonal sensitivity, pessimism were more frequent in male patients (p<0.05). Elderly depressed patients showed hypochondriasis symptom more frequently than younger patients (p<0.05). Conclusion: These results suggested that the depressive symptoms showed dissimilar in character according to the gender and age. Therefore proper diagnostic and therapeutic approaches will be needed for each patient's symptom characteristics.

중간뇌 중심회색질에서 Calbindin-D_(28K)의 신경해부학적 표지성

김상훈,장혁진,이진 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Purpose: We investigated whether the calbindin-D_(28K) (CB) immunoreactivity could be available as a neurochemical marker to identify different anatomical subdivisions in the midbrain periaqueductal gray (PAG) of laboratory animals. Materials and Methods: Immunohistochemistry for CB and histochemistry for cytochrome oxidase (CO) were carried out on coronally-sectioned midbrain slices of five species of animals including mice, hamsters, rats, rabbits and guinea pigs. Results: In the rat PAG, at the level of nucleus of trochlear nerve, CB immunoreactive perikarya and plexus of fibers were localized in three band-like areas including dorsolateral PAG (DL), the ventral part of lateral PAG (Lv) and the supraoculomotor cap nucleus (Su3C). The similar pattern in the distribution of CB immunoreactivity was noticed also in the rabbit and the guinea pig PAG at the corresponding level, with three areas of DL, Lv and the ventral part of ventrolateral PAG. In all the 5 species of animals, Su3C was readily marked with clusters of CB-immunoreactive perikarya and fibers. In the comparison between the CB-immunoreactivity and the CO activity in the PAG, CB-immunoreactive areas were coincidided with areas of the low CO activity. Conclusion: The present data suggest that the CB immunoreactivity can be regarded as a reliable neurochemical marker for the specific areas within the midbrain PAG.

센서 어레이를 이용한 휘발성유기화합물 측정기기 개발

홍철호,김동진,이장훈,권혁구 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.1

Air quality monitoring is a primary activity for industrial and social environment. The government push for pollutants that must be monitored. Especially, the VOCs(Volatile Organic Compounds), which are very harmful for human and environment, should be controlled under the government policy. We have been developed a VOCs measurement system which recognize various kinds and quantities of VOCs, such as benzene, toluene, and xylene(BTX). Especially, we designed sensor array with various kinds of gas sensor and ANN(Artificial Neural Network) algorithm. The measured values for BTX have errors of 1~4ppm.

CT 유도하의 경피적 폐생검 : 임상적 의의 및 합병증에 관한 연구 A Study of Clinical Significance and Complication

박재성,백상현,차장규,홍현숙,김대호,박성진,조준희,임한혁,이혜경 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2

Purpose : To determine the diagnostic accuracy and predicting factor of pneumothorax on CT-guided percutaneous transthoracic needle biopsy. Materials and Methods : Using automated biopsy devices, 107 CT-guided percutaneous needle biopsies of pulmonary lesions were performed. Final diagnosis was made with operation or other methods. We retrospectively analyzed the frequency of complications and diagnostic yields of 107 biopsies. The clinical features, treatment, and courses of complications were reviewed, and risk factors of pneumothorax such as depth and size of lesion, CT emphysema score of whole lung and pathway of needle, and the result of pulmonary function test were analyzed. Result : 96 biopsies(89.7%) yielded sufficient tissue for pathologic evaluation. For cases of malignant and benign disease, sensitivity was 91.5% and 87.5% respectively; the corresponding figures for diagnostic accuracy were 88.1% and 77.1%. So, sensitivity and diagnostic accuracy of percutaneous transthoracic needle biopsy was 89.7% and 83.2%. Eighteen(16.8%) of 107 patients developed pneumothorax and 3 of these required application of chest tube or percutaneous catheter drainage. In the group with pneumonthorax, the lesion was significantly smaller(p=0.029) and higher CT emphysema score of pathway of needle(p=0.032). But there were no significant difference between two groups(with or without pneumothorax) for depth of lesion, pulmonary function test(% predictive value of FEV1 and FEV1/FVC) and CT emphysema score of whole lung. Conclusion : CT-guided transthoracic needle biopsy of the pulmonary lesions is safe and easy method of obtaining specimens of good quality and quantity. It may be an useful procedure in the diagnosis of localized pulmonary lesions. For the prediction of pneumothorax, size of lesion and CT emphysema score of pathway of a needle are significant risk factors.

Activin Receptor-Like Kinase 5 Inhibitor Attenuates Fibrosis in Fibroblasts Derived from Peyronie's Plaque

Jang, Jin Hyuk,Ryu, Ji Kan,Suh, Jun Kyu 대한비뇨기과학회 2012 Investigative and Clinical Urology Vol.53 No.1

<P><B>Purpose</B></P><P>Transforming growth factor-β1 (TGF-β1) is the key fibrogenic cytokine associated with Peyronie's disease (PD). The aim of this study was to determine the antifibrotic effect of 3-((5-(6-Methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1<I>H</I>-imidazol-2-yl) methyl)benzamide (IN-1130), a small-molecule inhibitor of the TGF-β type I receptor activin receptor-like kinase 5 (ALK5), in fibroblasts isolated from human PD plaque.</P><P><B>Materials and Methods</B></P><P>Plaque tissue from a patient with PD was used for primary fibroblast culture, and we then characterized primary cultured cells. Fibroblasts were pretreated with IN-1130 (10 µM) and then stimulated with TGF-β1 protein (10 ng/ml). We determined the inhibitory effect of IN-1130 on TGF-β1-induced phosphorylation of Smad2 and Smad3 or the nuclear translocation of Smad proteins in fibroblasts. Western blot analyses for plasminogen activator inhibitor-1, fibronectin, collagen I, and collagen IV were performed to evaluate effect of IN-1130 on the production of extracellular matrix proteins.</P><P><B>Results</B></P><P>The treatment of fibroblasts with TGF-β1 significantly increased phosphorylation of Smad2 and Smad3 and induced translocation of Smad proteins from the cytoplasm to the nucleus. Pretreatment with IN-1130 substantially inhibited TGF-β1-induced phosphorylation of Smad2 and Smad3 and nuclear accumulation of Smad proteins. The TGF-β1-induced production of extracellular matrix proteins was also significantly inhibited by treatment with IN-1130 and returned to basal levels.</P><P><B>Conclusions</B></P><P>Overexpression of TGF-β and activation of Smad transcriptional factors are known to play a crucial role in the pathogenesis of PD. Thus, inhibition of the TGF-β signaling pathway by ALK5 inhibitor may represent a promising therapeutic strategy for treating PD.</P>

Advanced thin gas barriers film incorporating alternating structure of PEALD-based Al₂O₃/organic-inorganic nanohybrid layers

Jang, Jin Hyuk,Kim, Nahae,Li, Xinlin,An, Tae Kyu,Kim, Juyoung,Kim, Se Hyun Elsevier 2019 APPLIED SURFACE SCIENCE - Vol.475 No.-

<P><B>Abstract</B></P> <P>In this work, we reported excellent plasma-enhanced atomic layer deposition (PEALD)-based Al<SUB>2</SUB>O<SUB>3</SUB>/organic-inorganic (O-I) nanohybrid gas barrier film which exhibits ultralow water vapor transmission rate (WVTR), high activation energy for permeation, high optical transmission in visible light and sufficient flexibility. The values of WVTR and activation energy for permeation of our PEALD-based Al<SUB>2</SUB>O<SUB>3</SUB>/O-I nanohybrid 4 pair gas barrier film are obtained to be 7.83 × 10<SUP>−5</SUP> g/m<SUP>2</SUP>/day (60 °C, 90% RH) and 103.10 kJ/mol via the electrical calcium test. Optical transmission in visible light is 96.14% and critical bending radius 7 mm–9 mm. Introduction of O-I nanohybrid layers between PEALD-based Al<SUB>2</SUB>O<SUB>3</SUB> layers improved the properties of gas barrier films on anticorrosion, adhesion, and flexibility.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We demonstrated excellent Al<SUB>2</SUB>O<SUB>3</SUB>/organic-inorganic (O-I) nanohybrid gas barrier film. </LI> <LI> This barrier film provides good adhesion between O-I nanohybrid and Al<SUB>2</SUB>O<SUB>3</SUB> layers. </LI> <LI> This flexible and transparent film exhibits ultralow WVTR (7.83 × 10<SUP>−5</SUP> g/m<SUP>2</SUP>/day). </LI> </UL> </P>